{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:12:14Z","timestamp":1789020734812,"version":"build-2803163510"},"reference-count":17,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Paediatric Neurology"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1016\/j.ejpn.2007.05.008","type":"journal-article","created":{"date-parts":[[2007,7,11]],"date-time":"2007-07-11T11:27:44Z","timestamp":1184153264000},"page":"56-60","source":"Crossref","is-referenced-by-count":21,"title":["Proton MRS of a child with Sandhoff disease reveals elevated brain hexosamine"],"prefix":"10.1016","volume":"12","author":[{"given":"B.","family":"Wilken","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Dechent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Hanefeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Frahm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpn.2007.05.008_bib1","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1111\/j.1471-4159.1971.tb00204.x","article-title":"Enzyme alterations and lipid storage in three variants of Tay-Sachs disease","volume":"18","author":"Sandhoff","year":"1971","journal-title":"J Neurochem"},{"key":"10.1016\/j.ejpn.2007.05.008_bib2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1023\/B:BOLI.0000028777.38551.5a","article-title":"Juvenile Sandhoff disease \u2013 nine new cases and a review of the literature","volume":"27","author":"Hendriksz","year":"2004","journal-title":"J Inherit Metab Dis"},{"key":"10.1016\/j.ejpn.2007.05.008_bib3","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1093\/hmg\/11.11.1343","article-title":"Molecular pathophysiology in Tay-Sachs and Sandhoff diseases as revealed by gene expression profiling","volume":"11","author":"Myerowitz","year":"2002","journal-title":"Hum Mol Gen"},{"key":"10.1016\/j.ejpn.2007.05.008_bib4","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/BF00588086","article-title":"GM-2 gangliosidosis (Sandhoff\u2032s disease): two year follow-up by MRI","volume":"36","author":"K\u00f6lfen","year":"1994","journal-title":"Neuroradiology"},{"key":"10.1016\/j.ejpn.2007.05.008_bib5","first-page":"1219","article-title":"White matter changes associated with feline GM2 gangliosidosis (Sandhoff disease): correlation of MR findings with pathologic and ultrastructural abnormalities","volume":"16","author":"Kroll","year":"1995","journal-title":"AJNR"},{"key":"10.1016\/j.ejpn.2007.05.008_bib6","first-page":"1628","article-title":"Neuroimaging findings in late infantile GM 1 gangliosidosis","volume":"19","author":"Chen","year":"1998","journal-title":"AJNR"},{"key":"10.1016\/j.ejpn.2007.05.008_bib7","first-page":"840","article-title":"Unusual presentation of GM2 gangliosidosis mimicking a brain stem tumor in a 3-year-old girl","volume":"24","author":"Nassogne","year":"2003","journal-title":"AJNR"},{"key":"10.1016\/j.ejpn.2007.05.008_bib8","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/nbm.984","article-title":"MRS reveals additional hexose N-acetyl resonances in the brain of a mouse model for Sandhoff disease","volume":"18","author":"Lowe","year":"2005","journal-title":"NMR Biomed"},{"key":"10.1016\/j.ejpn.2007.05.008_bib9","first-page":"464","article-title":"Improvements in localized proton NMR spectroscopy of human brain. Water suppression, short echo times, and 1mL resolution","volume":"90","author":"Frahm","year":"1990","journal-title":"J Magn Reson"},{"key":"10.1016\/j.ejpn.2007.05.008_bib10","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/mrm.1910300604","article-title":"Estimation of metabolite concentrations from localized in vivo proton NMR spectra","volume":"30","author":"Provencher","year":"1993","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.ejpn.2007.05.008_bib11","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1055\/s-2007-973751","article-title":"Localized proton magnetic resonance spectroscopy of cerebral metabolites","volume":"27","author":"Frahm","year":"1996","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.ejpn.2007.05.008_bib12","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1203\/00006450-199910000-00019","article-title":"Regional age dependence of human brain metabolites from infancy to adulthood as detected by quantitative localized proton MRS","volume":"46","author":"Pouwels","year":"1999","journal-title":"Pediatr Res"},{"key":"10.1016\/j.ejpn.2007.05.008_bib13","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/ana.10052","article-title":"N-acetylaspartate is an axon-specific marker of mature white matter in vivo: a biochemical and immunohistochemical study on the rat optic nerv","volume":"51","author":"Bjartmar","year":"2002","journal-title":"Ann Neurol"},{"key":"10.1016\/j.ejpn.2007.05.008_bib14","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1159\/000111347","article-title":"Multinuclear NMR studies on the energy metabolism of glial and neuronal cells","volume":"15","author":"Brand","year":"1993","journal-title":"Dev Neurosci"},{"key":"10.1016\/j.ejpn.2007.05.008_bib15","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/nbm.1940060116","article-title":"Identification of scyllo-inositol in proton NMR spectra of human brain in vivo","volume":"6","author":"Michaelis","year":"1993","journal-title":"NMR Biomed"},{"key":"10.1016\/j.ejpn.2007.05.008_bib16","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1055\/s-2003-43254","article-title":"Quantitative proton magnetic resonance spectroscopy of children with adrenoleukodystrophy before and after hematopoietic stem cell transplantation","volume":"34","author":"Wilken","year":"2003","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.ejpn.2007.05.008_bib17","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.nbd.2004.04.012","article-title":"Improved outcome of N-butyldeoxygalactonojirimycin-mediated substrate reduction therapy in a mouse model of Sandhoff disease","volume":"16","author":"Andersson","year":"2004","journal-title":"Neuobiol Dis"}],"container-title":["European Journal of Paediatric Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090379807001031?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090379807001031?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,6]],"date-time":"2019-01-06T05:58:16Z","timestamp":1546754296000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1090379807001031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["S1090379807001031"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpn.2007.05.008","relation":{},"ISSN":["1090-3798"],"issn-type":[{"value":"1090-3798","type":"print"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}