{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:01:48Z","timestamp":1787760108049,"version":"build-2784847793"},"reference-count":49,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Paediatric Neurology"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1016\/j.ejpn.2012.01.007","type":"journal-article","created":{"date-parts":[[2012,2,14]],"date-time":"2012-02-14T13:47:12Z","timestamp":1329227232000},"page":"413-421","source":"Crossref","is-referenced-by-count":64,"title":["Hemiconvulsion\u2013hemiplegia\u2013epilepsy syndrome: Current understandings"],"prefix":"10.1016","volume":"16","author":[{"given":"St\u00e9phane","family":"Auvin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanina","family":"Bellavoine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Merdariu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Delano\u00eb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Elmaleh-Berg\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Gressens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odile","family":"Boespflug-Tanguy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpn.2012.01.007_bib1","first-page":"418","article-title":"H.H.E. syndrome; hemiconvulsions, hemiplegia, epilepsy","volume":"1","author":"Gastaut","year":"1960","journal-title":"Eksp Khirurgiia"},{"key":"10.1016\/j.ejpn.2012.01.007_bib2","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1111\/j.1469-8749.1971.tb08333.x","article-title":"A pneumoencephalographic demonstration of brain atrophy following status epilepticus","volume":"13","author":"Aicardi","year":"1971","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.ejpn.2012.01.007_bib3","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1159\/000116284","article-title":"Cranial computed tomographic and electroencephalographic abnormalities in children with post-hemiconvulsive hemiplegia","volume":"28","author":"Kataoka","year":"1988","journal-title":"Eur Neurol"},{"key":"10.1016\/j.ejpn.2012.01.007_bib4","first-page":"211","article-title":"Unilateral seizures: hemiconvulsions-hemiplegia syndrome (HH) and hemiconvulsions-hemiplegia-epilepsy syndrome (HHE)","author":"Roger","year":"1982","journal-title":"Electroencephalogr Clin Neurophysiol Suppl"},{"key":"10.1016\/j.ejpn.2012.01.007_bib5","series-title":"Epileptic syndromes in infancy, childhood and adolescence","first-page":"277","article-title":"The HHE syndrome","author":"Chauvel","year":"2005"},{"key":"10.1016\/j.ejpn.2012.01.007_bib6","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.seizure.2007.01.009","article-title":"Neuropathological and MRI findings in an acute presentation of hemiconvulsion-hemiplegia: a report with pathophysiological implications","volume":"16","author":"Auvin","year":"2007","journal-title":"Seizure"},{"key":"10.1016\/j.ejpn.2012.01.007_bib7","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1177\/088307380201700914","article-title":"Association between factor V Leiden mutation and the hemiconvulsion, hemiplegia, and epilepsy syndrome: report of two cases","volume":"17","author":"Scantlebury","year":"2002","journal-title":"J Child Neurol"},{"key":"10.1016\/j.ejpn.2012.01.007_bib8","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s003810050079","article-title":"Hemiconvulsion-hemiplegia-epilepsy syndrome. A\u00a0clinical, electroencephalographic and neuroradiological study","volume":"13","author":"Salih","year":"1997","journal-title":"Childs Nerv Syst"},{"key":"10.1016\/j.ejpn.2012.01.007_bib9","article-title":"Hemiconvulsion-hemiplegia-epilepsy syndrome in South African children: insights from a retrospective case series","author":"VanToorn","year":"2011","journal-title":"Eur J Paediatr Neurol"},{"key":"10.1016\/j.ejpn.2012.01.007_bib10","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.clineuro.2007.07.027","article-title":"Decompressive hemicraniectomy in a space-occupying presentation of hemiconvulsion-hemiplegia-epilepsy syndrome","volume":"109","author":"Berhouma","year":"2007","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1016\/j.ejpn.2012.01.007_bib11","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1177\/088307380201700103","article-title":"Hemiconvulsion-hemiplegia-epilepsy syndrome: characteristic early magnetic resonance imaging findings","volume":"17","author":"Freeman","year":"2002","journal-title":"J\u00a0Child Neurol"},{"key":"10.1016\/j.ejpn.2012.01.007_bib12","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1017\/S0012162205001751","article-title":"Atypical case of hemiconvulsions-hemiplegia-epilepsy syndrome revealing contralateral focal cortical dysplasia","volume":"47","author":"Bahi-Buisson","year":"2005","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.ejpn.2012.01.007_bib13","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1177\/088307380201700912","article-title":"Hemiconvulsion-hemiplegia syndrome and elevated interleukin-6: case report","volume":"17","author":"Kimura","year":"2002","journal-title":"J Child Neurol"},{"key":"10.1016\/j.ejpn.2012.01.007_bib14","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1469-8749.1969.tb01415.x","article-title":"Acute hemiplegia in infancy and childhood","volume":"11","author":"Aicardi","year":"1969","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.ejpn.2012.01.007_bib15","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.yebeh.2008.07.008","article-title":"Long-term cognitive outcome of hemiconvulsion-hemiplegia-epilepsy