{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T21:05:55Z","timestamp":1789074355522,"version":"build-2803163510"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32371174"],"award-info":[{"award-number":["32371174"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32171121"],"award-info":[{"award-number":["32171121"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700462"],"award-info":[{"award-number":["81700462"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.ejphar.2026.179278","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T15:11:31Z","timestamp":1787411491000},"page":"179278","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Activation of the dopamine D2 receptor enhances colonic motility via disinhibition of somatostatinergic signalling in rodents"],"prefix":"10.1016","volume":"1033","author":[{"given":"Cai-Feng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8802-4872","authenticated-orcid":false,"given":"Jun-Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4513-4622","authenticated-orcid":false,"given":"Jin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9478-3290","authenticated-orcid":false,"given":"Jin-Xia","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ejphar.2026.179278_bib1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3390\/ijms27010271","article-title":"Dopamine and the gut microbiota: interactions within the microbiota-gut-brain axis and therapeutic perspectives","volume":"27","author":"Barbu","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"10291","key":"10.1016\/j.ejphar.2026.179278_bib2","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","article-title":"Parkinson's disease","volume":"397","author":"Bloem","year":"2021","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.ejphar.2026.179278_bib3","doi-asserted-by":"crossref","DOI":"10.1177\/17562848251321123","article-title":"Itopride in functional dyspepsia: open-label, 1-year treatment follow-up of two multicenter, randomized, double-blind, placebo-controlled trials","volume":"18","author":"Broeders","year":"2025","journal-title":"Therapeut. Adv. Gastroenterol."},{"issue":"30","key":"10.1016\/j.ejphar.2026.179278_bib4","doi-asserted-by":"crossref","first-page":"5486","DOI":"10.3748\/wjg.v23.i30.5486","article-title":"Influence of gut microbiota on neuropsychiatric disorders","volume":"23","author":"Cenit","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.ejphar.2026.179278_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2019.104700","article-title":"Autonomic dysfunction in Parkinson'S disease: implications for pathophysiology, diagnosis, and treatment","volume":"134","author":"Chen","year":"2020","journal-title":"Neurobiol. Dis."},{"issue":"6","key":"10.1016\/j.ejphar.2026.179278_bib6","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/j.cell.2020.08.003","article-title":"The human and mouse enteric nervous system at single-cell resolution","volume":"182","author":"Drokhlyansky","year":"2020","journal-title":"Cell"},{"issue":"18","key":"10.1016\/j.ejphar.2026.179278_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241814377","article-title":"Slowed intestinal transit induced by less mucus in intestinal goblet cell piezo1-deficient mice through impaired epithelial homeostasis","volume":"24","author":"Fang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"14","key":"10.1016\/j.ejphar.2026.179278_bib8","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.1111\/bph.15047","article-title":"Source of dopamine in gastric juice and luminal dopamine-induced duodenal bicarbonate secretion via apical dopamine d(2) receptors","volume":"177","author":"Feng","year":"2020","journal-title":"Br. J. Pharmacol."},{"issue":"8","key":"10.1016\/j.ejphar.2026.179278_bib9","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/S0028-3908(00)00035-6","article-title":"Selective somatostatin sst(2) receptor blockade with the novel cyclic octapeptide, cyn-154806","volume":"39","author":"Feniuk","year":"2000","journal-title":"Neuropharmacology"},{"issue":"2","key":"10.1016\/j.ejphar.2026.179278_bib10","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1124\/jpet.115.228510","article-title":"Enteric dysfunctions in experimental Parkinson'S disease: alterations of excitatory cholinergic neurotransmission regulating colonic motility in rats","volume":"356","author":"Fornai","year":"2016","journal-title":"J. Pharmacol. Exp. Therapeut."},{"issue":"18","key":"10.1016\/j.ejphar.2026.179278_bib11","doi-asserted-by":"crossref","first-page":"4461","DOI":"10.3390\/ijms20184461","article-title":"Somatostatin as an active substance in the mammalian enteric nervous system","volume":"20","author":"Gonkowski","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.ejphar.2026.179278_bib12","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.amjmed.2019.03.001","article-title":"Parkinson's disease and parkinsonism","volume":"132","author":"Hayes","year":"2019","journal-title":"Am. J. Med."