{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:38:04Z","timestamp":1760297884514},"reference-count":22,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1016\/j.ejps.2007.11.003","type":"journal-article","created":{"date-parts":[[2007,12,5]],"date-time":"2007-12-05T14:48:38Z","timestamp":1196866118000},"page":"207-216","source":"Crossref","is-referenced-by-count":9,"title":["Novel dual labelled nucleus-directed conjugates containing correct and mutant nuclear localisation sequences"],"prefix":"10.1016","volume":"33","author":[{"given":"A.","family":"Sturzu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Regenbogen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Klose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Echner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Gharabaghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Heckl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2007.11.003_bib1","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1007\/s00775-003-0475-2","article-title":"Synthesis and visualization of a membrane-permeable MRI contrast agent","volume":"8","author":"Allen","year":"2003","journal-title":"J. Biol. Inorg. Chem."},{"key":"10.1016\/j.ejps.2007.11.003_bib2","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1021\/bc990168d","article-title":"Macrocyclic chelators with paramagnetic cations are internalized into mammalian cells via a HIV-tat derived membrane translocation peptide","volume":"11","author":"Bhorade","year":"2000","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.ejps.2007.11.003_bib3","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/(SICI)1522-2586(200002)11:2<182::AID-JMRI16>3.0.CO;2-5","article-title":"Physical, chemical, and biological evaluations of P760: a new gadolinium complex characterized by a low rate of interstitial diffusion","volume":"11","author":"Corot","year":"2000","journal-title":"J. Magn. Reson. Imag."},{"key":"10.1016\/j.ejps.2007.11.003_bib4","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1128\/JVI.71.1.75-83.1997","article-title":"The human T-cell lymphotropic virus type 1 Tof protein contains a bipartite nuclear localization signal that is able to functionally replace the amino-terminal domain of Rex","volume":"71","author":"D\u2019Agostino","year":"1997","journal-title":"J. Virol."},{"key":"10.1016\/j.ejps.2007.11.003_bib5","first-page":"4272","article-title":"Gadolinium in human glioblastoma cells for Gadolinium neutron capture therapy","volume":"61","author":"De Stasio","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejps.2007.11.003_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1083\/jcb.111.1.1","article-title":"The permeability of the nuclear envelope in dividing and nondividing cell cultures","volume":"111","author":"Feldherr","year":"1990","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.ejps.2007.11.003_bib7","first-page":"2097","article-title":"Trifunctional somatostatin-based derivatives designed for targeted radiotherapy using auger electron emitters","volume":"12","author":"Ginj","year":"2005","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.ejps.2007.11.003_bib8","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1021\/bc0500084","article-title":"Cell uptake and radiotoxicity studies of an nuclear localization signal peptide-intercalator conjugate labeled with [99mTc(CO)3]+","volume":"16","author":"Haefliger","year":"2005","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.ejps.2007.11.003_bib9","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1042\/bj3110705","article-title":"The regulation of protein transport to the nucleus by phosphorylation","volume":"311","author":"Jans","year":"1995","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejps.2007.11.003_bib10","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/0092-8674(84)90457-4","article-title":"A short amino acid sequence able to specify nuclear location","volume":"39","author":"Kalderon","year":"1984","journal-title":"Cell"},{"key":"10.1016\/j.ejps.2007.11.003_bib11","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1097\/00004424-199008000-00010","article-title":"Gd\u2013DOTA. Pharmacokinetics and tolerability after intravenous injection into healthy volunteers","volume":"25","author":"Le Mignon","year":"1990","journal-title":"Invest. Radiol."},{"key":"10.1016\/j.ejps.2007.11.003_bib12","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/73780","article-title":"In vivo visualization of gene expression using magnetic resonance imaging","volume":"18","author":"Louie","year":"2000","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ejps.2007.11.003_bib13","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0010-8545(01)00336-8","article-title":"Complexes of tetraazacycles bearing methylphosphinic\/phosphonic acid pendant arms with copper(II), zinc(II) and lanthanides(III). A comparison with their acetic acid analogues","volume":"216","author":"Lukes","year":"2001","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.ejps.2007.11.003_bib14","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1002\/mrm.1910030517","article-title":"Gd(DOTA): an alternative to Gd(DTPA) as a T1,2 relaxation agent for NMR imaging or spectroscopy","volume":"3","author":"Magerstadt","year":"1986","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.ejps.2007.11.003_bib15","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/j.1600-0749.1989.tb00213.x","article-title":"Induction of DNA double-strand breaks by 157Gd neutron capture","volume":"2","author":"Martin","year":"1989","journal-title":"Pigment. Cell Res."},{"key":"10.1016\/j.ejps.2007.11.003_bib16","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1006\/mvre.1995.1038","article-title":"Polyarginine and eosinophil-derived major basic protein increase microvascular permeability independently of histamine or nitric oxide release","volume":"50","author":"Minnicozzi","year":"1995","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.ejps.2007.11.003_bib17","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1002\/anie.200462519","article-title":"A cobaltocenium-peptide bioconjugate shows enhanced cellular uptake and directed nuclear delivery","volume":"44","author":"Noor","year":"2005","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.ejps.2007.11.003_bib18","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1148\/radiology.205.3.9393539","article-title":"Intracranial tumor in children: MR imaging findings within 24h of craniotomy","volume":"205","author":"Oser","year":"1997","journal-title":"Radiology"},{"key":"10.1016\/j.ejps.2007.11.003_bib19","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1162\/153535003322750673","article-title":"Synthesis and characterization of a Gd\u2013DOTA-D-permeation peptide for magnetic resonance relaxation enhancement of intracellular targets","volume":"2","author":"Prantner","year":"2003","journal-title":"Mol. Imag."},{"key":"10.1016\/j.ejps.2007.11.003_bib20","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S1074-5521(02)00189-8","article-title":"Cellular import mediated by nuclear localization signal peptide sequences","volume":"9","author":"Ragin","year":"2002","journal-title":"Chem. Biol."},{"key":"10.1016\/j.ejps.2007.11.003_bib21","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1002\/j.1460-2075.1994.tb06418.x","article-title":"Nuclear localization of p85s6k: functional requirement for entry into S phase","volume":"13","author":"Reinhard","year":"1994","journal-title":"EMBO J."},{"key":"10.1016\/j.ejps.2007.11.003_bib22","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/S0006-3495(03)74947-9","article-title":"Real-time imaging of nuclear permeation by EGFP in single intact cells","volume":"84","author":"Wei","year":"2003","journal-title":"Biophys. J."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098707004137?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098707004137?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T04:39:12Z","timestamp":1588135152000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098707004137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["S0928098707004137"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2007.11.003","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}