{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T06:32:45Z","timestamp":1793082765932,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100020734","name":"Guizhou Province Department of Science and Technology and Guizhou Normal University Joint Foundation","doi-asserted-by":"publisher","award":["zk[2025]483"],"award-info":[{"award-number":["zk[2025]483"]}],"id":[{"id":"10.13039\/501100020734","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012459","name":"Chongqing Graduate Student Research Innovation Project","doi-asserted-by":"publisher","award":["gzlcx20253290"],"award-info":[{"award-number":["gzlcx20253290"]}],"id":[{"id":"10.13039\/501100012459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010891","name":"Guizhou Provincial Health Commission","doi-asserted-by":"publisher","award":["gzwkj2026-505"],"award-info":[{"award-number":["gzwkj2026-505"]}],"id":[{"id":"10.13039\/501100010891","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002865","name":"Chongqing Municipal Science and Technology Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017957","name":"Health Commission of Guizhou Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007957","name":"Chongqing Municipal Education Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.ejphar.2026.179415","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:08:35Z","timestamp":1791904115000},"page":"179415","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Dihydroquercetin derived from Huanglong Decoction improves acute pancreatitis and related intestinal damage through STAT3\/ERK\/ZBP1 pathway"],"prefix":"10.1016","volume":"1037","author":[{"given":"Sha","family":"Ran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihua","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2026.179415_bib1","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.3465","article-title":"Semi-quantitative determination of protein expression using immunohistochemistry staining and analysis: an integrated protocol","volume":"9","author":"Crowe","year":"2019","journal-title":"Bio Protoc"},{"key":"10.1016\/j.ejphar.2026.179415_bib2","article-title":"A novel antidiabetic peptide GPAGAP from Andrias davidianus collagen hydrolysates: screening, action mechanism prediction and improving insulin resistance in HepG2 cells","volume":"1","author":"Dong","year":"2024","journal-title":"Food Med. Homol"},{"key":"10.1016\/j.ejphar.2026.179415_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114620","article-title":"Nicotinamide mononucleotide ameliorates hypertriglyceridemia pancreatitis via NAD(+)\/SIRT1-mediated TXNIP suppression and NOTCH pathway for accelerated repair-associated processes","volume":"155","author":"Duan","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2026.179415_bib4","first-page":"965","article-title":"Clinical effect of acupuncture combined with huanglong decoction on 60 cases of senile Qi deficiency and intestinal dryness constipation","volume":"13","author":"Fu","year":"2018","journal-title":"World Journal of Integrated Chinese and Western Medicine"},{"key":"10.1016\/j.ejphar.2026.179415_bib5","first-page":"4","article-title":"Effects of huanglong decoction on mRNA and protein expression levels of intestinal mucosal epithelial Claudin-1 and occludin in sepsis rat","volume":"22","author":"Fu","year":"2015","journal-title":"Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care"},{"key":"10.1016\/j.ejphar.2026.179415_bib6","article-title":"Dihydroquercetin regulates HIF-1alpha\/AKT\/NR2B signalling to improve impaired brain function in rats with metabolic syndrome","volume":"10","author":"Fu","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.ejphar.2026.179415_bib7","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1007\/s00705-016-2749-3","article-title":"Virus-inhibiting activity of dihydroquercetin, a flavonoid from Larix sibirica, against coxsackievirus B4 in a model of viral pancreatitis","volume":"161","author":"Galochkina","year":"2016","journal-title":"Arch. Virol."},{"key":"10.1016\/j.ejphar.2026.179415_bib8","doi-asserted-by":"crossref","first-page":"823","DOI":"10.2147\/JIR.S445929","article-title":"Nomogram and web calculator based on lasso-logistic regression for predicting persistent organ failure in acute pancreatitis patients","volume":"17","author":"Gao","year":"2024","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.ejphar.2026.179415_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156767","article-title":"Costunolide: targeting endothelial cell PANoptosis to mitigate lung injury in acute pancreatitis mice","volume":"142","author":"Ge","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ejphar.2026.179415_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110770","article-title":"Intestinal barrier damage, systemic inflammatory response syndrome, and acute lung injury: a troublesome trio for acute pancreatitis","volume":"132","author":"Ge","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2026.179415_bib11","first-page":"101","article-title":"Hypertriglyceridemia-induced acute pancreatitis: progress on disease mechanisms and treatment modalities","volume":"27","author":"Guo","year":"2019","journal-title":"Discov. Med."