},{"issue":"8","key":"10.1016\/j.ejphar.2026.179278_bib13","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.tim.2020.11.007","article-title":"Microbial modulation of the development and physiology of the enteric nervous system","volume":"29","author":"Joly","year":"2021","journal-title":"Trends Microbiol."},{"issue":"8","key":"10.1016\/j.ejphar.2026.179278_bib14","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1038\/aps.2017.159","article-title":"Pharmacokinetic and pharmacodynamic evidence for developing an oral formulation of octreotide against gastric mucosal injury","volume":"39","author":"Li","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"issue":"3","key":"10.1016\/j.ejphar.2026.179278_bib15","doi-asserted-by":"crossref","first-page":"C393","DOI":"10.1152\/ajpcell.00261.2017","article-title":"Dopamine promotes colonic mucus secretion through dopamine d(5) receptor in rats","volume":"316","author":"Li","year":"2019","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"20","key":"10.1016\/j.ejphar.2026.179278_bib16","doi-asserted-by":"crossref","first-page":"R979","DOI":"10.1016\/j.cub.2025.08.020","article-title":"The enteric nervous system","volume":"35","author":"Linden","year":"2025","journal-title":"Curr. Biol. : CB"},{"issue":"11","key":"10.1016\/j.ejphar.2026.179278_bib17","article-title":"Rasagiline, an inhibitor of mao-b, decreases colonic motility through elevating colonic dopamine content","volume":"30","author":"Liu","year":"2018","journal-title":"Neuro Gastroenterol. Motil."},{"issue":"3","key":"10.1016\/j.ejphar.2026.179278_bib18","doi-asserted-by":"crossref","first-page":"C327","DOI":"10.1152\/ajpcell.00385.2021","article-title":"Activation of dopamine d(2) receptor promotes pepsinogen secretion by suppressing somatostatin release from the mouse gastric mucosa","volume":"322","author":"Liu","year":"2022","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"7","key":"10.1016\/j.ejphar.2026.179278_bib19","article-title":"Berberine improves depression-like behaviors and gastrointestinal dysfunction in 6-hydroxydopamine-induced Parkinson'S disease rats","volume":"37","author":"Liu","year":"2025","journal-title":"Neuro Gastroenterol. Motil."},{"issue":"41","key":"10.1016\/j.ejphar.2026.179278_bib20","doi-asserted-by":"crossref","first-page":"5657","DOI":"10.3748\/wjg.v29.i41.5657","article-title":"Colorectal motility patterns and psychiatric traits in functional constipation and constipation-predominant irritable bowel syndrome: a study from China","volume":"29","author":"Lv","year":"2023","journal-title":"World J. Gastroenterol."},{"issue":"4","key":"10.1016\/j.ejphar.2026.179278_bib21","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/s41590-025-02097-8","article-title":"An sstr2-somatostatin chemotactic axis drives t cell progenitor homing to the intestines","volume":"26","author":"Oc\u00f3n","year":"2025","journal-title":"Nat. Immunol."},{"issue":"5","key":"10.1016\/j.ejphar.2026.179278_bib22","doi-asserted-by":"crossref","first-page":"558","DOI":"10.3390\/biology14050558","article-title":"The role of somatostatin in the gastrointestinal tract","volume":"14","author":"Papantoniou","year":"2025","journal-title":"Biology"},{"issue":"10","key":"10.1016\/j.ejphar.2026.179278_bib23","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.3390\/microorganisms12102036","article-title":"Impact of enteric nervous cells on irritable bowel syndrome: potential treatment options","volume":"12","author":"Pastras","year":"2024","journal-title":"Microorganisms"},{"issue":"2","key":"10.1016\/j.ejphar.2026.179278_bib24","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1006\/bbrc.1994.1088","article-title":"All five cloned human somatostatin receptors (hsstr1-5) are functionally coupled to adenylyl cyclase","volume":"198","author":"Patel","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.ejphar.2026.179278_bib25","doi-asserted-by":"crossref","first-page":"G345","DOI":"10.1152\/ajpgi.00225.2023","article-title":"Gastrointestinal dysmotility in rodent models of Parkinson'S disease","volume":"326","author":"Pellegrini","year":"2024","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"10","key":"10.1016\/j.ejphar.2026.179278_bib26","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1111\/ejn.16307","article-title":"Characterizing enteric neurons in dopamine transporter (dat)-cre reporter mice reveals dopaminergic subtypes with dual-transmitter content","volume":"59","author":"Recinto","year":"2024","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ejphar.2026.179278_bib27","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev-physiol-021317-121515","article-title":"Unexpected roles for the second brain: enteric nervous system as master regulator of bowel function","volume":"81","author":"Schneider","year":"2019","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.ejphar.2026.179278_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.autneu.2022.103041","article-title":"The multiple roles of dopamine receptor activation in the modulation of gastrointestinal motility and mucosal function","volume":"244","author":"Serio","year":"2023","journal-title":"Auton Neurosci. Basic Clin."