{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:25:59Z","timestamp":1792085159608,"version":"4.4.0"},"reference-count":171,"publisher":"Elsevier BV","issue":"4","content-domain":{"domain":["ejpn-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Paediatric Neurology"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1016\/j.ejpn.2013.02.003","type":"journal-article","created":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T11:30:25Z","timestamp":1364815825000},"page":"334-347","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Advancing the management of childhood epilepsies"],"prefix":"10.1016","volume":"17","author":[{"given":"J. Helen","family":"Cross","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Kluger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieven","family":"Lagae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpn.2013.02.003_bib1","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1111\/j.1528-1157.1992.tb01689.x","article-title":"Epilepsy in children: prevalence, disability, and handicap","volume":"33","author":"Sillanp\u00e4\u00e4","year":"1992","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2013.02.003_bib2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1177\/088307380401900406","article-title":"Prevalence of epilepsy in Turkish children between the ages of 0 and 16 years","volume":"19","author":"Serdaro\u011flu","year":"2004","journal-title":"J\u00a0Child Neurol"},{"key":"10.1016\/j.ejpn.2013.02.003_bib3","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1136\/adc.2004.064477","article-title":"The misdiagnosis of epilepsy in children admitted to a tertiary epilepsy centre with paroxysmal events","volume":"91","author":"Uldall","year":"2006","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.ejpn.2013.02.003_bib4","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/NRL.0b013e3181d9d6b7","article-title":"Pediatric epilepsy syndromes","volume":"16","author":"Muthugovindan","year":"2010","journal-title":"Neurologist"},{"key":"10.1016\/j.ejpn.2013.02.003_bib5","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1136\/adc.2004.062455","article-title":"Diagnoses made in a secondary care \u2018fits, faints, and funny turns\u2019 clinic","volume":"91","author":"Hindley","year":"2006","journal-title":"Arch Dis Child"},{"issue":"Suppl. 3","key":"10.1016\/j.ejpn.2013.02.003_bib6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1046\/j.1528-1157.43.s.3.3.x","article-title":"Epileptic syndromes in childhood: clinical features, outcomes, and treatment","volume":"43","author":"Camfield","year":"2002","journal-title":"Epilepsia"},{"issue":"Suppl. 1","key":"10.1016\/j.ejpn.2013.02.003_bib7","first-page":"S3","article-title":"All children who experience epileptic falls do not necessarily have Lennox-Gastaut syndrome\u2026 but many do","volume":"13","author":"Arzimanoglou","year":"2011","journal-title":"Epileptic Disord"},{"key":"10.1016\/j.ejpn.2013.02.003_bib8","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1111\/j.1528-1157.1998.tb01413.x","article-title":"Lamotrigine and seizure aggravation in severe myoclonic epilepsy","volume":"39","author":"Guerrini","year":"1998","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2013.02.003_bib9","series-title":"Aicardi\u2019s epilepsy in children","first-page":"58","article-title":"Epilepsies with predominantly myoclonic seizures","author":"Arzimanoglou","year":"2004"},{"key":"10.1016\/j.ejpn.2013.02.003_bib10","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1212\/01.WNL.0000123693.82339.FC","volume":"62","author":"French","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.ejpn.2013.02.003_bib11","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1212\/01.WNL.0000123695.22623.32","volume":"62","author":"French","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.ejpn.2013.02.003_bib12","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1111\/j.1528-1167.2006.00585.x","article-title":"ILAE treatment guidelines: evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes","volume":"47","author":"Glauser","year":"2006","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2013.02.003_bib13","series-title":"The epilepsies: the diagnosis and management of the epilepsies in adults and children in primary and secondary care","author":"National Institute for Health and Clinical Excellence","year":"2012"},{"key":"10.1016\/j.ejpn.2013.02.003_bib14","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.nurt.2006.10.004","article-title":"Clinical development of antiepileptic drugs for children","volume":"4","author":"Garofalo","year":"2007","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.ejpn.2013.02.003_bib15","doi-asserted-by":"crossref","first-page":"17","DOI":"10.2165\/00003495-200868010-00002","article-title":"Antiepileptic drug development in children: considerations for a revisited strategy","volume":"68","author":"Chiron","year":"2008","journal-title":"Drugs"},{"key":"10.1016\/j.ejpn.2013.02.003_bib16","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1212\/WNL.52.7.1338","article-title":"A double-blind, randomized trial of topiramate as adjunctive therapy for partial-onset seizures in children. Topiramate YP Study Group","volume":"52","author":"Elterman","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.ejpn.2013.02.003_bib17","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1212\/WNL.53.8.1724","article-title":"A placebo-controlled trial of lamotrigine add-on therapy for partial seizures in children. Lamictal Pediatric Partial Seizure Study Group","volume":"53","author":"Duchowny","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.ejpn.2013.02.003_bib18","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1111\/j.1528-1157.1999.tb00833.x","article-title":"Gabapentin as add-on therapy in children with refractory partial seizures: a 12-week, multicentre, double-blind, placebo-controlled study. Gabapentin Paediatric Study Group","volume":"40","author":"Appleton","year":"1999","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2013.02.003_bib19","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1212\/WNL.54.12.2237","article-title":"Adjunctive therapy with oxcarbazepine in children with partial seizures. The Oxcarbazepine Pediatric Study Group","volume":"54","author":"Glauser","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.ejpn.2013.02.003_bib20","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1212\/01.wnl.0000217916.00225.3a","article-title":"Double-blind placebo-controlled trial of adjunctive levetiracetam in pediatric partial seizures","volume":"66","author":"Glauser","year":"2006","journal-title":"Neurology"},{"issue":"Suppl. 