{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:30:44Z","timestamp":1759332644865,"version":"3.30.2"},"reference-count":41,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2004,2,1]],"date-time":"2004-02-01T00:00:00Z","timestamp":1075593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2004,2]]},"DOI":"10.1016\/j.ejps.2003.10.019","type":"journal-article","created":{"date-parts":[[2003,12,22]],"date-time":"2003-12-22T21:49:35Z","timestamp":1072129775000},"page":"283-293","source":"Crossref","is-referenced-by-count":20,"title":["Reversal of P-glycoprotein mediated vincristine resistance of L1210\/VCR cells by analogues of pentoxifylline"],"prefix":"10.1016","volume":"21","author":[{"given":"Ivana","family":"Kups\u00e1kov\u00e1","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfons","family":"Ryb\u00e1r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Do\u010dolomansk\u00fd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuzana","family":"Drobn\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Stein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Walther","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miroslav","family":"Baran\u010d\u0131\u0301k","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Breier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2003.10.019_BIB1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0928-0987(01)00139-7","article-title":"SB203580, a specific inhibitor of p38-MAPK pathway, is a new reversal agent of P-glycoprotein-mediated multidrug resistance","volume":"14","author":"Baran\u010d\u0131\u0301k","year":"2001","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2003.10.019_BIB2","doi-asserted-by":"crossref","first-page":"447","DOI":"10.33549\/physiolres.930000.49.447","article-title":"Glutathione S-transferase does not play a role in multidrug resistance of L1210\/VCR cell line","volume":"49","author":"Boh\u00e1\u010dov\u00e1","year":"2000","journal-title":"Physiol. Res."},{"key":"10.1016\/j.ejps.2003.10.019_BIB3","unstructured":"Bolger, M.B., 2003. Therapeutics I, http:\/\/www.usc.edu\/hsc\/pharmacy\/curriculum\/l2\/Phar414\/PhysicoChemicalProp02.PDF."},{"key":"10.1016\/j.ejps.2003.10.019_BIB4","first-page":"297","article-title":"Effect of pentoxifylline on P-glycoprotein mediated vincristine resistance of L1210 mouse leukemic cell line","volume":"41","author":"Breier","year":"1994","journal-title":"Neoplasma"},{"key":"10.1016\/j.ejps.2003.10.019_BIB5","first-page":"287","article-title":"Time dependence of [3H]-vincristine accumulation by L1210 mouse leukemic cells. Effect of P-glycoprotein overexpression","volume":"13","author":"Breier","year":"1994","journal-title":"Gen. Physiol. Biophys."},{"key":"10.1016\/j.ejps.2003.10.019_BIB6","unstructured":"Breier, A., Drobn\u00e1, Z., Boh\u00e1\u010dov\u00e1, V., Baran\u010d\u0131\u0301k, M., 1998. Resistance of L1210 mouse leukemic cell line characterized by overexpression of ATP dependent drug transporter to several drugs. Chem. Pap.\u2014Chem. Zvesti 52 Sp. Iss., 418\u2013419."},{"key":"10.1016\/j.ejps.2003.10.019_BIB7","first-page":"100","article-title":"Cytotoxic activity of several unrelated drugs on L1210 mouse leukemic cell sublines with P-glycoprotein (PGP) mediated multidrug resistance (MDR) phenotype. A QSAR study","volume":"47","author":"Breier","year":"2000","journal-title":"Neoplasma"},{"key":"10.1016\/j.ejps.2003.10.019_BIB8","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1021\/jm980469t","article-title":"Potentiation of cADPR-induced Ca(2+)-release by methylxanthine analogues","volume":"42","author":"Cavallaro","year":"1999","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejps.2003.10.019_BIB9","first-page":"619","article-title":"Inhibition of DNA biosynthesis by vincristine and pentoxifylline in murine p388 leukemia-cells resistant to doxorubicin","volume":"37","author":"Chitnis","year":"1990","journal-title":"Neoplasma"},{"key":"10.1016\/j.ejps.2003.10.019_BIB10","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S0165-1838(00)00110-7","article-title":"Alkylxanthines as research tools","volume":"81","author":"Daly","year":"2000","journal-title":"J. Autonom. Nerv. Syst."},{"key":"10.1016\/j.ejps.2003.10.019_BIB11","first-page":"103","article-title":"Pentoxifylline influences drug transport activity of P-glycoprotein and decreases mdr1 gene expression in multidrug resistant mouse leukemic L1210\/VCR cells","volume":"21","author":"Drobn\u00e1","year":"2002","journal-title":"Gen. Physiol. Biophys."},{"key":"10.1016\/j.ejps.2003.10.019_BIB12","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1146\/annurev.bi.62.070193.002125","article-title":"Biochemistry of multidrug-resistance mediated by the multidrug transporter","volume":"62","author":"Gottesman","year":"1993","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.ejps.2003.10.019_BIB13","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1021\/jm00204a012","article-title":"Antitumor 1-(X-aryl)-3,3-dialkyltriazenes. 