{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:55:23Z","timestamp":1791471323171,"version":"4.3.4"},"reference-count":92,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Anusandhan National Research Foundation","doi-asserted-by":"publisher","award":["ANRF\/PAIR\/2025\/000029\/PAIR"],"award-info":[{"award-number":["ANRF\/PAIR\/2025\/000029\/PAIR"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","award":["191620090321"],"award-info":[{"award-number":["191620090321"]}],"id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.ejphar.2026.179359","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T15:19:54Z","timestamp":1789744794000},"page":"179359","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Targeting MicroRNAs in doxorubicin-induced cardiotoxicity: A systematic review of transfection studies"],"prefix":"10.1016","volume":"1035","author":[{"given":"Inderjit Singh","family":"Dhami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satinder","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurjit Kaur","family":"Bhatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarabjit Singh","family":"Mastana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5480-2584","authenticated-orcid":false,"given":"Jasvinder Singh","family":"Bhatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2026.179359_bib1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ijbiomac.2014.02.028","article-title":"Intercalation of antitumor drug doxorubicin and its analogue by DNA duplex: structural features and biological implications","volume":"66","author":"Agudelo","year":"2014","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejphar.2026.179359_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121390","article-title":"Metformin ameliorates doxorubicin-induced cardiotoxicity targeting HMGB1\/TLR4\/NLRP3 signaling pathway in mice","volume":"316","author":"Alzokaky","year":"2023","journal-title":"Life Sci."},{"issue":"9","key":"10.1016\/j.ejphar.2026.179359_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10092307","article-title":"A comprehensive review on collagen type I development of biomaterials for tissue engineering: from biosynthesis to bioscaffold","volume":"10","author":"Amirrah","year":"2022","journal-title":"Biomedicines"},{"issue":"10","key":"10.1016\/j.ejphar.2026.179359_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines13102331","article-title":"The role of miRNAs in chemotherapy-induced cardiotoxicity","volume":"13","author":"Anastasiou","year":"2025","journal-title":"Biomedicines"},{"issue":"4","key":"10.1016\/j.ejphar.2026.179359_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/toxics13040277","article-title":"Pathophysiology of doxorubicin-mediated cardiotoxicity","volume":"13","author":"Arrigoni","year":"2025","journal-title":"Toxics"},{"issue":"7","key":"10.1016\/j.ejphar.2026.179359_bib6","article-title":"Cancer therapy-related cardiotoxicity: a comprehensive retrospective analysis at Najran cancer center, Saudi Arabia","volume":"15","author":"Badheeb","year":"2023","journal-title":"Cureus"},{"issue":"3","key":"10.1016\/j.ejphar.2026.179359_bib7","doi-asserted-by":"crossref","first-page":"H1015","DOI":"10.1152\/ajpheart.00023.2006","article-title":"Cardiac fibroblasts: friend or foe?","volume":"291","author":"Baudino","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"5","key":"10.1016\/j.ejphar.2026.179359_bib8","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.jaccao.2024.07.016","article-title":"Anthracycline cardiotoxicity in adult cancer patients: JACC: cardiooncology State-of-the-Art review","volume":"6","author":"Camilli","year":"2024","journal-title":"JACC CardioOncol"},{"key":"10.1016\/j.ejphar.2026.179359_bib9","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/1521020","article-title":"Oxidative stress and cellular response to doxorubicin: a common factor in the complex milieu of anthracycline cardiotoxicity","author":"Cappetta","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ejphar.2026.179359_bib10","article-title":"Cardioprotective effect of paeonol on chronic heart failure induced by doxorubicin via regulating the miR-21-5p\/S-Phase kinase-associated protein 2 axis","volume":"9","author":"Chen","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"issue":"18","key":"10.1016\/j.ejphar.2026.179359_bib11","doi-asserted-by":"crossref","first-page":"14539","DOI":"10.18632\/oncotarget.24465","article-title":"Doxorubicin-induced loss of DNA topoisomerase II and DNMT1- dependent suppression of MiR-125b induces chemoresistance in ALK-positive cells","volume":"9","author":"Congras","year":"2018","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.ejphar.2026.179359_bib12","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s11192-016-1964-8","article-title":"Protocol for a retrospective, controlled cohort study of the impact of a change in nature journals' editorial policy for life sciences research on the completeness of reporting study design and