},{"key":"10.1016\/j.ejphar.2026.179415_bib12","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/bfgp\/elt028","article-title":"The IL-10\/STAT3-mediated anti-inflammatory response: recent developments and future challenges","volume":"12","author":"Hutchins","year":"2013","journal-title":"Brief. Funct. Genom."},{"key":"10.1016\/j.ejphar.2026.179415_bib13","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1248\/cpb.40.3081","article-title":"Phytochemical studies of seeds of medicinal plants. II. A new dihydroflavonol glycoside and a new 3-methyl-1-butanol glycoside from seeds of Platycodon grandiflorum A. de Candolle","volume":"40","author":"Inada","year":"1992","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.ejphar.2026.179415_bib14","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/s41586-020-2129-8","article-title":"Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation","volume":"580","author":"Jiao","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2026.179415_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiolchem.2020.107402","article-title":"A comprehensive application: molecular docking and network pharmacology for the prediction of bioactive constituents and elucidation of mechanisms of action in component-based Chinese medicine","volume":"90","author":"Jiao","year":"2021","journal-title":"Comput. Biol. Chem."},{"key":"10.1016\/j.ejphar.2026.179415_bib16","first-page":"15","article-title":"General preventive effect of flavonoids isolated from plants at experimental acute pancreatitis","volume":"8","author":"Kayumov","year":"2024","journal-title":"Acta Scientific Nutritional Health"},{"key":"10.1016\/j.ejphar.2026.179415_bib17","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13916","article-title":"Mechanisms linking hypertriglyceridemia to acute pancreatitis","volume":"237","author":"Kiss","year":"2023","journal-title":"Acta Physiol."},{"key":"10.1016\/j.ejphar.2026.179415_bib18","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/s41418-024-01279-5","article-title":"Sensing of mitochondrial DNA by ZBP1 promotes RIPK3-mediated necroptosis and ferroptosis in response to diquat poisoning","volume":"31","author":"Lai","year":"2024","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ejphar.2026.179415_bib19","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1007\/s11938-020-00322-x","article-title":"Management of severe acute pancreatitis","volume":"18","author":"Lee","year":"2020","journal-title":"Curr. Treat. Options Gastroenterol."},{"key":"10.1016\/j.ejphar.2026.179415_bib20","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/s41420-025-02451-7","article-title":"Inhibition of Zbp1-PANoptosome-mediated PANoptosis effectively attenuates acute pancreatitis","volume":"11","author":"Li","year":"2025","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.ejphar.2026.179415_bib21","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.3748\/wjg.v23.i20.3615","article-title":"Perspectives of traditional Chinese medicine in pancreas protection for acute pancreatitis","volume":"23","author":"Li","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.ejphar.2026.179415_bib22","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.cellsig.2005.08.007","article-title":"ERK is an anti-inflammatory signal that suppresses expression of NF-kappaB-dependent inflammatory genes by inhibiting IKK activity in endothelial cells","volume":"18","author":"Maeng","year":"2006","journal-title":"Cell. Signal."},{"key":"10.1016\/j.ejphar.2026.179415_bib23","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1126\/science.1233606","article-title":"Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay","volume":"341","author":"Martinez Molina","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2026.179415_bib24","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.intimp.2019.04.018","article-title":"Baicalein attenuates pancreatic inflammatory injury through regulating MAPK, STAT 3 and NF-kappaB activation","volume":"72","author":"Pu","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2026.179415_bib25","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1111\/bph.14169","article-title":"Dihydrodiosgenin protects against experimental acute pancreatitis and associated lung injury through mitochondrial protection and PI3K\u03b3\/Akt inhibition","volume":"175","author":"Shen","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179415_bib26","doi-asserted-by":"crossref","first-page":"978","DOI":"10.3390\/jcm13040978","article-title":"Recent treatment strategies for acute pancreatitis","volume":"13","author":"Song","year":"2024","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.ejphar.2026.179415_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109656","article-title":"Material basis and molecular mechanisms of dachengqi decoction in the treatment of acute pancreatitis based on network pharmacology","volume":"121","author":"Sun","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2026.179415_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156926","article-title":"Eriodictyol from scutellariae barbata alleviates inflammation and necrosis via ZBP1-dependent signaling in acute pancreatitis","volume":"145","author":"Tian","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ejphar.2026.179415_bib29","doi-asserted-by":"crossref","first-page":"5214","DOI":"10.3390\/nu14245214","article-title":"Dihydroquercetin supplementation improved hepatic lipid dysmetabolism mediated by gut microbiota in high-fat diet (HFD)-fed mice","volume":"14","author":"Wang","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.ejphar.2026.179415_bib30","article-title":"Perspectives on organ-on-a-chip technology for natural products evaluation","volume":"1","author":"Wang","year":"2024","journal-title":"Food Med. Homol."