{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:18:59Z","timestamp":1790104739140,"version":"4.0.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejpn-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Paediatric Neurology"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.ejpn.2019.02.007","type":"journal-article","created":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T19:09:41Z","timestamp":1550862581000},"page":"384-391","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Neurological complications in childhood nephrotic syndrome: A systematic review"],"prefix":"10.1016","volume":"23","author":[{"given":"Stella","family":"Stabouli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina","family":"Chrysaidou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan C.","family":"Kupferman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios I.","family":"Zafeiriou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpn.2019.02.007_bib1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0140-6736(03)14184-0","article-title":"Nephrotic syndrome in childhood","volume":"362","author":"Eddy","year":"2003","journal-title":"Lancet (London England)"},{"key":"10.1016\/j.ejpn.2019.02.007_bib2","doi-asserted-by":"crossref","first-page":"513","DOI":"10.2215\/CJN.10131011","article-title":"Epidemiology and pathophysiology of nephrotic syndrome-associated thromboembolic disease","volume":"7","author":"Kerlin","year":"2012","journal-title":"Clin J Am Soc Nephrol CJASN"},{"key":"10.1016\/j.ejpn.2019.02.007_bib3","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1007\/s10157-014-1005-y","article-title":"Case series of thromboembolic complications in childhood nephrotic syndrome: hacettepe experience","volume":"19","author":"Tavil","year":"2015","journal-title":"Clin Exp Nephrol"},{"key":"10.1016\/j.ejpn.2019.02.007_bib4","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s00467-011-1873-2","article-title":"Posterior reversible encephalopathy syndrome in children with kidney diseases","volume":"27","author":"Ishikura","year":"2012","journal-title":"Paediatr Nephrol (Berlin, Germany)"},{"key":"10.1016\/j.ejpn.2019.02.007_bib5","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1136\/bmjebm-2017-110853","article-title":"Methodological quality and synthesis of case series and case reports","volume":"23","author":"Murad","year":"2018","journal-title":"BMJ Evid Based Med"},{"key":"10.1016\/j.ejpn.2019.02.007_bib6","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s00431-008-0833-8","article-title":"Wernicke's encephalopathy in a patient with nephrotic syndrome","volume":"168","author":"Nishida","year":"2009","journal-title":"Eur J Paediatr"},{"key":"10.1016\/j.ejpn.2019.02.007_bib7","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/S0387-7604(02)00094-3","article-title":"Latent cerebral hypoperfusion in a boy with persistent nephrotic syndrome","volume":"24","author":"Ito","year":"2002","journal-title":"Brain Dev"},{"key":"10.1016\/j.ejpn.2019.02.007_bib8","first-page":"135","article-title":"Nephrotic syndrome and Guillan-Barre Syndrome: a rare association in child","volume":"21","author":"Bouyahia","year":"2010","journal-title":"Saudi J Kidney Dis Transplant \u2013 Offic Publ Saudi Center Organ Transplant Saudi Arabia"},{"key":"10.1016\/j.ejpn.2019.02.007_bib9","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s00467-003-1349-0","article-title":"Minimal change nephrotic syndrome with Guillain-Barre syndrome","volume":"19","author":"Ilyas","year":"2004","journal-title":"Paediatr Nephrol (Berlin, Germany)"},{"key":"10.1016\/j.ejpn.2019.02.007_bib10","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s004310050887","article-title":"Kinking and stenosis of the carotid artery associated with homolateral ischaemic brain infarction in a patient treated with cyclosporin A","volume":"157","author":"Huemer","year":"1998","journal-title":"Eur J Paediatr"},{"key":"10.1016\/j.ejpn.2019.02.007_bib11","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/BF00862081","article-title":"Superior sagittal sinus thrombosis in a child with nephrotic syndrome","volume":"10","author":"Divekar","year":"1996","journal-title":"Paediatr Nephrol (Berlin, Germany)"},{"key":"10.1016\/j.ejpn.2019.02.007_bib12","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s00431-006-0147-7","article-title":"Cerebral sinovenous thrombosis and idiopathic nephrotic syndrome in childhood: report of four new cases and review of the literature","volume":"165","author":"Fluss","year":"2006","journal-title":"Eur J Paediatr"},{"key":"10.1016\/j.ejpn.2019.02.007_bib13","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s10157-013-0917-2","article-title":"Thromboembolic complications in childhood