{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:49:41Z","timestamp":1793213381973,"version":"4.5.0"},"reference-count":16,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejpn-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Paediatric Neurology"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.ejpn.2022.12.010","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T20:41:10Z","timestamp":1672778470000},"page":"117-121","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Pediatric recurrent acute necrotizing encephalomyelitis, RANBP2 genotype and Sars-CoV-2 infection: Diagnosis, pathogenesis and targeted treatments from a case study"],"prefix":"10.1016","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3779-0355","authenticated-orcid":false,"given":"Cristina","family":"Forest","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6192-9137","authenticated-orcid":false,"given":"Michele","family":"Laudisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Malaventura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Tugnoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1300-7829","authenticated-orcid":false,"given":"Giuditta","family":"Pellino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9081-9946","authenticated-orcid":false,"given":"Elisabetta","family":"Marangoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Baldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Borgatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9396-8683","authenticated-orcid":false,"given":"Maura","family":"Pugliatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5130-1450","authenticated-orcid":false,"given":"Agnese","family":"Suppiej","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.ejpn.2022.12.010_bib1","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1136\/jnnp.58.5.555","article-title":"Acute necrotising encephalopathy of childhood: a new syndrome presenting with multifocal, symmetric brain lesions","volume":"58","author":"Mizuguchi","year":"1995","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"issue":"1","key":"10.1016\/j.ejpn.2022.12.010_bib2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ajhg.2008.12.009","article-title":"Infection-triggered familial or recurrent cases of acute necrotizing encephalopathy caused by mutations in a component of the nuclear pore","volume":"84","author":"Neilson","year":"2009","journal-title":"RANBP2. Am J Hum Genet."},{"issue":"7","key":"10.1016\/j.ejpn.2022.12.010_bib3","doi-asserted-by":"crossref","first-page":"3548","DOI":"10.3390\/ijms23073548","article-title":"Roles of nucleoporin RanBP2\/nup358 in acute necrotizing encephalopathy type 1 (ANE1) and viral infection","volume":"23","author":"Jiang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.ejpn.2022.12.010_bib4","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1001\/jamaneurol.2020.1127","article-title":"Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in wuhan, China","volume":"77","author":"Mao","year":"2020","journal-title":"JAMA Neurol."},{"issue":"2","key":"10.1016\/j.ejpn.2022.12.010_bib5","doi-asserted-by":"crossref","first-page":"E119","DOI":"10.1148\/radiol.2020201187","article-title":"COVID-19-associated acute hemorrhagic necrotizing encephalopathy: imaging features","volume":"296","author":"Poyiadji","year":"2020","journal-title":"Radiology"},{"issue":"1","key":"10.1016\/j.ejpn.2022.12.010_bib6","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1080\/19491034.2022.2069071","article-title":"Workshop on RanBP2\/Nup358 and acute necrotizing encephalopathy","volume":"13","author":"Palazzo","year":"2022","journal-title":"Nucleus"},{"key":"10.1016\/j.ejpn.2022.12.010_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2020.102194","article-title":"Genetic acute necrotizing encephalopathy associated with RANBP2: clinical and therapeutic implications in pediatrics","volume":"43","author":"Levine","year":"2020","journal-title":"Mult Scler Relat Disord"},{"issue":"3","key":"10.1016\/j.ejpn.2022.12.010_bib8","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.braindev.2014.05.007","article-title":"A\u00a0severity score for acute necrotizing encephalopathy","volume":"37","author":"Yamamoto","year":"2015","journal-title":"Brain Dev."},{"issue":"10","key":"10.1016\/j.ejpn.2022.12.010_bib9","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1177\/0883073820927915","article-title":"Presentation and outcome of acute necrotizing encephalopathy of childhood: a 10-year single-center retrospective study from Hong Kong","volume":"35","author":"Chow","year":"2020","journal-title":"J.\u00a0Child Neurol."},{"key":"10.1016\/j.ejpn.2022.12.010_bib10","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/792578","article-title":"Acute necrotizing encephalopathy: an underrecognized clinicoradiologic disorder","volume":"2015","author":"Wu","year":"2015","journal-title":"Mediat. Inflamm."},{"issue":"2","key":"10.1016\/j.ejpn.2022.12.010_bib11","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ejpn.2014.11.010","article-title":"RANBP2 mutation and acute necrotizing encephalopathy: 2 cases and a literature review of the expanding clinico-radiological phenotype","volume":"19","author":"Singh","year":"2015","journal-title":"Eur. J. Paediatr. Neurol."},{"key":"10.1016\/j.ejpn.2022.12.010_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.628811","article-title":"Clinical manifestations and pathogenesis of acute necrotizing encephalopathy: the interface between systemic infection and neurologic injury","volume":"12","author":"Shukla","year":"2022","journal-title":"Front. Neurol."},{"key":"10.1016\/j.ejpn.2022.12.010_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.872734","article-title":"Case report: acute necrotizing encephalopathy following COVID-19 vaccine","volume":"13","author":"Bensaidane","year":"2022","journal-title":"Front. Neurol."},{"issue":"1","key":"10.1016\/j.ejpn.2022.12.010_bib14","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1186\/s12879-022-07610-0","article-title":"COVID-19 related acute necrotizing encephalopathy with extremely high interleukin-6 and RANBP2 mutation in a patient with recently immunized inactivated virus vaccine and no pulmonary involvement","volume":"22","author":"Pongpitakmetha","year":"2022","journal-title":"BMC Infect. Dis."},{"issue":"1","key":"10.1016\/j.ejpn.2022.12.010_bib15","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13578-021-00568-7","article-title":"Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor","volume":"11","author":"Lee","year":"2021","journal-title":"Cell Biosci."},{"issue":"12","key":"10.1016\/j.ejpn.2022.12.010_bib16","doi-asserted-by":"crossref","first-page":"11277","DOI":"10.18632\/aging.103524","article-title":"Re-analysis of SARS-CoV-2-infected host cell proteomics time-course data by impact pathway analysis and network analysis: a potential link with inflammatory response","volume":"12","author":"Bock","year":"2020","journal-title":"Aging (Albany NY)"}],"container-title":["European Journal of Paediatric Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090379822001751?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090379822001751?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T18:41:09Z","timestamp":1761072069000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1090379822001751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":16,"alternative-id":["S1090379822001751"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpn.2022.12.010","relation":{},"ISSN":["1090-3798"],"issn-type":[{"value":"1090-3798","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pediatric recurrent acute necrotizing encephalomyelitis, RANBP2 genotype and Sars-CoV-2 infection: Diagnosis, pathogenesis and targeted treatments from a case study","name":"articletitle","label":"Article Title"},{"value":"European Journal of Paediatric Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpn.2022.12.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}