6","key":"10.1016\/j.ejpn.2013.02.003_bib21","first-page":"263","article-title":"Preliminary results from the CATZ Study: a Phase III, double-blind, randomized, placebo-controlled trial to assess the efficacy and safety of adjunctive zonisamide in pediatric patients with partial-onset seizures","volume":"52","author":"Rosati","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2013.02.003_bib22","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/S0140-6736(07)60460-7","article-title":"The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial","volume":"369","author":"Marson","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.ejpn.2013.02.003_bib23","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/S0140-6736(07)60461-9","article-title":"The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial","volume":"369","author":"Marson","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.ejpn.2013.02.003_bib24","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1055\/s-0031-1277177","article-title":"Refractory focal epilepsy in a patient with methylmalonic aciduria: case report on positive and long-lasting effect of rufinamide","volume":"42","author":"von St\u00fclpnagel","year":"2011","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.ejpn.2013.02.003_bib25","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1055\/s-0031-1275346","article-title":"Epilepsy with myoclonic absences-favourable response to add-on rufinamide treatment in 3 cases","volume":"42","author":"H\u00e4usler","year":"2011","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.ejpn.2013.02.003_bib26","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1111\/j.1528-1167.2010.02639.x","article-title":"Panayiotopoulos syndrome: a clinical, EEG, and neuropsychological study of 93 consecutive patients","volume":"51","author":"Specchio","year":"2010","journal-title":"Epilepsia"},{"issue":"Suppl. 2","key":"10.1016\/j.ejpn.2013.02.003_bib27","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1046\/j.1528-1157.44.s.2.1.x","article-title":"Chronic management of seizures in the syndromes of idiopathic generalized epilepsy","volume":"44","author":"Bourgeois","year":"2003","journal-title":"Epilepsia"},{"issue":"Suppl. 2","key":"10.1016\/j.ejpn.2013.02.003_bib28","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1528-1167.2006.00690.x","article-title":"The natural history of myoclonic astatic epilepsy (Doose syndrome) and Lennox-Gastaut syndrome","volume":"47","author":"Stephani","year":"2006","journal-title":"Epilepsia"},{"issue":"8 Suppl. 5","key":"10.1016\/j.ejpn.2013.02.003_bib29","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1212\/WNL.58.8_suppl_5.S27","article-title":"Depression and epilepsy: how closely related are they?","volume":"58","author":"Kanner","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.ejpn.2013.02.003_bib30","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S0006-3223(03)00469-4","article-title":"Depression in epilepsy: prevalence, clinical semiology, pathogenic mechanisms, and treatment","volume":"54","author":"Kanner","year":"2003","journal-title":"Biol Psychiatry"},{"issue":"Suppl. 1","key":"10.1016\/j.ejpn.2013.02.003_bib31","first-page":"S15","article-title":"Evolution and management of Lennox-Gastaut syndrome through adolescence and into adulthood: are seizures always the primary issue?","volume":"13","author":"Kerr","year":"2011","journal-title":"Epileptic Disord"},{"key":"10.1016\/j.ejpn.2013.02.003_bib32","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0920-1211(98)00106-5","article-title":"Clinical aspects and biological bases of drug-resistant epilepsies","volume":"34","author":"Regesta","year":"1999","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.ejpn.2013.02.003_bib33","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/j.1528-1167.2009.02397.x","article-title":"Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies","volume":"51","author":"Kwan","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2013.02.003_bib34","first-page":"3","article-title":"Definition of intractable epilepsy","volume":"16","author":"Sinha","year":"2011","journal-title":"Neurosciences (Riyadh)"},{"key":"10.1016\/j.ejpn.2013.02.003_bib35","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.eplepsyres.2010.07.013","article-title":"Statistical process control (SPC)\u2013a simple objective method for monitoring seizure frequency and evaluating effectiveness of drug interventions in refractory childhood epilepsy","volume":"91","author":"Pujar","year":"2010","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.ejpn.2013.02.003_bib36","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1053\/seiz.2002.0593","article-title":"Refractory epilepsy: a progressive, intractable but preventable condition?","volume":"11","author":"Kwan","year":"2002","journal-title":"Seizure"},{"key":"10.1016\/j.ejpn.2013.02.003_bib37","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.0013-9580.2005.31904.x","article-title":"Potential role of drug transporters in the pathogenesis of medically intractable epilepsy","volume":"46","author":"Kwan","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2013.02.003_bib38","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1046\/j.1528-1157.2003.21803.x","article-title":"Major vault protein, a marker of drug resistance, is upregulated in refractory epilepsy","volume":"44","author":"Sisodiya","year":"2003","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2013.02.003_bib39","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/ana.21064","article-title":"Results of treatment changes in patients with apparently drug-resistant chronic epilepsy","volume":"62","author":"Luciano","year":"2007","journal-title":"Ann Neurol"},{"key":"10.1016\/j.ejpn.2013.02.003_bib40","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/ana.21166","article-title":"Likelihood of seizure remission in an adult population with refractory epilepsy","volume":"62","author":"Callaghan","year":"2007","journal-title":"Ann Neurol"},{"key":"10.1016\/j.ejpn.2013.02.003_bib41","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1111\/j.1528-1167.2008.01601.x","article-title":"Seizure remission and relapse in adults with intractable epilepsy: a cohort study","volume":"49","author":"Choi","year":"2008","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2013.02.003_bib42","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1212\/01.wnl.0000286959.22040.6e","article-title":"Quantifying the