{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:41:37Z","timestamp":1762101697953,"version":"3.40.5"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Hungarian National Science and Research Foundation (OTKA)"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.ejps.2015.03.026","type":"journal-article","created":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T12:29:18Z","timestamp":1428582558000},"page":"27-35","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["2\u2032[18F]-fluoroethylrhodamine B is a promising radiotracer to measure P-glycoprotein function"],"prefix":"10.1016","volume":"74","author":[{"given":"Gy\u00f6rgy","family":"Trencs\u00e9nyi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Istv\u00e1n","family":"Kert\u00e9sz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zo\u00e1rd T.","family":"Krasznai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e1bor","family":"M\u00e1t\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6190-9128","authenticated-orcid":false,"given":"G\u00e1bor","family":"Szal\u00f3ki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Szab\u00f3 Judit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levente","family":"K\u00e1rp\u00e1ti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4202-4564","authenticated-orcid":false,"given":"Zolt\u00e1n","family":"Krasznai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ter\u00e9z","family":"M\u00e1ri\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katalin","family":"Goda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2015.03.026_b0005","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/BF01534700","article-title":"Isolation and genetic characterization of human KB cell lines resistant to multiple drugs","volume":"11","author":"Akiyama","year":"1985","journal-title":"Somat. Cell Mol. Genet."},{"key":"10.1016\/j.ejps.2015.03.026_b0010","doi-asserted-by":"crossref","first-page":"52629","DOI":"10.1074\/jbc.M308175200","article-title":"Transition state analysis of the coupling of drug transport to ATP hydrolysis by P-glycoprotein","volume":"278","author":"Al-Shawi","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejps.2015.03.026_b0015","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/S0076-6879(98)92039-0","article-title":"Drug-stimulatable ATPase activity in crude membranes of human MDR1-transfected mammalian cells","volume":"292","author":"Ambudkar","year":"1998","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.ejps.2015.03.026_b0020","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0009-2614(81)80219-9","article-title":"Molecular forms of rhodamine B","volume":"79","author":"Arbeloa","year":"1981","journal-title":"Chem. Phys. Lett."},{"key":"10.1016\/j.ejps.2015.03.026_b0025","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1007\/s11095-005-5271-y","article-title":"Quantitative assessment of HIV-1 protease inhibitor interactions with drug efflux transporters in the blood\u2013brain barrier","volume":"22","author":"Bachmeier","year":"2005","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejps.2015.03.026_b0030","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.nucmedbio.2012.06.013","article-title":"[11C]Rhodamine-123: synthesis and biodistribution in rodents","volume":"39","author":"Bao","year":"2012","journal-title":"Nucl. Med. Biol."},{"key":"10.1016\/j.ejps.2015.03.026_b0035","doi-asserted-by":"crossref","first-page":"11004","DOI":"10.1021\/jm301453p","article-title":"Effect of the prosthetic group on the pharmacologic properties of 18F-labeled rhodamine B, a potential myocardial perfusion agent for positron emission tomography (PET)","volume":"55","author":"Bartholom\u00e4","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejps.2015.03.026_b0040","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2174\/187152013804487380","article-title":"New insight into P-glycoprotein as a drug target","volume":"13","author":"Breier","year":"2013","journal-title":"Anticancer Agents Med. Chem."},{"key":"10.1016\/j.ejps.2015.03.026_b0045","doi-asserted-by":"crossref","first-page":"21020","DOI":"10.1016\/S0021-9258(19)36791-2","article-title":"Characterization of the azidopine and vinblastine binding site of P-glycoprotein","volume":"267","author":"Brugemann","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejps.2015.03.026_b0050","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/0005-2736(73)90191-0","article-title":"Active outward transport of daunomycin in resistant Ehrlich ascites tumor cells","volume":"323","author":"Dano","year":"1973","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejps.2015.03.026_b0055","doi-asserted-by":"crossref","first-page":"13844","DOI":"10.1016\/S0021-9258(17)38802-6","article-title":"Mitochondrial and plasma membrane potentials cause unusual accumulation and retention of rhodamine 123 by human breast adenocarcinoma-derived MCF-7 cells","volume":"260","author":"Davis","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejps.2015.03.026_b0060","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1023\/A:1011988024295","article-title":"BBB transport and P-glycoprotein functionality using MDR1A (\u2212\/\u2212) and wild type mice. Total brain versus microdialysis concentration profiles of rhodamine-123","volume":"15","author":"De Lange","year":"1998","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejps.2015.03.026_b0065","doi-asserted-by":"crossref","first-page":"32367","DOI":"10.1074\/jbc.M400735200","article-title":"Weak base permeability characteristics influence the intracellular sequestration site in the multidrug-resistant human leukemic cell line HL-60","volume":"279","author":"Duvvuri","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejps.2015.03.026_b0070","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1351\/pac200072071391","article-title":"Ionic Liquids. Green solvents for the future","volume":"72","author":"Earle","year":"2000","journal-title":"Pure Appl. Chem."