{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:08:13Z","timestamp":1792656493324,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81073080"],"award-info":[{"award-number":["81073080"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.ejps.2014.09.001","type":"journal-article","created":{"date-parts":[[2014,9,9]],"date-time":"2014-09-09T12:48:23Z","timestamp":1410266903000},"page":"21-28","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"special_numbering":"C","title":["Curcumol induces HSC-T6 cell death through suppression of Bcl-2: Involvement of PI3K and NF-\u03baB pathways"],"prefix":"10.1016","volume":"65","author":[{"given":"Gang","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiqian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianjiao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingcai","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2014.09.001_b0005","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1097\/MEG.0b013e3283585863","article-title":"Association of insulin resistance, viral load, and adipokine levels with liver histology in patients with chronic hepatitis C: an observational, multicenter study in Turkey","volume":"24","author":"Aksu","year":"2012","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ejps.2014.09.001_b0060","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.bcp.2011.09.025","article-title":"The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 modulates cytokine expression in macrophages via p50 nuclear factor \u03baB inhibition, in a PI3K-independent mechanism","volume":"83","author":"Avni","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejps.2014.09.001_b0015","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.jhep.2010.11.006","article-title":"Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver","volume":"54","author":"Begriche","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ejps.2014.09.001_b0145","doi-asserted-by":"crossref","first-page":"20727","DOI":"10.1074\/jbc.M111.231381","article-title":"Mapping the IkappaB kinase beta (IKKbeta)-binding interface of the B14 protein, a vaccinia virus inhibitor of IKKbeta-mediated activation of nuclear factor kappaB","volume":"286","author":"Benfield","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejps.2014.09.001_b0040","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jhep.2012.09.016","article-title":"Activation of toll-like receptor 3 attenuates alcoholic liver injury by stimulating Kupffer cells and stellate cells to produce interleukin-10 in mice","volume":"58","author":"Byun","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ejps.2014.09.001_b0130","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1177\/0960327112438928","article-title":"Sulfasalazine prevents the increase in TGF-\u03b2, COX-2, nuclear NF\u03baB translocation and fibrosis in CCl4-induced liver cirrhosis in the rat","volume":"31","author":"Ch\u00e1vez","year":"2012","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.ejps.2014.09.001_b0150","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1002\/hep.510300327","article-title":"Persistent activation of nuclear factor-kappaB in cultured rat hepatic stellate cells involves the induction of potentially novel Rel-like factors and prolonged changes in the expression of IkappaB family proteins","volume":"30","author":"Elsharkawy","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.ejps.2014.09.001_b0155","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.fct.2013.02.051","article-title":"Anti-fibrotic effects of puerarin on CCl4-induced hepatic fibrosis in rats possibly through the regulation of PPAR-\u03b3 expression and inhibition of PI3K\/Akt pathway","volume":"56","author":"Guo","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ejps.2014.09.001_b0075","doi-asserted-by":"crossref","first-page":"6780","DOI":"10.3748\/wjg.v11.i43.6780","article-title":"Effects of different ingredients of zedoary on gene expression of HSC-T6 cells","volume":"11","author":"Jiang","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.ejps.2014.09.001_b0055","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1111\/jgh.12147","article-title":"Paeonol inhibits hepatic fibrogenesis via disrupting nuclear factor-\u03baB pathway in activated stellate cells: in vivo and in vitro studies","volume":"28","author":"Kong","year":"2013","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ejps.2014.09.001_b0050","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0168-8278(00)80159-2","article-title":"Nuclear factor kappaB in proliferation, activation, and apoptosis in rat hepatic stellate cells","volume":"33","author":"Lang","year":"2000","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ejps.2014.09.001_b0105","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.ejps.2012.03.003","article-title":"Hydroxysafflor yellow A induces apoptosis in activated hepatic stellate cells through ERK1\/2 pathway in vitro","volume":"46","author":"Li","year":"2012","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2014.09.001_b0025","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.freeradbiomed.2013.02.027","article-title":"Astragaloside IV suppresses collagen production of activated hepatic stellate cells via oxidative stress-mediated p38 MAPK pathway","volume":"60","author":"Li","year":"2013","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.ejps.2014.09.001_b0035","first-page":"e505","article-title":"Cannabidiol causes activated hepatic stellate cell death through a mechanism of endoplasmic reticulum stress-induced apoptosis","author":"Lim","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejps.2014.09.001_b0020","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.jhep.2010.11.035","article-title":"Inhibition of PDGF, TGF-\u03b2, and Abl signaling and reduction of liver fibrosis by the small molecule Bcr-Abl tyrosine kinase antagonist