{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:55:56Z","timestamp":1791471356167,"version":"4.3.4"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82571948"],"award-info":[{"award-number":["82571948"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.ejphar.2026.179342","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T09:44:26Z","timestamp":1789119866000},"page":"179342","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Bradykinin signaling axis promotes inflammatory cervical remodeling under LPS-induced maternal systemic inflammation via MAPK-mediated PTGS2 upregulation"],"prefix":"10.1016","volume":"1035","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4188-2551","authenticated-orcid":false,"given":"Yijie","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Ru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liling","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.ejphar.2026.179342_bib1","doi-asserted-by":"crossref","DOI":"10.1111\/aji.70085","article-title":"Decreased IL-33 expression in the cervix in LPS-induced preterm birth and the potential role of mast cells: a murine model","volume":"93","author":"Avci","year":"2025","journal-title":"Am. J. Reprod. Immunol."},{"issue":"7","key":"10.1016\/j.ejphar.2026.179342_bib2","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41577-021-00634-8","article-title":"Crosstalk between the renin-angiotensin, complement and kallikrein-kinin systems in inflammation","volume":"22","author":"Bekassy","year":"2022","journal-title":"Nat. Rev. Immunol."},{"issue":"Suppl. 2","key":"10.1016\/j.ejphar.2026.179342_bib3","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12978-025-02033-x","article-title":"Born too soon: global epidemiology of preterm birth and drivers for change","volume":"22","author":"Bradley","year":"2025","journal-title":"Reprod. Health"},{"issue":"1","key":"10.1016\/j.ejphar.2026.179342_bib4","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/s41467-022-28620-1","article-title":"Microbial-driven preterm labour involves crosstalk between the innate and adaptive immune response","volume":"13","author":"Chan","year":"2022","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.ejphar.2026.179342_bib5","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/s41372-019-0563-y","article-title":"Preterm birth and mortality in adulthood: a systematic review","volume":"40","author":"Crump","year":"2020","journal-title":"J. Perinatol."},{"issue":"9","key":"10.1016\/j.ejphar.2026.179342_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/ph13090215","article-title":"Kinins and their receptors in infectious diseases","volume":"13","author":"Dagnino","year":"2020","journal-title":"Pharmaceuticals"},{"issue":"5","key":"10.1016\/j.ejphar.2026.179342_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/children10050907","article-title":"Maternal infection and preterm birth: from molecular basis to clinical implications","volume":"10","author":"Daskalakis","year":"2023","journal-title":"Children"},{"issue":"5","key":"10.1016\/j.ejphar.2026.179342_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0020036","article-title":"Cleavage of kininogen and subsequent bradykinin release by the complement component: mannose-binding lectin-associated serine protease (MASP)-1","volume":"6","author":"Dob\u00f3","year":"2011","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.ejphar.2026.179342_bib9","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1016\/S0002-9440(10)63567-5","article-title":"A new model for inflammation-induced preterm birth: the role of platelet-activating factor and toll-like receptor-4","volume":"163","author":"Elovitz","year":"2003","journal-title":"Am. J. Pathol."},{"issue":"11","key":"10.1016\/j.ejphar.2026.179342_bib10","article-title":"Unlocking the cervix: biological mechanisms and research gaps in preterm birth","volume":"16","author":"F\u00e9lix","year":"2024","journal-title":"Cureus"},{"issue":"6","key":"10.1016\/j.ejphar.2026.179342_bib11","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1007\/s00404-024-07902-7","article-title":"Cellular dynamics of cervical remodelling: insights from preterm and term labour","volume":"311","author":"F\u00e9lix","year":"2025","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.ejphar.2026.179342_bib12","first-page":"811","article-title":"Transcriptomic analysis of cervical remodeling impairment in preterm birth rats induced by lipopolysaccharide","author":"Gao","year":"2025","journal-title":"J. Tongji Univ. (Med. Sci.)"},{"issue":"6","key":"10.1016\/j.ejphar.2026.179342_bib13","doi-asserted-by":"crossref","first-page":"R1024","DOI":"10.1152\/ajpregu.00664.2003","article-title":"Maternal LPS induces cytokines in the amniotic fluid and corticotropin releasing hormone in the fetal rat brain","volume":"286","author":"Gayle","year":"2004","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"9606","key":"10.1016\/j.ejphar.2026.179342_bib14","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(08)60074-4","article-title":"Epidemiology and causes of preterm birth","volume":"371","author":"Goldenberg","year":"2008","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.ejphar.2026.179342_bib15","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.ajpath.2011.04.024","article-title":"Complement activation triggers metalloproteinases release inducing cervical remodeling and preterm birth in mice","volume":"179","author":"Gonzalez","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ejphar.2026.179342_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1477-5751-8-1","article-title":"Failure of E. coli bacteria to induce preterm delivery in the rat","volume":"8","author":"Hirsch","year":"2009","journal-title":"J. Negat. Results Biomed."