},{"key":"10.1016\/j.ejps.2015.03.026_b0075","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.ejps.2005.11.002","article-title":"The role of transporters in drug interactions","volume":"27","author":"Endres","year":"2006","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2015.03.026_b0080","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.pharmthera.2009.03.017","article-title":"Drug interactions at the blood\u2013brain barrier: Fact or fantasy?","volume":"123","author":"Eyal","year":"2009","journal-title":"Pharmacol. Therapeut."},{"key":"10.1016\/j.ejps.2015.03.026_b0085","doi-asserted-by":"crossref","first-page":"e33253","DOI":"10.1371\/journal.pone.0033253","article-title":"Characterization of Rhodamine-123 as a tracer dye for use in in vitro drug transport assays","volume":"7","author":"Forster","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ejps.2015.03.026_b0090","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1006\/abio.2002.5650","article-title":"A high-throughput screening microplate test for the interaction of drugs with P-glycoprotein","volume":"305","author":"Garrigues","year":"2002","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ejps.2015.03.026_b0095","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2174\/1567201043480036","article-title":"The role of ABC transporters in drug resistance, metabolism and toxicity","volume":"1","author":"Glavinas","year":"2004","journal-title":"Curr. Drug Deliv."},{"key":"10.1016\/j.ejps.2015.03.026_b0100","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.nucmedbio.2009.12.005","article-title":"Biodistribution and stability studies of [18F] Fluoroethylrhodamine B, a potential PET myocardial agent","volume":"37","author":"Gottumukkala","year":"2010","journal-title":"Nucl. Med. Biol."},{"key":"10.1016\/j.ejps.2015.03.026_b0105","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.apradiso.2009.08.013","article-title":"Synthesis of fluorine-18 labeled rhodamine B: A potential PET myocardial perfusion agent","volume":"68","author":"Heinrich","year":"2010","journal-title":"Appl. Radiat. Isotopes."},{"key":"10.1016\/j.ejps.2015.03.026_b0110","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.2174\/1381612003398834","article-title":"Monitoring interactions at ATP-dependent drug efflux pumps","volume":"6","author":"Hendrikse","year":"2000","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.ejps.2015.03.026_b0115","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/oxfordjournals.jbchem.a130549","article-title":"Disruption of charge separation followed by that of the proton gradient in the mitochondrial membrane by CCCP","volume":"76","author":"Hirose","year":"1974","journal-title":"J. Biochem."},{"key":"10.1016\/j.ejps.2015.03.026_b0120","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/j.1745-6584.1999.tb01114.x","article-title":"Fluorescent dye and media properties affecting sorption and tracer selection","volume":"37","author":"Kasnavia","year":"1999","journal-title":"Ground Water"},{"key":"10.1016\/j.ejps.2015.03.026_b0125","doi-asserted-by":"crossref","first-page":"4281","DOI":"10.1021\/jo034109b","article-title":"Significantly enhanced reactivities of the nucleophilic substitution reactions in ionic liquid","volume":"68","author":"Kim","year":"2003","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.ejps.2015.03.026_b0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejps.2014.08.002","article-title":"18FDG a PET tumor diagnostic tracer is not a substrate of the ABC transporter P-glycoprotein","volume":"64","author":"Krasznai","year":"2014","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2015.03.026_b0135","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.nima.2012.12.079","article-title":"Performance evaluation and optimization of the MiniPET-II scanner","volume":"707","author":"Lajtos","year":"2013","journal-title":"Nucl. Inst. Methods Phys. Res. A"},{"key":"10.1016\/j.ejps.2015.03.026_b0140","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/0006-2952(86)90221-2","article-title":"Adriamycin accumulation and metabolism in adriamycin-sensitive and -resistant human ovarian cancer cell lines","volume":"35","author":"Louie","year":"1986","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejps.2015.03.026_b0145","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0925-4439(97)00026-4","article-title":"Structure-activity relationships of P-glycoprotein interacting drugs: kinetic characterization of their effects on ATPase activity","volume":"1361","author":"Litman","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejps.2015.03.026_b0150","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/PL00000912","article-title":"From MDR to MXR: new understanding of multidrug resistance systems, their properties and clinical significance","volume":"58","author":"Litman","year":"2001","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ejps.2015.03.026_b0155","doi-asserted-by":"crossref","first-page":"774","DOI":"10.2174\/138920011798356980","article-title":"PET and SPECT radiotracers to assess function and expression of ABC transporters in vivo","volume":"12","author":"Mairinger","year":"2011","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.ejps.2015.03.026_b0160","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ejps.2005.02.010","article-title":"Biphasic accumulation kinetics of [99mTc]-hexakis-2- methoxyisobutyl isonitrile in tumour cells and its modulation by lipophilic P-glycoprotein ligands","volume":"25","author":"M\u00e1ri\u00e1n","year":"2005","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2015.03.026_b0165","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1529\/biophysj.106.089581","article-title":"Interaction of verapamil with lipid membranes and P-glycoprotein: connecting thermodynamics and membrane structure with functional activity","volume":"91","author":"Meier","year":"2006","journal-title":"Biophys. J."