Nilotinib","volume":"55","author":"Liu","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ejps.2014.09.001_b0120","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.jep.2012.07.009","article-title":"Anti-cancer properties of terpenoids isolated from Rhizoma Curcumae\u2014a review","volume":"143","author":"Lu","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejps.2014.09.001_b0045","doi-asserted-by":"crossref","first-page":"31359","DOI":"10.1074\/jbc.M112.364018","article-title":"Interrogation of inhibitor of nuclear factor \u03baB \u03b1\/nuclear factor \u03baB (I\u03baB\u03b1\/NF-\u03baB) negative feedback loop dynamics: from single cells to live animals in vivo","volume":"287","author":"Moss","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejps.2014.09.001_b0100","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1136\/gut.2005.082701","article-title":"Overexpression of Bcl-2 by activated human hepatic stellate cells: resistance to apoptosis as a mechanism of progressive hepatic fibrogenesis in humans","volume":"55","author":"Novo","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.ejps.2014.09.001_b0010","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1002\/hep.21107","article-title":"Mechanisms of alcohol-induced hepatic fibrosis: a summary of the Ron Thurman Symposium","volume":"43","author":"Purohit","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.ejps.2014.09.001_b0140","doi-asserted-by":"crossref","DOI":"10.12659\/MSM.882196","article-title":"18\u03b1-Glycyrrhizin induces apoptosis and suppresses activation of rat hepatic stellate cells","volume":"18","author":"Qu","year":"2012","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.ejps.2014.09.001_b0065","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1007\/s10495-012-0742-1","article-title":"Dracorhodin perchlorate inhibits PI3K\/Akt and NF-\u03baB activation, up-regulates the expression of p53, and enhances apoptosis","volume":"17","author":"Rasul","year":"2012","journal-title":"Apoptosis"},{"key":"10.1016\/j.ejps.2014.09.001_b0030","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.cgh.2013.01.005","article-title":"Translating an understanding of the pathogenesis of hepatic fibrosis to novel therapies","volume":"11","author":"Rockey","year":"2013","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ejps.2014.09.001_b0070","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1002\/hep.23186","article-title":"Inhibition of phosphatidylinositol 3-kinase signaling in hepatic stellate cells blocks the progression of hepatic fibrosis","volume":"50","author":"Son","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.ejps.2014.09.001_b0085","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.ajpath.2012.11.032","article-title":"Absence of Nogo-B (reticulon 4B) facilitates hepatic stellate cell apoptosis and diminishes hepatic fibrosis in mice","volume":"182","author":"Tashiro","year":"2013","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ejps.2014.09.001_b0160","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/hep.24701","article-title":"Osteopontin, an oxidant stress sensitive cytokine, up-regulates collagen-I via integrin \u03b1(V)\u03b2(3) engagement and PI3K\/pAkt\/NF\u03baB signaling","volume":"55","author":"Urtasun","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.ejps.2014.09.001_b0115","first-page":"746426","article-title":"Inhibitory effect of curcumol on Jak2-STAT signal pathway molecules of fibroblast-like synoviocytes in patients with rheumatoid arthritis","volume":"2012","author":"Wang","year":"2012","journal-title":"Evid. Based Complement Alternat. Med."},{"key":"10.1016\/j.ejps.2014.09.001_b0135","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1126\/science.1133289","article-title":"Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak","volume":"315","author":"Willis","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.ejps.2014.09.001_b0125","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1053\/gast.2001.27188","article-title":"Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats","volume":"121","author":"Wright","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejps.2014.09.001_b0080","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s12032-010-9431-5","article-title":"Curcumol induces apoptosis via caspases-independent mitochondrial pathway in human lung adenocarcinoma ASTC-a-1 cells","volume":"28","author":"Zhang","year":"2011","journal-title":"Med. Oncol."},{"key":"10.1016\/j.ejps.2014.09.001_b0110","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s10495-012-0791-5","article-title":"Tetramethylpyrazine induces G0\/G1 cell cycle arrest and stimulates mitochondrial-mediated and caspase-dependent apoptosis through modulating ERK\/p53 signaling in hepatic stellate cells in vitro","volume":"18","author":"Zhang","year":"2013","journal-title":"Apoptosis"},{"key":"10.1016\/j.ejps.2014.09.001_b0165","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1002\/jnr.22714","article-title":"Luteolin protects against reactive oxygen species-mediated cell death induced by zinc toxicity via the PI3K-Akt-NF-\u03baB-ERK-dependent pathway","volume":"89","author":"Zhou","year":"2011","journal-title":"J. Neurosci. Res."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092809871400342X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092809871400342X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,29]],"date-time":"2018-09-29T23:50:14Z","timestamp":1538265014000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092809871400342X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":31,"alternative-id":["S092809871400342X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2014.09.001","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Curcumol induces HSC-T6 cell death through suppression of Bcl-2: Involvement of PI3K and NF-\u03baB pathways","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2014.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}