{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T17:16:43Z","timestamp":1782494203909,"version":"3.54.5"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.ejps.2016.10.006","type":"journal-article","created":{"date-parts":[[2016,10,10]],"date-time":"2016-10-10T16:05:21Z","timestamp":1476115521000},"page":"373-380","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["Prediction of drug intestinal absorption in human using the Ussing chamber system: A comparison of intestinal tissues from animals and humans"],"prefix":"10.1016","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4557-0886","authenticated-orcid":false,"given":"Masateru","family":"Miyake","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihisa","family":"Koga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Yoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chie","family":"Emoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Mukai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Toguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2016.10.006_bb0005","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/0006-291X(91)91647-U","article-title":"Correlation between oral drug absorption in humans and apparent drug permeability coefficient in human intestinal epithelial (caco-2) cells","volume":"175","author":"Artursson","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejps.2016.10.006_bb0010","doi-asserted-by":"crossref","DOI":"10.1002\/jps.21280","article-title":"The co-crystal approach to improve the exposure of a water-insoluble compound: AMG 517 sorbic acid co-crystal characterization and pharmacokinetics","volume":"97","author":"Bak","year":"2008","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2016.10.006_bb0015","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1021\/mp100015x","article-title":"Effect of variations in the amounts of P-glycoprotein (ABCB1), BCRP (ABCG2) and CYP3A4 along the human small intestine on PBPK models for predicting intestinal first pass","volume":"7","author":"Bruyere","year":"2010","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejps.2016.10.006_bb0020","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/BF02354288","article-title":"We may not measure the correct intestinal wall permeability coefficient of drugs, alternative absorptive clearance concept","volume":"23","author":"Chiou","year":"1995","journal-title":"J. Pharmacokinet. Biopharm."},{"key":"10.1016\/j.ejps.2016.10.006_bb0025","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1080\/10717540600640278","article-title":"Improving the dissolution rate of poorly water soluble drug by solid dispersion and solid solution: pros and cons","volume":"14","author":"Chokshi","year":"2007","journal-title":"Drug Deliv."},{"key":"10.1016\/j.ejps.2016.10.006_bb0030","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1046\/j.1365-2125.2000.00228.x","article-title":"Absorption of lefradafiban from different sites of the gastrointestinal tract","volume":"50","author":"Drewe","year":"2000","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejps.2016.10.006_bb0035","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/j.addr.2012.09.042","article-title":"Intestinal drug transporters: an overview","volume":"65","author":"Estudante","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejps.2016.10.006_bb0040","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1021\/mp800203k","article-title":"Amorphous pharmaceutical solids: characterization, stabilization, and development of marketable formulations of poorly soluble drugs with improved oral absorption","volume":"5","author":"Gao","year":"2008","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejps.2016.10.006_bb0045","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1002\/jps.20906","article-title":"Combined use of crystalline salt forms and precipitation inhibitors to improve oral absorption of celecoxib from solid oral formulations","volume":"96","author":"Guzm\u00e1n","year":"2007","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2016.10.006_bb0050","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/bdd.751","article-title":"Pancreatoduodenectomy as a source of human small intestine for Ussing chamber investigations and comparative studies with rat tissue","volume":"32","author":"Haslam","year":"2011","journal-title":"Biopharm. Drug Dispos."},{"key":"10.1016\/j.ejps.2016.10.006_bb0055","doi-asserted-by":"crossref","first-page":"903","DOI":"10.3109\/00498254.2011.590242","article-title":"Sex differences in pharmacokinetics of cilostazol in rats","volume":"41","author":"Kamada","year":"2011","journal-title":"Xenobiotica"},{"key":"10.1016\/j.ejps.2016.10.006_bb0060","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1021\/mp800061r","article-title":"Enhanced bioavailability of a poorly soluble VR1 antagonist using an amorphous solid dispersion approach: a case study","volume":"5","author":"Kennedy","year":"2008","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejps.2016.10.006_bb0065","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0378-5173(00)00614-1","article-title":"Self-emulsifying drug delivery systems (SEDDS) of coenzyme Q10: formulation development and bioavailability assessment","volume":"212","author":"Kommuru","year":"2001","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2016.10.006_bb0070","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.addr.2007.06.016","article-title":"Animal data: the contributions of the Ussing chamber and perfusion systems to predicting human oral drug delivery in vivo","volume":"59","author":"Lennern\u00e4s","year":"2007","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejps.2016.10.006_bb0075","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/jps.20522","article-title":"Characterization of a novel polymorphic form of celecoxib","volume":"95","author":"Lu","year":"2006","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2016.10.006_bb0080","doi-asserted-by":"crossref","first-page":"171","DOI":"10.2133\/dmpk.19.171","article-title":"The organic anion transporter (OATP) family","volume":"19","author":"Mikkaichi","year":"2004","journal-title":"Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.ejps.2016.10.006_bb0085","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1002\/jps.10362","article-title":"Combinatorial use of sodium laurate with taurine or l-glutamine enhances colonic absorption of rebamipide, poorly absorbable antiulcer drug, without any serious histopathological mucosal damages","volume":"92","author":"Miyake","year":"2003","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2016.10.006_bb0090","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1002\/jps.23609","article-title":"Establishment of novel prediction system of intestinal absorption in humans using human intestinal tissues","volume":"102","author":"Miyake","year":"2013","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2016.10.006_bb0095","first-page":"361","article-title":"Absorption improvement of poorly absorbable drug from small intestine","volume":"74","author":"Miyake","year":"2014","journal-title":"Yakuzaigaku"},{"key":"10.1016\/j.ejps.2016.10.006_bb0100","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0022-3565(24)39291-2","article-title":"Expression and localization of multidrug resistant protein mrp2 in rat small intestine","volume":"293","author":"Mottino","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejps.2016.10.006_bb0105","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1021\/cg0503346","article-title":"Phase solubility diagrams of cocrystals are explained by solubility product and solution complexation","volume":"6","author":"Nehm","year":"2006","journal-title":"Cryst. Growth Des."