{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:49:16Z","timestamp":1792111756147,"version":"4.4.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1016\/j.ejps.2010.09.019","type":"journal-article","created":{"date-parts":[[2010,10,7]],"date-time":"2010-10-07T04:39:57Z","timestamp":1286426397000},"page":"3-10","source":"Crossref","is-referenced-by-count":142,"title":["Assessment of gastrointestinal pH, fluid and lymphoid tissue in the guinea pig, rabbit and pig, and implications for their use in drug development"],"prefix":"10.1016","volume":"42","author":[{"given":"Hamid A.","family":"Merchant","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma L.","family":"McConnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandrasekaran","family":"Ramaswamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rucha P.","family":"Kulkarni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul W.","family":"Basit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudaxshina","family":"Murdan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2010.09.019_bib0005","first-page":"9","article-title":"Effects of type and level of fibre on digestive physiology and performance in reproducing and growing rabbits","volume":"15","author":"Alvarez","year":"2007","journal-title":"World Rabbit Sci."},{"issue":"6","key":"10.1016\/j.ejps.2010.09.019_bib0010","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1136\/gut.27.6.667","article-title":"Distribution of immunoglobulin producing cells is different in normal human appendix and colon mucosa","volume":"27","author":"Bjerke","year":"1986","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.ejps.2010.09.019_bib0015","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1172\/JCI107158","article-title":"Some characteristics of the rabbit vermiform appendix as a secreting organ","volume":"52","author":"Blackwood","year":"1973","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.ejps.2010.09.019_bib0020","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1136\/gut.6.3.225","article-title":"Number, size, and distribution of Peyer's patches in the human small intestine. Part I. The development of Peyer's patches","volume":"6","author":"Cornes","year":"1965","journal-title":"Gut"},{"issue":"9","key":"10.1016\/j.ejps.2010.09.019_bib0025","first-page":"716","article-title":"Peyer's patches in the human gut","volume":"58","author":"Cornes","year":"1965","journal-title":"Proc. R. Soc. Med."},{"key":"10.1016\/j.ejps.2010.09.019_bib0030","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/jmor.1050670208","article-title":"Organization of the mucosa and lymphatic structures in the rabbit appendix","volume":"67","author":"Crabb","year":"1940","journal-title":"J. Morphol."},{"issue":"8","key":"10.1016\/j.ejps.2010.09.019_bib0035","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1381\/0960892055002158","article-title":"Size, volume and weight of the stomach in patients with morbid obesity compared to controls","volume":"15","author":"Csendes","year":"2005","journal-title":"Obes. Surg."},{"issue":"5(2)","key":"10.1016\/j.ejps.2010.09.019_bib0040","first-page":"A408","article-title":"The amount and composition of large bowel contents in man","volume":"98","author":"Cummings","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejps.2010.09.019_bib0045","series-title":"Applied Anatomy: The Construction of the Human Body","author":"Davis","year":"1913"},{"issue":"6","key":"10.1016\/j.ejps.2010.09.019_bib0050","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00428-002-0651-8","article-title":"Histological and immunohistochemical study of the lymphoid tissue in the normal stomach of the gnotobiotic pig","volume":"441","author":"Driessen","year":"2002","journal-title":"Virchows Arch."},{"issue":"8","key":"10.1016\/j.ejps.2010.09.019_bib0055","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1136\/gut.29.8.1035","article-title":"Measurement of gastrointestinal pH profiles in normal ambulant human subjects","volume":"29","author":"Evans","year":"1988","journal-title":"Gut"},{"issue":"6","key":"10.1016\/j.ejps.2010.09.019_bib0060","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/j.1365-2036.1989.tb00254.x","article-title":"pH-profile and regional transit times of the normal gut measured by a radiotelemetry device","volume":"3","author":"Fallingborg","year":"1989","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"4","key":"10.1016\/j.ejps.2010.09.019_bib0065","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/0021-9975(88)90062-X","article-title":"Occurrence of multinucleated giant cells in the appendix of clinically healthy rabbits","volume":"99","author":"Feinstein","year":"1988","journal-title":"J. Comp. Pathol."},{"issue":"6","key":"10.1016\/j.ejps.2010.09.019_bib0070","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/0046-8177(93)90235-9","article-title":"Gastric lymphoid follicles in Helicobacter pylori infection: frequency, distribution, and response to triple therapy","volume":"24","author":"Genta","year":"1993","journal-title":"Hum. Pathol."