{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T04:10:47Z","timestamp":1791864647688,"version":"4.3.4"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Ministry of Chemicals & Fertilizers, Govt. of India"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.ejps.2016.05.012","type":"journal-article","created":{"date-parts":[[2016,5,14]],"date-time":"2016-05-14T00:37:48Z","timestamp":1463186268000},"page":"224-234","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":218,"special_numbering":"C","title":["Intranasal delivery of nanoparticle encapsulated tarenflurbil: A potential brain targeting strategy for Alzheimer's disease"],"prefix":"10.1016","volume":"92","author":[{"given":"Eameema","family":"Muntimadugu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raju","family":"Dhommati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venu Gopala Swami","family":"Challa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Shaheen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wahid","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2016.05.012_bb0005","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3109\/10611860903483396","article-title":"Intranasal drug delivery of didanosine-loaded chitosan nanoparticles for brain targeting; an attractive route against infections caused by AIDS viruses","volume":"18","author":"Al-Ghananeem","year":"2010","journal-title":"J. Drug Target."},{"key":"10.1016\/j.ejps.2016.05.012_bb0010","doi-asserted-by":"crossref","first-page":"669","DOI":"10.4155\/tde.15.23","article-title":"The use of solid lipid nanoparticles for sustained drug release","volume":"6","author":"Attama","year":"2015","journal-title":"Ther. Deliv."},{"key":"10.1016\/j.ejps.2016.05.012_bb0015","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1615\/CritRevTherDrugCarrierSyst.v21.i5.20","article-title":"PLGA nanoparticles in drug delivery: the state of the art","volume":"21","author":"Bala","year":"2004","journal-title":"Crit. Rev. Ther. Drug Carrier Syst."},{"key":"10.1016\/j.ejps.2016.05.012_bb0020","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S1474-4422(11)70072-2","article-title":"The projected effect of risk factor reduction on Alzheimer's disease prevalence","volume":"10","author":"Barnes","year":"2011","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ejps.2016.05.012_bb0025","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/jemt.10090","article-title":"Functional expression and localization of P-glycoprotein at the blood brain barrier","volume":"57","author":"Bendayan","year":"2002","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.ejps.2016.05.012_bb0030","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0168-3659(99)00219-9","article-title":"Controlled release of \u03b2-estradiol from PLAGA microparticles: the effect of organic phase solvent on encapsulation and release","volume":"65","author":"Birnbaum","year":"2000","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejps.2016.05.012_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep13809","article-title":"Polymeric and solid lipid nanoparticles for sustained release of carbendazim and tebuconazole in agricultural applications","volume":"5","author":"Campos","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejps.2016.05.012_bb0040","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1080\/00032710802119137","article-title":"Simple rapid validated RP-LC method for the estimation of flurbiprofen in rabbit serum and aqueous humor","volume":"41","author":"Chandran","year":"2008","journal-title":"Anal. Lett."},{"key":"10.1016\/j.ejps.2016.05.012_bb0045","doi-asserted-by":"crossref","first-page":"32","DOI":"10.4088\/PCC.v09n0106","article-title":"Changing the course of Alzheimer's disease: anti-amyloid disease-modifying treatments on the horizon","volume":"9","author":"Christensen","year":"2007","journal-title":"Prim. Care Companion. J. Clin. Psychiatry"},{"key":"10.1016\/j.ejps.2016.05.012_bb0050","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nrd2896","article-title":"Alzheimer's disease: strategies for disease modification","volume":"9","author":"Citron","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejps.2016.05.012_bb0055","doi-asserted-by":"crossref","first-page":"50393","DOI":"10.1074\/jbc.M309026200","article-title":"Enhanced viscoelasticity of human cystic fibrotic sputum correlates with increasing microheterogeneity in particle transport","volume":"278","author":"Dawson","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejps.2016.05.012_bb0060","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1021\/bp0342553","article-title":"Transport of polymeric nanoparticle gene carriers in gastric mucus","volume":"20","author":"Dawson","year":"2004","journal-title":"Biotechnol. Prog."},{"key":"10.1016\/j.ejps.2016.05.012_bb0065","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1158\/1078-0432.CCR-06-2854","article-title":"The blood-brain barrier and cancer: transporters, treatment, and Trojan horses","volume":"13","author":"Deeken","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ejps.2016.05.012_bb0070","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.colsurfb.2014.06.037","article-title":"Surface engineered nanostructured lipid carriers for efficient nose to brain delivery of ondansetron HCl using Delonix regia gum as a natural mucoadhesive polymer","volume":"122","author":"Devkar","year":"2014","journal-title":"Colloids Surf. B"},{"key":"10.1016\/j.ejps.2016.05.012_bb0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11051-015-2875-y","article-title":"Comparative study of chitosan-and PEG-coated lipid and PLGA nanoparticles as oral delivery systems for cannabinoids","volume":"17","author":"Duran-Lobato","year":"2015","journal-title":"J. Nanopart. Res."