{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:26:59Z","timestamp":1788319619241,"version":"build-2803163510"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T00:00:00Z","timestamp":1574380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011110","name":"UCB","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011110","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejpn-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Paediatric Neurology"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.ejpn.2019.11.007","type":"journal-article","created":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T02:50:16Z","timestamp":1574304616000},"page":"68-76","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Safety and tolerability of adjunctive brivaracetam in children with focal seizures: Interim analysis of pooled data from two open-label trials"],"prefix":"10.1016","volume":"25","author":[{"given":"Anup D.","family":"Patel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Badalamenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Gasalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Elmoufti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Peer","family":"Elshoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpn.2019.11.007_bib1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1684\/epd.2015.0736","article-title":"Incidence, prevalence and aetiology of seizures and epilepsy in children","volume":"17","author":"Camfield","year":"2015","journal-title":"Epileptic Disord"},{"key":"10.1016\/j.ejpn.2019.11.007_bib2","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1007\/s12098-014-1533-1","article-title":"Refractory epilepsy in children","volume":"81","author":"Aneja","year":"2014","journal-title":"Indian J Pediatr"},{"key":"10.1016\/j.ejpn.2019.11.007_bib3","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1528-1157.2000.tb00184.x","article-title":"The impact of childhood epilepsy on neurocognitive and behavioral performance: a prospective longitudinal study","volume":"41","author":"Bailet","year":"2000","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2019.11.007_bib4","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2015-3944","article-title":"Determinants of social outcomes in adults with childhood-onset epilepsy","volume":"137","author":"Berg","year":"2016","journal-title":"Pediatrics"},{"key":"10.1016\/j.ejpn.2019.11.007_bib5","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1111\/epi.13421","article-title":"Long-term socioeconomic consequences and health care costs of childhood and adolescent-onset epilepsy","volume":"57","author":"Jennum","year":"2016","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2019.11.007_bib6","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.seizure.2018.09.016","article-title":"Short-term and longer-term effects of brivaracetam on cognition and behavior in a naturalistic clinical setting-preliminary data","volume":"62","author":"Witt","year":"2018","journal-title":"Seizure"},{"key":"10.1016\/j.ejpn.2019.11.007_bib7","series-title":"Briviact\u00ae (brivaracetam) Summary of Product Characteristics","year":"2018"},{"key":"10.1016\/j.ejpn.2019.11.007_bib8","series-title":"Briviact\u00ae (brivaracetam) C-V Prescribing Information","year":"2018"},{"key":"10.1016\/j.ejpn.2019.11.007_bib9","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/epi.12433","article-title":"Brivaracetam as adjunctive treatment for uncontrolled partial epilepsy in adults: a phase III randomized, double-blind, placebo-controlled trial","volume":"55","author":"Biton","year":"2014","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2019.11.007_bib10","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/epi.12432","article-title":"Adjunctive brivaracetam in adults with uncontrolled focal epilepsy: results from a double-blind, randomized, placebo-controlled trial","volume":"55","author":"Ryvlin","year":"2014","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2019.11.007_bib11","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1111\/epi.13212","article-title":"A\u00a0randomized, double-blind, placebo-controlled, multicenter, parallel-group study to evaluate the efficacy and safety of adjunctive brivaracetam in adult patients with uncontrolled partial-onset seizures","volume":"56","author":"Klein","year":"2015","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2019.11.007_bib12","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s00228-017-2230-6","article-title":"Brivaracetam population pharmacokinetics in children with epilepsy aged 1 month to 16 years","volume":"73","author":"Schoemaker","year":"2017","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.ejpn.2019.11.007_bib13","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s40262-017-0597-2","article-title":"Extrapolation of a brivaracetam exposure-response model from adults to children with focal seizures","volume":"57","author":"Schoemaker","year":"2018","journal-title":"Clin Pharmacokinet"},{"issue":"Suppl 1","key":"10.1016\/j.ejpn.2019.11.007_bib14","first-page":"390","article-title":"Safety and tolerability of adjunctive brivaracetam administered as oral solution in pediatric patients aged at least 1 month to 16 years with epilepsy","volume":"14","author":"Liu","year":"2013","journal-title":"Epilepsy Curr"},{"key":"10.1016\/j.ejpn.2019.11.007_bib15","first-page":"S278","article-title":"Interim safety and tolerability analysis from an open-label, long-term follow-up study of adjunctive brivaracetam in pediatric patients with epilepsy","volume":"82","author":"Badalamenti","year":"2017","journal-title":"Ann Neurol"},{"key":"10.1016\/j.ejpn.2019.11.007_bib16","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1528-1157.1989.tb05316.x","article-title":"Proposal for revised classification of epilepsies and epileptic syndromes","volume":"30","author":"Commission on Classification and Terminology of the International League Against Epilepsy","year":"1989","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2019.11.007_bib17","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1176\/appi.ajp.2011.10111704","article-title":"The Columbia-Suicide