},{"key":"10.1016\/j.ejphar.2026.179415_bib31","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1016\/j.jchromb.2009.04.037","article-title":"A highly sensitive and robust UPLC\u2013MS with electrospray ionization method for quantitation of taxifolin in rat plasma","volume":"877","author":"Wang","year":"2009","journal-title":"J. Chromatogr., B: Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.ejphar.2026.179415_bib32","doi-asserted-by":"crossref","first-page":"4771","DOI":"10.3748\/wjg.v30.i45.4771","article-title":"Reactive oxygen species and oxidative stress in acute pancreatitis: pathogenesis and new therapeutic interventions","volume":"30","author":"Xia","year":"2024","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.ejphar.2026.179415_bib33","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1007\/s10753-019-01077-z","article-title":"Emodin attenuates severe acute pancreatitis via antioxidant and anti-inflammatory activity","volume":"42","author":"Xia","year":"2019","journal-title":"Inflammation"},{"key":"10.1016\/j.ejphar.2026.179415_bib35","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1097\/MPA.0000000000001931","article-title":"Traditional Chinese medicine formulas alleviate acute pancreatitis: pharmacological activities and mechanisms","volume":"50","author":"Yang","year":"2021","journal-title":"Pancreas"},{"key":"10.1016\/j.ejphar.2026.179415_bib34","doi-asserted-by":"crossref","first-page":"494","DOI":"10.3390\/molecules21040494","article-title":"UHPLC-MS\/MS determination, pharmacokinetic, and bioavailability study of taxifolin in rat plasma after oral administration of its nanodispersion","volume":"21","author":"Yang","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.ejphar.2026.179415_bib36","article-title":"An in-silico assessment suggests the potential effects of goji (fruit of Lycium barbarum L.) against aging-related diseases","volume":"2","author":"Yao","year":"2025","journal-title":"Food Med. Homol."},{"key":"10.1016\/j.ejphar.2026.179415_bib37","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1186\/s12931-023-02594-0","article-title":"Deficiency of S100A8\/A9 attenuates pulmonary microvascular leakage in septic mice","volume":"24","author":"Yu","year":"2023","journal-title":"Respir. Res."},{"key":"10.1016\/j.ejphar.2026.179415_bib38","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1007\/s00253-017-8686-6","article-title":"Dihydroquercetin ameliorated acetaminophen-induced hepatic cytotoxicity via activating JAK2\/STAT3 pathway and autophagy","volume":"102","author":"Zai","year":"2018","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.ejphar.2026.179415_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155533","article-title":"Dihydroquercetin improves experimental acute liver failure by targeting ferroptosis and mitochondria-mediated apoptosis through the SIRT1\/p53 axis","volume":"128","author":"Zeng","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ejphar.2026.179415_bib40","first-page":"131","article-title":"The origin and development of huanglong decoction","volume":"54","author":"Zhang","year":"2024","journal-title":"Zhonghua Yi Shi Za Zhi"},{"key":"10.1016\/j.ejphar.2026.179415_bib41","article-title":"Escin sodium improves the prognosis of acute pancreatitis via promoting cell apoptosis by suppression of the ERK\/STAT3 signaling pathway","author":"Zhang","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ejphar.2026.179415_bib42","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1128\/IAI.00309-20","article-title":"STAT3 promotes schistosome-induced liver injury by inflammation, oxidative stress, proliferation, and apoptosis signal pathway","volume":"89","author":"Zhao","year":"2021","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ejphar.2026.179415_bib43","doi-asserted-by":"crossref","first-page":"814","DOI":"10.17305\/bb.2025.13046","article-title":"Mitochondrial dysfunction triggers Zbp1-mediated necroptosis and inflammation in acute lung injury","volume":"26","author":"Zhou","year":"2025","journal-title":"Biomol. Biomed."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926008976?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926008976?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T05:34:01Z","timestamp":1793079241000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299926008976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":43,"alternative-id":["S0014299926008976"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.179415","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dihydroquercetin derived from Huanglong Decoction improves acute pancreatitis and related intestinal damage through STAT3\/ERK\/ZBP1 pathway","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.179415","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"179415"}}