response to antiepileptic drugs: effect of past treatment history","volume":"70","author":"Schiller","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.ejpn.2013.02.003_bib43","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.eplepsyres.2010.11.005","article-title":"Seizure remission in adults with long-standing intractable epilepsy: an extended follow-up","volume":"93","author":"Choi","year":"2011","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.ejpn.2013.02.003_bib44","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1111\/j.0013-9580.2003.15003.x","article-title":"Long-term outcome of nonsurgical candidates with medically refractory localization-related epilepsy","volume":"44","author":"Selwa","year":"2003","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2013.02.003_bib45","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1111\/j.1528-1167.2006.00813.x","article-title":"Assessment of the long-term effects of epilepsy surgery with three different reference groups","volume":"47","author":"Bien","year":"2006","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2013.02.003_bib46","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1440-1754.2004.00308.x","article-title":"Quality of life of adolescents suffering from epilepsy living in the community","volume":"40","author":"Benavente-Aguilar","year":"2004","journal-title":"J Paediatr Child Health"},{"key":"10.1016\/j.ejpn.2013.02.003_bib47","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1177\/08830738060210040601","article-title":"Optimizing epilepsy management in teenagers","volume":"21","author":"Sheth","year":"2006","journal-title":"J Child Neurol"},{"issue":"Suppl. 9","key":"10.1016\/j.ejpn.2013.02.003_bib48","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1528-1167.2007.01402.x","article-title":"Weight issues for people with epilepsy\u2013a review","volume":"48","author":"Ben-Menachem","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2013.02.003_bib49","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S1474-4422(08)70292-8","article-title":"Lennox-Gastaut syndrome: a consensus approach on diagnosis, assessment, management, and trial methodology","volume":"8","author":"Arzimanoglou","year":"2009","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.ejpn.2013.02.003_bib50","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1469-8749.2011.03919.x","article-title":"Outcomes in pediatric neurology: a review of conceptual issues and recommendations. The 2010 Ronnie Mac Keith Lecture","volume":"53","author":"Ronen","year":"2011","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.ejpn.2013.02.003_bib51","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1111\/j.1528-1167.2011.02989.x","article-title":"Refractory absence epilepsy associated with GLUT-1 deficiency syndrome","volume":"52","author":"Byrne","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2013.02.003_bib52","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.braindev.2009.04.013","article-title":"Glucose transporter type 1 deficiency: ketogenic diet in three patients with atypical phenotype","volume":"32","author":"Veggiotti","year":"2010","journal-title":"Brain Dev"},{"issue":"Suppl. 8","key":"10.1016\/j.ejpn.2013.02.003_bib53","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1528-1167.2008.01833.x","article-title":"Glucose transporter deficiency syndrome (GLUT1DS) and the ketogenic diet","volume":"49","author":"Klepper","year":"2008","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2013.02.003_bib54","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1111\/j.1469-8749.2011.03961.x","article-title":"A modified Atkins diet is promising as a treatment for glucose transporter type 1 deficiency syndrome","volume":"53","author":"Ito","year":"2011","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.ejpn.2013.02.003_bib55","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.ajhg.2009.08.005","article-title":"Folate receptor alpha defect causes cerebral folate transport deficiency: a treatable neurodegenerative disorder associated with disturbed myelin metabolism","volume":"85","author":"Steinfeld","year":"2009","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ejpn.2013.02.003_bib56","doi-asserted-by":"crossref","first-page":"E113","DOI":"10.1111\/j.1440-1754.2010.01866.x","article-title":"Pyridoxine-dependent epilepsy: an under-recognised cause of intractable seizures","volume":"48","author":"Yeghiazaryan","year":"2012","journal-title":"J Paediatr Child Health"},{"key":"10.1016\/j.ejpn.2013.02.003_bib57","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1093\/brain\/awq143","article-title":"Genotypic and phenotypic spectrum of pyridoxine-dependent epilepsy (ALDH7A1 deficiency)","volume":"133","author":"Mills","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.ejpn.2013.02.003_bib58","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1212\/WNL.0b013e318227046d","article-title":"De novo SCN1A mutations in migrating partial seizures of infancy","volume":"77","author":"Carranza Rojo","year":"2011","journal-title":"Neurology"},{"issue":"Suppl. 2","key":"10.1016\/j.ejpn.2013.02.003_bib59","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1528-1167.2011.02997.x","article-title":"The genetics of Dravet syndrome","volume":"52","author":"Marini","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2013.02.003_bib60","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1111\/j.1528-1167.2011.03063.x","article-title":"Spectrum of phenotypes in female patients with epilepsy due to protocadherin 19 mutations","volume":"52","author":"Specchio","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2013.02.003_bib61","doi-asserted-by":"crossref","first-page":"E1959","DOI":"10.1002\/humu.21373","article-title":"Mutations and deletions in PCDH19 account for various familial or isolated epilepsies in females","volume":"32","author":"Depienne","year":"2011","journal-title":"Hum Mutat"},{"key":"10.1016\/j.ejpn.2013.02.003_bib62","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/ng.149","article-title":"X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment","volume":"40","author":"Dibbens","year":"2008","journal-title":"Nat Genet"},{"issue":"Suppl. 