execution","volume":"108","author":"Cramond","year":"2016","journal-title":"Scientometrics"},{"issue":"51","key":"10.1016\/j.ejphar.2026.179359_bib13","doi-asserted-by":"crossref","first-page":"E5537","DOI":"10.1073\/pnas.1414665111","article-title":"Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling","volume":"111","author":"Dhingra","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"10","key":"10.1016\/j.ejphar.2026.179359_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25105272","article-title":"miRNA expression profiles in isolated ventricular cardiomyocytes: insights into doxorubicin-induced cardiotoxicity","volume":"25","author":"Dominguez Romero","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2026.179359_bib15","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8819771","article-title":"Protective effect of miR-204 on doxorubicin-induced cardiomyocyte injury via HMGB1","author":"Du","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ejphar.2026.179359_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.815916","article-title":"MicroRNA-194-5p attenuates doxorubicin-induced cardiomyocyte apoptosis and endoplasmic reticulum stress by targeting P21-Activated kinase 2","volume":"9","author":"Fa","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.ejphar.2026.179359_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.117924","article-title":"Right ventricular dysfunction following surgical repair of tetralogy of fallot: molecular pathways and therapeutic prospects","volume":"184","author":"Fan","year":"2025","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.ejphar.2026.179359_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2022.119411","article-title":"Sirt3 activates autophagy to prevent DOX-Induced senescence by inactivating PI3K\/AKT\/mTOR pathway in A549 cells","volume":"1870","author":"Fan","year":"2023","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.ejphar.2026.179359_bib19","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.addr.2020.06.005","article-title":"Exploiting the dynamics of the EPR effect and strategies to improve the therapeutic effects of nanomedicines by using EPR effect enhancers","volume":"157","author":"Fang","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"1","key":"10.1016\/j.ejphar.2026.179359_bib20","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/s41467-020-14349-2","article-title":"Preclinical development of a miR-132 inhibitor for heart failure treatment","volume":"11","author":"Foinquinos","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejphar.2026.179359_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2024.115302","article-title":"Navigating the landscape of RNA delivery systems in cardiovascular disease therapeutics","volume":"208","author":"Gil-Cabrerizo","year":"2024","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"11","key":"10.1016\/j.ejphar.2026.179359_bib22","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.bcp.2006.04.011","article-title":"NF-kappaB activation by reactive oxygen species: fifteen years later","volume":"72","author":"Gloire","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179359_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109784","article-title":"Irigenin treatment alleviates doxorubicin (DOX)-induced cardiotoxicity by suppressing apoptosis, inflammation and oxidative stress via the increase of miR-425","volume":"125","author":"Guo","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2026.179359_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.737826","article-title":"microRNA-377 signaling modulates anticancer drug-induced cardiotoxicity in mice","volume":"8","author":"Henderson","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"issue":"17","key":"10.1016\/j.ejphar.2026.179359_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231710146","article-title":"Dapagliflozin mitigates doxorubicin-caused myocardium damage by regulating AKT-mediated oxidative stress, cardiac remodeling, and inflammation","volume":"23","author":"Hsieh","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2026.179359_bib26","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/1512326","article-title":"miR-200a attenuated doxorubicin-induced cardiotoxicity through upregulation of Nrf2 in mice","author":"Hu","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"32","key":"10.1016\/j.ejphar.2026.179359_bib27","article-title":"Systematic analysis of doxorubicin-induced myocardial injury mechanisms using network toxicology and molecular docking strategy","volume":"104","author":"Jiang","year":"2025","journal-title":"Medicine (Baltim.)"