{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:26:16Z","timestamp":1792124776287,"version":"4.4.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Paediatric Neurology"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1016\/j.ejpn.2012.05.004","type":"journal-article","created":{"date-parts":[[2012,6,13]],"date-time":"2012-06-13T02:28:49Z","timestamp":1339554529000},"page":"582-586","source":"Crossref","is-referenced-by-count":141,"title":["Management of epilepsy associated with tuberous sclerosis complex (TSC): Clinical recommendations"],"prefix":"10.1016","volume":"16","author":[{"given":"Paolo","family":"Curatolo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergiusz","family":"J\u00f3\u017awiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rima","family":"Nabbout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpn.2012.05.004_bib1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S1470-2045(07)70411-4","article-title":"Possible mechanisms of disease development in tuberous sclerosis","volume":"9","author":"Jozwiak","year":"2008","journal-title":"Lancet Oncol"},{"issue":"9639","key":"10.1016\/j.ejpn.2012.05.004_bib2","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0140-6736(08)61279-9","article-title":"Tuberous sclerosis","volume":"372","author":"Curatolo","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.ejpn.2012.05.004_bib3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1528-1167.2009.02341.x","article-title":"Mammalian target of rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: from tuberous sclerosis to common acquired epilepsies","volume":"51","author":"Wong","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2012.05.004_bib4","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.braindev.2008.09.013","article-title":"Recent advances in neurobiology of tuberous sclerosis complex","volume":"31","author":"Napolioni","year":"2009","journal-title":"Brain Dev"},{"key":"10.1016\/j.ejpn.2012.05.004_bib5","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1111\/j.1528-1167.2009.02474.x","article-title":"The natural history of epilepsy in tuberous sclerosis complex","volume":"51","author":"Chu-Shore","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2012.05.004_bib6","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1111\/j.1528-1157.1990.tb05516.x","article-title":"Topographic comparative study of magnetic resonance imaging and electroencephalography in 34 children with tuberous sclerosis","volume":"31","author":"Cusmai","year":"1990","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2012.05.004_bib7","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1136\/adc.2003.026815","article-title":"The relation of infantile spasms, tubers, and intelligence in tuberous sclerosis complex","volume":"89","author":"O'Callaghan","year":"2004","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.ejpn.2012.05.004_bib8","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1212\/01.wnl.0000280578.99900.96","article-title":"Overlapping neurologic and cognitive phenotypes in patients with TSC1 or TSC2 mutations","volume":"70","author":"Jansen","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.ejpn.2012.05.004_bib9","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1056\/NEJMoa1001671","article-title":"Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis","volume":"363","author":"Krueger","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejpn.2012.05.004_bib10","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1007\/s00381-010-1128-8","article-title":"Epilepsy secondary to tuberous sclerosis: lessons learned and current challenges","volume":"26","author":"Moavero","year":"2010","journal-title":"Childs Nerv Syst"},{"key":"10.1016\/j.ejpn.2012.05.004_bib11","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1177\/088307389901400201","article-title":"Vigabatrin in the treatment of infantile spasms in tuberous sclerosis: literature review","volume":"14","author":"Hancock","year":"1999","journal-title":"J\u00a0Child Neurol"},{"key":"10.1016\/j.ejpn.2012.05.004_bib12","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/ana.21331","article-title":"Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex","volume":"63","author":"Zeng","year":"2008","journal-title":"Ann Neurol"},{"key":"10.1016\/j.ejpn.2012.05.004_bib13","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1242\/dmm.002386","article-title":"Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia","volume":"2","author":"Ljungberg","year":"2009","journal-title":"Dis Model Mech"},{"key":"10.1016\/j.ejpn.2012.05.004_bib14","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nm1788","article-title":"Reversal of learning deficits in a Tsc2+\/\u2212 mouse model of tuberous sclerosis","volume":"14","author":"Ehninger","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.ejpn.2012.05.004_bib15","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1212\/WNL.51.5.1263","article-title":"Surgical treatment of epilepsy in tuberous sclerosis: strategies and results in 18 patients","volume":"51","author":"Guerreiro","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.ejpn.2012.05.004_bib16","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1212\/WNL.0b013e3181ce5d9e","article-title":"Noninvasive testing, early surgery, and seizure freedom in tuberous sclerosis complex","volume":"74","author":"Wu","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.ejpn.2012.05.004_bib17","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1111\/j.1528-1167.2007.01117.x","article-title":"Epilepsy surgery in tuberous sclerosis: a systematic review","volume":"48","author":"Jansen","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2012.05.004_bib18","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.yebeh.2008.04.001","article-title":"Vagus nerve stimulation for intractable epilepsy in tuberous sclerosis complex","volume":"13","author":"Major","year":"2008","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.ejpn.2012.05.004_bib19","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.yebeh.2009.08.018","article-title":"Refractory epilepsy in tuberous sclerosis: vagus nerve stimulation with or without subsequent resective surgery","volume":"16","author":"Elliott","year":"2009","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.ejpn.2012.05.004_bib20","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1111\/j.1528-1167.2005.00266.x","article-title":"Tuberous sclerosis complex and the ketogenic diet","volume":"46","author":"Kossoff","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2012.05.004_bib21","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1038\/sj.ejhg.5201625","article-title":"Tuberous sclerosis","volume":"14","author":"Yates","year":"2006","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.ejpn.2012.05.004_bib22","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.ejpn.2011.03.010","article-title":"Antiepileptic treatment before the onset of seizures reduces epilepsy severity and risk of mental retardation in infants with tuberous sclerosis complex","volume":"15","author":"J\u00f3\u017awiak","year":"2011","journal-title":"Eur J Paediatr Neurol"},{"key":"10.1016\/j.ejpn.2012.05.004_bib23","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.ejpn.2009.03.003","article-title":"Early control of seizures improves long-term outcome in children with tuberous sclerosis complex","volume":"14","author":"Bombardieri","year":"2010","journal-title":"Eur J Paediatr Neurol"},{"key":"10.1016\/j.ejpn.2012.05.004_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eplepsyres.2004.07.010","article-title":"Progress report on new antiepileptic drugs: a summary of the Seventh Eilat Conference (EILAT VII)","volume":"61","author":"Bialer","year":"2004","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.ejpn.2012.05.004_bib25","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1023\/A:1026237730283","article-title":"Visual field defects in pediatric patients on vigabatrin monotherapy","volume":"107","author":"Ascaso","year":"2003","journal-title":"Doc Ophthalmol"},{"key":"10.1016\/j.ejpn.2012.05.004_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0035885","article-title":"The interaction between early life epilepsy and autistic-like behavioral consequences: a role for the Mammalian Target of Rapamycin (mTOR) pathway","volume":"7","author":"Talos","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ejpn.2012.05.004_bib27","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1177\/0883073808324535","article-title":"Rapamycin reduces seizure frequency in\u00a0tuberous sclerosis complex","volume":"24","author":"Muncy","year":"2009","journal-title":"J Child Neurol"},{"key":"10.1016\/j.ejpn.2012.05.004_bib28","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ejpn.2011.09.006","article-title":"Effective everolimus treatment of inoperable, life-threatening subependymal giant cell astrocytoma and intractable epilepsy in a patient with tuberous sclerosis complex","volume":"16","author":"Perek-Polnik","year":"2012","journal-title":"Eur J Paediatr Neurol"}],"container-title":["European Journal of Paediatric Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090379812001237?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090379812001237?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T16:50:50Z","timestamp":1542905450000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1090379812001237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S1090379812001237"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpn.2012.05.004","relation":{},"ISSN":["1090-3798"],"issn-type":[{"value":"1090-3798","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}