2","key":"10.1016\/j.ejpn.2013.02.003_bib63","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1469-8749.2011.03965.x","article-title":"Molecular genetics of Dravet syndrome","volume":"53","author":"De Jonghe","year":"2011","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.ejpn.2013.02.003_bib64","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/humupd\/dmn047","article-title":"The use of cell-free fetal nucleic acids in maternal blood for non-invasive prenatal diagnosis","volume":"15","author":"Wright","year":"2009","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.ejpn.2013.02.003_bib65","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1136\/jmg.2006.041467","article-title":"CDKL5 mutations cause infantile spasms, early onset seizures, and severe mental retardation in female patients","volume":"43","author":"Archer","year":"2006","journal-title":"J Med Genet"},{"key":"10.1016\/j.ejpn.2013.02.003_bib66","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/j.1528-1167.2009.02308.x","article-title":"Xp22.3 genomic deletions involving the CDKL5 gene in girls with early onset epileptic encephalopathy","volume":"51","author":"Mei","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2013.02.003_bib67","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1097\/01.jnen.0000229987.17548.6e","article-title":"POLG1 mutations associated with progressive encephalopathy in childhood","volume":"65","author":"Kollberg","year":"2006","journal-title":"J\u00a0Neuropathol Exp Neurol"},{"key":"10.1016\/j.ejpn.2013.02.003_bib68","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.seizure.2010.01.002","article-title":"POLG DNA testing as an emerging standard of care before instituting valproic acid therapy for pediatric seizure disorders","volume":"19","author":"Saneto","year":"2010","journal-title":"Seizure"},{"key":"10.1016\/j.ejpn.2013.02.003_bib69","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1212\/WNL.0b013e31820e7b25","article-title":"POLG1 manifestations in childhood","volume":"76","author":"Isohanni","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.ejpn.2013.02.003_bib70","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1111\/j.1528-1167.2012.03516.x","article-title":"Targeted next generation sequencing as a diagnostic tool in epileptic disorders","volume":"53","author":"Lemke","year":"2012","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2013.02.003_bib71","first-page":"1249","article-title":"Genetic testing in neurological diseases","volume":"259","author":"Biskup","year":"2012","journal-title":"J\u00a0Neurol"},{"key":"10.1016\/j.ejpn.2013.02.003_bib72","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.cell.2007.02.006","article-title":"Epigenetics: a landscape takes shape","volume":"128","author":"Goldberg","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.ejpn.2013.02.003_bib73","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2174\/1874467210902010095","article-title":"Biochemical, molecular and epigenetic mechanisms of valproic acid neuroprotection","volume":"2","author":"Monti","year":"2009","journal-title":"Curr Mol Pharmacol"},{"key":"10.1016\/j.ejpn.2013.02.003_bib74","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.1529-8027.2011.00355.x","article-title":"Levetiracetam exhibits protective properties on rat Schwann cells in\u00a0vitro","volume":"16","author":"Stettner","year":"2011","journal-title":"J\u00a0Peripher Nerv Syst"},{"key":"10.1016\/j.ejpn.2013.02.003_bib75","series-title":"Underlying mechanisms of epilepsy","first-page":"219","article-title":"A tale of two epiphenomena: the complex interplay of epigenetics and epilepsy","author":"Foti","year":"2011"},{"key":"10.1016\/j.ejpn.2013.02.003_bib76","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1684\/epd.2010.0303","article-title":"The evolution of antiepileptic drug development and regulation","volume":"12","author":"Arzimanoglou","year":"2010","journal-title":"Epileptic Disord"},{"key":"10.1016\/j.ejpn.2013.02.003_bib77","doi-asserted-by":"crossref","first-page":"965","DOI":"10.2165\/11317650-000000000-00000","article-title":"Visual field loss in patients with refractory partial epilepsy treated with vigabatrin: final results from an open-label, observational, multicentre study","volume":"23","author":"Wild","year":"2009","journal-title":"CNS Drugs"},{"key":"10.1016\/j.ejpn.2013.02.003_bib78","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1055\/s-0029-1234103","article-title":"Effectiveness of low dose of topiramate following rapid titration in multiply handicapped children and difficult-to-treat epilepsy","volume":"40","author":"Kluger","year":"2009","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.ejpn.2013.02.003_bib79","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1517\/13543784.9.4.829","article-title":"An assessment of rufinamide as an anti-epileptic in comparison with other drugs in clinical development","volume":"9","author":"Jain","year":"2000","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1016\/j.ejpn.2013.02.003_bib80","series-title":"Inovelon\u00ae summary of product characteristics","year":"2012"},{"key":"10.1016\/j.ejpn.2013.02.003_bib81","series-title":"BANZEL\u2122 prescribing information","year":"2011"},{"key":"10.1016\/j.ejpn.2013.02.003_bib82","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1212\/01.wnl.0000303813.95800.0d","article-title":"Rufinamide for generalized seizures associated with Lennox-Gastaut syndrome","volume":"70","author":"Glauser","year":"2008","journal-title":"Neurology"},{"issue":"Suppl. 5","key":"10.1016\/j.ejpn.2013.02.003_bib83","first-page":"219","article-title":"An ongoing European non-interventional registry study of patients with Lennox-Gastaut Syndrome: interim analysis","volume":"53","author":"Nikanorova","year":"2012","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2013.02.003_bib84","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.yebeh.2008.12.013","article-title":"Effectiveness and tolerability of rufinamide in children and adults with refractory epilepsy: first European experience","volume":"14","author":"Kluger","year":"2009","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.ejpn.2013.02.003_bib85","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.yebeh.2010.01.005","article-title":"First European long-term experience with the orphan drug rufinamide in childhood-onset refractory epilepsy","volume":"17","author":"Kluger","year":"2010","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.ejpn.2013.02.003_bib86","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.seizure.2010.09.008","article-title":"Rufinamide in children and adults with Lennox-Gastaut syndrome: first Italian multicenter experience","volume":"19","author":"Coppola","year":"2010","journal-title":"Seizure"},{"key":"10.1016\/j.ejpn.2013.02.003_bib87","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.pediatrneurol.2010.04.003","article-title":"Experience with rufinamide in a pediatric population: a single center\u2019s experience","volume":"43","author":"Vendrame","year":"2010","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.ejpn.2013.02.003_bib88","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/j.1600-0404.2010.01334.x","article-title":"Adjunctive rufinamide in Lennox-Gastaut syndrome: a long-term, open-label extension study","volume":"122","author":"Kluger","year":"2010","journal-title":"Acta Neurol Scand"},{"issue":"Suppl. 