{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:11:00Z","timestamp":1785435060458,"version":"3.56.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ejpn-journal.com","clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Paediatric Neurology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.ejpn.2024.08.003","type":"journal-article","created":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T15:51:18Z","timestamp":1723909878000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["CSF-profile and hypocretin levels in children with narcolepsy type 1 and 2"],"prefix":"10.1016","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1109-9606","authenticated-orcid":false,"given":"Maike","family":"Josler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0685-0914","authenticated-orcid":false,"given":"Ines","family":"El Naggar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annikki","family":"Bertolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Kutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Roll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva-Maria","family":"Wendel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Schl\u00fcter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandy","family":"Siegert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3161-8703","authenticated-orcid":false,"given":"Anette","family":"Hackenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer M.","family":"Zuberi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Otto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Rost\u00e1sy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpn.2024.08.003_bib1","author":"Yamasaki"},{"key":"10.1016\/j.ejpn.2024.08.003_bib2","series-title":"Fundamentals of Sleep Medicine","first-page":"451","article-title":"Hypersomnias of central origin","author":"Berry","year":"2012"},{"issue":"1","key":"10.1016\/j.ejpn.2024.08.003_bib3","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.sleep.2010.05.010","article-title":"The clinical features of cataplexy: a questionnaire study in narcolepsy patients with and without hypocretin-1 deficiency","volume":"12","author":"Overeem","year":"2011","journal-title":"Sleep Med."},{"key":"10.1016\/j.ejpn.2024.08.003_bib4","first-page":"14","article-title":"Epidemiology and pathophysiology of childhood narcolepsy","volume":"25","author":"Dye","year":"2018","journal-title":"Paediatr. Respir. Rev."},{"issue":"11","key":"10.1016\/j.ejpn.2024.08.003_bib5","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1212\/WNL.57.11.2029","article-title":"Age at onset of narcolepsy in two large populations of patients in France and Quebec","volume":"57","author":"Dauvilliers","year":"2001","journal-title":"Neurology"},{"issue":"11","key":"10.1016\/j.ejpn.2024.08.003_bib6","doi-asserted-by":"crossref","first-page":"e1034","DOI":"10.1212\/WNL.0000000000008094","article-title":"Validation of multiple sleep latency test for the diagnosis of pediatric narcolepsy type 1","volume":"93","author":"Pizza","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.ejpn.2024.08.003_bib7","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2147\/NSS.S140143","article-title":"Assessing narcolepsy with cataplexy in children and adolescents: development of a cataplexy diary and the ESS-Chad","volume":"9","author":"Wang","year":"2017","journal-title":"Nat. Sci. Sleep"},{"issue":"2","key":"10.1016\/j.ejpn.2024.08.003_bib9","first-page":"29","article-title":"Narcolepsy-cataplexy syndrome associated with DRB1*0806-DQB*0602 haplotype in a Caucasian patient","volume":"2","author":"Peraita-Adrados","year":"1999","journal-title":"Sleep Res. Online"},{"issue":"12","key":"10.1016\/j.ejpn.2024.08.003_bib10","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1212\/WNL.57.12.2253","article-title":"CSF hypocretin\/orexin levels in narcolepsy and other neurological conditions","volume":"57","author":"Ripley","year":"2001","journal-title":"Neurology"},{"issue":"12","key":"10.1016\/j.ejpn.2024.08.003_bib11","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1136\/jnnp.74.12.1667","article-title":"CSF hypocretin-1 levels in narcolepsy, Kleine-Levin syndrome, and other hypersomnias and neurological conditions","volume":"74","author":"Dauvilliers","year":"2003","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.ejpn.2024.08.003_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.smrv.2020.101306","article-title":"Diagnosis of central disorders of hypersomnolence: a reappraisal by European experts","volume":"52","author":"Lammers","year":"2020","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.ejpn.2024.08.003_bib13","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.sleep.2017.01.014","article-title":"Validation of the Epworth sleepiness Scale for children and adolescents using rasch analysis","volume":"33","author":"Janssen","year":"2017","journal-title":"Sleep Med."