{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T20:26:05Z","timestamp":1761164765607,"version":"build-2065373602"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejpn-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Paediatric Neurology"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.ejpn.2022.04.001","type":"journal-article","created":{"date-parts":[[2022,4,16]],"date-time":"2022-04-16T11:24:56Z","timestamp":1650108296000},"page":"11-18","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Opioid analgesia and temperature regulation are associated with EEG background activity and MRI outcomes in neonates with mild-to-moderate hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia"],"prefix":"10.1016","volume":"39","author":[{"given":"Zamzam","family":"Mahdi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bohdana","family":"Marandyuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrice","family":"Desnous","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Sophie","family":"Liet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasheda Arman","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7818-6720","authenticated-orcid":false,"given":"Veronica","family":"Birca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Claude","family":"D\u00e9carie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4281-526X","authenticated-orcid":false,"given":"Sophie","family":"Tremblay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory Anton","family":"Lodygensky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ala","family":"Birca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9088-1950","authenticated-orcid":false,"given":"Elana F.","family":"Pinchefsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Dehaes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpn.2022.04.001_bib1","first-page":"Cd003311","article-title":"Cooling for newborns with hypoxic ischaemic encephalopathy","author":"Jacobs","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.ejpn.2022.04.001_bib2","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1111\/apa.14222","article-title":"Painful procedures can affect post-natal growth and neurodevelopment in preterm infants","volume":"107","author":"Coviello","year":"2018","journal-title":"Acta Paediatr."},{"key":"10.1016\/j.ejpn.2022.04.001_bib3","doi-asserted-by":"crossref","first-page":"944","DOI":"10.2174\/138945012800675768","article-title":"General anesthetics in pediatric anesthesia: influences on the developing brain","volume":"13","author":"McCann","year":"2012","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.ejpn.2022.04.001_bib4","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/S0140-6736(04)16251-X","article-title":"Effects of morphine analgesia in ventilated preterm neonates: primary outcomes from the NEOPAIN randomised trial","volume":"363","author":"Anand","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.ejpn.2022.04.001_bib5","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/ana.24601","article-title":"Midazolam dose correlates with abnormal hippocampal growth and neurodevelopmental outcome in preterm infants","volume":"79","author":"Duerden","year":"2016","journal-title":"Ann. Neurol."},{"issue":"Suppl 10","key":"10.1016\/j.ejpn.2022.04.001_bib6","first-page":"S140","article-title":"Analgesics and sedatives in critically Ill newborns and infants: the impact on long-term neurodevelopment","volume":"58","author":"Schiller","year":"2018","journal-title":"J.\u00a0Clin. Pharmacol."},{"key":"10.1016\/j.ejpn.2022.04.001_bib7","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1203\/00006450-200109000-00017","article-title":"Twenty-four hours of mild hypothermia in unsedated newborn pigs starting after a severe global hypoxic-ischemic insult is not neuroprotective","volume":"50","author":"Thoresen","year":"2001","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ejpn.2022.04.001_bib8","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1172\/JCI119153","article-title":"Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs","volume":"99","author":"Gunn","year":"1997","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.ejpn.2022.04.001_bib9","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1038\/s41372-018-0126-7","article-title":"Association between sedation-analgesia and neurodevelopment outcomes in neonatal hypoxic-ischemic encephalopathy","volume":"38","author":"Natarajan","year":"2018","journal-title":"J.\u00a0Perinatol."},{"key":"10.1016\/j.ejpn.2022.04.001_bib10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1089\/ther.2018.0052","article-title":"Preemptive morphine during therapeutic hypothermia after neonatal encephalopathy: a secondary analysis","volume":"10","author":"Liow","year":"2020","journal-title":"Ther. Hypothermia Temp. Manag."