Severity Rating Scale: initial validity and internal consistency findings from three multisite studies with adolescents and adults","volume":"168","author":"Posner","year":"2011","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.ejpn.2019.11.007_bib18","series-title":"Manual for Child Behavior Checklist\/4-18 and 1991 profile","author":"Achenbach","year":"1991"},{"key":"10.1016\/j.ejpn.2019.11.007_bib19","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1542\/pir.21.8.265","article-title":"The Child Behavior Checklist and related forms for assessing behavioral\/emotional problems and competencies","volume":"21","author":"Achenbach","year":"2000","journal-title":"Pediatr Rev"},{"key":"10.1016\/j.ejpn.2019.11.007_bib20","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1080\/09297049.2017.1365829","article-title":"Utility of the Behavior Rating Inventory of Executive Function - Preschool version (BRIEF-P) in young children with epilepsy","volume":"24","author":"Maiman","year":"2018","journal-title":"Child Neuropsychol"},{"key":"10.1016\/j.ejpn.2019.11.007_bib21","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1076\/chin.6.3.235.3152","article-title":"Behavior rating inventory of executive function","volume":"6","author":"Baron","year":"2000","journal-title":"Child Neuropsychol"},{"key":"10.1016\/j.ejpn.2019.11.007_bib22","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1111\/epi.12233","article-title":"A\u00a0randomized phase III trial of adjunctive zonisamide in pediatric patients with partial epilepsy","volume":"54","author":"Guerrini","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2019.11.007_bib23","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1111\/epi.12548","article-title":"Adjunctive zonisamide therapy in the long-term treatment of children with partial epilepsy: results of an open-label extension study of a phase III, randomized, double-blind, placebo-controlled trial","volume":"55","author":"Guerrini","year":"2014","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2019.11.007_bib24","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1111\/j.1528-1157.1999.tb00833.x","article-title":"Gabapentin as add-on therapy in children with refractory partial seizures: a 12-week, multicentre, double-blind, placebo-controlled study. Gabapentin Paediatric Study Group","volume":"40","author":"Appleton","year":"1999","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2019.11.007_bib25","first-page":"269","article-title":"Gabapentin as add-on therapy in children with refractory partial seizures: a 24-week, multicentre, open-label study","volume":"43","author":"Appleton","year":"2001","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.ejpn.2019.11.007_bib26","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1212\/WNL.53.8.1724","article-title":"A\u00a0placebo-controlled trial of lamotrigine add-on therapy for partial seizures in children. Lamictal Pediatric Partial Seizure Study Group","volume":"53","author":"Duchowny","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.ejpn.2019.11.007_bib27","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1212\/WNL.52.7.1338","article-title":"A\u00a0double-blind, randomized trial of topiramate as adjunctive therapy for partial-onset seizures in children. Topiramate YP Study Group","volume":"52","author":"Elterman","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.ejpn.2019.11.007_bib28","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1212\/WNL.54.12.2237","article-title":"Adjunctive therapy with oxcarbazepine in children with partial seizures. The Oxcarbazepine Pediatric Study Group","volume":"54","author":"Glauser","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.ejpn.2019.11.007_bib29","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1212\/01.wnl.0000217916.00225.3a","article-title":"Double-blind placebo-controlled trial of adjunctive levetiracetam in pediatric partial seizures","volume":"66","author":"Glauser","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.ejpn.2019.11.007_bib30","first-page":"1735","article-title":"Common cold","volume":"53","author":"Worrall","year":"2007","journal-title":"Can Fam Physician"},{"key":"10.1016\/j.ejpn.2019.11.007_bib31","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1111\/epi.13416","article-title":"Safety, tolerability, and seizure control during long-term treatment with adjunctive brivaracetam for partial-onset seizures","volume":"57","author":"Toledo","year":"2016","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2019.11.007_bib32","doi-asserted-by":"crossref","first-page":"239","DOI":"10.5455\/medarh.2017.71.239-242","article-title":"Effects of carbamazepine and valproate on serum aspartate aminotransferase, alanine aminotransferase and gamma-glutamyltransferase in children","volume":"71","author":"Hadzagic-Catibusic","year":"2017","journal-title":"Med Arch"},{"key":"10.1016\/j.ejpn.2019.11.007_bib33","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jns.2014.05.043","article-title":"Epilepsy and its main psychiatric comorbidities in adults and children","volume":"343","author":"Verrotti","year":"2014","journal-title":"J\u00a0Neurol Sci"},{"key":"10.1016\/j.ejpn.2019.11.007_bib34","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.ejpn.2017.02.003","article-title":"Psychiatric and behavioral side effects of anti-epileptic drugs in adolescents and children with epilepsy","volume":"21","author":"Chen","year":"2017","journal-title":"Eur J Paediatr Neurol"},{"key":"10.1016\/j.ejpn.2019.11.007_bib35","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.braindev.2017.01.006","article-title":"Cognitive and behavioral effects of new antiepileptic drugs in pediatric epilepsy","volume":"39","author":"Moavero","year":"2017","journal-title":"Brain Dev"},{"key":"10.1016\/j.ejpn.2019.11.007_bib36","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/S1474-4422(12)70153-9","article-title":"Adverse effects of antiepileptic drugs","volume":"11","author":"Perucca","year":"2012","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.ejpn.2019.11.007_bib37","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.yebeh.2017.04.003","article-title":"Psychiatric