1","key":"10.1016\/j.ejpn.2013.02.003_bib89","first-page":"S27","article-title":"Rufinamide from clinical trials to clinical practice in the United States and Europe","volume":"13","author":"Resnick","year":"2011","journal-title":"Epileptic Disord"},{"key":"10.1016\/j.ejpn.2013.02.003_bib90","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.clinthera.2011.01.016","article-title":"Bioavailability of three rufinamide oral suspensions compared with the marketed 400-mg tablet formulation: results from a randomized-sequence, open-label, four-period, four-sequence crossover study in healthy subjects","volume":"33","author":"Critchley","year":"2011","journal-title":"Clin Ther"},{"key":"10.1016\/j.ejpn.2013.02.003_bib91","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1111\/j.1528-1157.1994.tb01780.x","article-title":"Treatment of severe myoclonic epilepsy in infants with bromide and its borderline variant","volume":"35","author":"Oguni","year":"1994","journal-title":"Epilepsia"},{"issue":"Suppl. 2","key":"10.1016\/j.ejpn.2013.02.003_bib92","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1469-8749.2011.03967.x","article-title":"Current therapeutic procedures in Dravet syndrome","volume":"53","author":"Chiron","year":"2011","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.ejpn.2013.02.003_bib93","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1111\/j.1528-1167.2011.03046.x","article-title":"Therapy for hyperthermia-induced seizures in Scn1a mutant rats","volume":"52","author":"Hayashi","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2013.02.003_bib94","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1055\/s-0032-1307454","article-title":"Bromide in patients with SCN1A-mutations manifesting as Dravet syndrome","volume":"43","author":"Lotte","year":"2012","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.ejpn.2013.02.003_bib95","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1111\/j.1528-1167.2012.03495.x","article-title":"Successful use of fenfluramine as an add-on treatment for Dravet syndrome","volume":"53","author":"Ceulemans","year":"2012","journal-title":"Epilepsia"},{"issue":"Suppl. 6","key":"10.1016\/j.ejpn.2013.02.003_bib96","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.0013-9580.2004.455003.x","article-title":"Pregabalin pharmacology and its relevance to clinical practice","volume":"45","author":"Ben-Menachem","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2013.02.003_bib97","doi-asserted-by":"crossref","first-page":"661","DOI":"10.2165\/11536200-000000000-00000","article-title":"A comparison of the pharmacokinetics and pharmacodynamics of pregabalin and gabapentin","volume":"49","author":"Bockbrader","year":"2010","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.ejpn.2013.02.003_bib98","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.nurt.2006.11.004","article-title":"Brivaracetam (UCB 34714)","volume":"4","author":"von Rosenstiel","year":"2007","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.ejpn.2013.02.003_bib99","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1517\/14656566.2011.591380","article-title":"Brivaracetam for the treatment of epilepsy","volume":"12","author":"Schulze-Bonhage","year":"2011","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/j.ejpn.2013.02.003_bib100","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.nurt.2006.10.005","article-title":"Eslicarbazepine acetate (BIA\u00a02-093)","volume":"4","author":"Almeida","year":"2007","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.ejpn.2013.02.003_bib101","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1517\/13543780802635107","article-title":"Eslicarbazepine acetate: a new option for the treatment of focal epilepsy","volume":"18","author":"Mestre","year":"2009","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1016\/j.ejpn.2013.02.003_bib102","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eplepsyres.2006.10.008","article-title":"Progress report on new antiepileptic drugs: a summary of the Eighth Eilat Conference (EILAT VIII)","volume":"73","author":"Bialer","year":"2007","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.ejpn.2013.02.003_bib103","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1056\/NEJM200002033420503","article-title":"Early identification of refractory epilepsy","volume":"342","author":"Kwan","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejpn.2013.02.003_bib104","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1517\/14656566.2010.517194","article-title":"Pharmacotherapy for children and adolescents with epilepsy","volume":"12","author":"Verrotti","year":"2011","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/j.ejpn.2013.02.003_bib105","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jneumeth.2011.06.014","article-title":"KCNQ2\/3 openers show differential selectivity and site of action across multiple KCNQ channels","volume":"200","author":"Zhang","year":"2011","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.ejpn.2013.02.003_bib106","doi-asserted-by":"crossref","first-page":"887","DOI":"10.2165\/11205950-000000000-00000","article-title":"Retigabine (ezogabine): in partial-onset seizures in adults with epilepsy","volume":"25","author":"Deeks","year":"2011","journal-title":"CNS Drugs"},{"key":"10.1016\/j.ejpn.2013.02.003_bib107","doi-asserted-by":"crossref","first-page":"56","DOI":"10.5698\/1535-7511-11.2.56","article-title":"Revisiting AMPA receptors as an antiepileptic drug target","volume":"11","author":"Rogawski","year":"2011","journal-title":"Epilepsy Curr"},{"key":"10.1016\/j.ejpn.2013.02.003_bib108","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/j.1528-1167.2011.03024.x","article-title":"Modern antiepileptic drug development has failed to deliver: ways out of the current dilemma","volume":"52","author":"L\u00f6scher","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2013.02.003_bib109","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1093\/brain\/awh077","article-title":"Potassium channel antibody-associated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitis","volume":"127","author":"Vincent","year":"2004","journal-title":"Brain"},{"key":"10.1016\/j.ejpn.2013.02.003_bib110","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/WCO.0b013e32833735fe","article-title":"The growing recognition of immunotherapy-responsive seizure disorders with autoantibodies to specific neuronal proteins","volume":"23","author":"Vincent","year":"2010","journal-title":"Curr Opin Neurol"},{"key":"10.1016\/j.ejpn.2013.02.003_bib111","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1136\/adc.2010.183897","article-title":"Limbic encephalitis in children and adolescents","volume":"96","author":"Haberlandt","year":"2011","journal-title":"Arch Dis Child"},{"issue":"Suppl. 