},{"key":"10.1016\/j.ejpn.2022.04.001_bib11","doi-asserted-by":"crossref","first-page":"100892","DOI":"10.1016\/j.eclinm.2021.100892","article-title":"Morphine and fentanyl exposure during therapeutic hypothermia does not impair neurodevelopment","volume":"36","author":"Gundersen","year":"2021","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.ejpn.2022.04.001_bib12","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1203\/01.PDR.0000157676.45088.8C","article-title":"Use of opioids in asphyxiated term neonates: effects on neuroimaging and clinical outcome","volume":"57","author":"Angeles","year":"2005","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ejpn.2022.04.001_bib13","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1203\/pdr.0b013e318045bde9","article-title":"Relationship between opioid therapy, tissue-damaging procedures, and brain metabolites as measured by proton MRS in asphyxiated term neonates","volume":"61","author":"Angeles","year":"2007","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ejpn.2022.04.001_bib14","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1097\/WNP.0b013e3182872ac2","article-title":"EEG background patterns and prognostication of neonatal encephalopathy in the era of hypothermia","volume":"30","author":"Tsuchida","year":"2013","journal-title":"J.\u00a0Clin. Neurophysiol."},{"key":"10.1016\/j.ejpn.2022.04.001_bib15","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1212\/WNL.0b013e31820af91a","article-title":"Video-EEG monitoring in newborns with hypoxic-ischemic encephalopathy treated with hypothermia","volume":"76","author":"Nash","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.ejpn.2022.04.001_bib16","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1016\/j.clinph.2015.12.013","article-title":"Rewarming affects EEG background in term newborns with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia","volume":"127","author":"Birca","year":"2016","journal-title":"Clin. Neurophysiol."},{"key":"10.1016\/j.ejpn.2022.04.001_bib17","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1542\/peds.2004-1695","article-title":"Rebound seizures during rewarming","volume":"114","author":"Battin","year":"2004","journal-title":"Pediatrics"},{"key":"10.1016\/j.ejpn.2022.04.001_bib19","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jpeds.2019.11.030","article-title":"Is it time for a randomized controlled trial of hypothermia for mild hypoxic-ischemic encephalopathy?","volume":"220","author":"Chawla","year":"2020","journal-title":"J.\u00a0Pediatr."},{"key":"10.1016\/j.ejpn.2022.04.001_bib20","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1001\/archneur.1976.00500100030012","article-title":"Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study","volume":"33","author":"Sarnat","year":"1976","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.ejpn.2022.04.001_bib21","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/WNP.0b013e3182872b24","article-title":"American clinical neurophysiology society standardized EEG terminology and categorization for the description of continuous EEG monitoring in neonates: report of the American Clinical Neurophysiology Society critical care monitoring committee","volume":"30","author":"Tsuchida","year":"2013","journal-title":"J.\u00a0Clin. Neurophysiol."},{"key":"10.1016\/j.ejpn.2022.04.001_bib22","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1016\/j.clinph.2012.02.087","article-title":"Peak-to-peak amplitude in neonatal brain monitoring of premature infants","volume":"123","author":"O'Reilly","year":"2012","journal-title":"Clin. Neurophysiol."},{"key":"10.1016\/j.ejpn.2022.04.001_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.siny.2006.07.011","article-title":"Continuous brain-function monitoring: state of the art in clinical practice","volume":"11","author":"Hellstrom-Westas","year":"2006","journal-title":"Semin. Fetal Neonatal Med."},{"key":"10.1016\/j.ejpn.2022.04.001_bib24","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jpeds.2017.09.043","article-title":"A\u00a0novel magnetic resonance imaging score predicts neurodevelopmental outcome after perinatal asphyxia and therapeutic hypothermia","volume":"192","author":"Weeke","year":"2018","journal-title":"J.\u00a0Pediatr."},{"key":"10.1016\/j.ejpn.2022.04.001_bib25","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1001\/archpediatrics.2012.284","article-title":"Prognostic utility of magnetic resonance imaging in neonatal hypoxic-ischemic encephalopathy: substudy of a randomized trial","volume":"166","author":"Cheong","year":"2012","journal-title":"Arch. Pediatr. Adolesc. Med."