},{"key":"10.1016\/j.ejps.2016.05.012_bb0080","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ejps.2012.04.013","article-title":"Development and evaluation of rivastigmine loaded chitosan nanoparticles for brain targeting","volume":"47","author":"Fazil","year":"2012","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2016.05.012_bb0085","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ejpb.2009.09.003","article-title":"Drug delivery to the brain using surfactant-coated poly (lactide-co-glycolide) nanoparticles: influence of the formulation parameters","volume":"74","author":"Gelperina","year":"2010","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejps.2016.05.012_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep13065","article-title":"Formulation strategy for the delivery of cyclosporine A: comparison of two polymeric nanospheres","volume":"5","author":"Goyal","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejps.2016.05.012_bb0095","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1002\/jps.20318","article-title":"Nasal drug administration: potential for targeted central nervous system delivery","volume":"94","author":"Graff","year":"2005","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2016.05.012_bb0100","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1001\/jama.2009.1866","article-title":"Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial","volume":"302","author":"Green","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.ejps.2016.05.012_bb0105","doi-asserted-by":"crossref","first-page":"313","DOI":"10.2147\/DDDT.S77702","article-title":"Solid lipid nanoparticles loaded with iron to overcome barriers for treatment of iron deficiency anemia","volume":"9","author":"Hosny","year":"2015","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.ejps.2016.05.012_bb0110","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1211\/0022357022539","article-title":"Is nose-to-brain transport of drugs in man a reality?","volume":"56","author":"Illum","year":"2004","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejps.2016.05.012_bb0115","doi-asserted-by":"crossref","first-page":"757","DOI":"10.3233\/JAD-2009-1092","article-title":"Why did tarenflurbil fail in Alzheimer's disease?","volume":"17","author":"Imbimbo","year":"2009","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.ejps.2016.05.012_bb0120","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/ana.24188","article-title":"A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease","volume":"76","author":"Karran","year":"2014","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ejps.2016.05.012_bb0125","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.addr.2011.11.002","article-title":"Intranasal delivery of biologics to the central nervous system","volume":"64","author":"Lochhead","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejps.2016.05.012_bb0130","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/nrn1728","article-title":"Drug resistance in brain diseases and the role of drug efflux transporters","volume":"6","author":"Loscher","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ejps.2016.05.012_bb0135","doi-asserted-by":"crossref","first-page":"709","DOI":"10.2217\/nnm.14.27","article-title":"Targeting nanoparticles across the blood-brain barrier with monoclonal antibodies","volume":"9","author":"Loureiro","year":"2014","journal-title":"Nanomedicine"},{"key":"10.1016\/j.ejps.2016.05.012_bb0140","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.ejps.2012.12.007","article-title":"Bromocriptine loaded chitosan nanoparticles intended for direct nose to brain delivery: pharmacodynamic, pharmacokinetic and scintigraphy study in mice model","volume":"48","author":"Md","year":"2013","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2016.05.012_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/alzrt225","article-title":"Nanoparticulate flurbiprofen reduces amyloid-\u03b242 generation in an in vitro blood\u2013brain barrier model","volume":"5","author":"Meister","year":"2013","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.ejps.2016.05.012_bb0150","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1080\/10611860903055470","article-title":"Effect of physicochemical properties on intranasal nanoparticle transit into murine olfactory epithelium","volume":"17","author":"Mistry","year":"2009","journal-title":"J. Drug Target."},{"key":"10.1016\/j.ejps.2016.05.012_bb0155","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.ijpharm.2009.06.019","article-title":"Nanoparticles for direct nose-to-brain delivery of drugs","volume":"379","author":"Mistry","year":"2009","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2016.05.012_bb0160","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jconrel.2007.01.016","article-title":"Estradiol loaded PLGA nanoparticles for oral administration: effect of polymer molecular weight and copolymer composition on release behavior in vitro and in vivo","volume":"119","author":"Mittal","year":"2007","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejps.2016.05.012_bb0165","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.colsurfb.2016.03.075","article-title":"CD44 targeted chemotherapy for co-eradication of breast cancer stem cells and cancer cells using polymeric nanoparticles of salinomycin and paclitaxel","volume":"143","author":"Muntimadugu","year":"2016","journal-title":"Colloids Surf. B"},{"key":"10.1016\/j.ejps.2016.05.012_bb0170","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/nrd2591","article-title":"Strategies in the design of nanoparticles for therapeutic applications","volume":"9","author":"Petros","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejps.2016.05.012_bb0175","series-title":"The Global Impact of Dementia. An Analysis of Prevalence, Incidence, Cost and Trends","article-title":"World Alzheimer Report 2015","author":"Prince","year":"2015"},{"key":"10.1016\/j.ejps.2016.05.012_bb0180","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJMra0909142","article-title":"Mechanisms of disease","volume":"362","author":"Querfurth","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejps.2016.05.012_bb0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1741-7015-7-7","article-title":"Recent developments in Alzheimer's disease therapeutics","volume":"7","author":"Rafii","year":"2009","journal-title":"BMC Med."