{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T17:00:29Z","timestamp":1778864429261,"version":"3.51.4"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473151"],"award-info":[{"award-number":["81473151"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jiangsu Province Ordinary College and University Innovative Research Programs","award":["KYLX15_0638"],"award-info":[{"award-number":["KYLX15_0638"]}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.ejps.2016.08.040","type":"journal-article","created":{"date-parts":[[2016,8,31]],"date-time":"2016-08-31T02:17:32Z","timestamp":1472609852000},"page":"341-350","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Development of protocatechualdehyde proliposomes-based sustained-release pellets with improved bioavailability and desired pharmacokinetic behavior for angina chronotherapy"],"prefix":"10.1016","volume":"93","author":[{"given":"Shuangshuang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxiang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panpan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulong","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2016.08.040_bb0005","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1749-8546-1-3","article-title":"Preclinical and clinical examinations of Salvia miltiorrhiza and its tanshinones in ischemic conditions","volume":"1","author":"Adams","year":"2006","journal-title":"Chin. Med."},{"key":"10.1016\/j.ejps.2016.08.040_bb0010","first-page":"493","article-title":"Improved oral delivery of resveratrol using proliposomal formulation: investigation of various factors contributing to prolonged absorption of unmetabolized resveratrol","volume":"11","author":"Basavaraj","year":"2014","journal-title":"Drug Deliv."},{"key":"10.1016\/j.ejps.2016.08.040_bb0015","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ejpb.2004.05.007","article-title":"Preliminary assessment of carrageenan as excipient for extrusion\/spheronisation","volume":"59","author":"Bornh\u00f6ft","year":"2005","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejps.2016.08.040_bb0020","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3177\/jnsv.57.118","article-title":"In vitro antioxidant and anti-inflammatory activities of protocatechualdehyde isolated from Phellinus gilvus","volume":"57","author":"Chang","year":"2011","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"10.1016\/j.ejps.2016.08.040_bb0025","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ejpb.2008.08.005","article-title":"Production of pellets via extrusion-spheronisation without the incorporation of microcrystalline cellulose: a critical review","volume":"71","author":"Dukic-Ott","year":"2009","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejps.2016.08.040_bb0030","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1080\/01932691.2011.599233","article-title":"A study of size, microscopic morphology, and dispersion mechanism of structures generated on hydration of proliposomes","volume":"33","author":"Elhissi","year":"2012","journal-title":"J. Dispers. Sci. Technol."},{"key":"10.1016\/j.ejps.2016.08.040_bb0035","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ijpharm.2008.02.003","article-title":"Novel use of Eudragit\u00ae NE 30D\/Eudragit\u00ae L 30D-55 blends as functional coating materials in time-delayed drug release applications","volume":"357","author":"El-Malah","year":"2008","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2016.08.040_bb0040","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ijpharm.2011.02.016","article-title":"Suitability of kappa-carrageenan pellets for the formulation of multiparticulate tablets with modified release","volume":"409","author":"Ghanam","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2016.08.040_bb0045","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ejps.2011.06.010","article-title":"Structural properties of so-called NSAID\u2013phospholipid-complexes","volume":"44","author":"H\u00fcsch","year":"2011","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2016.08.040_bb0050","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.ejpb.2011.10.010","article-title":"Bioavailability enhancement of zaleplon via proliposomes: role of surface charge","volume":"80","author":"Janga","year":"2012","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejps.2016.08.040_bb0055","first-page":"5079","article-title":"Preparation and evaluation of cyclosporin A-containing proliposomes: a comparison of the supercritical antisolvent process with the conventional film method","volume":"9","author":"Karn","year":"2014","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.ejps.2016.08.040_bb0060","article-title":"Chronopharmacology: as a therapy for cardiovascular disease","volume":"1","author":"Krishna","year":"2012","journal-title":"Pharm. Innov."