},{"key":"10.1016\/j.ejpn.2022.04.001_bib26","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1007\/s00246-013-0712-6","article-title":"Multi-tiered analysis of brain injury in neonates with congenital heart disease","volume":"34","author":"Mulkey","year":"2013","journal-title":"Pediatr. Cardiol."},{"key":"10.1016\/j.ejpn.2022.04.001_bib27","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.pediatrneurol.2020.11.015","article-title":"MRI score ability to detect abnormalities in mild hypoxic ischemic encephalopathy","volume":"116","author":"Machie","year":"2020","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.ejpn.2022.04.001_bib28","doi-asserted-by":"crossref","first-page":"100984","DOI":"10.1016\/j.eclinm.2021.100984","article-title":"Incidental findings on brain MR imaging of asymptomatic term neonates in the Developing Human Connectome Project","volume":"38","author":"Carney","year":"2021","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.ejpn.2022.04.001_bib29","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1148\/radiol.2422060133","article-title":"Intracranial hemorrhage in asymptomatic neonates: prevalence on MR images and relationship to obstetric and neonatal risk factors","volume":"242","author":"Looney","year":"2007","journal-title":"Radiology"},{"key":"10.1016\/j.ejpn.2022.04.001_bib30","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/pan.12257","article-title":"Neurotoxicity of sedative and analgesia drugs in young infants with congenital heart disease: 4-year follow-up","volume":"24","author":"Garcia Guerra","year":"2014","journal-title":"Paediatr. Anaesth."},{"key":"10.1016\/j.ejpn.2022.04.001_bib33","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2217\/pmt.13.61","article-title":"Early repetitive pain in preterm infants in relation to the developing brain","volume":"4","author":"Ranger","year":"2014","journal-title":"Pain Manag."},{"key":"10.1016\/j.ejpn.2022.04.001_bib34","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000341769","article-title":"Effects of repetitive exposure to pain and morphine treatment on the neonatal rat brain","volume":"103","author":"D\u00fchrsen","year":"2013","journal-title":"Neonatology"},{"key":"10.1016\/j.ejpn.2022.04.001_bib35","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/s41372-019-0533-4","article-title":"Opioid and benzodiazepine use during therapeutic hypothermia in encephalopathic neonates","volume":"40","author":"Berube","year":"2020","journal-title":"J.\u00a0Perinatol."},{"key":"10.1016\/j.ejpn.2022.04.001_bib36","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.jopan.2014.07.016","article-title":"A\u00a0review of the effects of sedation on thermoregulation: Insights for the cardiac catheterization laboratory","volume":"31","author":"Conway","year":"2016","journal-title":"J.\u00a0PeriAnesthesia Nurs."},{"key":"10.1016\/j.ejpn.2022.04.001_bib37","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/S0003-4975(10)62823-8","article-title":"Suppression of shivering decreases oxygen consumption and improves hemodynamic stability during postoperative rewarming","volume":"43","author":"Zwischenberger","year":"1987","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.ejpn.2022.04.001_bib38","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s12028-009-9280-2","article-title":"Effect of shivering on brain tissue oxygenation during induced normothermia in patients with severe brain injury","volume":"12","author":"Oddo","year":"2010","journal-title":"Neurocritical Care"},{"key":"10.1016\/j.ejpn.2022.04.001_bib39","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3389\/fped.2020.00239","article-title":"Management of multi organ dysfunction in neonatal encephalopathy","volume":"8","author":"O'Dea","year":"2020","journal-title":"Front Pediatr"},{"key":"10.1016\/j.ejpn.2022.04.001_bib40","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/164_2018_118","article-title":"Brown adipose tissue in human infants","volume":"251","author":"Lidell","year":"2019","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.ejpn.2022.04.001_bib41","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.mri.2013.10.003","article-title":"MRI detection of brown adipose tissue with low fat content in newborns with hypothermia","volume":"32","author":"Hu","year":"2014","journal-title":"Magn. Reson. Imag."