3","key":"10.1016\/j.ejpn.2013.02.003_bib112","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1528-1167.2011.03031.x","article-title":"Autoantibodies and epilepsy","volume":"52","author":"Bien","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2013.02.003_bib113","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1097\/WCO.0b013e3283446f05","article-title":"Autoimmune epilepsies","volume":"24","author":"Irani","year":"2011","journal-title":"Curr Opin Neurol"},{"key":"10.1016\/j.ejpn.2013.02.003_bib114","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1002\/ana.22307","article-title":"Faciobrachial dystonic seizures precede Lgi1 antibody limbic encephalitis","volume":"69","author":"Irani","year":"2011","journal-title":"Ann Neurol"},{"key":"10.1016\/j.ejpn.2013.02.003_bib115","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.braindev.2008.05.004","article-title":"FIRES: febrile infection responsive epileptic (FIRE) encephalopathies of school age","volume":"31","author":"van Baalen","year":"2009","journal-title":"Brain Dev"},{"key":"10.1016\/j.ejpn.2013.02.003_bib116","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1111\/j.1528-1167.2010.02535.x","article-title":"Febrile infection-related epilepsy syndrome (FIRES): a nonencephalitic encephalopathy in childhood","volume":"51","author":"van Baalen","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2013.02.003_bib117","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.seizure.2010.11.013","article-title":"Anti-NMDA receptor encephalitis presenting with imaging findings and clinical features mimicking Rasmussen syndrome","volume":"20","author":"Greiner","year":"2011","journal-title":"Seizure"},{"key":"10.1016\/j.ejpn.2013.02.003_bib118","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1111\/j.1469-8749.2011.04008.x","article-title":"Elevated VGKC-complex antibodies in a boy with fever-induced refractory epileptic encephalopathy in school-age children (FIRES)","volume":"53","author":"Illingworth","year":"2011","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.ejpn.2013.02.003_bib119","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1093\/brain\/awh415","article-title":"Pathogenesis, diagnosis and treatment of Rasmussen encephalitis: a European consensus statement","volume":"128","author":"Bien","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.ejpn.2013.02.003_bib120","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1111\/j.1528-1167.2010.02703.x","article-title":"Efficacy of ketogenic diet in severe refractory status epilepticus initiating fever induced refractory epileptic encephalopathy in school age children (FIRES)","volume":"51","author":"Nabbout","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2013.02.003_bib121","first-page":"263","article-title":"Role of surgery in pediatric epilepsy","volume":"44","author":"Daniel","year":"2007","journal-title":"Indian Pediatr"},{"key":"10.1016\/j.ejpn.2013.02.003_bib122","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1212\/WNL.0b013e3181e0f17a","article-title":"Improved outcomes in pediatric epilepsy surgery: the UCLA experience, 1986\u20132008","volume":"74","author":"Hemb","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.ejpn.2013.02.003_bib123","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1111\/j.1528-1167.2006.00569.x","article-title":"Proposed criteria for referral and evaluation of children for epilepsy surgery: recommendations of the Subcommission for Pediatric Epilepsy Surgery","volume":"47","author":"Cross","year":"2006","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2013.02.003_bib124","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1528-1167.2007.01421.x","article-title":"Defining the spectrum of international practice in pediatric epilepsy surgery patients","volume":"49","author":"Harvey","year":"2008","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2013.02.003_bib125","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S1474-4422(04)00807-5","article-title":"More fat and fewer seizures: dietary therapies for epilepsy","volume":"3","author":"Kossoff","year":"2004","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.ejpn.2013.02.003_bib126","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1111\/j.1528-1167.2011.03287.x","article-title":"The ketogenic and related diets in adolescents and adults \u2013 a review","volume":"52","author":"Payne","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2013.02.003_bib127","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/S1474-4422(08)70092-9","article-title":"The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial","volume":"7","author":"Neal","year":"2008","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.ejpn.2013.02.003_bib128","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/j.1528-1167.2008.01765.x","article-title":"Optimal clinical management of children receiving the ketogenic diet: recommendations of the International Ketogenic Diet Study Group","volume":"50","author":"Kossoff","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2013.02.003_bib129","first-page":"492","article-title":"Efficacy of the Atkins diet as therapy for intractable epilepsy in children","volume":"13","author":"Tonekaboni","year":"2010","journal-title":"Arch Iran Med"},{"key":"10.1016\/j.ejpn.2013.02.003_bib130","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1528-1167.2006.00438.x","article-title":"A modified Atkins diet is effective for the treatment of intractable pediatric epilepsy","volume":"47","author":"Kossoff","year":"2006","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2013.02.003_bib131","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/j.1528-1167.2006.00910.x","article-title":"Use of a modified Atkins diet in intractable childhood