{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:35:51Z","timestamp":1786988151676,"version":"build-2736575974"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"T\u00c1MOP","award":["4.2.1 B-09\/1\/KMR"],"award-info":[{"award-number":["4.2.1 B-09\/1\/KMR"]}]},{"DOI":"10.13039\/501100003549","name":"OTKA","doi-asserted-by":"crossref","award":["T 73804"],"award-info":[{"award-number":["T 73804"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.ejps.2016.04.028","type":"journal-article","created":{"date-parts":[[2016,4,29]],"date-time":"2016-04-29T17:24:19Z","timestamp":1461950659000},"page":"105-114","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Site- and species-specific hydrolysis rates of heroin"],"prefix":"10.1016","volume":"89","author":[{"given":"Levente","family":"Sz\u00f6cs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"Orgov\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerg\u0151","family":"T\u00f3th","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rta","family":"Kraszni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lajos","family":"Gerg\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e1ndor","family":"Hosztafi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9la","family":"Nosz\u00e1l","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2016.04.028_bb0005","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1039\/P29860001537","article-title":"The methyl-ester of alpha-aminophenylacetic acid \u2014 pH-dependence and phosphate catalysis of hydrolysis. J.Chem. Soc","volume":"2","author":"Blinkovsky","year":"1986","journal-title":"Perkin Trans."},{"key":"10.1016\/j.ejps.2016.04.028_bb0010","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0014-5793(97)00710-2","article-title":"3-Methoxynaltrexone, a selective heroin\/morphine-6beta-glucuronide antagonist","volume":"412","author":"Brown","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ejps.2016.04.028_bb0015","first-page":"587","article-title":"Medical prescription of heroin to treatment resistant heroin addicts: two randomised controlled trials","volume":"29","author":"BVan den Brink","year":"2003","journal-title":"J. Drug Issues"},{"key":"10.1016\/j.ejps.2016.04.028_bb0020","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1111\/j.1476-5381.2010.00700.x","article-title":"Biochemical and molecular analysis of carboxylesterase-mediated hydrolysis of cocaine and heroin","volume":"160","author":"Hatfield","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejps.2016.04.028_bb0025","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1039\/P29720001021","article-title":"Proton ionisation constants and kinetics of base hydrolysis of some \u03b1-amino-acid esters in aqueous solution. Part III. Hydrolysis and intramolecular aminolysis of \u03b1,\u03b1-diamino-acid methyl esters","volume":"2","author":"Hay","year":"1972","journal-title":"J. Chem. Soc. Perkin Trans."},{"key":"10.1016\/j.ejps.2016.04.028_bb0030","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jpba.2012.10.033","article-title":"Stability of heroin, 6-monoacetylmorphine, and morphine in biological samples and validation of an LC\u2013MS assay for delayed analyses of pharmacokinetic samples in rats","volume":"74","author":"Jones","year":"2013","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.ejps.2016.04.028_bb0035","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.drugalcdep.2005.04.008","article-title":"Development of pharmaceutical heroin preparations for medical co-prescription to opioid dependent patients","volume":"80","author":"Klous","year":"2005","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.ejps.2016.04.028_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejps.2015.06.026","article-title":"Species-specific lipophilicity of morphine antagonists","volume":"78","author":"Mazak","year":"2015","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2016.04.028_bb0045","doi-asserted-by":"crossref","first-page":"14507","DOI":"10.1021\/jp0620116","article-title":"Characterization of ester hydrolysis in terms of microscopic rate constants","volume":"110","author":"Noszal","year":"2006","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.ejps.2016.04.028_bb0050","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1139\/y83-132","article-title":"Diacetylmorphine (heroin) hydrolases in human blood","volume":"61","author":"Owen","year":"1983","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.ejps.2016.04.028_bb0055","doi-asserted-by":"crossref","first-page":"6467","DOI":"10.1021\/bi400709v","article-title":"Fundamental reaction pathway and free energy profile for butyrylcholinesterase-catalyzed hydrolysis of heroin","volume":"52","author":"Qiao","year":"2013","journal-title":"Biochem."