syndrome affecting the left cerebral hemisphere","volume":"13","author":"Mirsattari","year":"2008","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.ejpn.2012.01.007_bib16","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1212\/01.wnl.0000289192.50924.93","article-title":"Surgical treatment of delayed epilepsy in hemiconvulsion-hemiplegia-epilepsy syndrome","volume":"70","author":"Kim","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.ejpn.2012.01.007_bib17","doi-asserted-by":"crossref","DOI":"10.1007\/s10072-010-0286-5","article-title":"A new case of idiopathic hemiplegia hemiconvulsion syndrome","author":"Franzoni","year":"2010","journal-title":"Neurol Sci"},{"key":"10.1016\/j.ejpn.2012.01.007_bib18","first-page":"17","article-title":"Anatomopathology and pathogeny of the hemiconvulsion-hemiplegia-epilepsy syndrome. Part I","volume":"22","author":"Mori","year":"1978","journal-title":"J\u00a0Neurosurg Sci"},{"key":"10.1016\/j.ejpn.2012.01.007_bib19","first-page":"1","article-title":"Anatomopathology and pathogeny of the hemiconvulsion-hemiplegia-epilepsy syndrome. Part II","volume":"23","author":"Mori","year":"1979","journal-title":"J\u00a0Neurosurg Sci"},{"key":"10.1016\/j.ejpn.2012.01.007_bib20","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1528-1157.1970.tb03880.x","article-title":"Convulsive status epilepticus in infants and children. A study of 239 cases","volume":"11","author":"Aicardi","year":"1970","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2012.01.007_bib21","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1177\/08830738060210061601","article-title":"Hemiconvulsion-hemiplegia-epilepsy syndrome as a presenting feature of L-2-hydroxyglutaric aciduria","volume":"21","author":"Lee","year":"2006","journal-title":"J Child Neurol"},{"key":"10.1016\/j.ejpn.2012.01.007_bib22","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/BF02820211","article-title":"Hemiconvulsion, hemiplegia, epilepsy syndrome and inherited protein S deficiency","volume":"73","author":"Mondal","year":"2006","journal-title":"Indian J Pediatr"},{"key":"10.1016\/j.ejpn.2012.01.007_bib23","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1212\/WNL.45.11.2058","article-title":"Frequency and characteristics of dual pathology in patients with lesional epilepsy","volume":"45","author":"Cendes","year":"1995","journal-title":"Neurology"},{"key":"10.1016\/j.ejpn.2012.01.007_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3988\/jcn.2008.4.1.1","article-title":"Role of neuroimaging in the presurgical evaluation of epilepsy","volume":"4","author":"Wehner","year":"2008","journal-title":"J Clin Neurol"},{"key":"10.1016\/j.ejpn.2012.01.007_bib25","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1111\/j.1528-1167.2008.01699.x","article-title":"Human herpes virus 6B: a possible role in epilepsy?","volume":"49","author":"Theodore","year":"2008","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2012.01.007_bib26","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.arcped.2009.02.001","article-title":"Febrile seizures: current understanding of pathophysiological mechanisms","volume":"16","author":"Auvin","year":"2009","journal-title":"Arch Pediatr"},{"key":"10.1016\/j.ejpn.2012.01.007_bib27","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.braindev.2003.12.003","article-title":"Hemiconvulsion-hemiplegia syndrome and primary human herpesvirus 7 infection","volume":"26","author":"Kawada","year":"2004","journal-title":"Brain Dev"},{"key":"10.1016\/j.ejpn.2012.01.007_bib28","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1080\/00365540050165857","article-title":"Herpesvirus DNA detection in cerebral spinal fluid: differences in clinical presentation between alpha-, beta-, and gamma-herpesviruses","volume":"32","author":"Studahl","year":"2000","journal-title":"Scand J Infect Dis"},{"key":"10.1016\/j.ejpn.2012.01.007_bib29","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/hipo.1076","article-title":"Resistance of immature hippocampus to morphologic and physiologic alterations following status epilepticus or kindling","volume":"11","author":"Haas","year":"2001","journal-title":"Hippocampus"},{"key":"10.1016\/j.ejpn.2012.01.007_bib30","doi-asserted-by":"crossref","first-page":"8382","DOI":"10.1523\/JNEUROSCI.18-20-08382.1998","article-title":"Patterns of status epilepticus-induced neuronal injury during development and long-term consequences","volume":"18","author":"Sankar","year":"1998","journal-title":"J Neurosci"},{"issue":"Suppl. 5","key":"10.1016\/j.ejpn.2012.01.007_bib31","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1528-1167.2007.01286.x","article-title":"Inflammation exacerbates seizure-induced injury in the immature brain","volume":"48","author":"Auvin","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2012.01.007_bib32","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.brainres.2004.02.070","article-title":"Preventing hyperthermia decreases brain damage following neonatal hypoxic-ischemic seizures","volume":"1011","author":"Yager","year":"2004","journal-title":"Brain Res"},{"key":"10.1016\/j.ejpn.2012.01.007_bib33","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0079-6123(06)62017-7","article-title":"Cellular mechanisms of neuronal damage from hyperthermia","volume":"162","author":"White","year":"2007","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.ejpn.2012.01.007_bib34","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.nbd.2008.12.018","article-title":"Age-dependent