{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:08:36Z","timestamp":1790050116743,"version":"4.0.1"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.ejps.2014.06.010","type":"journal-article","created":{"date-parts":[[2014,6,22]],"date-time":"2014-06-22T13:46:56Z","timestamp":1403444816000},"page":"309-316","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Topical treatment of L. major infected BALB\/c mice with a novel diselenide chitosan hydrogel formulation"],"prefix":"10.1016","volume":"62","author":[{"given":"Juana","family":"Schwartz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u00f1igo","family":"Navarro-Blasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Nguewa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan A.","family":"Palop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan M.","family":"Irache","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Sanmart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Socorro","family":"Espuelas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2014.06.010_b0005","doi-asserted-by":"crossref","first-page":"283","DOI":"10.2174\/156720110793360612","article-title":"Topical dermatological drug delivery: quo vadis?","volume":"7","author":"Akomeah","year":"2010","journal-title":"Curr. Drug Deliv."},{"key":"10.1016\/j.ejps.2014.06.010_b0010","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.actatropica.2012.06.004","article-title":"Colloidal, in vitro and in vivo anti-leishmanial properties of transfersomes containing paromomycin sulfate in susceptible BALB\/c mice","volume":"124","author":"Bavarsad","year":"2012","journal-title":"Acta Trop."},{"key":"10.1016\/j.ejps.2014.06.010_b0015","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.2174\/0929867311320210005","article-title":"Trypanosomatidae diseases: from the current therapy to the efficacious role of trypanothione reductase in drug discovery","volume":"20","author":"Bernardes","year":"2013","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ejps.2014.06.010_b0025","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3109\/08982100903015025","article-title":"Topical delivery and in vivo antileishmanial activity of paromomycin-loaded liposomes for treatment of cutaneous leishmaniasis","volume":"20","author":"Carneiro","year":"2010","journal-title":"J. Liposome Res."},{"key":"10.1016\/j.ejps.2014.06.010_b0020","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1517\/17425247.2012.701204","article-title":"Drug delivery systems for the topical treatment of cutaneous leishmaniasis","volume":"9","author":"Carneiro","year":"2012","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.ejps.2014.06.010_b0030","first-page":"203","article-title":"In vitro skin permeation of paromomycin from topical formulations across normal and stripped hairless mouse skin","volume":"13","author":"Castro","year":"2003","journal-title":"Stp. Pharma. Sci."},{"key":"10.1016\/j.ejps.2014.06.010_b0035","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1586\/eri.11.59","article-title":"Chitosan preparations for wounds and burns: antimicrobial and wound-healing effects","volume":"9","author":"Dai","year":"2011","journal-title":"Expert Rev. Anti Infect. Ther."},{"key":"10.1016\/j.ejps.2014.06.010_b0040","first-page":"1","article-title":"Screening strategies to identify new chemical diversity for drug development to treat kinetoplastid infections","author":"Don","year":"2013","journal-title":"Parasitology"},{"key":"10.1016\/j.ejps.2014.06.010_b0045","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1128\/AAC.26.5.745","article-title":"Development of topical treatment for cutaneous leishmaniasis caused by Leishmania major in experimental animals","volume":"26","author":"El-On","year":"1984","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejps.2014.06.010_b0050","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1081\/DDC-120030423","article-title":"In vitro skin permeation and retention of paromomycin from liposomes for topical treatment of the cutaneous leishmaniasis","volume":"30","author":"Ferreira","year":"2004","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.ejps.2014.06.010_b0055","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1684\/ejd.2009.0676","article-title":"Topical delivery of cosmetics and drugs. Molecular aspects of percutaneous absorption and delivery","volume":"19","author":"Forster","year":"2009","journal-title":"Eur. J. Dermatol."},{"key":"10.1016\/j.ejps.2014.06.010_b0060","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/PL00012154","article-title":"Studies on the binding mechanism of fluoroquinolones to melanin","volume":"6","author":"Fukuda","year":"2000","journal-title":"J. Infect. Chemother."},{"key":"10.1016\/j.ejps.2014.06.010_b0070","first-page":"538","article-title":"Topical treatment for cutaneous leishmaniasis","volume":"3","author":"Garnier","year":"2002","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"10.1016\/j.ejps.2014.06.010_b0065","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1211\/jpp.58.8.0004","article-title":"In-vitro and in-vivo studies on a topical formulation of sitamaquine dihydrochloride for cutaneous leishmaniasis","volume":"58","author":"Garnier","year":"2006","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejps.2014.06.010_b0075","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1093\/jac\/dkm303","article-title":"In vivo studies on the antileishmanial activity of buparvaquone and its prodrugs","volume":"60","author":"Garnier","year":"2007","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.ejps.2014.06.010_b0080","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1159\/000288163","article-title":"Enhanced absorption through damaged skin: an overview of the in vitro human model","volume":"23","author":"Gattu","year":"2010","journal-title":"Skin Pharmacol. Physiol."},{"key":"10.1016\/j.ejps.2014.06.010_b0085","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0022-1759(92)90191-U","article-title":"A new and simple method for studying the binding and ingestion steps in the phagocytosis of yeasts","volume":"154","author":"Giaimis","year":"1992","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.ejps.2014.06.010_b0090","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.actatropica.2004.10.007","article-title":"Activity of a paromomycin hydrophilic formulation for topical treatment of infections by Leishmania (Leishmania) amazonensis and Leishmania (Viannia) braziliensis","volume":"93","author":"Goncalves","year":"2005","journal-title":"Acta Trop."