},{"key":"10.1016\/j.ejps.2016.04.028_bb0060","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1039\/C3OB42464B","article-title":"Reaction pathways and free energy profiles for cholinesterase-catalyzed hydrolysis of 6-monoacetylmorphine","volume":"12","author":"Qiao","year":"2014","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.ejps.2016.04.028_bb0065","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1067\/mcp.2001.117981","article-title":"Arterial and venous pharmacokinetics of intravenous heroin in subjects who are addicted to narcotics","volume":"70","author":"Rentsch","year":"2001","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ejps.2016.04.028_bb0070","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1039\/j29680000548","article-title":"Arrhenius parameters for the alkaline hydrolysis of esters in aqueous solution. Part III. Methyl betaine methyl ester","author":"Robson Wright","year":"1968","journal-title":"J. Chem. Soc. B"},{"key":"10.1016\/j.ejps.2016.04.028_bb0075","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2174\/157488406775268219","article-title":"Pharmacokinetics and pharmacokinetic variability of heroin and its metabolites: review of the literature","volume":"1","author":"Rook","year":"2006","journal-title":"Curr. Clin. Pharmacol."},{"key":"10.1016\/j.ejps.2016.04.028_bb0080","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0022-3565(24)36555-3","article-title":"Antisense mapping of MOR-1 in rats: distinguishing between morphine and morphine-6beta-glucuronide antinociception","volume":"281","author":"Rossi","year":"1997","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejps.2016.04.028_bb0085","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0378-5173(94)00401-P","article-title":"The kinetics and mechanism of the hydrolysis of cyclopentolate hydrochloride in alkaline solutions","volume":"120","author":"Roy","year":"1995","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2016.04.028_bb0090","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1046\/j.1440-1681.1999.03090.x","article-title":"Human erythrocyte but not brain acetylcholinesterase hydrolyses heroin to morphine","volume":"26","author":"Salmon","year":"1999","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.ejps.2016.04.028_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1139\/y86-001","article-title":"The therapeutic use of heroin: a review of the pharmacological literature","volume":"64","author":"Sawynok","year":"1986","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.ejps.2016.04.028_bb0100","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0006-2952(01)00689-X","article-title":"Mu opioid receptor-mediated g-protein activation by heroin metabolites: evidence for greater efficacy of 6-monoacetylmorphine compared with morphine","volume":"62","author":"Selley","year":"2001","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejps.2016.04.028_bb0105","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0006-2952(76)90333-6","article-title":"Identification of an arylesterase as the enzyme hydrolysing diacetylmorphine (heroin) in human plasma","volume":"25","author":"Smith","year":"1976","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejps.2016.04.028_bb0110","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1007\/s00216-003-2390-3","article-title":"Determination of microscopic acid-base parameters from NMR-pH titrations","volume":"378","author":"Szakacs","year":"2004","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.ejps.2016.04.028_bb0115","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.euroneuro.2003.08.008","article-title":"Pharmacological treatments for heroin and cocaine addiction","volume":"13","author":"van den Brink","year":"2003","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.ejps.2016.04.028_bb0120","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/BF02490606","article-title":"HPCE analysis of hydrolysing morphine derivatives. Quantitation of decomposition rate and mobility","volume":"51","author":"Visky","year":"2000","journal-title":"Chromatographia"},{"key":"10.1016\/j.ejps.2016.04.028_bb0125","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1046\/j.1360-0443.1999.9479612.x","article-title":"Mechanisms of fatal opioid overdose","volume":"94","author":"White","year":"1999","journal-title":"Addiction"}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098716301348?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098716301348?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T19:08:40Z","timestamp":1748891320000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098716301348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":25,"alternative-id":["S0928098716301348"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2016.04.028","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Site- and species-specific hydrolysis rates of heroin","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2016.04.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}