},{"key":"10.1016\/j.ejpn.2022.04.001_bib42","series-title":"Handbook of Clinical Neurology","first-page":"799","article-title":"Chapter 50 - thermoregulation following spinal cord injury","author":"Price","year":"2018"},{"key":"10.1016\/j.ejpn.2022.04.001_bib43","doi-asserted-by":"crossref","first-page":"12578","DOI":"10.1038\/s41598-021-92139-6","article-title":"Thermal Index for early non-invasive assessment of brain injury in newborns treated with therapeutic hypothermia: preliminary report","volume":"11","author":"Walas","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejpn.2022.04.001_bib44","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1113\/JP278790","article-title":"Active cooling temperature required to achieve therapeutic hypothermia correlates with short-term outcome in neonatal hypoxic-ischaemic encephalopathy","volume":"598","author":"Mietzsch","year":"2020","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.ejpn.2022.04.001_bib45","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/s41372-021-01302-4","article-title":"Blanket temperature during therapeutic hypothermia and outcomes in hypoxic ischemic encephalopathy","volume":"42","author":"Flibotte","year":"2022","journal-title":"J.\u00a0Perinatol."},{"key":"10.1016\/j.ejpn.2022.04.001_bib46","doi-asserted-by":"crossref","first-page":"4013","DOI":"10.1113\/JP277820","article-title":"Core temperature after birth in babies with neonatal encephalopathy in a sub-Saharan African hospital setting","volume":"597","author":"Enweronu-Laryea","year":"2019","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.ejpn.2022.04.001_bib47","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1146\/annurev.physiol.64.081501.155856","article-title":"Hypoxia-induced anapyrexia: implications and putative mediators","volume":"64","author":"Steiner","year":"2002","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.ejpn.2022.04.001_bib48","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/pr.2017.51","article-title":"Rectal temperature in the first five hours after hypoxia-ischemia critically affects neuropathological outcomes in neonatal rats","volume":"83","author":"Wood","year":"2018","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ejpn.2022.04.001_bib49","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1152\/jappl.1996.80.3.1021","article-title":"Effect of hypoglycemia on thermoregulatory responses","volume":"80","author":"Passias","year":"1996","journal-title":"J.\u00a0Appl. Physiol."},{"key":"10.1016\/j.ejpn.2022.04.001_bib50","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsx144","article-title":"Neonatal sleep-wake analyses predict 18-month neurodevelopmental outcomes","volume":"40","author":"Shellhaas","year":"2017","journal-title":"Sleep"},{"key":"10.1016\/j.ejpn.2022.04.001_bib51","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/JPN.0b013e31829dc2d3","article-title":"Sleep-wake cycling in a neonate admitted to the NICU: a video-EEG case study during hypothermia treatment","volume":"27","author":"Axelin","year":"2013","journal-title":"J.\u00a0Perinat. Neonatal Nurs."},{"key":"10.1016\/j.ejpn.2022.04.001_bib52","doi-asserted-by":"crossref","first-page":"e131","DOI":"10.1542\/peds.2009-2938","article-title":"Effect of hypothermia on amplitude-integrated electroencephalogram in infants with asphyxia","volume":"126","author":"Thoresen","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.ejpn.2022.04.001_bib53","article-title":"Neuroprotective effects and mechanisms of fentanyl preconditioning against brain ischemia","volume":"10","author":"Wang","year":"2006","journal-title":"Crit. Care"},{"key":"10.1016\/j.ejpn.2022.04.001_bib54","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1159\/000489808","article-title":"Neuroprotection against hypoxic\/ischemic injury: \u03b4-opioid receptors and BDNF-TrkB pathway","volume":"47","author":"Sheng","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.ejpn.2022.04.001_bib55","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.clp.2016.04.002","article-title":"Pathophysiology of birth asphyxia","volume":"43","author":"Rainaldi","year":"2016","journal-title":"Clin. Perinatol."},{"key":"10.1016\/j.ejpn.2022.04.001_bib56","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/jcph.775","article-title":"Decreased morphine clearance in neonates with hypoxic ischemic encephalopathy receiving hypothermia","volume":"57","author":"Frymoyer","year":"2017","journal-title":"J.\u00a0Clin. Pharmacol."},{"key":"10.1016\/j.ejpn.2022.04.001_bib57","doi-asserted-by":"crossref","first-page":"F448","DOI":"10.1136\/adc.2005.082263","article-title":"Pharmacological therapy for analgesia and sedation in the newborn","volume":"91","author":"Anand","year":"2006","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"10.1016\/j.ejpn.2022.04.001_bib58","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1001\/jama.290.18.2419","article-title":"Routine morphine infusion in preterm newborns who received ventilatory support: a randomized controlled trial","volume":"290","author":"Simons","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.ejpn.2022.04.001_bib59","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1136\/archdischild-2019-317050","article-title":"Pre-emptive opioid sedation during