},{"key":"10.1016\/j.ejps.2014.06.010_b0100","first-page":"CD005067","article-title":"Interventions for Old World cutaneous leishmaniasis","author":"Gonzalez","year":"2008","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.ejps.2014.06.010_b0095","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD004834.pub2","article-title":"Interventions for American cutaneous and mucocutaneous leishmaniasis","author":"Gonzalez","year":"2009","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.ejps.2014.06.010_b0105","doi-asserted-by":"crossref","first-page":"216","DOI":"10.4269\/ajtmh.11-0812","article-title":"Drug discovery algorithm for cutaneous leishmaniasis","volume":"88","author":"Grogl","year":"2013","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.ejps.2014.06.010_b0110","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1128\/AAC.01319-08","article-title":"Effect of topical liposomes containing paromomycin sulfate in the course of Leishmania major infection in susceptible BALB\/c mice","volume":"53","author":"Jaafari","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejps.2014.06.010_b0115","doi-asserted-by":"crossref","first-page":"e381","DOI":"10.1371\/journal.pntd.0000381","article-title":"Is paromomycin an effective and safe treatment against cutaneous leishmaniasis? A meta-analysis of 14 randomized controlled trials","volume":"3","author":"Kim","year":"2009","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.ejps.2014.06.010_b0120","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ijpharm.2013.02.040","article-title":"Skin penetration enhancers","volume":"447","author":"Lane","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2014.06.010_b0125","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1111\/j.1468-2494.2012.00747.x","article-title":"Rational formulation design","volume":"34","author":"Lane","year":"2012","journal-title":"Int. J. Cosmet. Sci."},{"key":"10.1016\/j.ejps.2014.06.010_b0130","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1021\/jm030868a","article-title":"Synthesis, in vitro evaluation, and antileishmanial activity of water-soluble prodrugs of buparvaquone","volume":"47","author":"Mantyla","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejps.2014.06.010_b0135","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1007\/s40265-013-0132-1","article-title":"Therapeutic options for old world cutaneous leishmaniasis and new world cutaneous and mucocutaneous leishmaniasis","volume":"73","author":"Monge-Maillo","year":"2013","journal-title":"Drugs"},{"key":"10.1016\/j.ejps.2014.06.010_b0140","unstructured":"OECD, 2004. Test No. 428: Skin Absorption. In Vitro Method. OECD Publishing."},{"key":"10.1016\/j.ejps.2014.06.010_b0145","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/j.1468-2494.2012.00753.x","article-title":"The role of vehicle interactions on permeation of an active through model membranes and human skin","volume":"34","author":"Oliveira","year":"2012","journal-title":"Int. J. Cosmet. Sci."},{"key":"10.1016\/j.ejps.2014.06.010_b0150","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.1016\/j.ejmech.2011.04.054","article-title":"Selenocyanates and diselenides: a new class of potent antileishmanial agents","volume":"46","author":"Plano","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejps.2014.06.010_b0155","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.exppara.2008.12.004","article-title":"Selective leishmanicidal effect of 1,3,4-thiadiazole derivatives and possible mechanism of action against Leishmania species","volume":"121","author":"Poorrajab","year":"2009","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.ejps.2014.06.010_b0160","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1023\/A:1015810312465","article-title":"Predicting skin permeability","volume":"9","author":"Potts","year":"1992","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejps.2014.06.010_b0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jinorgbio.2012.02.025","article-title":"In vitro anti-leishmania evaluation of nickel complexes with a triazolopyrimidine derivative against Leishmania infantum and Leishmania braziliensis","volume":"112","author":"Ramirez-Macias","year":"2012","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.ejps.2014.06.010_b0170","doi-asserted-by":"crossref","first-page":"4809","DOI":"10.1128\/AAC.00628-13","article-title":"Pharmacokinetics and absorption of paromomycin and gentamicin from topical creams used to treat cutaneous leishmaniasis","volume":"57","author":"Ravis","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejps.2014.06.010_b0175","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S1473-3099(07)70209-8","article-title":"Cutaneous leishmaniasis","volume":"7","author":"Reithinger","year":"2007","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.ejps.2014.06.010_b0180","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1093\/jac\/dkp500","article-title":"In vitro activity of anti-leishmanial drugs against Leishmania donovani is host cell dependent","volume":"65","author":"Seifert","year":"2010","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.ejps.2014.06.010_b0185","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.bmcl.2012.10.110","article-title":"Chemotherapy of leishmaniasis part X: synthesis and bioevaluation of novel terpenyl heterocycles","volume":"23","author":"Tiwari","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejps.2014.06.010_b9025","unstructured":"WHO, 2010. Control of the leishmaniasis: report of a meeting of the WHO Expert Committee on the Control of Leishmaniasis, WHO technical report series 949, Geneva, 1\u2013185."},{"key":"10.1016\/j.ejps.2014.06.010_b0190","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/ics.12001","article-title":"Predicting skin penetration of actives from complex cosmetic formulations: an evaluation of inter formulation and inter active effects during formulation optimization for transdermal delivery","volume":"34","author":"Wiechers","year":"2012","journal-title":"Int. J. Cosmet. Sci."},{"key":"10.1016\/j.ejps.2014.06.010_b0195","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1007\/s11095-009-9915-1","article-title":"Drug delivery to the skin from sub-micron polymeric particle formulations: influence of particle size and polymer hydrophobicity","volume":"26","author":"Wu","year":"2009","journal-title":"Pharm. Res."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092809871400270X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092809871400270X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T07:18:00Z","timestamp":1597994280000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092809871400270X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":40,"alternative-id":["S092809871400270X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2014.06.010","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Topical treatment of L. major infected BALB\/c mice with a novel diselenide chitosan hydrogel formulation","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2014.06.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}