},{"key":"10.1016\/j.ejps.2016.08.040_bb0065","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1272\/jnms.78.4","article-title":"Variant angina and coronary artery spasm: the clinical spectrum, pathophysiology, and management","volume":"78","author":"Kusama","year":"2011","journal-title":"J. Nippon Med. Sch."},{"key":"10.1016\/j.ejps.2016.08.040_bb0070","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ejpb.2012.09.021","article-title":"Bioavailability and foam cells permeability enhancement of Salvianolic acid B pellets based on drug-phospholipids complex technique","volume":"83","author":"Li","year":"2013","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejps.2016.08.040_bb0075","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1124\/dmd.108.020560","article-title":"UDP-glucuronosyltransferase 1A6 is the major isozyme responsible for protocatechuic aldehyde glucuronidation in human liver microsomes","volume":"36","author":"Liu","year":"2008","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejps.2016.08.040_bb0080","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1124\/dmd.108.021592","article-title":"Plasma and urinary tanshinol from salvia miltiorrhiza (Danshen) can be used as pharmacokinetic markers for cardiotonic pills, a cardiovascular herbal medicine","volume":"36","author":"Lu","year":"2008","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejps.2016.08.040_bb0085","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.jconrel.2010.07.122","article-title":"Drug delivery system based on chronobiology\u2013a review","volume":"147","author":"Mandal","year":"2010","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejps.2016.08.040_bb0090","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/bdd.248","article-title":"Application of in vitro\u2013in vivo correlations (IVIVC) in setting formulation release specifications","volume":"21","author":"Modi","year":"2000","journal-title":"Biopharm. Drug Dispos."},{"key":"10.1016\/j.ejps.2016.08.040_bb0095","first-page":"116","article-title":"Protocatechuic aldehyde inhibits migration and proliferation of vascular smooth muscle cells and intravascular thrombosis","volume":"423","author":"Moon","year":"2012","journal-title":"Res. Commun."},{"key":"10.1016\/j.ejps.2016.08.040_bb0100","doi-asserted-by":"crossref","first-page":"303","DOI":"10.2174\/1389201016666150118134256","article-title":"Proliposomes for oral delivery: progress and challenges","volume":"16","author":"Nekkanti","year":"2014","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.ejps.2016.08.040_bb0105","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.ejpb.2012.02.009","article-title":"Hypoglycemic activity and oral bioavailability of insulin-loaded liposomes containing bile salts in rats: the effect of cholate type, particle size and administered dose","volume":"81","author":"Niu","year":"2012","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejps.2016.08.040_bb0110","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.addr.2010.01.006","article-title":"Chronotherapeutic strategy: rhythm monitoring, manipulation and disruption","volume":"62","author":"Ohdo","year":"2010","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejps.2016.08.040_bb0115","first-page":"661","article-title":"Enhanced the oral bioavailability of salvianolic acid B by phospholipid complex loaded nanoparticles","volume":"63","author":"Peng","year":"2008","journal-title":"Die Pharm. Int. J. Pharm."},{"key":"10.1016\/j.ejps.2016.08.040_bb0120","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/j.biomaterials.2011.10.072","article-title":"A rapid-acting, long-acting insulin formulation based on a phospholipid complex loaded PHBHHx nanoparticles","volume":"33","author":"Peng","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejps.2016.08.040_bb0125","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0939-6411(99)00009-0","article-title":"The use of carrageenan in mixture with microcrystalline cellulose and its functionality for making tablets","volume":"48","author":"Picker","year":"1999","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejps.2016.08.040_bb0130","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0378-5173(03)00184-4","article-title":"Convolution method to predict drug concentration profiles of 2, 3, 5, 6-tetramethylpyrazine following transdermal application","volume":"259","author":"Qi","year":"2003","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2016.08.040_bb0135","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.fitote.2009.11.001","article-title":"Supramolecular phospholipids-polyphenolics interactions: the PHYTOSOME strategy to improve the bioavailability of phytochemicals","volume":"81","author":"Semalty","year":"2010","journal-title":"Fitoterapia"},{"key":"10.1016\/j.ejps.2016.08.040_bb0140","first-page":"150","article-title":"Proliposomes: a brief overview of novel delivery system","volume":"4","author":"Shaji","year":"2013","journal-title":"Int J Pharm. Bio. Sci"},{"key":"10.1016\/j.ejps.2016.08.040_bb0145","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0168-3659(02)00238-9","article-title":"Preparation and evaluation of proliposomes containing salmon calcitonin","volume":"84","author":"Song","year":"2002","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejps.2016.08.040_bb0150","first-page":"35","article-title":"Preparation and properties of a silybin-phospholipid complex","volume":"63","author":"Song","year":"2008","journal-title":"Die Pharm. Int. J. Pharm."