},{"key":"10.1016\/j.ejps.2016.10.006_bb0110","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1365-2885.2010.01218.x","article-title":"Feasibility of the Ussing chamber technique for the determination of in vitro jejunal permeability of passively absorbed compounds in different animal species","volume":"34","author":"Neirinckx","year":"2011","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.ejps.2016.10.006_bb0115","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1007\/BF02236743","article-title":"Intestinal permeability in humans is increased after radiation therapy","volume":"43","author":"Nejdfors","year":"2000","journal-title":"Dis. Colon Rectum"},{"key":"10.1016\/j.ejps.2016.10.006_bb0120","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.ejps.2012.02.025","article-title":"Human small intestinal and colonic tissue mounted in the Ussing chamber as a tool for characterizing the intestinal absorption of drugs","volume":"46","author":"Rozehnal","year":"2012","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2016.10.006_bb0125","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1007\/s11095-008-9676-2","article-title":"Dissolution improvement and the mechanism of the improvement from cocrystallization of poorly water-soluble compounds","volume":"25","author":"Shiraki","year":"2008","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejps.2016.10.006_bb0130","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.ejps.2014.07.009","article-title":"Human and simulated intestinal fluids as solvent systems to explore food effects on intestinal solubility and permeability","volume":"63","author":"Stappaerts","year":"2014","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2016.10.006_bb0135","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1002\/jps.10490","article-title":"Limited infruence of P-glycoprotein on small-intestinal absorption of cilostazol, a high absorptive permeability drug","volume":"92","author":"Toyobuku","year":"2003","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2016.10.006_bb0140","doi-asserted-by":"crossref","first-page":"879","DOI":"10.3109\/03639049709148694","article-title":"In vitro absorption studies and their relevance to absorption from the GI tract","volume":"23","author":"Ungell","year":"1997","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.ejps.2016.10.006_bb9000","series-title":"Pharmaceutical Performulation and Formulation: A Practical Guide from Candidate Drug Selection to Commercial Dosage Form","first-page":"97","article-title":"Biopharmaceutical support in candidate drugselection.","author":"Ungell","year":"2001"},{"key":"10.1016\/j.ejps.2016.10.006_bb0145","series-title":"Cell Culture Models of Biological Barriers; In vitro Test Systems for Drug Absorption and Delivery","first-page":"164","article-title":"Transport Studies Using Intestinal Tissue ex-Vivo","author":"Ungell","year":"2002"},{"key":"10.1016\/j.ejps.2016.10.006_bb0150","series-title":"Pharmaceutical Performulation and Formulation: A Practical Guide from Candidate Drug Selection to Commercial Dosage Form","first-page":"97","article-title":"Biopharmaceutical Support in Candidate Drug Selection","author":"Ungell","year":"2001"},{"key":"10.1016\/j.ejps.2016.10.006_bb0155","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1021\/js970218s","article-title":"Membrane transport of drugs in different regions of the intestinal tract of the rat","volume":"87","author":"Ungell","year":"1998","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2016.10.006_bb0160","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1748-1716.1951.tb00800.x","article-title":"Active transport of sodium as the source of electric current in the short-circuited isolated frog skin","volume":"23","author":"Ussing","year":"1951","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/j.ejps.2016.10.006_bb0165","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1248\/bpb1978.4.879","article-title":"A pharmacokinetic analysis program (MULTI) for microcomputer","volume":"4","author":"Yamaoka","year":"1981","journal-title":"J. Pharmacobiodyn."},{"key":"10.1016\/j.ejps.2016.10.006_bb0170","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1021\/mp070028i","article-title":"Biopharmaceutics classification of selected beta-blockers: solubility and permeability class membership","volume":"4","author":"Yang","year":"2007","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejps.2016.10.006_bb0175","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1023\/A:1012102522787","article-title":"In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man\u2014fact or myth","volume":"14","author":"Yee","year":"1997","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejps.2016.10.006_bb0180","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1023\/A:1020444330011","article-title":"Rate-limited steps of human oral absorption and QSAR studies","volume":"19","author":"Zhao","year":"2002","journal-title":"Pharm. Res."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098716304298?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098716304298?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T04:48:02Z","timestamp":1749617282000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098716304298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":37,"alternative-id":["S0928098716304298"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2016.10.006","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prediction of drug intestinal absorption in human using the Ussing chamber system: A comparison of intestinal tissues from animals and humans","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2016.10.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}