{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:27:43Z","timestamp":1789543663894,"version":"build-2803163510"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.ejps.2015.05.006","type":"journal-article","created":{"date-parts":[[2015,5,8]],"date-time":"2015-05-08T06:49:48Z","timestamp":1431067788000},"page":"173-180","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Prediction of pH dependent absorption using in vitro, in silico, and in vivo rat models: Early liability assessment during lead optimization"],"prefix":"10.1016","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4573-8642","authenticated-orcid":false,"given":"Ajay","family":"Saxena","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devang","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shweta","family":"Padmanabhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashyendra Singh","family":"Gautam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gajendra Singh","family":"Chowan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandhya","family":"Mandlekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sridhar","family":"Desikan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2015.05.006_b0005","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0939-6411(99)00070-3","article-title":"Gastric pH profiles of beagle dogs and their use as an alternative to human testing","volume":"49","author":"Akimoto","year":"2000","journal-title":"European Journal of Pharmaceutics and Biopharmaceutics: Official Journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V"},{"key":"10.1016\/j.ejps.2015.05.006_b0010","doi-asserted-by":"crossref","first-page":"4756","DOI":"10.1002\/jps.22669","article-title":"Effect of gastric pH on the pharmacokinetics of a BCS class II compound in dogs: utilization of an artificial stomach and duodenum dissolution model and GastroPlus, simulations to predict absorption","volume":"100","author":"Bhattachar","year":"2011","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2015.05.006_b0015","unstructured":"Chen, J.X., M; Bao, L., Chan O.H., Wong, H., 2006. Characterization of Rat Stomach pH Following Famotidine and Pentagastrin Pre-treatment (T2301). AAPS National Meeting, San Antanio, TX Oct 29\u2013Nov 2."},{"key":"10.1016\/j.ejps.2015.05.006_b0020","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1128\/AAC.39.8.1671","article-title":"Effects of an acidic beverage (Coca-Cola) on absorption of ketoconazole","volume":"39","author":"Chin","year":"1995","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejps.2015.05.006_b0025","first-page":"524","article-title":"Insights into the future of gastric acid suppression. Nature reviews","volume":"6","author":"DeVault","year":"2009","journal-title":"Gastroenterol. Hepatol."},{"key":"10.1016\/j.ejps.2015.05.006_b0030","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1023\/A:1016353705970","article-title":"Comparison of canine and human gastrointestinal physiology","volume":"3","author":"Dressman","year":"1986","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejps.2015.05.006_b0035","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1002\/jps.22486","article-title":"Development of a canine model to enable the preclinical assessment of pH-dependent absorption of test compounds","volume":"100","author":"Fancher","year":"2011","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2015.05.006_b0040","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/jps.20242","article-title":"Using a novel multicompartment dissolution system to predict the effect of gastric pH on the oral absorption of weak bases with poor intrinsic solubility","volume":"94","author":"Gu","year":"2005","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2015.05.006_b0045","first-page":"1781","article-title":"Decreased intrinsic factor secretion in AIDS: relation to parietal cell acid secretory capacity and vitamin B12 malabsorption","volume":"87","author":"Herzlich","year":"1992","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.ejps.2015.05.006_b0050","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ejps.2005.08.011","article-title":"A strategy for preclinical formulation development using GastroPlus as pharmacokinetic simulation tool and a statistical screening design applied to a dog study","volume":"27","author":"Kuentz","year":"2006","journal-title":"Eur. J. Pharm. Sci.: Off. J. Eur. Fed. Pharm. Sci."},{"key":"10.1016\/j.ejps.2015.05.006_b0055","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1111\/j.1365-2036.2009.03993.x","article-title":"Systematic review: impaired drug absorption related to the co-administration of antisecretory therapy","volume":"29","author":"Lahner","year":"2009","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.ejps.2015.05.006_b0060","doi-asserted-by":"crossref","first-page":"502","DOI":"10.7326\/0003-4819-109-6-502","article-title":"Gastric secretory failure in patients with the acquired immunodeficiency syndrome (AIDS)","volume":"109","author":"Lake-Bakaar","year":"1988","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.ejps.2015.05.006_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/S0090-9556(25)06742-X","article-title":"Species similarities and differences in pharmacokinetics","volume":"23","author":"Lin","year":"1995","journal-title":"Drug Metabol. Dispos."