{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:44:23Z","timestamp":1791312263630,"version":"4.3.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.ejps.2010.08.008","type":"journal-article","created":{"date-parts":[[2010,8,27]],"date-time":"2010-08-27T06:11:17Z","timestamp":1282889477000},"page":"589-596","source":"Crossref","is-referenced-by-count":43,"title":["Preservation of viability and antibacterial activity of Lactobacillus spp. in calcium alginate beads"],"prefix":"10.1016","volume":"41","author":[{"given":"Mariya I.","family":"Brachkova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Duarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o F.","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2010.08.008_bib0005","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s00535-008-2296-0","article-title":"Probiotics and immunity","volume":"44","author":"Borchers","year":"2009","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.ejps.2010.08.008_bib0010","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/0141-0229(87)90082-2","article-title":"Survival kinetics of lactic acid starter cultures during and after freeze drying","volume":"9","author":"Bozoglu","year":"1987","journal-title":"Enzyme Microb. Technol."},{"key":"10.1016\/j.ejps.2010.08.008_bib0015","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.ijantimicag.2006.08.002","article-title":"Survey of extended-spectrum beta-lactamases in Escherichia coli isolates from a Portuguese hospital and characterisation of a novel class 1 integron (In60A) carrying the blaCTX-M-9 gene","volume":"28","author":"Br\u00edzio","year":"2006","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.ejps.2010.08.008_bib0020","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1128\/AEM.58.5.1429-1434.1992","article-title":"Lactococcus lactis release from calcium alginate beads","volume":"58","author":"Champagne","year":"1992","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ejps.2010.08.008_bib0025","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1128\/AAC.49.1.477-478.2005","article-title":"First description of CTX-M-15-producing Klebsiella pneumoniae in Portugal","volume":"49","author":"Concei\u00e7\u00e3o","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejps.2010.08.008_bib0030","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0378-5173(00)00560-3","article-title":"Survival and stability of bifidobacteria loaded in alginate poly-l-lysine microparticles","volume":"210","author":"Cui","year":"2000","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2010.08.008_bib0035","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.imbio.2005.05.024","article-title":"Effects of milk fermented by Lactobacillus helveticus R389 on immune cells associated to mammary glands in normal and a breast cancer model","volume":"210","author":"de Moreno de LeBlanc","year":"2005","journal-title":"Immunobiology"},{"key":"10.1016\/j.ejps.2010.08.008_bib0040","doi-asserted-by":"crossref","first-page":"i3","DOI":"10.1093\/jac\/dkl373","article-title":"Antibiotic resistance-action to promote new technologies: report of an EU. Intergovernmental Conference held in Birmingham, UK, 12\u201313 December 2005","volume":"58","author":"Finch","year":"2006","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.ejps.2010.08.008_bib0045","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.phymed.2005.06.002","article-title":"Abietanes from Plectranthus grandidentatus and P. hereroensis against methicillin- and vancomycin-resistant bacteria","volume":"13","author":"Gaspar-Marques","year":"2006","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ejps.2010.08.008_bib0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2006.04.017","article-title":"Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan\u2014a review","volume":"114","author":"George","year":"2006","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejps.2010.08.008_bib0055","doi-asserted-by":"crossref","first-page":"647862","DOI":"10.1155\/2009\/647862","article-title":"Lactobacillus rhamnosus GG suppresses meningitic E. coli K1 penetration across human intestinal epithelial cells in vitro and protects neonatal rats against experimental hematogenous meningitis","volume":"2009","author":"Huang","year":"2009","journal-title":"Int. J. Microbiol."},{"key":"10.1016\/j.ejps.2010.08.008_bib0180","first-page":"1208","article-title":"Regular nonsporing gram-positive rods","volume":"vol.2","author":"Kandler","year":"1986"},{"key":"10.1016\/j.ejps.2010.08.008_bib0065","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1128\/AEM.56.10.3112-3116.1990","article-title":"Enhancing the viability of Lactobacillus plantarum inoculum by immobilizing the cells in calcium-alginate beads incorporating cryoprotectants","volume":"56","author":"Kearney","year":"1990","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ejps.2010.08.008_bib0070","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1128\/AEM.66.2.869-873.2000","article-title":"Survival of Bifidobacterium longum immobilized in calcium alginate beads in simulated gastric juices and bile salt solution","volume":"66","author":"Ki-Yong","year":"2000","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ejps.2010.08.008_bib0075","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.3168\/jds.S0022-0302(01)74572-9","article-title":"Cell release from alginate-immobilized Lactococcus lactis ssp. lactis in chitosan and alginate coated beads","volume":"84","author":"Klinkenberg","year":"2001","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.ejps.2010.08.008_bib0080","series-title":"Applications of Cell Immobilisation Biotechnology","first-page":"295","article-title":"Immobilised cell technologies for the dairy industry","author":"Lacroix","year":"2005"},{"key":"10.1016\/j.ejps.2010.08.008_bib0085","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1099\/mic.0.28654-0","article-title":"Inhibition of expression of a staphylococcal superantigen-like protein by a soluble factor from Lactobacillus reuteri","volume":"152","author":"Laughton","year":"2006","journal-title":"Microbiology"},{"key":"10.1016\/j.ejps.2010.08.008_bib0090","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1080\/08910600802408095","article-title":"Relationship between number of bacteria and their probiotic effects","volume":"20","author":"Minelli","year":"2008","journal-title":"Microb. Ecol. Health Dis."