},{"issue":"10","key":"10.1016\/j.ejpn.2024.08.003_bib14","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsaa066","article-title":"Defining disrupted nighttime sleep and assessing its diagnostic utility for pediatric narcolepsy type 1","volume":"43","author":"Maski","year":"2020","journal-title":"Sleep"},{"issue":"1","key":"10.1016\/j.ejpn.2024.08.003_bib15","doi-asserted-by":"crossref","first-page":"289","DOI":"10.5664\/jcsm.9638","article-title":"Disrupted nighttime sleep and sleep instability in narcolepsy","volume":"18","author":"Maski","year":"2022","journal-title":"J. Clin. Sleep Med."},{"issue":"1","key":"10.1016\/j.ejpn.2024.08.003_bib16","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/sleep\/28.1.113","article-title":"Practice parameters for clinical use of the multiple sleep latency test and the maintenance of wakefulness test","volume":"28","author":"Littner","year":"2005","journal-title":"Sleep"},{"issue":"2","key":"10.1016\/j.ejpn.2024.08.003_bib17","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/clinchem\/41.2.256","article-title":"External quality assessment in clinical neurochemistry: survey of analysis for cerebrospinal fluid (CSF) proteins based on CSF\/serum quotients","volume":"41","author":"Reiber","year":"1995","journal-title":"Clin. Chem."},{"issue":"2","key":"10.1016\/j.ejpn.2024.08.003_bib18","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0022-510X(00)00501-3","article-title":"Cerebrospinal fluid analysis: disease-related data patterns and evaluation programs","volume":"184","author":"Reiber","year":"2001","journal-title":"J. Neurol. Sci."},{"issue":"8","key":"10.1016\/j.ejpn.2024.08.003_bib19","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1136\/jnnp.57.8.897","article-title":"Cerebrospinal fluid in the diagnosis of multiple sclerosis: a consensus report","volume":"57","author":"Andersson","year":"1994","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"7","key":"10.1016\/j.ejpn.2024.08.003_bib20","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.sleep.2013.04.013","article-title":"Elevated glial fibrillary acidic protein levels in the cerebrospinal fluid of patients with narcolepsy","volume":"14","author":"Feneberg","year":"2013","journal-title":"Sleep Med."},{"issue":"Pt 12","key":"10.1016\/j.ejpn.2024.08.003_bib21","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1093\/brain\/awt277","article-title":"Clinical and polysomnographic course of childhood narcolepsy with cataplexy","volume":"136","author":"Pizza","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.ejpn.2024.08.003_bib22","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.sleep.2019.07.022","article-title":"Prevalence of attention deficit hyperactivity disorder symptoms in narcolepsy: a systematic review","volume":"65","author":"Kim","year":"2020","journal-title":"Sleep Med."},{"key":"10.1016\/j.ejpn.2024.08.003_bib23","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.sleep.2023.06.021","article-title":"Associations between psychiatric comorbid disorders and executive dysfunctions in hypocretin-1 deficient pediatric narcolepsy type1","volume":"109","author":"Hansen","year":"2023","journal-title":"Sleep Med."},{"issue":"4","key":"10.1016\/j.ejpn.2024.08.003_bib24","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1365-2869.2004.00422.x","article-title":"The clinical spectrum of narcolepsy with cataplexy: a reappraisal","volume":"13","author":"Sturzenegger","year":"2004","journal-title":"J. Sleep Res."},{"issue":"7\u20138","key":"10.1016\/j.ejpn.2024.08.003_bib25","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.sleep.2006.10.010","article-title":"Health-related quality of life in patients with narcolepsy","volume":"8","author":"Dodel","year":"2007","journal-title":"Sleep Med."},{"issue":"6","key":"10.1016\/j.ejpn.2024.08.003_bib26","doi-asserted-by":"crossref","DOI":"10.1111\/jsr.13387","article-title":"European guideline and expert statements on the management of narcolepsy in adults and children","volume":"30","author":"Bassetti","year":"2021","journal-title":"J. Sleep Res."},{"issue":"2","key":"10.1016\/j.ejpn.2024.08.003_bib27","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/s41583-018-0097-x","article-title":"The neurobiological basis of narcolepsy","volume":"20","author":"Mahoney","year":"2019","journal-title":"Nat. Rev. Neurosci."}],"container-title":["European Journal of Paediatric Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090379824001247?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090379824001247?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T01:09:01Z","timestamp":1732928941000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1090379824001247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":26,"alternative-id":["S1090379824001247"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpn.2024.08.003","relation":{},"ISSN":["1090-3798"],"issn-type":[{"value":"1090-3798","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CSF-profile and hypocretin levels in children with narcolepsy type 1 and 2","name":"articletitle","label":"Article Title"},{"value":"European Journal of Paediatric Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpn.2024.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}