},{"key":"10.1016\/j.ejps.2015.05.006_b0070","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1016\/j.bmcl.2013.03.022","article-title":"Synthesis and evaluation of carbamoylmethylene linked prodrugs of BMS-582949, a clinical p38alpha inhibitor","volume":"23","author":"Liu","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejps.2015.05.006_b0075","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1021\/mp400283j","article-title":"Investigation of the rat model for preclinical evaluation of pH-dependent oral absorption in humans","volume":"10","author":"Lubach","year":"2013","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejps.2015.05.006_b0080","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/jps.2600750313","article-title":"Comparison of gastrointestinal pH in dogs and humans: implications on the use of the beagle dog as a model for oral absorption in humans","volume":"75","author":"Lui","year":"1986","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2015.05.006_b0085","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1208\/s12248-012-9372-3","article-title":"The use of modeling tools to drive efficient oral product design","volume":"14","author":"Mathias","year":"2012","journal-title":"AAPS J."},{"key":"10.1016\/j.ejps.2015.05.006_b0090","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/oxfordjournals.bmb.a011663","article-title":"Interactions between H. pylori infection, gastric acid secretion and anti-secretory therapy","volume":"54","author":"McColl","year":"1998","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.ejps.2015.05.006_b0095","doi-asserted-by":"crossref","first-page":"3970","DOI":"10.1021\/mp400256h","article-title":"Impaired drug absorption due to high stomach pH: a review of strategies for mitigation of such effect to enable pharmaceutical product development","volume":"10","author":"Mitra","year":"2013","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejps.2015.05.006_b0100","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1021\/mp200062a","article-title":"Using absorption simulation and gastric pH modulated dog model for formulation development to overcome achlorhydria effect","volume":"8","author":"Mitra","year":"2011","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejps.2015.05.006_b0105","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1248\/bpb.24.313","article-title":"Assessment of gastric acidity of Japanese subjects over the last 15 years","volume":"24","author":"Morihara","year":"2001","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ejps.2015.05.006_b0110","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.ejpb.2011.01.023","article-title":"Volume to dissolve applied dose (VDAD) and apparent dissolution rate (ADR): tools to predict in vivo bioavailability from orally applied drug suspensions","volume":"78","author":"Muenster","year":"2011","journal-title":"European Journal of Pharmaceutics and Biopharmaceutics: Official Journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V"},{"key":"10.1016\/j.ejps.2015.05.006_b0115","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1023\/A:1018970323716","article-title":"Upper gastrointestinal pH in seventy-nine healthy, elderly, North American men and women","volume":"10","author":"Russell","year":"1993","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejps.2015.05.006_b0120","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1023\/A:1018918316253","article-title":"PH-related changes in the absorption of dipyridamole in the elderly","volume":"11","author":"Russell","year":"1994","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejps.2015.05.006_b0125","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1007\/s11095-006-0162-4","article-title":"Oral absorption of poorly water-soluble drugs: computer simulation of fraction absorbed in humans from a miniscale dissolution test","volume":"23","author":"Takano","year":"2006","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejps.2015.05.006_b0130","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1007\/s11095-008-9637-9","article-title":"Rate-limiting steps of oral absorption for poorly water-soluble drugs in dogs; prediction from a miniscale dissolution test and a physiologically-based computer simulation","volume":"25","author":"Takano","year":"2008","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejps.2015.05.006_b0135","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1592\/phco.26.3.341","article-title":"Inhibition of atazanavir oral absorption by lansoprazole gastric acid suppression in healthy volunteers","volume":"26","author":"Tomilo","year":"2006","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.ejps.2015.05.006_b0140","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1007\/s11095-004-1185-3","article-title":"PH-dependent dissolution in vitro and absorption in vivo of weakly basic drugs: development of a canine model","volume":"22","author":"Zhou","year":"2005","journal-title":"Pharm. Res."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092809871500202X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092809871500202X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T21:17:06Z","timestamp":1748380626000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092809871500202X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":28,"alternative-id":["S092809871500202X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2015.05.006","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prediction of pH dependent absorption using in vitro, in silico, and in vivo rat models: Early liability assessment during lead optimization","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2015.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}