nephrotic syndrome: a clinical profile","volume":"18","author":"Suri","year":"2014","journal-title":"Clin Exp Nephrol"},{"key":"10.1016\/j.ejpn.2019.02.007_bib14","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.pediatrneurol.2004.11.004","article-title":"Superior sagittal sinus thrombosis in steroid-resistant nephrotic syndrome","volume":"32","author":"Papachristou","year":"2005","journal-title":"Paediatr Neurol"},{"key":"10.1016\/j.ejpn.2019.02.007_bib15","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S1052-5149(02)00064-3","article-title":"Sinovenous thrombosis in children","volume":"13","author":"Shroff","year":"2003","journal-title":"Neuroimag Clin North Am"},{"key":"10.1016\/j.ejpn.2019.02.007_bib16","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jpeds.2009.01.070","article-title":"Epidemiology and risk factors for thromboembolic complications of childhood nephrotic syndrome: a Midwest Paediatric Nephrology Consortium (MWPNC) study","volume":"155","author":"Kerlin","year":"2009","journal-title":"J Paediatr"},{"key":"10.1016\/j.ejpn.2019.02.007_bib17","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1007\/s00467-013-2525-5","article-title":"Venous thromboembolism in paediatric nephrotic syndrome","volume":"29","author":"Kerlin","year":"2014","journal-title":"Paediatr Nephrol (Berlin, Germany)"},{"key":"10.1016\/j.ejpn.2019.02.007_bib18","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1007\/s00467-015-3241-0","article-title":"The non-immunosuppressive management of childhood nephrotic syndrome","volume":"31","author":"McCaffrey","year":"2016","journal-title":"Paediatr Nephrol (Berlin, Germany)"},{"key":"10.1016\/j.ejpn.2019.02.007_bib19","doi-asserted-by":"crossref","first-page":"512","DOI":"10.2174\/157016111203140518172048","article-title":"Hypercoagulability and nephrotic syndrome","volume":"12","author":"Gigante","year":"2014","journal-title":"Curr Vasc Pharmacol"},{"key":"10.1016\/j.ejpn.2019.02.007_bib20","doi-asserted-by":"crossref","first-page":"454","DOI":"10.5414\/CN107863","article-title":"Assessment of genetic risk factors for thromboembolic complications in adults with idiopathic nephrotic syndrome","volume":"79","author":"Sahin","year":"2013","journal-title":"Clin Nephrol"},{"key":"10.1016\/j.ejpn.2019.02.007_bib21","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1161\/01.CIR.0000087598.05977.45","article-title":"Cerebral venous thrombosis in children: a multifactorial origin","volume":"108","author":"Heller","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.ejpn.2019.02.007_bib22","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1007\/s00467-015-3173-8","article-title":"Platelet abnormalities in nephrotic syndrome","volume":"31","author":"Eneman","year":"2016","journal-title":"Paediatr Nephrol (Berlin, Germany)"},{"key":"10.1016\/j.ejpn.2019.02.007_bib23","doi-asserted-by":"crossref","first-page":"R101","DOI":"10.1530\/EJE-15-0308","article-title":"Mechanisms in endocrinology: the spectrum of haemostatic abnormalities in glucocorticoid excess and defect","volume":"173","author":"Isidori","year":"2015","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.ejpn.2019.02.007_bib24","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1161\/CIRCULATIONAHA.107.716951","article-title":"High absolute risks and predictors of venous and arterial thromboembolic events in patients with nephrotic syndrome: results from a large retrospective cohort study","volume":"117","author":"Mahmoodi","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.ejpn.2019.02.007_bib25","doi-asserted-by":"crossref","first-page":"e737S","DOI":"10.1378\/chest.11-2308","article-title":"Antithrombotic therapy in neonates and children: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of chest Physicians evidence-based clinical practice guidelines","volume":"141","author":"Monagle","year":"2012","journal-title":"Chest"},{"key":"10.1016\/j.ejpn.2019.02.007_bib26","first-page":"127","article-title":"Cerebral sinus venous thrombosis in a child with nephrotic syndrome","volume":"19","author":"Al-Rumayyan","year":"2014","journal-title":"Neurosciences (Riyadh, Saudi Arabia)"},{"key":"10.1016\/j.ejpn.2019.02.007_bib27","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13052-016-0227-x","article-title":"Antithrombotic prophylaxis in a patient with nephrotic syndrome and congenital protein S deficiency","volume":"42","author":"Artoni","year":"2016","journal-title":"Ital J Paediatr"},{"key":"10.1016\/j.ejpn.2019.02.007_bib28","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0887-8994(01)00265-X","article-title":"Clinical spectrum of reversible posterior leukoencephalopathy syndrome","volume":"24","author":"Kwon","year":"2001","journal-title":"Paediatr