{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T09:46:51Z","timestamp":1786268811182,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["ejpn-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Paediatric Neurology"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.ejpn.2014.04.013","type":"journal-article","created":{"date-parts":[[2014,4,24]],"date-time":"2014-04-24T03:03:39Z","timestamp":1398308619000},"page":"604-608","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Lacosamide in children with refractory status epilepticus. A multicenter Italian experience"],"prefix":"10.1016","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0974-0596","authenticated-orcid":false,"given":"Salvatore","family":"Grosso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelia","family":"Zamponi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaldo","family":"Bartocci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Cesaroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Cappanera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanna","family":"Di Bartolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Balestri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpn.2014.04.013_bib1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1528-1157.1981.tb06159.x","article-title":"Proposal for revised clinical and electroencephalographic classification of epileptic seizures","volume":"22","year":"1981","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2014.04.013_bib2","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1056\/NEJM199809173391202","article-title":"A comparison of four treatments for generalized convulsive status epilepticus, Veterans Affairs Status Epilepticus Cooperative Study Group","volume":"339","author":"Treiman","year":"1998","journal-title":"N Engl J Med"},{"issue":"Suppl. 1","key":"10.1016\/j.ejpn.2014.04.013_bib3","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1528-1167.2006.00658.x","article-title":"The management of refractory status epilepticus: an update","volume":"47","author":"Lowenstein","year":"2006","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2014.04.013_bib4","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1111\/j.1365-2125.2007.02931.x","article-title":"Anticonvulsant therapy for status epilepticus","volume":"63","author":"Prasad","year":"2007","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.ejpn.2014.04.013_bib5","first-page":"CD001905","article-title":"Drug management for acute tonic-clonic convulsions including convulsive status epilepticus in children","author":"Appleton","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.ejpn.2014.04.013_bib6","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1111\/j.1528-1167.2008.01706_3.x","article-title":"The drug treatment of status epilepticus in Europe: consensus document from a workshop at the first London Colloquium on Status Epilepticus","volume":"49","author":"Shorvon","year":"2008","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2014.04.013_bib7","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/j.1468-1331.2009.02917.x","article-title":"EFNS guideline on the management of status epilepticus","volume":"17","author":"Meierkord","year":"2010","journal-title":"Eur J Neurol"},{"issue":"Suppl. 8","key":"10.1016\/j.ejpn.2014.04.013_bib8","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1528-1167.2007.01349.x","article-title":"The use of valproate and new antiepileptic drugs in status epilepticus","volume":"48","author":"Trinka","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2014.04.013_bib9","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1056\/NEJMoa002141","article-title":"A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticus","volume":"345","author":"Alldredge","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejpn.2014.04.013_bib10","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.pediatrneurol.2008.01.001","article-title":"Treatment of refractory status epilepticus: literature review and a proposed protocol","volume":"38","author":"Abend","year":"2008","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.ejpn.2014.04.013_bib11","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1093\/brain\/awr215","article-title":"The treatment of super-refractory status epilepticus: a critical review of available therapies and a clinical treatment protocol","volume":"134","author":"Shorvon","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.ejpn.2014.04.013_bib12","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1093\/brain\/aws091","article-title":"The outcome of therapies in refractory and super-refractory convulsive status epilepticus and recommendations for therapy","volume":"135","author":"Shorvon","year":"2012","journal-title":"Brain"},{"issue":"Suppl. 