},{"issue":"2","key":"10.1016\/j.ejphar.2026.179359_bib28","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1159\/000491896","article-title":"MicroRNA-29b regulates the mitochondria-dependent apoptotic pathway by targeting bax in doxorubicin cardiotoxicity","volume":"48","author":"Jing","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"issue":"28","key":"10.1016\/j.ejphar.2026.179359_bib29","doi-asserted-by":"crossref","first-page":"46663","DOI":"10.18632\/oncotarget.16944","article-title":"Autophagy and mitophagy in the context of doxorubicin-induced cardiotoxicity","volume":"8","author":"Koleini","year":"2017","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.ejphar.2026.179359_bib30","doi-asserted-by":"crossref","first-page":"760","DOI":"10.7150\/ijbs.65258","article-title":"Underlying the mechanisms of doxorubicin-induced acute cardiotoxicity: oxidative stress and cell death","volume":"18","author":"Kong","year":"2022","journal-title":"Int. J. Biol. Sci."},{"issue":"3","key":"10.1016\/j.ejphar.2026.179359_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/biom13030568","article-title":"MicroRNA in the diagnosis and treatment of doxorubicin-induced cardiotoxicity","volume":"13","author":"Kuang","year":"2023","journal-title":"Biomolecules"},{"issue":"3","key":"10.1016\/j.ejphar.2026.179359_bib32","doi-asserted-by":"crossref","first-page":"e143","DOI":"10.1016\/j.clml.2024.10.008","article-title":"Incidence, risk factors and early prediction of doxorubicin-induced cardiotoxicity by global longitudinal strain and cardiac biomarkers in Indian patients with lymphoma: a prospective observational study","volume":"25","author":"Kumar","year":"2025","journal-title":"Clin. Lymphoma Myeloma Leuk."},{"issue":"10","key":"10.1016\/j.ejphar.2026.179359_bib33","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1161\/CIRCRESAHA.116.307505","article-title":"Mitochondrial metabolism in aging heart","volume":"118","author":"Lesnefsky","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2026.179359_bib34","article-title":"Mechanism of action of non-coding RNAs and traditional Chinese medicine in myocardial fibrosis: focus on the TGF-beta\/Smad signaling pathway","volume":"14","author":"Li","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179359_bib35","article-title":"miR-451 silencing inhibited doxorubicin exposure-induced cardiotoxicity in mice","author":"Li","year":"2019","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.ejphar.2026.179359_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.110008","article-title":"Exploring the role of ferroptosis in the doxorubicin-induced chronic cardiotoxicity using a murine model","volume":"363","author":"Li","year":"2022","journal-title":"Chem. Biol. Interact."},{"issue":"10","key":"10.1016\/j.ejphar.2026.179359_bib37","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.7150\/ijms.41980","article-title":"Inhibition of miR-25 attenuates doxorubicin-induced apoptosis, reactive oxygen species production and DNA damage by targeting PTEN","volume":"17","author":"Li","year":"2020","journal-title":"Int. J. Med. Sci."},{"issue":"1","key":"10.1016\/j.ejphar.2026.179359_bib38","doi-asserted-by":"crossref","DOI":"10.3892\/ijmm.2021.4958","article-title":"MicroRNA-133b alleviates doxorubicin-induced cardiomyocyte apoptosis and cardiac fibrosis by targeting PTBP1 and TAGLN2","volume":"48","author":"Li","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.ejphar.2026.179359_bib39","article-title":"Rutaecarpine inhibits doxorubicin-induced oxidative stress and apoptosis by activating AKT signaling pathway","volume":"8","author":"Liao","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"issue":"11","key":"10.1016\/j.ejphar.2026.179359_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e22011","article-title":"Taxifolin protects against doxorubicin-induced cardiotoxicity and ferroptosis by adjusting microRNA-200a-mediated Nrf2 signaling pathway","volume":"9","author":"Lin","year":"2023","journal-title":"Heliyon"},{"issue":"1","key":"10.1016\/j.ejphar.2026.179359_bib41","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41514-024-00135-7","article-title":"A review of the pathophysiological mechanisms of doxorubicin-induced cardiotoxicity and aging","volume":"10","author":"Linders","year":"2024","journal-title":"NPJ Aging"},{"issue":"2","key":"10.1016\/j.ejphar.2026.179359_bib42","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.bbrc.2019.10.157","article-title":"MiR-124 attenuates doxorubicin-induced cardiac injury via inhibiting p66Shc-mediated oxidative stress","volume":"521","author":"Liu","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"7","key":"10.1016\/j.ejphar.2026.179359_bib43","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1111\/jcmm.17230","article-title":"MicroRNA-495-3p diminishes doxorubicin-induced cardiotoxicity through activating AKT","volume":"26","author":"Meng","year":"2022","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.ejphar.2026.179359_bib44","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.yjmcc.2019.08.009","article-title":"Doxorubicin induces cardiomyocyte pyroptosis via the TINCR-mediated posttranscriptional stabilization of NLR family pyrin domain containing 3","volume":"136","author":"Meng","year":"2019","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"2","key":"10.1016\/j.ejphar.2026.179359_bib45","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1124\/pr.56.2.6","article-title":"Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity","volume":"56","author":"Minotti","year":"2004","journal-title":"Pharmacol. Rev."