{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T09:48:58Z","timestamp":1784972938201,"version":"3.55.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"3-4","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1016\/j.ejps.2013.08.010","type":"journal-article","created":{"date-parts":[[2013,8,24]],"date-time":"2013-08-24T20:46:23Z","timestamp":1377377183000},"page":"420-428","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Enhancement effect of P-gp inhibitors on the intestinal absorption and antiproliferative activity of bestatin"],"prefix":"10.1016","volume":"50","author":[{"given":"Xiaokui","family":"Huo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyong","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2013.08.010_b0005","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.ejps.2008.12.005","article-title":"Effect of P-glycoprotein inhibitor, verapamil, on oral bioavailability and pharmacokinetics of irinotecan in rats","volume":"36","author":"Bansal","year":"2009","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2013.08.010_b0010","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1093\/jnci\/85.8.632","article-title":"Induction of multidrug resistance in human cells by transient exposure to different chemotherapeutic drugs","volume":"85","author":"Chaudhary","year":"1993","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.ejps.2013.08.010_b0015","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1146\/annurev-pharmtox-010611-134529","article-title":"Drug transporters in drug efficacy and toxicity","volume":"10","author":"Degorter","year":"2012","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.ejps.2013.08.010_b0020","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1124\/dmd.110.035881","article-title":"The utility of in vitro data in making accurate predictions of human P-glycoprotein-mediated drug-drug interactions: a case study for AZD5672","volume":"39","author":"Elsby","year":"2011","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejps.2013.08.010_b0025","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nrd3028","article-title":"Membrane transporters in drug development","volume":"9","author":"Giacomini","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejps.2013.08.010_b0030","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0304-3835(02)00086-1","article-title":"Aminopeptidase inhibitors bestatin and actinonin inhibit cell proliferation of myeloma cells predominantly by intracellular interactions","volume":"182","author":"Gruji\u0107","year":"2002","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ejps.2013.08.010_b0035","doi-asserted-by":"crossref","first-page":"602","DOI":"10.3109\/00498254.2010.500744","article-title":"Intestinal absorption mechanisms of ginsenoside Rh2: stereoselectivity and involvement of ABC transporters","volume":"40","author":"Gu","year":"2010","journal-title":"Xenobiotica"},{"key":"10.1016\/j.ejps.2013.08.010_b0040","doi-asserted-by":"crossref","first-page":"238080","DOI":"10.1155\/2010\/238080","article-title":"Mechanisms of the regulation of the intestinal Na+\/H+ exchanger NHE3","volume":"2010","author":"He","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.ejps.2013.08.010_b0045","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1016\/0006-2952(93)90431-U","article-title":"Transport of bestatin in rat renal brush-border membrane vesicles","volume":"45","author":"Hori","year":"1993","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejps.2013.08.010_b0050","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/sj.clpt.6100054","article-title":"Drug interaction studies: study design, data analysis, and implications for dosing and labeling","volume":"81","author":"Huang","year":"2007","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ejps.2013.08.010_b0055","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1124\/dmd.110.033019","article-title":"Role of p-glycoprotein in region-specific gastrointestinal absorption of talinolol in rats","volume":"38","author":"Kagan","year":"2010","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejps.2013.08.010_b0060","doi-asserted-by":"crossref","first-page":"6669","DOI":"10.1158\/0008-5472.CAN-07-6627","article-title":"CHR-2797: an antiproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells","volume":"68","author":"Krige","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejps.2013.08.010_b0065","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.peptides.2011.01.019","article-title":"Uptake, transport and regulation of JBP485 by PEPT1 in vitro and in vivo","volume":"32","author":"Liu","year":"2011","journal-title":"Peptides"},{"key":"10.1016\/j.ejps.2013.08.010_b0070","unstructured":"Liu, K.J., He, J.H., Su, X.D., Sim, H.M., Xie, J.D., Chen, X.G., Wang, F., Liang, Y.J., Singh, S., Sodani, K., Talele, T.T., Ambudkar, S.V., Chen, Z.S., Wu, H.Y., Fu, L.W., 2012. Saracatinib (AZD0530) is a potent modulator of ABCB1-mediated multidrug resistance in vitro and in vivo. Int. J. Cancer (doi: 10.1002\/ijc.27649), in press."},{"key":"10.1016\/j.ejps.2013.08.010_b0075","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.cyto.2008.10.011","article-title":"Bestatin, an inhibitor for aminopeptidases, modulates the production of cytokines and chemokines by activated monocytes and macrophages","volume":"44","author":"Lkhagvaa","year":"2008","journal-title":"Cytokine"},{"key":"10.1016\/j.ejps.2013.08.010_b0080","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/1097-0142(20000901)89:5<1037::AID-CNCR13>3.0.CO;2-Z","article-title":"Correlation of toxicity with pharmacokinetics of pegylated liposomal doxorubicin (Doxil) in metastatic breast carcinoma","volume":"89","author":"Lyass","year":"2000","journal-title":"Cancer"},{"key":"10.1016\/j.ejps.2013.08.010_b0085","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1750-3639.2009.00267.x","article-title":"Reduced activity of CD13\/aminopeptidase N (APN) in aggressive meningiomas is associated with increased levels of SPARC","volume":"20","author":"Mawrin","year":"2010","journal-title":"Brain Pathol."