},{"key":"10.1016\/j.ejps.2010.08.008_bib0095","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1128\/AEM.58.2.545-550.1992","article-title":"Production of concentrated Lactococcus lactis subsp. cremoris suspensions in calcium alginate beads","volume":"58","author":"Morin","year":"1992","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ejps.2010.08.008_bib0100","article-title":"Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically","volume":"vol. 23, no. 2","author":"National Committee for Clinical Laboratory Standards (NCCLS)","year":"2003"},{"key":"10.1016\/j.ejps.2010.08.008_bib0105","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1742-481X.2008.00577.x","article-title":"Bacteriotherapy with Lactobacillus plantarum in burns","volume":"6","author":"Peral","year":"2009","journal-title":"Int. Wound J."},{"key":"10.1016\/j.ejps.2010.08.008_bib0110","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1053\/j.seminhematol.2009.03.007","article-title":"Advances in antibacterial therapy against emerging bacterial pathogens","volume":"46","author":"Pournaras","year":"2009","journal-title":"Semin. Hematol."},{"key":"10.1016\/j.ejps.2010.08.008_bib0115","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/BF01042371","article-title":"Continuous yoghurt production with Lactobacillus bulgaricus and Streptococcus thermophilus entrapped in Ca-alginate","volume":"7","author":"Prevost","year":"1985","journal-title":"Biotechnol. Lett."},{"key":"10.1016\/j.ejps.2010.08.008_bib0120","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/S0966-842X(01)02132-1","article-title":"Can bacterial interference prevent infection?","volume":"9","author":"Reid","year":"2001","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.ejps.2010.08.008_bib0130","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.3168\/jds.S0022-0302(93)77523-2","article-title":"Improving survival of culture bacteria in frozen desserts by microentrapment","volume":"76","author":"Sheu","year":"1993","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.ejps.2010.08.008_bib0135","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1136\/adc.2008.137414","article-title":"Wold AE. Spray bacteriotherapy decreases middle ear fluid in children with secretory otitis media","volume":"94","author":"Skovbjerg","year":"2009","journal-title":"Arch. Dis. Child"},{"key":"10.1016\/j.ejps.2010.08.008_bib0140","first-page":"231","article-title":"Basic aspects and industrial strategies for the preservation of microorganisms by freezing and drying","volume":"vol. 137","author":"Souzu","year":"2004"},{"key":"10.1016\/j.ejps.2010.08.008_bib0145","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/jobm.200410532","article-title":"Characterization of bacteriocins produced by lactic acid bacteria isolated from spoiled black olives","volume":"45","author":"Todorov","year":"2005","journal-title":"J. Basic Microbiol."},{"key":"10.1016\/j.ejps.2010.08.008_bib0150","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1006\/fstl.2001.0759","article-title":"Resistance of immobilized lactic acid bacteria to the inhibitory effect of quaternary ammonium sanitizers","volume":"34","author":"Trauth","year":"2001","journal-title":"Lebensm-Wiss. U.-Technol."},{"key":"10.1016\/j.ejps.2010.08.008_bib0155","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1111\/j.1469-0691.2005.01142.x","article-title":"Interference of Lactobacillus plantarum with Pseudomonas aeruginosa in vitro and in infected burns: the potential use of probiotics in wound treatment","volume":"11","author":"Valdez","year":"2005","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.ejps.2010.08.008_bib0160","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0966-7822(94)00043-7","article-title":"Physico-chemical properties of alginate gel beads","volume":"3","author":"Velings","year":"1995","journal-title":"Polym. Gels Netw."},{"key":"10.1016\/j.ejps.2010.08.008_bib0165","series-title":"Applications of Cell Immobilisation Biotechnology","first-page":"439","article-title":"Stabilisation of probiotic microorganisms","author":"Viernstein","year":"2005"},{"key":"10.1016\/j.ejps.2010.08.008_bib0170","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1111\/j.1365-2672.1995.tb00953.x","article-title":"Continuous production of bacteriocins, brevicin, nisin and pediocin, using calcium alginate-immobilized bacteria","volume":"79","author":"Wan","year":"1995","journal-title":"J. Appl. Bacteriol."},{"key":"10.1016\/j.ejps.2010.08.008_bib0175","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s12195-008-0014-x","article-title":"Calcium concentration effects on the mechanical and biochemical properties of chondrocyte-alginate constructs","volume":"1","author":"Wan","year":"2008","journal-title":"Cell. Mol. Bioeng."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098710003064?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098710003064?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T20:12:19Z","timestamp":1591819939000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098710003064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0928098710003064"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2010.08.008","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}