epilepsy","volume":"48","author":"Kang","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2013.02.003_bib132","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1111\/j.1528-1167.2010.02941.x","article-title":"Efficacy and tolerability of the modified Atkins diet in adults with pharmacoresistant epilepsy: a prospective observational study","volume":"52","author":"Smith","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2013.02.003_bib133","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1111\/j.1528-1167.2012.03406.x","article-title":"E-mail management of the modified Atkins Diet for adults with epilepsy is feasible and effective","volume":"53","author":"Cervenka","year":"2012","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2013.02.003_bib134","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1111\/j.1528-1167.2008.01959.x","article-title":"Efficacy, safety, and tolerability of the low glycemic index treatment in pediatric epilepsy","volume":"50","author":"Muzykewicz","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2013.02.003_bib135","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/ncpneuro0750","article-title":"Technology insight: neuroengineering and epilepsy-designing devices for seizure control","volume":"4","author":"Stacey","year":"2008","journal-title":"Nat Clin Pract Neurol"},{"key":"10.1016\/j.ejpn.2013.02.003_bib136","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.ejpn.2012.01.001","article-title":"Clinical outcomes, quality of life, and costs associated with implantation of vagus nerve stimulation therapy in pediatric patients with drug-resistant epilepsy","volume":"16","author":"Helmers","year":"2012","journal-title":"Eur J Paediatr Neurol"},{"key":"10.1016\/j.ejpn.2013.02.003_bib137","series-title":"Investigational procedure guidance 50: Vagus nerve stimulation for refractory epilepsy in children","author":"National Institute for Health and Clinical Excellence","year":"2004"},{"key":"10.1016\/j.ejpn.2013.02.003_bib138","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1212\/WNL.49.1.293","article-title":"Assessment of vagus nerve stimulation for epilepsy: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology","volume":"49","author":"Fisher","year":"1997","journal-title":"Neurology"},{"key":"10.1016\/j.ejpn.2013.02.003_bib139","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1111\/j.1528-1167.2010.02536.x","article-title":"Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy","volume":"51","author":"Fisher","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2013.02.003_bib140","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1111\/j.1528-1167.2007.01181.x","article-title":"Electrical stimulation of the hippocampal epileptic foci for seizure control: a double-blind, long-term follow-up study","volume":"48","author":"Velasco","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2013.02.003_bib141","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jocn.2011.03.043","article-title":"Refractory epilepsy and deep brain stimulation","volume":"19","author":"Pereira","year":"2012","journal-title":"J Clin Neurosci"},{"key":"10.1016\/j.ejpn.2013.02.003_bib142","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.nurt.2009.01.017","article-title":"Convection-enhanced delivery in the treatment of epilepsy","volume":"6","author":"Rogawski","year":"2009","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.ejpn.2013.02.003_bib143","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1111\/j.1528-1167.2010.02700.x","article-title":"Continuous local intrahippocampal delivery of adenosine reduces seizure frequency in rats with spontaneous seizures","volume":"51","author":"Van Dycke","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2013.02.003_bib144","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.eplepsyres.2006.02.003","article-title":"Effect of intracerebroventricular continuous infusion of valproic acid versus single i.p. and i.c.v. injections in the amygdala kindling epilepsy model","volume":"70","author":"Serralta","year":"2006","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.ejpn.2013.02.003_bib145","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.nurt.2009.01.015","article-title":"Intraventricular and intracerebral delivery of anti-epileptic drugs in the kindling model","volume":"6","author":"Barcia","year":"2009","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.ejpn.2013.02.003_bib146","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.neulet.2009.12.042","article-title":"Comparison of the antiepileptic properties of transmeningeally delivered muscimol, lidocaine, midazolam, pentobarbital and GABA, in rats","volume":"469","author":"Baptiste","year":"2010","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.ejpn.2013.02.003_bib147","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.neulet.2011.02.075","article-title":"Periodic transmeningeal muscimol maintains its antiepileptic efficacy over three weeks without inducing tolerance, in rats","volume":"494","author":"Tang","year":"2011","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.ejpn.2013.02.003_bib148","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1002\/jps.20935","article-title":"Formulation of spray-dried phenytoin loaded poly(epsilon-caprolactone) microcarrier intended for brain delivery to treat epilepsy","volume":"96","author":"Li","year":"2007","journal-title":"J Pharm Sci"},{"key":"10.1016\/j.ejpn.2013.02.003_bib149","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.expneurol.2008.12.021","article-title":"GDNF released from encapsulated cells suppresses seizure activity in the epileptic hippocampus","volume":"216","author":"Kanter-Schlifke","year":"2009","journal-title":"Exp Neurol"},{"key":"10.1016\/j.ejpn.2013.02.003_bib150","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.expneurol.2009.05.018","article-title":"Antiepileptic effects of silk-polymer based adenosine release in kindled rats","volume":"219","author":"Szybala","year":"2009","journal-title":"Exp Neurol"},{"key":"10.1016\/j.ejpn.2013.02.003_bib151","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.nurt.2009.01.002","article-title":"Intranasal delivery of antiepileptic medications for treatment of seizures","volume":"6","author":"Wermeling","year":"2009","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.ejpn.2013.02.003_bib152","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0140-6736(00)03591-1","article-title":"Anticipation of epileptic seizures from standard EEG recordings","volume":"357","author":"Le Van Quyen","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.ejpn.2013.02.003_bib153","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1016\/j.clinph.2008.08.025","article-title":"Automated