},{"issue":"2","key":"10.1016\/j.ejps.2010.09.019_bib0075","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1172\/JCI103423","article-title":"Gastrointestinal water and electroyltes. IV. The equilibration of deuterium oxide (D2O) in gastrointestinal contents and the proportion of total body water (T.B.W.) in the gastrointestinal tract","volume":"36","author":"Gotch","year":"1957","journal-title":"J. Clin. Invest."},{"issue":"8","key":"10.1016\/j.ejps.2010.09.019_bib0080","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1007\/s11095-008-9580-9","article-title":"Interplay between intestinal pH, transit time and feed status on the in vivo performance of pH responsive ileo-colonic release systems","volume":"25","author":"Ibekwe","year":"2008","journal-title":"Pharm. Res."},{"issue":"12","key":"10.1016\/j.ejps.2010.09.019_bib0085","doi-asserted-by":"crossref","first-page":"3128","DOI":"10.1007\/s10620-008-0301-3","article-title":"A glass of water immediately increases gastric pH in healthy subjects","volume":"53","author":"Karamanolis","year":"2008","journal-title":"Dig. Dis. Sci."},{"issue":"3\u20134","key":"10.1016\/j.ejps.2010.09.019_bib0090","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.ejps.2009.02.015","article-title":"Fabrication and in vivo evaluation of highly pH-responsive acrylic microparticles for targeted gastrointestinal delivery","volume":"37","author":"Kendall","year":"2009","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2010.09.019_bib0095","first-page":"189","article-title":"The number and distribution of lymphoid follicles in the human large intestine","volume":"149","author":"Langman","year":"1986","journal-title":"J. Anat."},{"issue":"2","key":"10.1016\/j.ejps.2010.09.019_bib0100","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.ijpharm.2008.05.012","article-title":"Gut instincts: explorations in intestinal physiology and drug delivery","volume":"364","author":"McConnell","year":"2008","journal-title":"Int. J. Pharm."},{"issue":"1","key":"10.1016\/j.ejps.2010.09.019_bib0105","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1211\/jpp.60.1.0008","article-title":"Measurements of rat and mouse gastrointestinal pH, fluid and lymphoid tissue, and implications for in-vivo experiments","volume":"60","author":"McConnell","year":"2008","journal-title":"J. Pharm. Pharmacol."},{"issue":"5","key":"10.1016\/j.ejps.2010.09.019_bib0110","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.vaccine.2007.11.071","article-title":"Colonic antigen administration induces significantly higher humoral levels of colonic and vaginal IgA, and serum IgG compared to oral administration","volume":"26","author":"McConnell","year":"2008","journal-title":"Vaccine"},{"issue":"5","key":"10.1016\/j.ejps.2010.09.019_bib0115","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1080\/10611860902839502","article-title":"Colonic treatments and targets: issues and opportunities","volume":"17","author":"McConnell","year":"2009","journal-title":"J. Drug Target"},{"issue":"5","key":"10.1016\/j.ejps.2010.09.019_bib0120","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1136\/gut.30.5.573","article-title":"Comparison of gastric body and antral pH: a 24 hour ambulatory study in healthy volunteers","volume":"30","author":"McLauchlan","year":"1989","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.ejps.2010.09.019_bib0125","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1023\/A:1018970323716","article-title":"Upper gastrointestinal pH in seventy-nine healthy, elderly, North American men and women","volume":"10","author":"Russell","year":"1993","journal-title":"Pharm. Res."},{"issue":"10","key":"10.1016\/j.ejps.2010.09.019_bib0130","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1111\/j.1365-2036.2005.02683.x","article-title":"Intestinal fluid volumes and transit of dosage forms as assessed by magnetic resonance imaging","volume":"22","author":"Schiller","year":"2005","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"7","key":"10.1016\/j.ejps.2010.09.019_bib0135","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1136\/gut.26.7.672","article-title":"Gut associated lymphoid tissue: a morphological and immunocytochemical study of the human appendix","volume":"26","author":"Spencer","year":"1985","journal-title":"Gut"}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098710003453?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098710003453?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T10:51:35Z","timestamp":1544179895000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098710003453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":27,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S0928098710003453"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2010.09.019","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]}}}