{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:12:26Z","timestamp":1787238746756,"version":"build-2736575974"},"reference-count":29,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","ejpn-journal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Paediatric Neurology"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.ejpn.2016.03.007","type":"journal-article","created":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T05:50:52Z","timestamp":1459489852000},"page":"611-615","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Increased insulin-like growth factor-1 levels in cerebrospinal fluid of advanced subacute sclerosing panencephalitis patients"],"prefix":"10.1016","volume":"20","author":[{"given":"Deniz","family":"Y\u0131lmaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"Y\u00fcksel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didem","family":"G\u00f6kkurt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hava","family":"Oguz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banu","family":"Anlar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpn.2016.03.007_bib1","series-title":"Viral infections of the human nervous system","first-page":"1","article-title":"Measles virus infection and subacute sclerosing panencephalitis","author":"Anlar","year":"2013"},{"key":"10.1016\/j.ejpn.2016.03.007_bib2","first-page":"133","article-title":"Neurofibrillary pathology in subacute sclerosing panencephalitis","volume":"2","author":"Wisniewski","year":"1991","journal-title":"Dementia"},{"key":"10.1016\/j.ejpn.2016.03.007_bib3","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/0197-4580(96)00069-3","article-title":"On the relationship between measles virus and Alzheimer neurofibrillary tangles in subacute sclerosing panencephalitis","volume":"17","author":"Bancher","year":"1996","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.ejpn.2016.03.007_bib4","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.neurobiolaging.2008.04.002","article-title":"Defects in IGF-1 receptor, insulin receptor and IRS-1\/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling","volume":"31","author":"Moloney","year":"2010","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.ejpn.2016.03.007_bib5","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1212\/WNL.54.9.1828","article-title":"CSF insulin-like growth factor-1 in infantile neuronal ceroid lipofuscinosis","volume":"54","author":"Riikonen","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.ejpn.2016.03.007_bib6","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/S0166-2236(03)00163-2","article-title":"Potential roles of insulin and IGF-1 in Alzheimer's disease","volume":"26","author":"Gasparini","year":"2003","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.ejpn.2016.03.007_bib7","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.braindev.2011.07.001","article-title":"Cerebrospinal fluid apolipoprotein E levels in subacute sclerosing panencephalitis","volume":"34","author":"Y\u00fcksel","year":"2012","journal-title":"Brain Dev"},{"key":"10.1016\/j.ejpn.2016.03.007_bib8","doi-asserted-by":"crossref","first-page":"5086","DOI":"10.1210\/en.2005-0063","article-title":"Tau is hyperphosphorylated in the insulin-like growth factor-I null brain","volume":"146","author":"Cheng","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejpn.2016.03.007_bib9","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/path.2912","article-title":"Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes","volume":"225","author":"Liu","year":"2011","journal-title":"J Pathol"},{"key":"10.1016\/j.ejpn.2016.03.007_bib10","first-page":"493","article-title":"Clinical staging, course and frequency","volume":"32","author":"Jabbour","year":"1975","journal-title":"Arch Neurol"},{"key":"10.1016\/j.ejpn.2016.03.007_bib11","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1212\/WNL.42.3.488","article-title":"Intraventricular interferon and oral inosiplex in the treatment of subacute sclerosing panencephalitis","volume":"42","author":"Yalaz","year":"1992","journal-title":"Neurology"},{"key":"10.1016\/j.ejpn.2016.03.007_bib12","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.jocn.2009.08.013","article-title":"Expression of insulin-like growth factor-1 and insulin-like growth factor binding proteins in the serum and cerebrospinal fluid of patients with Parkinson's disease","volume":"17","author":"Mashayekhi","year":"2010","journal-title":"J Clin Neurosci"},{"issue":"10","key":"10.1016\/j.ejpn.2016.03.007_bib13","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1212\/WNL.0000000000000749","article-title":"Neuronal loss is an early component of subacute sclerosing panencephalitis","volume":"83","author":"Y\u00fcksel","year":"2014","journal-title":"Neurology"},{"issue":"12","key":"10.1016\/j.ejpn.2016.03.007_bib14","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1177\/088307380101601206","article-title":"Tissue inflammatory response in subacute sclerosing panencephalitis (SSPE)","volume":"16","author":"Anlar","year":"2001","journal-title":"J Child Neurol"},{"key":"10.1016\/j.ejpn.2016.03.007_bib15","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ejphar.2004.02.050","article-title":"The role of insulin and insulin-like growth factor I in the molecular and cellular mechanisms underlying the pathology of Alzheimer's