},{"key":"10.1016\/j.ejphar.2026.179342_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1228647","article-title":"Immune-checkpoint proteins, cytokines, and microbiome impact on patients with cervical insufficiency and preterm birth","volume":"14","author":"Jeong","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2026.179342_bib18","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.mce.2014.11.008","article-title":"Oxytocin activates NF-\u03baB-mediated inflammatory pathways in human gestational tissues","volume":"403","author":"Kim","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"issue":"1","key":"10.1016\/j.ejphar.2026.179342_bib19","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1124\/pr.57.1.2","article-title":"International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences","volume":"57","author":"Leeb-Lundberg","year":"2005","journal-title":"Pharmacol. Rev."},{"issue":"10063","key":"10.1016\/j.ejphar.2026.179342_bib20","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1016\/S0140-6736(16)31593-8","article-title":"Global, regional, and national causes of under-5 mortality in 2000-15: an updated systematic analysis with implications for the Sustainable Development Goals","volume":"388","author":"Liu","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2026.179342_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1527065","article-title":"Bradykinin B1 receptor signaling triggers complement activation on endothelial cells","volume":"16","author":"Lopatko Fagerstr\u00f6m","year":"2025","journal-title":"Front. Immunol."},{"issue":"4s","key":"10.1016\/j.ejphar.2026.179342_bib22","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.1016\/j.ajog.2024.07.039","article-title":"Cervical function in pregnancy and disease: new insights from single-cell analysis","volume":"232","author":"Madhukaran","year":"2025","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"14","key":"10.1016\/j.ejphar.2026.179342_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/cells14141045","article-title":"Complement modulation mitigates inflammation-mediated preterm birth and fetal neural inflammation","volume":"14","author":"McElwee","year":"2025","journal-title":"Cells"},{"issue":"14","key":"10.1016\/j.ejphar.2026.179342_bib24","doi-asserted-by":"crossref","first-page":"6773","DOI":"10.1111\/jcmm.16681","article-title":"Pro-inflammatory signals induce 20\u03b1-HSD expression in myometrial cells: a key mechanism for local progesterone withdrawal","volume":"25","author":"Nadeem","year":"2021","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.ejphar.2026.179342_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.873727","article-title":"The bradykinin System contributes to the regulation of prostaglandin-endoperoxide synthase 2 expression in human amnion fibroblasts: implications for term and preterm birth","volume":"13","author":"Ni","year":"2022","journal-title":"Front. Endocrinol."},{"issue":"10409","key":"10.1016\/j.ejphar.2026.179342_bib26","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/S0140-6736(23)00878-4","article-title":"National, regional, and global estimates of preterm birth in 2020, with trends from 2010: a systematic analysis","volume":"402","author":"Ohuma","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2026.179342_bib27","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/2127642","article-title":"Chlorogenic acid as a positive regulator in LPS-PG-Induced inflammation via TLR4\/MyD88-Mediated NF-\u03baB and PI3K\/MAPK signaling cascades in human gingival fibroblasts","volume":"2022","author":"Park","year":"2022","journal-title":"Mediat. Inflamm."},{"issue":"2","key":"10.1016\/j.ejphar.2026.179342_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/diagnostics16020191","article-title":"Reframing cervical insufficiency as a dynamic process in the preterm birth continuum: from fixed disease to a modifiable condition","volume":"16","author":"Park","year":"2026","journal-title":"Diagnostics"},{"issue":"2","key":"10.1016\/j.ejphar.2026.179342_bib29","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S2352-4642(21)00311-4","article-title":"Global, regional, and national causes of under-5 mortality in 2000-19: an updated systematic analysis with implications for the Sustainable Development Goals","volume":"6","author":"Perin","year":"2022","journal-title":"Lancet Child Adolesc. Health"},{"issue":"1","key":"10.1016\/j.ejphar.2026.179342_bib30","doi-asserted-by":"crossref","first-page":"8234","DOI":"10.1038\/s41598-025-93282-0","article-title":"N,N-dimethylacetamide blocks inflammation-induced preterm birth and remediates maternal systemic immune responses","volume":"15","author":"Reznik","year":"2025","journal-title":"Sci. Rep."},{"issue":"6198","key":"10.1016\/j.ejphar.2026.179342_bib31","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1126\/science.1251816","article-title":"Preterm labor: one syndrome, many causes","volume":"345","author":"Romero","year":"2014","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.ejphar.2026.179342_bib32","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1055\/s-2006-956773","article-title":"The role of inflammation and infection in preterm birth","volume":"25","author":"Romero","year":"2007","journal-title":"Semin. Reprod. Med."},{"key":"10.1016\/j.ejphar.2026.179342_bib33","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.jare.2020.05.021","article-title":"Modulation of proteomic and inflammatory signals by Bradykinin in podocytes","volume":"24","author":"Saoud","year":"2020","journal-title":"J. Adv. Res."