Neurol"},{"key":"10.1016\/j.ejpn.2019.02.007_bib29","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/nep.12518","article-title":"Reversible posterior encephalopathy syndrome in children with nephrotic syndrome","volume":"20","author":"Zhou","year":"2015","journal-title":"Nephrology (Carlton, Vic)"},{"key":"10.1016\/j.ejpn.2019.02.007_bib30","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1007\/s00467-007-0578-z","article-title":"Posterior reversible encephalopathy syndrome in the paediatric renal population","volume":"22","author":"Onder","year":"2007","journal-title":"Paediatr Nephrol (Berlin, Germany)"},{"key":"10.1016\/j.ejpn.2019.02.007_bib31","first-page":"2531","article-title":"Nephrotic state as a risk factor for developing posterior reversible encephalopathy syndrome in paediatric patients with nephrotic syndrome","volume":"23","author":"Ishikura","year":"2008","journal-title":"Nephrol Dial Transplant \u2013 Offic Publ Eur Dial Transplant Assoc Eur Renal Assoc"},{"key":"10.1016\/j.ejpn.2019.02.007_bib32","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1053\/j.ajkd.2006.04.076","article-title":"Posterior reversible encephalopathy syndrome in children: its high prevalence and more extensive imaging findings","volume":"48","author":"Ishikura","year":"2006","journal-title":"Am J Kidney Dis \u2013 Offic J Natl Kidney Found"},{"key":"10.1016\/j.ejpn.2019.02.007_bib33","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1056\/NEJM199602223340803","article-title":"A reversible posterior leukoencephalopathy syndrome","volume":"334","author":"Hinchey","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejpn.2019.02.007_bib34","first-page":"439","article-title":"Cyclosporin-A induced posterior reversible encephalopathy syndrome","volume":"19","author":"Saeed","year":"2008","journal-title":"Saudi J Kidney Dis Transplant \u2013 Offic Publ Saudi Center Organ Transplant Saudi Arabia"},{"key":"10.1016\/j.ejpn.2019.02.007_bib35","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/ped.12084","article-title":"Severe posterior reversible encephalopathy syndrome resolved with craniectomy","volume":"55","author":"Nagaoka","year":"2013","journal-title":"Paediatr Int \u2013 Offic J Japan Paediatr Soc"},{"key":"10.1016\/j.ejpn.2019.02.007_bib36","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s00381-013-2342-y","article-title":"Posterior reversible encephalopathy syndrome in children: report of three cases","volume":"30","author":"Akin","year":"2014","journal-title":"Child's Nerv Syst ChNS \u2013 Offic J Int Soc Paediatr Neurosurg"},{"key":"10.1016\/j.ejpn.2019.02.007_bib37","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s10157-010-0380-2","article-title":"Children with posterior reversible encephalopathy syndrome associated with atypical diffusion-weighted imaging and apparent diffusion coefficient","volume":"15","author":"Ishikura","year":"2011","journal-title":"Clin Exp Nephrol"},{"key":"10.1016\/j.ejpn.2019.02.007_bib38","first-page":"4433","article-title":"Posterior reversible encephalopathy syndrome in a child with steroid-resistant nephrotic syndrome: a case report and review of literature","volume":"7","author":"Zhang","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"10.1016\/j.ejpn.2019.02.007_bib39","doi-asserted-by":"crossref","first-page":"406","DOI":"10.5414\/CN106976","article-title":"Recurrent posterior reversible encephalopathy syndrome in nephrotic syndrome: case report and review of the literature","volume":"78","author":"Yamada","year":"2012","journal-title":"Clin Nephrol"},{"key":"10.1016\/j.ejpn.2019.02.007_bib40","first-page":"957","article-title":"Posterior reversible encephalopathy syndrome","volume":"21","author":"Akl","year":"2010","journal-title":"Saudi J Kidney Dis Transplant \u2013 Offic Publ Saudi Center Organ Transplant Saudi Arabia"}],"container-title":["European Journal of Paediatric Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090379818303817?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090379818303817?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T18:36:26Z","timestamp":1761071786000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1090379818303817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["S1090379818303817"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpn.2019.02.007","relation":{},"ISSN":["1090-3798"],"issn-type":[{"value":"1090-3798","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neurological complications in childhood nephrotic syndrome: A systematic review","name":"articletitle","label":"Article Title"},{"value":"European Journal of Paediatric Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpn.2019.02.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}