},{"issue":"3","key":"10.1016\/j.ejphar.2026.179359_bib46","first-page":"335","article-title":"Molecular mechanisms of cardiotoxicity: a review on major side-effect of doxorubicin","volume":"79","author":"Mobaraki","year":"2017","journal-title":"Indian J. Pharmaceut. Sci."},{"issue":"1","key":"10.1016\/j.ejphar.2026.179359_bib47","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1161\/CIRCHEARTFAILURE.114.001180","article-title":"Sexual dimorphism of doxorubicin-mediated cardiotoxicity: potential role of energy metabolism remodeling","volume":"8","author":"Moulin","year":"2015","journal-title":"Circ Heart Fail"},{"issue":"8","key":"10.1016\/j.ejphar.2026.179359_bib48","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.jacbts.2020.04.014","article-title":"Autosis A new target to prevent cell death","volume":"5","author":"Nah","year":"2020","journal-title":"JACC, Basic Transl. Sci."},{"issue":"9","key":"10.1016\/j.ejphar.2026.179359_bib49","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/s41419-019-1901-x","article-title":"miR-146a attenuates apoptosis and modulates autophagy by targeting TAF9b\/P53 pathway in doxorubicin-induced cardiotoxicity","volume":"10","author":"Pan","year":"2019","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.ejphar.2026.179359_bib50","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-46216-7","article-title":"Doxorubicin-induced modulation of TGF-beta signaling cascade in mouse fibroblasts: insights into cardiotoxicity mechanisms","volume":"13","author":"Patricelli","year":"2023","journal-title":"Sci. Rep."},{"issue":"24","key":"10.1016\/j.ejphar.2026.179359_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252413335","article-title":"The role of MicroRNAs in the pathogenesis of doxorubicin-induced vascular remodeling","volume":"25","author":"Podyacheva","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.ejphar.2026.179359_bib52","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1681\/ASN.2010121308","article-title":"TGF-beta\/Smad3 signaling promotes renal fibrosis by inhibiting miR-29","volume":"22","author":"Qin","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.ejphar.2026.179359_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111708","article-title":"Doxorubicin-induced cardiotoxicity: an update on the molecular mechanism and novel therapeutic strategies for effective management","volume":"139","author":"Rawat","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"7700","key":"10.1016\/j.ejphar.2026.179359_bib54","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/s41586-018-0016-3","article-title":"Advanced maturation of human cardiac tissue grown from pluripotent stem cells","volume":"556","author":"Ronaldson-Bouchard","year":"2018","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.ejphar.2026.179359_bib55","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s10741-017-9653-0","article-title":"Role of microRNAs in doxorubicin-induced cardiotoxicity: an overview of preclinical models and cancer patients","volume":"23","author":"Ruggeri","year":"2018","journal-title":"Heart Fail. Rev."},{"issue":"5","key":"10.1016\/j.ejphar.2026.179359_bib56","doi-asserted-by":"crossref","first-page":"5451","DOI":"10.1002\/jcp.27486","article-title":"An overview of microRNAs: biology, functions, therapeutics, and analysis methods","volume":"234","author":"Saliminejad","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"5","key":"10.1016\/j.ejphar.2026.179359_bib57","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1200\/JCO.2002.20.5.1215","article-title":"Cardiac dysfunction in the trastuzumab clinical trials experience","volume":"20","author":"Seidman","year":"2002","journal-title":"J. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.ejphar.2026.179359_bib58","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1161\/HYPERTENSIONAHA.118.12286","article-title":"Novel role of T cells and IL-6 (Interleukin-6) in angiotensin II-Induced microvascular dysfunction","volume":"73","author":"Senchenkova","year":"2019","journal-title":"Hypertension"},{"issue":"12","key":"10.1016\/j.ejphar.2026.179359_bib59","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/s41576-023-00611-y","article-title":"microRNAs in action: biogenesis, function and regulation","volume":"24","author":"Shang","year":"2023","journal-title":"Nat. Rev. Genet."},{"issue":"1","key":"10.1016\/j.ejphar.2026.179359_bib60","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12964-023-01077-5","article-title":"Role of oxidative stress and inflammation-related signaling pathways in doxorubicin-induced cardiomyopathy","volume":"21","author":"Shi","year":"2023","journal-title":"Cell Commun. Signal."},{"issue":"1","key":"10.1016\/j.ejphar.2026.179359_bib61","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S1734-1140(09)70018-0","article-title":"Anthracycline-induced cardiotoxicity: overview of studies examining the roles of oxidative stress and free cellular iron","volume":"61","author":"Simunek","year":"2009","journal-title":"Pharmacol. Rep."