seizure onset detection for accurate onset time determination in intracranial EEG","volume":"119","author":"Chan","year":"2008","journal-title":"Clin Neurophysiol"},{"key":"10.1016\/j.ejpn.2013.02.003_bib154","first-page":"6608","article-title":"Detection of nocturnal frontal lobe seizures in pediatric patients by means of accelerometers: a first study","volume":"2009","author":"Cuppens","year":"2009","journal-title":"Conf Proc IEEE Eng Med Biol Soc"},{"key":"10.1016\/j.ejpn.2013.02.003_bib155","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1007\/s11517-010-0648-4","article-title":"Automatic video detection of body movement during sleep based on optical flow in pediatric patients with epilepsy","volume":"48","author":"Cuppens","year":"2010","journal-title":"Med Biol Eng Comput"},{"key":"10.1016\/j.ejpn.2013.02.003_bib156","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1142\/S0129065711002808","article-title":"Application of recurrence quantification analysis for the automated identification of epileptic EEG signals","volume":"21","author":"Acharya","year":"2011","journal-title":"Int J Neural Syst"},{"key":"10.1016\/j.ejpn.2013.02.003_bib157","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/978-3-211-33081-4_41","article-title":"A novel closed-loop stimulation system in the control of focal, medically refractory epilepsy","volume":"97","author":"Fountas","year":"2007","journal-title":"Acta Neurochir Suppl"},{"key":"10.1016\/j.ejpn.2013.02.003_bib158","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.nurt.2007.10.069","article-title":"Responsive cortical stimulation for the treatment of epilepsy","volume":"5","author":"Sun","year":"2008","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.ejpn.2013.02.003_bib159","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.nec.2011.07.007","article-title":"Responsive neurostimulation suppresses synchronized cortical rhythms in patients with epilepsy","volume":"22","author":"Sohal","year":"2011","journal-title":"Neurosurg Clin N Am"},{"key":"10.1016\/j.ejpn.2013.02.003_bib160","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1212\/WNL.0b013e3182302056","article-title":"Responsive cortical stimulation for the treatment of medically intractable partial epilepsy","volume":"77","author":"Morrell","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.ejpn.2013.02.003_bib161","doi-asserted-by":"crossref","first-page":"839","DOI":"10.2176\/nmc.50.839","article-title":"Application of focal cerebral cooling for the treatment of intractable epilepsy","volume":"50","author":"Fujii","year":"2010","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"10.1016\/j.ejpn.2013.02.003_bib162","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.nurt.2009.01.003","article-title":"Noninvasive brain stimulation protocols in the treatment of epilepsy: current state and perspectives","volume":"6","author":"Nitsche","year":"2009","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.ejpn.2013.02.003_bib163","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s10548-009-0116-3","article-title":"Prospects for clinical applications of transcranial magnetic stimulation and real-time EEG in epilepsy","volume":"22","author":"Rotenberg","year":"2010","journal-title":"Brain Topogr"},{"key":"10.1016\/j.ejpn.2013.02.003_bib164","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1159\/000282735","article-title":"Transcranial magnetic stimulation for drug-resistant epilepsies: rationale and clinical experience","volume":"63","author":"Kimiskidis","year":"2010","journal-title":"Eur Neurol"},{"key":"10.1016\/j.ejpn.2013.02.003_bib165","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.npep.2004.07.006","article-title":"Galanin and galanin receptors in epilepsy","volume":"38","author":"Mazarati","year":"2004","journal-title":"Neuropeptides"},{"key":"10.1016\/j.ejpn.2013.02.003_bib166","author":"NsGene"},{"key":"10.1016\/j.ejpn.2013.02.003_bib167","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2174\/157015909789152164","article-title":"Adenosine, ketogenic diet and epilepsy: the emerging therapeutic relationship between metabolism and brain activity","volume":"7","author":"Masino","year":"2009","journal-title":"Curr Neuropharmacol"},{"key":"10.1016\/j.ejpn.2013.02.003_bib168","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.eplepsyres.2009.03.019","article-title":"Adenosine augmentation therapies (AATs) for epilepsy: prospect of cell and gene therapies","volume":"85","author":"Boison","year":"2009","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.ejpn.2013.02.003_bib169","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.nurt.2009.01.016","article-title":"Transplantation of GABA-producing cells for seizure control in models of temporal lobe epilepsy","volume":"6","author":"Thompson","year":"2009","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.ejpn.2013.02.003_bib170","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1093\/brain\/awn079","article-title":"Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat\u00a0model of temporal lobe epilepsy","volume":"131","author":"No\u00e8","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.ejpn.2013.02.003_bib171","doi-asserted-by":"crossref","first-page":"11342","DOI":"10.1523\/JNEUROSCI.3329-06.2006","article-title":"Enhancing GABA(A) receptor alpha 1 subunit levels in hippocampal dentate gyrus inhibits epilepsy development in an animal model of temporal lobe epilepsy","volume":"26","author":"Raol","year":"2006","journal-title":"J Neurosci"}],"container-title":["European Journal of Paediatric Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090379813000251?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090379813000251?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T17:01:46Z","timestamp":1595610106000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1090379813000251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":171,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["S1090379813000251"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpn.2013.02.003","relation":{},"ISSN":["1090-3798"],"issn-type":[{"value":"1090-3798","type":"print"}],"subject":[],"published":{"date-parts":[[2013,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Advancing the management of childhood epilepsies","name":"articletitle","label":"Article Title"},{"value":"European Journal of Paediatric Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpn.2013.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}