side effects and antiepileptic drugs: observations from prospective audits","volume":"71","author":"Stephen","year":"2017","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.ejpn.2019.11.007_bib38","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/epi.13946","article-title":"Antiepileptic drug behavioral side effects and baseline hyperactivity in children and adolescents with new onset epilepsy","volume":"59","author":"Guilfoyle","year":"2018","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2019.11.007_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0149686","article-title":"Safety of levetiracetam in paediatrics: a systematic review","volume":"11","author":"Egunsola","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ejpn.2019.11.007_bib40","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.seizure.2014.06.004","article-title":"Behavioral side-effects of levetiracetam in children with epilepsy: a systematic review","volume":"23","author":"Halma","year":"2014","journal-title":"Seizure"},{"key":"10.1016\/j.ejpn.2019.11.007_bib41","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/epi.13638","article-title":"Evidence for a differential interaction of brivaracetam and levetiracetam with the synaptic vesicle 2A protein","volume":"58","author":"Wood","year":"2017","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2019.11.007_bib42","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1111\/j.1528-1167.2006.00973.x","article-title":"Modulation of AMPA receptors in cultured cortical neurons induced by the antiepileptic drug levetiracetam","volume":"48","author":"Carunchio","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2019.11.007_bib43","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1097\/WNF.0000000000000258","article-title":"Anger assessment in patients treated with brivaracetam","volume":"41","author":"Ortega","year":"2018","journal-title":"Clin Neuropharmacol"},{"key":"10.1016\/j.ejpn.2019.11.007_bib44","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.seizure.2016.07.007","article-title":"Response to Zhang et\u00a0al.: levetiracetam vs. brivaracetam for adults with refractory focal seizures: a meta-analysis and indirect comparison","volume":"41","author":"Borghs","year":"2016","journal-title":"Seizure"},{"key":"10.1016\/j.ejpn.2019.11.007_bib45","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1007\/s40263-017-0462-8","article-title":"Can matching-adjusted indirect comparison methods mitigate placebo response differences among patient populations in adjunctive trials of brivaracetam and levetiracetam?","volume":"31","author":"Swallow","year":"2017","journal-title":"CNS Drugs"},{"key":"10.1016\/j.ejpn.2019.11.007_bib46","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.yebeh.2013.09.020","article-title":"Screening for suicidal ideation in children with epilepsy","volume":"29","author":"Jones","year":"2013","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.ejpn.2019.11.007_bib47","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/jcpp.12831","article-title":"Annual research review: suicide among youth - epidemiology, (potential) etiology, and treatment","volume":"59","author":"Cha","year":"2018","journal-title":"J\u00a0Child Psychol Psychiatry"},{"key":"10.1016\/j.ejpn.2019.11.007_bib48","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13052-015-0153-3","article-title":"Suicide in pediatrics: epidemiology, risk factors, warning signs and the role of the pediatrician in detecting them","volume":"41","author":"Dilillo","year":"2015","journal-title":"Ital J Pediatr"},{"key":"10.1016\/j.ejpn.2019.11.007_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.ss6708a1","article-title":"Youth risk behavior surveillance - United States, 2017","volume":"67","author":"Kann","year":"2018","journal-title":"MMWR Surveill Summ"},{"key":"10.1016\/j.ejpn.2019.11.007_bib50","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1111\/epi.13766","article-title":"Psychiatric and behavioral comorbidities in epilepsy: a critical reappraisal","volume":"58","author":"Berg","year":"2017","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2019.11.007_bib51","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1111\/epi.13123","article-title":"Psychiatric disorders and suicidal behavior in neurotypical young adults with childhood-onset epilepsy","volume":"56","author":"Baldin","year":"2015","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejpn.2019.11.007_bib52","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S0002-7138(09)60232-6","article-title":"Overrepresentation of epileptics in a consecutive series of suicide attempters seen at a children's hospital, 1978-1983","volume":"25","author":"Brent","year":"1986","journal-title":"J\u00a0Am Acad Child Psychiatry"},{"key":"10.1016\/j.ejpn.2019.11.007_bib53","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.yebeh.2016.01.031","article-title":"Hospital care for mental health and substance abuse in children with epilepsy","volume":"57","author":"Thibault","year":"2016","journal-title":"Epilepsy Behav"}],"container-title":["European Journal of Paediatric Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090379819304167?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090379819304167?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T18:36:36Z","timestamp":1761071796000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1090379819304167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":53,"alternative-id":["S1090379819304167"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpn.2019.11.007","relation":{},"ISSN":["1090-3798"],"issn-type":[{"value":"1090-3798","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety and tolerability of adjunctive brivaracetam in children with focal seizures: Interim analysis of pooled data from two open-label trials","name":"articletitle","label":"Article Title"},{"value":"European Journal of Paediatric Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpn.2019.11.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Ltd on behalf of European Paediatric Neurology Society.","name":"copyright","label":"Copyright"}]}}