},{"issue":"1","key":"10.1016\/j.ejphar.2026.179359_bib62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00204-018-2356-z","article-title":"MicroRNAs in the diagnosis and prevention of drug-induced cardiotoxicity","volume":"93","author":"Skala","year":"2019","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ejphar.2026.179359_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2024.110140","article-title":"Mechanisms of doxorubicin-induced cardiac inflammation and fibrosis; therapeutic targets and approaches","volume":"761","author":"Song","year":"2024","journal-title":"Arch. Biochem. Biophys."},{"issue":"9","key":"10.1016\/j.ejphar.2026.179359_bib64","doi-asserted-by":"crossref","DOI":"10.1002\/adtp.202400036","article-title":"Sex differences in doxorubicin-induced cardiotoxicity: insights from transcriptome analysis","volume":"7","author":"Su","year":"2024","journal-title":"Adv. Therapeut."},{"key":"10.1016\/j.ejphar.2026.179359_bib65","article-title":"Doxorubicin-induced cardiac remodeling: mechanisms and mitigation strategies","author":"Sun","year":"2025","journal-title":"Cardiovasc. Drugs Ther."},{"issue":"36","key":"10.1016\/j.ejphar.2026.179359_bib66","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2117396119","article-title":"Mitochondrial outer membrane protein FUNDC2 promotes ferroptosis and contributes to doxorubicin-induced cardiomyopathy","volume":"119","author":"Ta","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.ejphar.2026.179359_bib67","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2174\/2211536607666180827111633","article-title":"MiRNAs: biology, biogenesis, their web-based tools, and databases","volume":"8","author":"Tafrihi","year":"2019","journal-title":"MicroRNA"},{"key":"10.1016\/j.ejphar.2026.179359_bib68","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.biocel.2017.05.006","article-title":"Doxorubicin-induced cardiomyocyte apoptosis: role of mitofusin 2","volume":"88","author":"Tang","year":"2017","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"19","key":"10.1016\/j.ejphar.2026.179359_bib69","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1161\/CIRCULATIONAHA.116.024145","article-title":"Defined engineered human myocardium with advanced maturation for applications in heart failure modeling and repair","volume":"135","author":"Tiburcy","year":"2017","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.ejphar.2026.179359_bib70","doi-asserted-by":"crossref","first-page":"14511","DOI":"10.3390\/ijms160714511","article-title":"MiR-21 protected cardiomyocytes against doxorubicin-induced apoptosis by targeting BTG2","volume":"16","author":"Tong","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.ejphar.2026.179359_bib71","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1124\/jpet.122.001234","article-title":"RNAi-Based therapeutics and novel RNA bioengineering technologies","volume":"384","author":"Traber","year":"2023","journal-title":"J. Pharmacol. Exp. Therapeut."},{"issue":"5","key":"10.1016\/j.ejphar.2026.179359_bib72","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25052464","article-title":"Use of microRNAs as diagnostic, prognostic, and therapeutic tools for glioblastoma","volume":"25","author":"Valle-Garcia","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"21","key":"10.1016\/j.ejphar.2026.179359_bib73","doi-asserted-by":"crossref","first-page":"6095","DOI":"10.1111\/febs.15583","article-title":"New insights into the activities and toxicities of the old anticancer drug doxorubicin","volume":"288","author":"van der Zanden","year":"2021","journal-title":"FEBS J."},{"issue":"10","key":"10.1016\/j.ejphar.2026.179359_bib74","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0076676","article-title":"Catalytic inhibitors of topoisomerase II differently modulate the toxicity of anthracyclines in cardiac and cancer cells","volume":"8","author":"Vavrova","year":"2013","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.ejphar.2026.179359_bib75","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1007\/s00018-020-03729-y","article-title":"Molecular mechanisms of doxorubicin-induced cardiotoxicity: novel roles of sirtuin 1-mediated signaling pathways","volume":"78","author":"Wang","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"issue":"5","key":"10.1016\/j.ejphar.2026.179359_bib76","article-title":"miR-21-5p prevents doxorubicin-induced cardiomyopathy by downregulating BTG2","volume":"9","author":"Wang","year":"2023","journal-title":"Heliyon"},{"issue":"10","key":"10.1016\/j.ejphar.2026.179359_bib77","doi-asserted-by":"crossref","first-page":"6344","DOI":"10.1002\/jcp.26615","article-title":"Protective effect of miR378* on doxorubicin-induced cardiomyocyte injury via calumenin","volume":"233","author":"Wang","year":"2018","journal-title":"J. Cell. Physiol."