},{"key":"10.1016\/j.ejps.2013.08.010_b0090","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/1097-0215(20001015)88:2<274::AID-IJC20>3.0.CO;2-5","article-title":"Cancer cell-targeted drug delivery utilizing oligopeptide transport activity","volume":"88","author":"Nakanishi","year":"2000","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ejps.2013.08.010_b0095","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1016\/j.febslet.2006.02.020","article-title":"Mechanisms and strategies to overcome multipledrugresistance in cancer","volume":"580","author":"Ozben","year":"2006","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ejps.2013.08.010_b0100","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1124\/dmd.107.019455","article-title":"Prediction of the pharmacokinetics of atorvastatin, cerivastatin, and indomethacin using kinetic models applied to isolated rat hepatocytes","volume":"36","author":"Paine","year":"2008","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejps.2013.08.010_b0105","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1034\/j.1600-0773.2002.t01-1-910403.x","article-title":"The involvement of P-glycoprotein in berberine absorption","volume":"91","author":"Pan","year":"2002","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.ejps.2013.08.010_b0110","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1021\/mp0500871","article-title":"P-glycoprotein recognition of substrates and circumvention through rational drug design","volume":"3","author":"Raub","year":"2006","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejps.2013.08.010_b0115","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1080\/1042819031000122033","article-title":"Aminopeptidase inhibitors inhibit proliferation and induce apoptosis of K562 and STI571-resistant K562 cell lines through the MAPK and GSK-3beta pathways","volume":"44","author":"Sawafuji","year":"2003","journal-title":"Leuk. Lymphoma."},{"key":"10.1016\/j.ejps.2013.08.010_b0120","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(02)00169-2","article-title":"Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview","volume":"55","author":"Schinkel","year":"2003","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejps.2013.08.010_b0125","first-page":"798","article-title":"Cellular uptake of 3H-bestatin in tissues of mice after its intravenous injection","volume":"25","author":"Scornik","year":"1997","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejps.2013.08.010_b0130","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/sj.leu.2401388","article-title":"Induction of apoptosis by bestatin (ubenimex) in human leukemic cell lines","volume":"13","author":"Sekine","year":"1999","journal-title":"Leukemia"},{"key":"10.1016\/j.ejps.2013.08.010_b0135","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1124\/jpet.107.127704","article-title":"Quantitation of doxorubicin uptake, efflux, and modulation of multidrug resistance (MDR) in MDR human cancer cells","volume":"324","author":"Shen","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejps.2013.08.010_b0140","doi-asserted-by":"crossref","first-page":"621","DOI":"10.2174\/138945011795378540","article-title":"Improving cancer chemotherapy with modulators of ABC drug transporters","volume":"12","author":"Shukla","year":"2011","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.ejps.2013.08.010_b0145","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.jchromb.2007.04.030","article-title":"Development of a quantitative LC-MS\/MS analytical method coupled with turbulent flow chromatography for digoxin for the in vitro P-gp inhibition assay","volume":"854","author":"Smalley","year":"2007","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life. Sci."},{"key":"10.1016\/j.ejps.2013.08.010_b0150","doi-asserted-by":"crossref","first-page":"4013","DOI":"10.1002\/jps.22652","article-title":"Establishment of in vitro P-glycoprotein inhibition assay and its exclusion criteria to assess the risk of drug-drug interaction at the drug discovery stage","volume":"100","author":"Sugimoto","year":"2011","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2013.08.010_b0155","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1023\/A:1016100715125","article-title":"Effects of grapefruit juice and orange juice on the intestinal efflux of P-glycoprotein substrates","volume":"19","author":"Tian","year":"2002","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejps.2013.08.010_b0160","first-page":"985","article-title":"Ubenimex capsule improves general performance and chemotherapy related toxicity in advanced gastric cancer cases","volume":"12","author":"Xu","year":"2011","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.ejps.2013.08.010_b0165","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1002\/ijc.22528","article-title":"Involvement of aminopeptidase N in enhanced chemosensitivity to paclitaxel in ovarian carcinoma in vitro and in vivo","volume":"120","author":"Yamashita","year":"2007","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ejps.2013.08.010_b0170","doi-asserted-by":"crossref","first-page":"827","DOI":"10.3109\/02841869009093009","article-title":"Bestatin in resected lung cancer. A randomized clinical trial","volume":"29","author":"Yasumitsu","year":"1990","journal-title":"Acta. Oncologica."},{"key":"10.1016\/j.ejps.2013.08.010_b0175","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1124\/dmd.110.032060","article-title":"Pharmacokinetic interaction between JBP485 and cephalexin in rats","volume":"38","author":"Zhang","year":"2010","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejps.2013.08.010_b0180","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.peptides.2012.01.007","article-title":"Organic anion transporters involved in the excretion of bestatin in the kidney","volume":"33","author":"Zhu","year":"2012","journal-title":"Peptides"}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098713003242?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098713003242?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,13]],"date-time":"2018-10-13T14:51:11Z","timestamp":1539442271000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098713003242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":36,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["S0928098713003242"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2013.08.010","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhancement effect of P-gp inhibitors on the intestinal absorption and antiproliferative activity of bestatin","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2013.08.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}