disease","volume":"490","author":"Carro","year":"2004","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.ejpn.2016.03.007_bib16","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/j.psyneuen.2013.02.006","article-title":"Serum but not cerebrospinal fluid levels of insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 (IGFBP-3) are increased in Alzheimer's disease","volume":"38","author":"Johansson","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.ejpn.2016.03.007_bib17","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0074-7742(07)79009-8","article-title":"The insulin-like growth factor system in multiple sclerosis","volume":"79","author":"Chesik","year":"2007","journal-title":"Int Rev Neurobiol"},{"key":"10.1016\/j.ejpn.2016.03.007_bib18","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/biof.5520330202","article-title":"Insulin like growth factor-1 and insulin like growth factor binding proteins in the cerebrospinal fluid and serum from patients with Alzheimer's disease","volume":"33","author":"Salehi","year":"2008","journal-title":"Biofactors"},{"key":"10.1016\/j.ejpn.2016.03.007_bib19","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1055\/s-2007-973497","article-title":"Apoptosis in brain biopsies of subacute sclerosing panencephalitis patients","volume":"30","author":"Anlar","year":"1999","journal-title":"Neuropediatrics"},{"issue":"12","key":"10.1016\/j.ejpn.2016.03.007_bib20","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1016\/j.euroneuro.2014.01.020","article-title":"Insulin and insulin-like growth factor receptors in the brain: physiological and pathological aspects","volume":"24","author":"Werner","year":"2014","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.ejpn.2016.03.007_bib21","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1182\/blood.V83.6.1569.1569","article-title":"Differential effect of growth hormone and insulin-like growth factor-I, insulin-like growth factor-II, and insulin on Ig production and growth in human plasma cells","volume":"83","author":"Kimata","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.ejpn.2016.03.007_bib22","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1084\/jem.180.2.727","article-title":"Growth hormone and insulin-like growth factor I induce immunoglobulin (Ig)E and IgG4 production by human B cells","volume":"180","author":"Kimata","year":"1994","journal-title":"J Exp Med"},{"issue":"1","key":"10.1016\/j.ejpn.2016.03.007_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00018-015-2042-8","article-title":"Behind the curtain of tauopathy: a show of multiple players orchestrating tau toxicity","volume":"73","author":"Huang","year":"2016","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.ejpn.2016.03.007_bib24","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.braindev.2009.11.009","article-title":"Tau proteins in the cerebrospinal fluid of patients with subacute sclerosingpanencephalitis","volume":"32","author":"Yuksel","year":"2010","journal-title":"Brain Dev"},{"key":"10.1016\/j.ejpn.2016.03.007_bib25","doi-asserted-by":"crossref","first-page":"19547","DOI":"10.1074\/jbc.272.31.19547","article-title":"Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons","volume":"272","author":"Hong","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ejpn.2016.03.007_bib26","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1034\/j.1600-0404.2002.01326.x","article-title":"Cerebrospinal fluid levels of insulin in patients with Alzheimer's disease","volume":"106","author":"Molina","year":"2002","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.ejpn.2016.03.007_bib27","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1002\/jnr.21787","article-title":"Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: parallels with Alzheimer's disease and correction by insulin","volume":"86","author":"Jolivalt","year":"2008","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.ejpn.2016.03.007_bib28","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1136\/jmg.2008.062141","article-title":"Intranasal insulin to improve developmental delay in children with 22q13 deletion syndrome: an exploratory clinical trial","volume":"46","author":"Schmidt","year":"2009","journal-title":"J Med Genet"},{"key":"10.1016\/j.ejpn.2016.03.007_bib29","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jns.2009.09.022","article-title":"Effects of insulinic therapy on cognitive impairment in patients with Alzheimer disease and diabetes mellitus type-2","volume":"288","author":"Plastino","year":"2010","journal-title":"J Neurol Sci"}],"container-title":["European Journal of Paediatric Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090379816000556?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090379816000556?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T21:57:59Z","timestamp":1600379879000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1090379816000556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["S1090379816000556"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpn.2016.03.007","relation":{},"ISSN":["1090-3798"],"issn-type":[{"value":"1090-3798","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased insulin-like growth factor-1 levels in cerebrospinal fluid of advanced subacute sclerosing panencephalitis patients","name":"articletitle","label":"Article Title"},{"value":"European Journal of Paediatric Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpn.2016.03.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}