},{"issue":"1","key":"10.1016\/j.ejphar.2026.179359_bib78","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1124\/jpet.121.001152","article-title":"The role of microRNA in the development, diagnosis, and treatment of cardiovascular disease: recent developments","volume":"384","author":"Wronska","year":"2023","journal-title":"J. Pharmacol. Exp. Therapeut."},{"issue":"5","key":"10.1016\/j.ejphar.2026.179359_bib79","doi-asserted-by":"crossref","DOI":"10.3390\/biom15050670","article-title":"Molecular insights into oxidative-stress-mediated cardiomyopathy and potential therapeutic strategies","volume":"15","author":"Xiong","year":"2025","journal-title":"Biomolecules"},{"issue":"8","key":"10.1016\/j.ejphar.2026.179359_bib80","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0024-3205(00)00990-5","article-title":"Effects by doxorubicin on the myocardium are mediated by oxygen free radicals","volume":"68","author":"Xu","year":"2001","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2026.179359_bib81","article-title":"miR-488-3p protects cardiomyocytes against doxorubicin-induced cardiotoxicity by inhibiting CyclinG1","author":"Yan","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.ejphar.2026.179359_bib82","first-page":"84","article-title":"Doxorubicin, DNA torsion, and chromatin dynamics","volume":"1845","author":"Yang","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejphar.2026.179359_bib83","article-title":"Dexrazoxane protects cardiomyocyte from doxorubicin-induced apoptosis by modulating miR-17-5p","author":"Yu","year":"2020","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.ejphar.2026.179359_bib84","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.60827","article-title":"Reduction of elevated proton leak rejuvenates mitochondria in the aged cardiomyocyte","volume":"9","author":"Zhang","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.ejphar.2026.179359_bib85","article-title":"Activation of Nrf2 by miR-152 inhibits doxorubicin-induced cardiotoxicity via attenuation of oxidative stress, inflammation, and apoptosis","author":"Zhang","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ejphar.2026.179359_bib86","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/7595374","article-title":"Inhibition of miR-128-3p attenuated doxorubicin-triggered acute cardiac injury in mice by the regulation of PPAR-gamma","volume":"2021","author":"Zhang","year":"2021","journal-title":"PPAR Res."},{"key":"10.1016\/j.ejphar.2026.179359_bib87","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.redox.2017.12.013","article-title":"MicroRNA-140-5p aggravates doxorubicin-induced cardiotoxicity by promoting myocardial oxidative stress via targeting Nrf2 and Sirt2","volume":"15","author":"Zhao","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.ejphar.2026.179359_bib88","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.redox.2018.02.026","article-title":"Protective effect of dioscin against doxorubicin-induced cardiotoxicity via adjusting microRNA-140-5p-mediated myocardial oxidative stress","volume":"16","author":"Zhao","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.ejphar.2026.179359_bib89","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101303","article-title":"Corrigendum to 'Protective effect of dioscin against doxorubicin-induced cardiotoxicity via adjusting microRNA-140-5p-mediated myocardial oxidative stress' [Redox Biol.], 2018, 16: 189-198","volume":"26","author":"Zhao","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.ejphar.2026.179359_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2024.111407","article-title":"MiR-24-3p modulates cardiac function in doxorubicin -induced heart failure via the Sp1\/PI3K signaling pathway","volume":"124","author":"Zheng","year":"2024","journal-title":"Cell. Signal."},{"issue":"9","key":"10.1016\/j.ejphar.2026.179359_bib91","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1681\/ASN.2010111168","article-title":"Smad3-mediated upregulation of miR-21 promotes renal fibrosis","volume":"22","author":"Zhong","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.ejphar.2026.179359_bib92","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115654","article-title":"Inhibiting mir-34a-5p regulates doxorubicin-induced autophagy disorder and alleviates myocardial pyroptosis by targeting Sirt3-AMPK pathway","volume":"168","author":"Zhong","year":"2023","journal-title":"Biomed. Pharmacother."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926008411?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926008411?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:18:18Z","timestamp":1791469098000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299926008411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":92,"alternative-id":["S0014299926008411"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.179359","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting MicroRNAs in doxorubicin-induced cardiotoxicity: A systematic review of transfection studies","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.179359","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2026 Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"179359"}}