1. Quantitative structure\u2013activity relationships vs. L1210 leukemia in mice","volume":"21","author":"Hatheway","year":"1978","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejps.2003.10.019_BIB14","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/0005-2736(76)90160-7","article-title":"Surface glycoprotein modulating drug permeability in Chinese-hamster ovary cell mutants","volume":"455","author":"Juliano","year":"1976","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejps.2003.10.019_BIB15","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0300-483X(94)02922-H","article-title":"Effect of TNF-alpha production inhibitors brl-61063 and pentoxifylline on the response of rats to poly-I-C","volume":"95","author":"Kaplan","year":"1995","journal-title":"Toxicology"},{"key":"10.1016\/j.ejps.2003.10.019_BIB16","first-page":"439","article-title":"Reversal effect of specific inhibitors of extracellular-signal regulated protein kinase pathway on P-glycoprotein mediated vincristine resistance of L1210 cells","volume":"20","author":"Ki\u0161uck\u00e1","year":"2001","journal-title":"Gen. Physiol. Biophys."},{"key":"10.1016\/j.ejps.2003.10.019_BIB17","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1007\/s002100000315","article-title":"Adenosine receptors and their ligands","volume":"362","author":"Klotz","year":"2000","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.ejps.2003.10.019_BIB18","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0928-0987(00)00114-7","article-title":"Multidrug resistance (MDR) in cancer\u2014mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs","volume":"11","author":"Krishna","year":"2000","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2003.10.019_BIB19","first-page":"471","article-title":"Carbonyl group of aliphatic side chain of pentoxifylline does not play role for P-glycoprotein antagonizing effect of pentoxifylline","volume":"21","author":"Kups\u00e1kov\u00e1","year":"2002","journal-title":"Gen. Physiol. Biophys."},{"key":"10.1016\/j.ejps.2003.10.019_BIB20","first-page":"215","article-title":"Drug transporters and their role in multidrug resistance of neoplastic cells","volume":"20","author":"Kva\u010dkajov\u00e1-Ki\u0161uck\u00e1","year":"2001","journal-title":"Gen. Physiol. Biophys."},{"key":"10.1016\/j.ejps.2003.10.019_BIB21","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1159\/000139480","article-title":"Structure\u2013activity relationship of xanthines and skeletal muscle ryanodine receptor\/Ca2+ release channel","volume":"54","author":"Liu","year":"1997","journal-title":"Pharmacology"},{"key":"10.1016\/j.ejps.2003.10.019_BIB22","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1002\/hep.510260517","article-title":"Effect of a xanthine analog on human hepatocellular carcinoma cells (Alexander) in culture and in xenografts in SCID mice","volume":"26","author":"Marucci","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.ejps.2003.10.019_BIB23","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1248\/bpb.18.431","article-title":"Effects of alkyl substituents of xanthine on phosphodiesterase isoenzymes","volume":"18","author":"Miyamoto","year":"1995","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ejps.2003.10.019_BIB24","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1517\/13543776.8.12.1587","article-title":"Recent strategies for the treatment of multi-drug resistance in cancer cells","volume":"8","author":"Ojima","year":"1998","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.ejps.2003.10.019_BIB25","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0928-0987(00)00189-5","article-title":"Prediction of drug transport processes using simple parameters and PLS statistics. The use of ACD\/logP and ACD\/ChemSketch descriptors","volume":"12","author":"\u00d6sterberg","year":"2001","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2003.10.019_BIB26","first-page":"73","article-title":"Adaptation of mouse leukemia-cells L1210 to vincristine\u2014evidence for expression of p-glycoprotein","volume":"39","author":"Polekov\u00e1","year":"1992","journal-title":"Neoplasma"},{"key":"10.1016\/j.ejps.2003.10.019_BIB27","first-page":"296","article-title":"Pentoxifylline stimulates drug-induced apoptosis in leukemic cells","volume":"45","author":"Rauko","year":"1998","journal-title":"Neoplasma"},{"key":"10.1016\/j.ejps.2003.10.019_BIB28","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1135\/cccc19931169","article-title":"1-(Oxoalkyl)-3,7,8-trialkyl-3,7-dihydro-1H-purine-2,6-diones","volume":"58","author":"Ryb\u00e1r","year":"1993","journal-title":"Collect. Czech. Chem. C"},{"key":"10.1016\/j.ejps.2003.10.019_BIB29","first-page":"47","article-title":"8-Substituted 7-(oxoalkyl)theophyllines","volume":"48","author":"Ryb\u00e1r","year":"1994","journal-title":"Chem. Pap.