{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:00:28Z","timestamp":1791838828287,"version":"4.3.4"},"reference-count":21,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"German Federal Ministry of Education and Research","award":["BMBF01EO1303"],"award-info":[{"award-number":["BMBF01EO1303"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejpn-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Paediatric Neurology"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.ejpn.2018.04.003","type":"journal-article","created":{"date-parts":[[2018,4,13]],"date-time":"2018-04-13T13:10:49Z","timestamp":1523625049000},"page":"870-877","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["CD59 deficiency presenting as polyneuropathy and Moyamoya syndrome with endothelial abnormalities of small brain vessels"],"prefix":"10.1016","volume":"22","author":[{"given":"Christian","family":"Klemann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janbernd","family":"Kirschner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Ammann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horst","family":"Urbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Moske-Eick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Zieger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam Ricarda","family":"Lorenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soroush","family":"Doostkam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Ehl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Korinthenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpn.2018.04.003_bib1","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.hoc.2015.01.006","article-title":"Congenital CD59 deficiency","volume":"29","author":"H\u00f6chsmann","year":"2015","journal-title":"Hematol Oncol Clin N Am"},{"key":"10.1016\/j.ejpn.2018.04.003_bib2","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1002\/eji.1830221029","article-title":"Paroxysmal nocturnal hemoglobinuria due to hereditary nucleotide deletion in the HRF20 (CD59) gene","volume":"22","author":"Motoyama","year":"1992","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.ejpn.2018.04.003_bib3","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1056\/NEJM199010253231707","article-title":"Inherited complete deficiency of 20-kilodalton homologous restriction factor (CD59) as a cause of paroxysmal nocturnal hemoglobinuria","volume":"323","author":"Yamashina","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejpn.2018.04.003_bib4","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1182\/blood-2012-07-441857","article-title":"CD59 deficiency is associated with chronic hemolysis and childhood relapsing immune-mediated polyneuropathy","volume":"121","author":"Nevo","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.ejpn.2018.04.003_bib5","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.ejpn.2015.07.001","article-title":"Devastating recurrent brain ischemic infarctions and retinal disease in pediatric patients with CD59 deficiency","volume":"19","author":"Ben-Zeev","year":"2015","journal-title":"Eur J Paediatr Neurol"},{"key":"10.1016\/j.ejpn.2018.04.003_bib6","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1056\/NEJMc1308104","article-title":"Targeted therapy with eculizumab for inherited CD59 deficiency","volume":"370","author":"H\u00f6chsmann","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejpn.2018.04.003_bib7","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1212\/WNL.0000000000001391","article-title":"Early-onset chronic axonal neuropathy, strokes, and hemolysis: inherited CD59 deficiency","volume":"84","author":"Haliloglu","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.ejpn.2018.04.003_bib8","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.hoc.2015.01.005","article-title":"Paroxysmal nocturnal hemoglobinuria: a complement-mediated hemolytic anemia","volume":"29","author":"DeZern","year":"2015","journal-title":"Hematol Oncol Clin N Am"},{"key":"10.1016\/j.ejpn.2018.04.003_bib9","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/tpj.2009.52","article-title":"Upregulating CD59: a new strategy for protection of neurons from complement-mediated degeneration","volume":"10","author":"Kolev","year":"2010","journal-title":"Pharmacogenomics J"},{"key":"10.1016\/j.ejpn.2018.04.003_bib10","doi-asserted-by":"crossref","first-page":"5434","DOI":"10.4049\/jimmunol.1201621","article-title":"Absence of CD59 exacerbates systemic autoimmunity in MRL\/lpr mice","volume":"189","author":"Miwa","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.ejpn.2018.04.003_bib11","doi-asserted-by":"crossref","first-page":"21","DOI":"10.5853\/jos.2015.01739","article-title":"Moyamoya disease: treatment and outcomes","volume":"18","author":"Kim","year":"2016","journal-title":"J Stroke"},{"key":"10.1016\/j.ejpn.2018.04.003_bib12","doi-asserted-by":"crossref","first-page":"2","DOI":"10.5853\/jos.2015.01627","article-title":"Moyamoya disease: epidemiology, clinical features, and diagnosis","volume":"18","author":"Kim","year":"2016","journal-title":"J Stroke"},{"key":"10.1016\/j.ejpn.2018.04.003_bib13","doi-asserted-by":"crossref","first-page":"12","DOI":"10.5853\/jos.2015.01760","article-title":"The pathophysiology of moyamoya disease: an update","volume":"18","author":"Bang","year":"2016","journal-title":"J Stroke"},{"key":"10.1016\/j.ejpn.2018.04.003_bib14","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0387-7604(95)00145-X","article-title":"Paroxysmal nocturnal hemoglobinuria presenting as moyamoya syndrome","volume":"18","author":"Lin","year":"1996","journal-title":"Brain Dev"},{"key":"10.1016\/j.ejpn.2018.04.003_bib15","series-title":"Outer-diameter narrowing of the internal carotid and middle cerebral arteries in moyamoya disease detected on 3D constructive interference in steady-state MR image: is arterial constrictive remodeling a major pathogenesis?","author":"Kaku","year":"2012"},{"key":"10.1016\/j.ejpn.2018.04.003_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2014.10.021","article-title":"High-resolution MR imaging of the arterial wall in moyamoya disease","author":"Yuan","year":"2015","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.ejpn.2018.04.003_bib17","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1161\/STROKEAHA.114.004761","article-title":"High-resolution magnetic resonance wall imaging findings of moyamoya disease","volume":"45","author":"Ryoo","year":"2014","journal-title":"Stroke"},{"key":"10.1016\/j.ejpn.2018.04.003_bib18","doi-asserted-by":"crossref","DOI":"10.1111\/ene.12202","article-title":"High resolution MRI difference between moyamoya disease and intracranial atherosclerosis","author":"Kim","year":"2013","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.ejpn.2018.04.003_bib19","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000135649","article-title":"Vessel wall contrast enhancement: a diagnostic sign of cerebral vasculitis","volume":"26","author":"K\u00fcker","year":"2008","journal-title":"Cerebrovasc Dis"},{"key":"10.1016\/j.ejpn.2018.04.003_bib20","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1136\/jnnp-2015-312020","article-title":"High-resolution intracranial vessel wall imaging: imaging beyond the lumen","volume":"87","author":"Alexander","year":"2016","journal-title":"J Neurol Neurosurg Psychiatr"},{"key":"10.1016\/j.ejpn.2018.04.003_bib21","doi-asserted-by":"crossref","first-page":"238","DOI":"10.5853\/jos.2015.17.3.238","article-title":"Vessel wall imaging of the intracranial and cervical carotid arteries","volume":"17","author":"Choi","year":"2015","journal-title":"J Stroke"}],"container-title":["European Journal of Paediatric Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090379817301319?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090379817301319?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T18:34:48Z","timestamp":1761071688000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1090379817301319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["S1090379817301319"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpn.2018.04.003","relation":{},"ISSN":["1090-3798"],"issn-type":[{"value":"1090-3798","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CD59 deficiency presenting as polyneuropathy and Moyamoya syndrome with endothelial abnormalities of small brain vessels","name":"articletitle","label":"Article Title"},{"value":"European Journal of Paediatric Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpn.2018.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}