therapeutic hypothermia","volume":"105","author":"Montaldo","year":"2020","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"10.1016\/j.ejpn.2022.04.001_bib60","doi-asserted-by":"crossref","first-page":"3846","DOI":"10.1016\/j.cub.2017.10.063","article-title":"Nociceptive cortical activity is dissociated from nociceptive behavior in newborn human infants under stress","volume":"27","author":"Jones","year":"2017","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ejpn.2022.04.001_bib61","first-page":"319","article-title":"Utilization of therapeutic hypothermia and neurological injury in neonates with mild hypoxic-ischemic encephalopathy: a report from children\u2019s hospital neonatal consortium","volume":"39","author":"Rao","year":"2020","journal-title":"Am. J. Perinatol."},{"key":"10.1016\/j.ejpn.2022.04.001_bib62","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1001\/jamapediatrics.2019.4011","article-title":"Two-Year neurodevelopmental outcomes after mild hypoxic ischemic encephalopathy in the era of therapeutic hypothermia","volume":"174","author":"Finder","year":"2020","journal-title":"JAMA Pediatr."},{"key":"10.1016\/j.ejpn.2022.04.001_bib63","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/s41390-019-0291-1","article-title":"Should therapeutic hypothermia be offered to babies with mild neonatal encephalopathy in the first 6 h after birth?","volume":"85","author":"El-Dib","year":"2019","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ejpn.2022.04.001_bib64","doi-asserted-by":"crossref","first-page":"101264","DOI":"10.1016\/j.siny.2021.101264","article-title":"Management of comfort and sedation in neonates with neonatal encephalopathy treated with therapeutic hypothermia","author":"McPherson","year":"2021","journal-title":"Semin. Fetal Neonatal Med."},{"key":"10.1016\/j.ejpn.2022.04.001_bib65","first-page":"322250","article-title":"Neonates with mild hypoxic-ischaemic encephalopathy receiving supportive care versus therapeutic hypothermia in California","author":"Yieh","year":"2021","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"10.1016\/j.ejpn.2022.04.001_bib66","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jpeds.2017.03.065","article-title":"The frequency and severity of magnetic resonance imaging abnormalities in infants with mild neonatal encephalopathy","volume":"187","author":"Walsh","year":"2017","journal-title":"J.\u00a0Pediatr."},{"key":"10.1016\/j.ejpn.2022.04.001_bib67","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1186\/s12887-019-1777-z","article-title":"Neurodevelopmental effect of intracranial hemorrhage observed in hypoxic ischemic brain injury in hypothermia-treated asphyxiated neonates - an MRI study","volume":"19","author":"Lakatos","year":"2019","journal-title":"BMC Pediatr."},{"key":"10.1016\/j.ejpn.2022.04.001_bib68","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jpeds.2020.11.015","article-title":"Limitations of conventional magnetic resonance imaging as a predictor of death or disability following neonatal hypoxic-ischemic encephalopathy in the late hypothermia trial","volume":"230","author":"Laptook","year":"2021","journal-title":"J.\u00a0Pediatr."},{"key":"10.1016\/j.ejpn.2022.04.001_bib69","first-page":"Cd003311","article-title":"Cooling for newborns with hypoxic ischaemic encephalopathy","volume":"2013","author":"Jacobs","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.ejpn.2022.04.001_bib70","doi-asserted-by":"crossref","first-page":"e844","DOI":"10.1542\/peds.2007-1987","article-title":"Elevated morphine concentrations in neonates treated with morphine and prolonged hypothermia for hypoxic ischemic encephalopathy","volume":"121","author":"R\u00f3ka","year":"2008","journal-title":"Pediatrics"}],"container-title":["European Journal of Paediatric Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090379822000575?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090379822000575?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T18:38:50Z","timestamp":1761071930000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1090379822000575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":67,"alternative-id":["S1090379822000575"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpn.2022.04.001","relation":{},"ISSN":["1090-3798"],"issn-type":[{"type":"print","value":"1090-3798"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Opioid analgesia and temperature regulation are associated with EEG background activity and MRI outcomes in neonates with mild-to-moderate hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia","name":"articletitle","label":"Article Title"},{"value":"European Journal of Paediatric Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpn.2022.04.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}