7","key":"10.1016\/j.ejpn.2014.04.013_bib13","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/epi.12307","article-title":"Treatment of convulsive status epilepticus in childhood: recommendations of the Italian League Against Epilepsy","volume":"54","author":"Capovilla","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2014.04.013_bib14","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.yebeh.2012.02.026","article-title":"Newer antiepileptic drugs in the treatment of status epilepticus: impact on prognosis","volume":"24","author":"Jaques","year":"2012","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.ejpn.2014.04.013_bib15","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/epi.12058","article-title":"Lacosamide as a new treatment option in status epilepticus","volume":"54","author":"H\u00f6fler","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2014.04.013_bib16","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1179\/1743132812Y.0000000128","article-title":"Refractory status epilepticus: new insights in presentation, treatment, and outcome","volume":"35","author":"Hocker","year":"2013","journal-title":"Neurol Res"},{"key":"10.1016\/j.ejpn.2014.04.013_bib17","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1001\/jamaneurol.2013.578","article-title":"Predictors of outcome in refractory status epilepticus","volume":"70","author":"Hocker","year":"2013","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.ejpn.2014.04.013_bib18","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1124\/mol.107.039867","article-title":"The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels","volume":"73","author":"Errington","year":"2008","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.ejpn.2014.04.013_bib19","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s12028-010-9501-8","article-title":"The use of lacosamide in refractory status epilepticus","volume":"14","author":"Goodwin","year":"2011","journal-title":"Neurocrit Care"},{"key":"10.1016\/j.ejpn.2014.04.013_bib20","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.yebeh.2008.12.009","article-title":"Intravenous lacosamide as successful treatment for nonconvulsive status epilepticus after failure of first-line therapy","volume":"14","author":"Kellinghaus","year":"2009","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.ejpn.2014.04.013_bib21","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.seizure.2011.12.008","article-title":"Intravenous lacosamide in refractory nonconvulsive status epilepticus","volume":"21","author":"Mantsakanyan","year":"2012","journal-title":"Seizure"},{"key":"10.1016\/j.ejpn.2014.04.013_bib22","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/j.1528-1167.2011.03204.x","article-title":"Intravenous lacosamide in status epilepticus and seizure clusters","volume":"52","author":"H\u00f6fler","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2014.04.013_bib23","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.seizure.2012.10.004","article-title":"Efficacy of intravenous lacosamide as an add-on treatment in refractory status epilepticus: a multicentric prospective study","volume":"22","author":"Mir\u00f3","year":"2013","journal-title":"Seizure"},{"key":"10.1016\/j.ejpn.2014.04.013_bib24","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.seizure.2011.03.005","article-title":"Successful treatment of childhood prolonged refractory status epilepticus with lacosamide","volume":"20","author":"Shiloh-Malawsky","year":"2011","journal-title":"Seizure"},{"key":"10.1016\/j.ejpn.2014.04.013_bib25","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1111\/j.1528-1167.2012.03419.x","article-title":"Treatment of refractory tonic status epilepticus with intravenous lacosamide","volume":"53","author":"Jain","year":"2012","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2014.04.013_bib26","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1600-0404.2010.01430.x","article-title":"Efficacy and safety of intravenous lacosamide in refractory nonconvulsive status epilepticus","volume":"123","author":"Koubeissi","year":"2011","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.ejpn.2014.04.013_bib27","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.seizure.2011.01.017","article-title":"Intravenous lacosamide \u2013 an effective add-on treatment of refractory status epilepticus","volume":"20","author":"Albers","year":"2011","journal-title":"Seizure"},{"key":"10.1016\/j.ejpn.2014.04.013_bib28","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s12028-011-9662-0","article-title":"Safety and efficacy of lacosamide in the intensive care unit","volume":"16","author":"Cherry","year":"2012","journal-title":"Neurocrit Care"},{"key":"10.1016\/j.ejpn.2014.04.013_bib29","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/j.1528-1167.2009.02388.x","article-title":"The ketogenic diet in treatment of two adults with prolonged nonconvulsive status epilepticus","volume":"51","author":"Wusthoff","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2014.04.013_bib30","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.yebeh.2011.02.006","article-title":"Atrioventricular block following lacosamide intoxication","volume":"20","author":"Krause","year":"2011","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.ejpn.2014.04.013_bib31","first-page":"211","article-title":"Use of lacosamide in children with refractory epilepsy","volume":"17","author":"Buck","year":"2012","journal-title":"J Pediatr Pharmacol Ther"}],"container-title":["European Journal of Paediatric Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090379814000774?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090379814000774?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T14:22:35Z","timestamp":1538662955000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1090379814000774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["S1090379814000774"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpn.2014.04.013","relation":{},"ISSN":["1090-3798"],"issn-type":[{"value":"1090-3798","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lacosamide in children with refractory status epilepticus. A multicenter Italian experience","name":"articletitle","label":"Article Title"},{"value":"European Journal of Paediatric Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpn.2014.04.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}