},{"issue":"2","key":"10.1016\/j.ejphar.2026.179342_bib34","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1530\/jrf.0.0470319","article-title":"The influence of drugs on the kinin-forming system in relation to pregnancy and parturition in the rat","volume":"47","author":"Senior","year":"1976","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.ejphar.2026.179342_bib35","first-page":"1","article-title":"Basic and clinical aspects of bradykinin receptor antagonists","volume":"69","author":"Sharma","year":"2014","journal-title":"Prog. Drug Res."},{"issue":"6","key":"10.1016\/j.ejphar.2026.179342_bib36","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.1210\/jc.2004-1390","article-title":"The mitogen-activated protein kinase dependent expression of prostaglandin H synthase-2 and interleukin-8 messenger ribonucleic acid by myometrial cells: the differential effect of stretch and interleukin-1{beta","volume":"90","author":"Sooranna","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"8","key":"10.1016\/j.ejphar.2026.179342_bib37","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1055\/s-0030-1249366","article-title":"Maternal serum interleukin-6, C-reactive protein, and matrix metalloproteinase-9 concentrations as risk factors for preterm birth <32 weeks and adverse neonatal outcomes","volume":"27","author":"Sorokin","year":"2010","journal-title":"Am. J. Perinatol."},{"issue":"6","key":"10.1016\/j.ejphar.2026.179342_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0232493","article-title":"Synthetic PreImplantation Factor (sPIF) reduces inflammation and prevents preterm birth","volume":"15","author":"Spinelli","year":"2020","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.ejphar.2026.179342_bib39","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.tem.2010.01.011","article-title":"Cervical remodeling during pregnancy and parturition","volume":"21","author":"Timmons","year":"2010","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.ejphar.2026.179342_bib40","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.ejphar.2014.08.013","article-title":"Differential regulation of astrocyte prostaglandin response by kinins: possible role for mitogen activated protein kinases","volume":"741","author":"Torika","year":"2014","journal-title":"Eur. J. Pharmacol."},{"issue":"Pt 2","key":"10.1016\/j.ejphar.2026.179342_bib41","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1113\/jphysiol.2004.067462","article-title":"Functional bradykinin B1 receptors are expressed in nociceptive neurones and are upregulated by the neurotrophin GDNF","volume":"560","author":"Vellani","year":"2004","journal-title":"J. Physiol."},{"issue":"3","key":"10.1016\/j.ejphar.2026.179342_bib42","doi-asserted-by":"crossref","first-page":"G601","DOI":"10.1152\/ajpgi.00022.2008","article-title":"Lipopolysaccharide activates innate immune responses in murine intestinal myofibroblasts through multiple signaling pathways","volume":"296","author":"Walton","year":"2009","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ejphar.2026.179342_bib43","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1477-7827-5-3","article-title":"Plasma membrane receptor mediated MAPK signaling pathways are activated in human uterine cervix at parturition","volume":"5","author":"Wang","year":"2007","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.ejphar.2026.179342_bib44","doi-asserted-by":"crossref","DOI":"10.1038\/s41522-026-00960-6","article-title":"A microbiota-host axis mediates prostaglandin sensitivity: lactobacillus crispatus as a biomarker and regulator of human labor induction","author":"Wang","year":"2026","journal-title":"npj Biofilms Microbiomes"},{"issue":"7","key":"10.1016\/j.ejphar.2026.179342_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e28483","article-title":"Preterm birth, a consequence of immune deviation mediated hyperinflammation","volume":"10","author":"Wei","year":"2024","journal-title":"Heliyon"},{"issue":"1","key":"10.1016\/j.ejphar.2026.179342_bib46","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1476-5381.1978.tb08636.x","article-title":"The action of bradykinin and oxytocin on the isolated whole uterus and myometrium of the rat in oestrus","volume":"64","author":"Whalley","year":"1978","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.ejphar.2026.179342_bib47","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1055\/s-2006-956777","article-title":"Dynamics of cervical remodeling during pregnancy and parturition: mechanisms and current concepts","volume":"25","author":"Word","year":"2007","journal-title":"Semin. Reprod. Med."},{"issue":"4","key":"10.1016\/j.ejphar.2026.179342_bib48","doi-asserted-by":"crossref","DOI":"10.1530\/REP-25-0146","article-title":"Progesterone regulation of cervix ripening in preterm and term birth in mice","volume":"170","author":"Yellon","year":"2025","journal-title":"Reproduction"},{"issue":"7","key":"10.1016\/j.ejphar.2026.179342_bib49","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1093\/molehr\/8.7.681","article-title":"Prostaglandin F(2alpha), cytokines and cyclic mechanical stretch augment matrix metalloproteinase-1 secretion from cultured human uterine cervical fibroblast cells","volume":"8","author":"Yoshida","year":"2002","journal-title":"Mol. Hum. Reprod."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926008241?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926008241?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:20:00Z","timestamp":1791469200000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299926008241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":49,"alternative-id":["S0014299926008241"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.179342","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bradykinin signaling axis promotes inflammatory cervical remodeling under LPS-induced maternal systemic inflammation via MAPK-mediated PTGS2 upregulation","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.179342","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"179342"}}