vascular changes induced by status epilepticus in rat forebrain: implications for epileptogenesis","volume":"34","author":"Marcon","year":"2009","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.ejpn.2012.01.007_bib35","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.neuroscience.2009.12.002","article-title":"Vascular changes in epilepsy: functional consequences and association with network plasticity in pilocarpine-induced experimental epilepsy","volume":"166","author":"Ndode-Ekane","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejpn.2012.01.007_bib36","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1136\/adc.82.1.62","article-title":"Clinical characteristics of febrile convulsions during primary HHV-6 infection","volume":"82","author":"Suga","year":"2000","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.ejpn.2012.01.007_bib37","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1136\/adc.2004.062216","article-title":"Human herpesviruses-6 and -7 each cause significant neurological morbidity in Britain and Ireland","volume":"90","author":"Ward","year":"2005","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.ejpn.2012.01.007_bib38","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.pediatrneurol.2011.04.010","article-title":"Hemiconvulsion-hemiplegia-epilepsy syndrome associated with CACNA1A S218L mutation","volume":"45","author":"Yamazaki","year":"2011","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.ejpn.2012.01.007_bib39","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0092-8674(00)81373-2","article-title":"Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4","volume":"87","author":"Ophoff","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.ejpn.2012.01.007_bib40","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S0140-6736(01)05971-2","article-title":"Human epilepsy associated with dysfunction of the brain P\/Q-type calcium channel","volume":"358","author":"Jouvenceau","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.ejpn.2012.01.007_bib41","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1212\/01.WNL.0000138571.48593.FC","article-title":"Childhood epilepsy, familial hemiplegic migraine, cerebellar ataxia, and a new CACNA1A mutation","volume":"63","author":"Kors","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.ejpn.2012.01.007_bib42","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1159\/000079546","article-title":"New CACNA1A gene mutation in a case of familial hemiplegic migraine with status epilepticus","volume":"52","author":"Beauvais","year":"2004","journal-title":"Eur Neurol"},{"key":"10.1016\/j.ejpn.2012.01.007_bib43","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1212\/WNL.56.9.1245","article-title":"Association between the alpha(1a) calcium channel gene CACNA1A and idiopathic generalized epilepsy","volume":"56","author":"Chioza","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.ejpn.2012.01.007_bib44","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1212\/WNL.54.2.510","article-title":"Decreased hemispheric water mobility in hemiplegic migraine related to mutation of CACNA1A gene","volume":"54","author":"Chabriat","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.ejpn.2012.01.007_bib45","first-page":"187","article-title":"Diffusion and perfusion MR imaging of cerebral ischemia","volume":"7","author":"Hossmann","year":"1995","journal-title":"Cerebrovasc Brain Metab Rev"},{"key":"10.1016\/j.ejpn.2012.01.007_bib46","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1136\/jnnp.2009.177279","article-title":"Early seizures and cerebral oedema after trivial head trauma associated with the CACNA1A S218L mutation","volume":"80","author":"Stam","year":"2009","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.ejpn.2012.01.007_bib47","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1469-8749.2009.03493.x","article-title":"Sporadic hemiplegic migraine and delayed cerebral oedema after minor head trauma: a novel de novo CACNA1A gene mutation","volume":"52","author":"Malpas","year":"2010","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.ejpn.2012.01.007_bib48","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/hipo.20239","article-title":"Kinin B1 and B2 receptors are overexpressed in the hippocampus of humans with temporal lobe epilepsy","volume":"17","author":"Perosa","year":"2007","journal-title":"Hippocampus"},{"key":"10.1016\/j.ejpn.2012.01.007_bib49","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1038\/jcbfm.2010.28","article-title":"Inhibition of bradykinin receptor B1 protects mice from focal brain injury by reducing blood\u2013brain barrier leakage and inflammation","volume":"30","author":"Raslan","year":"2010","journal-title":"J Cereb Blood Flow Metab"}],"container-title":["European Journal of Paediatric Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090379812000116?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090379812000116?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T18:04:41Z","timestamp":1713549881000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1090379812000116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S1090379812000116"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpn.2012.01.007","relation":{},"ISSN":["1090-3798"],"issn-type":[{"value":"1090-3798","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]}}}