},{"key":"10.1016\/j.ejps.2016.08.040_bb0155","doi-asserted-by":"crossref","first-page":"e104","DOI":"10.1016\/j.atherosclerosis.2007.03.028","article-title":"Ursolic acid from the Chinese herb danshen (Salvia miltiorrhiza L.) upregulates eNOS and downregulates Nox4 expression in human endothelial cells","volume":"195","author":"Steinkamp-Fenske","year":"2007","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ejps.2016.08.040_bb0160","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ijpharm.2005.06.028","article-title":"Effectiveness of submicron-sized, chitosan-coated liposomes in oral administration of peptide drugs","volume":"303","author":"Takeuchi","year":"2005","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2016.08.040_bb0165","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ejpb.2005.10.002","article-title":"Use of kappa-carrageenan as alternative pelletisation aid to microcrystalline cellulose in extrusion\/spheronisation. I. Influence of type and fraction of filler","volume":"63","author":"Thommes","year":"2006","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejps.2016.08.040_bb0170","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jchromb.2007.05.042","article-title":"Liquid chromatography-tandem mass spectrometry analysis of protocatechuic aldehyde and its phase I and II metabolites in rat","volume":"856","author":"Xu","year":"2007","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.ejps.2016.08.040_bb0175","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jconrel.2009.07.014","article-title":"Optimized preparation of vinpocetine proliposomes by a novel method and in vivo evaluation of its pharmacokinetics in New Zealand rabbits","volume":"140","author":"Xu","year":"2009","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejps.2016.08.040_bb0180","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ejps.2015.05.012","article-title":"Tanshinone IIA - loaded pellets developed for angina chronotherapy: deconvolution-based formulation design and optimization, pharmacokinetic and pharmacodynamic evaluation","volume":"76","author":"Yan","year":"2015","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2016.08.040_bb0185","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ejps.2014.08.008","article-title":"Proliposomes as a drug delivery system to decrease the hepatic first-pass metabolism: case study using a model drug","volume":"64","author":"Yanamandra","year":"2014","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2016.08.040_bb0190","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ijpharm.2005.10.001","article-title":"The preparation of silybin\u2013phospholipid complex and the study on its pharmacokinetics in rats","volume":"307","author":"Yanyu","year":"2006","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2016.08.040_bb0195","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ijpharm.2006.03.037","article-title":"Preparation of silymarin proliposome: a new way to increase oral bioavailability of silymarin in beagle dogs","volume":"319","author":"Yan-Yu","year":"2006","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2016.08.040_bb0200","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.fitote.2013.04.006","article-title":"Systematic review of recent advances in pharmacokinetics of four classical Chinese medicines used for the treatment of cerebrovascular disease","volume":"88","author":"Zeng","year":"2013","journal-title":"Fitoterapia"}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098716303293?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098716303293?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T00:19:11Z","timestamp":1589674751000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098716303293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":40,"alternative-id":["S0928098716303293"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2016.08.040","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of protocatechualdehyde proliposomes-based sustained-release pellets with improved bioavailability and desired pharmacokinetic behavior for angina chronotherapy","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2016.08.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}