\u2014Chem. Zvesti"},{"key":"10.1016\/j.ejps.2003.10.019_BIB30","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0378-4274(02)00227-8","article-title":"Effects of xanthine derivatives on the influx and efflux of doxorubicin in P388 and DOX-resistant P388 leukemia cells","volume":"135","author":"Sadzuka","year":"2002","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ejps.2003.10.019_BIB31","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0304-3835(98)00375-9","article-title":"Enhanced efficacy of 1-methyl-3-propyl-7-butylxanthine on the antitumor activity of doxorubicin against doxorubicin-resistant P388 leukemia","volume":"138","author":"Sadzuka","year":"1999","journal-title":"Cancer. Lett."},{"key":"10.1016\/j.ejps.2003.10.019_BIB32","first-page":"520","article-title":"Xanthine derivatives\u2014comparison between suppression of tumor-necrosis-factor-alpha production and inhibition of camp phosphodiesterase activity","volume":"78","author":"Semmler","year":"1993","journal-title":"Immunology"},{"key":"10.1016\/j.ejps.2003.10.019_BIB33","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0968-0896(00)00271-6","article-title":"Structure\u2013activity relationships in a series of 8-substituted xanthines as A1-adenosine receptor antagonists","volume":"9","author":"Strappaghetti","year":"2001","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejps.2003.10.019_BIB34","first-page":"11","article-title":"Overcoming of P-glycoprotein mediated vincristine resistance of L1210\/VCR mouse leukemic cells could be induced by pentoxifylline but not by theophylline and caffeine","volume":"43","author":"\u0160tefankov\u00e1","year":"1996","journal-title":"Neoplasma"},{"key":"10.1016\/j.ejps.2003.10.019_BIB35","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1093\/jnci\/88.19.1383","article-title":"Reversal of multidrug resistance by transduction of cytokine genes into human colon carcinoma cells","volume":"88","author":"Stein","year":"1996","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.ejps.2003.10.019_BIB36","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0928-0987(02)00082-9","article-title":"Effects of 12 Ca2+ antagonists on multidrug resistance, MDR1-mediated transport and MDR1 mRNA expression","volume":"16","author":"Takara","year":"2002","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2003.10.019_BIB37","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1351\/pac199769051137","article-title":"Glossary of terms used in computational drug design","volume":"69","author":"Van de Waterbeemd","year":"1997","journal-title":"Pure Appl. Chem."},{"key":"10.1016\/j.ejps.2003.10.019_BIB38","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1128\/CDLI.2.6.689-692.1995","article-title":"Effect of xanthine derivates and dexamethasone on streptococcus pneumoniae-stimulated production of tumor necrosis factor alpha, interleukin-1b (il-1b), and il-10 by human leukocytes","volume":"2","author":"Van Furth","year":"1995","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"10.1016\/j.ejps.2003.10.019_BIB39","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1089\/cbr.1994.9.143","article-title":"In-vitro effects of pentoxifylline and doxorubicin on cell-survival and DNA-damage in sensitive and MDR-p388 leukemia-cells","volume":"9","author":"Viladkar","year":"1994","journal-title":"Cancer Biother."},{"key":"10.1016\/j.ejps.2003.10.019_BIB40","first-page":"674","article-title":"RNA analysis using miniprep RNA in RT-PCR","volume":"17","author":"Walther","year":"1994","journal-title":"Biotechniques"},{"key":"10.1016\/j.ejps.2003.10.019_BIB41","first-page":"3029","article-title":"Multidrug-resistant phenotype of disease-oriented panels of human tumor cell lines used for anticancer drug screening","volume":"52","author":"Wu","year":"1992","journal-title":"Cancer Res."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092809870300294X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092809870300294X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T18:18:08Z","timestamp":1734200288000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092809870300294X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,2]]},"references-count":41,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2004,2]]}},"alternative-id":["S092809870300294X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2003.10.019","relation":{},"ISSN":["0928-0987"],"issn-type":[{"type":"print","value":"0928-0987"}],"subject":[],"published":{"date-parts":[[2004,2]]}}}