},{"key":"10.1016\/j.ejphar.2026.179278_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.652363","article-title":"Versatile functions of somatostatin and somatostatin receptors in the gastrointestinal system","volume":"12","author":"Shamsi","year":"2021","journal-title":"Front. Endocrinol."},{"issue":"2","key":"10.1016\/j.ejphar.2026.179278_bib30","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1152\/physrev.00018.2022","article-title":"The enteric nervous system","volume":"103","author":"Sharkey","year":"2023","journal-title":"Physiol. Rev."},{"issue":"5","key":"10.1016\/j.ejphar.2026.179278_bib31","doi-asserted-by":"crossref","first-page":"C1409","DOI":"10.1152\/ajpcell.00993.2024","article-title":"Blocking dopamine receptor 2 decreases gastrin levels in h. Pylori-infected mice through increasing gastric somatostatin content","volume":"328","author":"Shen","year":"2025","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"4","key":"10.1016\/j.ejphar.2026.179278_bib32","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1600-0404.2009.01178.x","article-title":"Serum somatostatin in early-stage Parkinson'S disease","volume":"121","author":"Shiraishi","year":"2010","journal-title":"Acta Neurol. Scand."},{"issue":"10","key":"10.1016\/j.ejphar.2026.179278_bib33","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.3390\/biomedicines13102400","article-title":"Intranasal 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) administration hampered contractile response of dopamine in isolated rat ileum","volume":"13","author":"Silva","year":"2025","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.ejphar.2026.179278_bib34","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41531-022-00295-x","article-title":"Gastrointestinal involvement in Parkinson'S disease: pathophysiology, diagnosis, and management","volume":"8","author":"Warnecke","year":"2022","journal-title":"npj Parkinson's Dis."},{"issue":"1","key":"10.1016\/j.ejphar.2026.179278_bib35","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1210\/endrev\/bnae022","article-title":"Structure and function of somatostatin and its receptors in endocrinology","volume":"46","author":"Zhang","year":"2025","journal-title":"Endocr. Rev."},{"issue":"5","key":"10.1016\/j.ejphar.2026.179278_bib36","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.trsl.2012.01.002","article-title":"Dopamine receptor d1 mediates the inhibition of dopamine on the distal colonic motility","volume":"159","author":"Zhang","year":"2012","journal-title":"Transl. Res. : J. Lab. Clin. Med."},{"issue":"2","key":"10.1016\/j.ejphar.2026.179278_bib37","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.trsl.2015.02.003","article-title":"Alteration of enteric monoamines with monoamine receptors and colonic dysmotility in 6-hydroxydopamine-induced Parkinson'S disease rats","volume":"166","author":"Zhang","year":"2015","journal-title":"Transl. Res. : J. Lab. Clin. Med."},{"issue":"3","key":"10.1016\/j.ejphar.2026.179278_bib38","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/bph.16226","article-title":"Dopamine regulates colonic glial cell-derived neurotrophic factor secretion through cholinergic dependent and independent pathways","volume":"181","author":"Zhang","year":"2024","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179278_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.770841","article-title":"Enhanced contractive tension and upregulated muscarinic receptor 2\/3 in colorectum contribute to constipation in 6-hydroxydopamine-induced Parkinson'S disease rats","volume":"13","author":"Zhang","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.ejphar.2026.179278_bib40","series-title":"Dopamine in the Gut","author":"Zhu","year":"2021"},{"issue":"4","key":"10.1016\/j.ejphar.2026.179278_bib41","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.cell.2021.01.027","article-title":"Structural insights into the human d1 and d2 dopamine receptor signaling complexes","volume":"184","author":"Zhuang","year":"2021","journal-title":"Cell"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926007600?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926007600?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:06:58Z","timestamp":1789070818000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299926007600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":41,"alternative-id":["S0014299926007600"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.179278","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of the dopamine D2 receptor enhances colonic motility via disinhibition of somatostatinergic signalling in rodents","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.179278","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"179278"}}