},{"key":"10.1016\/j.ejps.2015.03.026_b0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.apcata.2009.10.008","article-title":"Ionic liquids and catalysis: Recent progress from knowledge to applications","volume":"373","author":"Olivier-Bourbigou","year":"2010","journal-title":"Appl. Catal. A"},{"key":"10.1016\/j.ejps.2015.03.026_b0175","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.bbamem.2004.11.005","article-title":"Single amino acid (482) variants of the ABCG2 multidrug transporter: major differences in transport capacity and substrate recognition","volume":"1668","author":"Ozvegy-Laczka","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"issue":"79","key":"10.1016\/j.ejps.2015.03.026_b0180","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1124\/mol.110.067611","article-title":"Molecular dissection of dual pseudosymmetric solute translocation pathways in human P-glycoprotein","volume":"2011","author":"Parveen","year":"2011","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejps.2015.03.026_b0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-022X(03)00032-0","article-title":"Rhodamine B as a mitochondrial probe for measurement and monitoring of mitochondrial membrane potential in drug-sensitive and -resistant cells","volume":"57","author":"Reungpatthanaphong","year":"2003","journal-title":"J. Biochem. Biophys. Methods"},{"key":"10.1016\/j.ejps.2015.03.026_b0190","doi-asserted-by":"crossref","first-page":"4854","DOI":"10.1016\/S0021-9258(18)42909-2","article-title":"Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase","volume":"267","author":"Sarkadi","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejps.2015.03.026_b0195","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0006-3495(99)77214-0","article-title":"Measurement of mitochondrial membrane potential using fluorescent rhodamine derivatives","volume":"76","author":"Scaduto","year":"1999","journal-title":"Biophys. J."},{"key":"10.1016\/j.ejps.2015.03.026_b0200","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/BF02110329","article-title":"Drug-stimulated ATPase activity of the human P-glycoprotein","volume":"27","author":"Scarborough","year":"1995","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.ejps.2015.03.026_b0205","doi-asserted-by":"crossref","first-page":"7762","DOI":"10.1016\/S0021-9258(19)57466-X","article-title":"Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins","volume":"261","author":"Shen","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejps.2015.03.026_b0210","doi-asserted-by":"crossref","first-page":"415","DOI":"10.2967\/jnumed.110.079608","article-title":"Transport of selected PET radiotracers by human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2): An in vitro screening","volume":"52","author":"Tournier","year":"2011","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.ejps.2015.03.026_b0215","first-page":"405","article-title":"In vivo studies of unlabeled and radioiodinated rhodamine-123","volume":"19","author":"Vora","year":"1992","journal-title":"Nucl. Med. Biol."},{"key":"10.1016\/j.ejps.2015.03.026_b0220","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1006\/bbrc.1995.1872","article-title":"Effect of the P-glycoprotein inhibitor, cyclosporine A, on the distribution of rhodamine-123 to the brain: an in vivo microdialysis study in freely moving rats","volume":"211","author":"Wang","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejps.2015.03.026_b0225","first-page":"1476","article-title":"Expression of multidrug resistance protein and messenger RNA correlate with (99m)Tc-MIBI imaging in patients with lung cancer","volume":"42","author":"Zhou","year":"2001","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.ejps.2015.03.026_b0230","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1021\/mp200025m","article-title":"64Cu-labeled lissamine rhodamine B: a promising PET radiotracer targeting tumor mitochondria","volume":"8","author":"Zhou","year":"2011","journal-title":"Mol. Pharm."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098715001426?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098715001426?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T19:11:12Z","timestamp":1651691472000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098715001426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":46,"alternative-id":["S0928098715001426"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2015.03.026","relation":{},"ISSN":["0928-0987"],"issn-type":[{"type":"print","value":"0928-0987"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"2\u2032[18F]-fluoroethylrhodamine B is a promising radiotracer to measure P-glycoprotein function","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2015.03.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}