},{"key":"10.1016\/j.ejps.2016.05.012_bb0190","doi-asserted-by":"crossref","first-page":"4169","DOI":"10.1016\/j.actbio.2011.07.025","article-title":"Development and evaluation of olanzapine-loaded PLGA nanoparticles for nose-to-brain delivery: in vitro and in vivo studies","volume":"7","author":"Seju","year":"2011","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ejps.2016.05.012_bb0195","first-page":"59","article-title":"Optimisation and stability assessment of solid lipid nanoparticles using particle size and zeta potential","volume":"25","author":"Shah","year":"2014","journal-title":"J. Phys. Sci."},{"key":"10.1016\/j.ejps.2016.05.012_bb0200","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2174\/22117385113019990005","article-title":"Formulation and evaluation of solid lipid nanoparticles of quetiapine fumarate and quetiapine hemifumarate for brain delivery in rat model","volume":"1","author":"Shikha","year":"2013","journal-title":"Pharm. Nanotechnol."},{"key":"10.1016\/j.ejps.2016.05.012_bb0205","first-page":"123","article-title":"Submicron-sized parenteral carrier systems based on solid lipids","volume":"1","author":"Siekmann","year":"1992","journal-title":"Pharm. Pharmacol. Lett."},{"key":"10.1016\/j.ejps.2016.05.012_bb0210","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1166\/jbn.2012.1366","article-title":"Preparation and characterization of monensin loaded PLGA nanoparticles: in vitro anti-malarial activity against Plasmodium falciparum","volume":"8","author":"Surolia","year":"2012","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.ejps.2016.05.012_bb0215","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ijpharm.2015.03.065","article-title":"Adenosine conjugated lipidic nanoparticles for enhanced tumor targeting","volume":"486","author":"Swami","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2016.05.012_bb0220","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.neuroscience.2008.01.013","article-title":"Delivery of interferon-\u03b2 to the monkey nervous system following intranasal administration","volume":"152","author":"Thorne","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejps.2016.05.012_bb0225","doi-asserted-by":"crossref","first-page":"4940","DOI":"10.1002\/ejic.201300594","article-title":"Green synthesis of chitosan-stabilized copper nanoparticles","volume":"2013","author":"Tokarek","year":"2013","journal-title":"Eur. J. Inorg. Chem."},{"key":"10.1016\/j.ejps.2016.05.012_bb0230","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ijpharm.2006.02.055","article-title":"Evaluation of brain-targeting for the nasal delivery of estradiol by the microdialysis method","volume":"317","author":"Wang","year":"2006","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2016.05.012_bb0235","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.ejps.2005.01.009","article-title":"Transfer of morphine along the olfactory pathway to the central nervous system after nasal administration to rodents","volume":"24","author":"Westin","year":"2005","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2016.05.012_bb0240","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S1474-4422(08)70090-5","article-title":"Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: a randomised phase II trial","volume":"7","author":"Wilcock","year":"2008","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ejps.2016.05.012_bb0245","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1016\/j.biomaterials.2004.07.050","article-title":"Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs","volume":"26","author":"Win","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejps.2016.05.012_bb0250","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2174\/156720110790396517","article-title":"Formulation optimization of etoposide loaded PLGA nanoparticles by double factorial design and their evaluation","volume":"7","author":"Yadav","year":"2010","journal-title":"Curr. Drug Deliv."},{"key":"10.1016\/j.ejps.2016.05.012_bb0255","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1177\/1756285612461679","article-title":"Current and future treatments for Alzheimer's disease","volume":"6","author":"Yiannopoulou","year":"2013","journal-title":"Ther. Adv. Neurol. Disord."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098716301701?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098716301701?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T18:06:37Z","timestamp":1655921197000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098716301701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":51,"alternative-id":["S0928098716301701"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2016.05.012","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intranasal delivery of nanoparticle encapsulated tarenflurbil: A potential brain targeting strategy for Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2016.05.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}