{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T02:57:34Z","timestamp":1778554654995,"version":"3.51.4"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Astellas Research Technologies Co., Ltd."},{"name":"Astellas Pharma Inc"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.ejps.2016.10.037","type":"journal-article","created":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T21:48:16Z","timestamp":1478036896000},"page":"551-559","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["An automated method by which effects of compounds on locomotor activity and spontaneous neuropathic pain-specific movements can be simultaneously evaluated in rats with chronic-constriction nerve injury"],"prefix":"10.1016","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3003-723X","authenticated-orcid":false,"given":"Kazuaki","family":"Niikura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanobu","family":"Iino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukiko","family":"Funatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritsuko","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2016.10.037_bb0005","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.ejphar.2006.03.008","article-title":"Potent analgesic effects of a putative sodium channel blocker M58373 on formalin-induced and neuropathic pain in rats","volume":"536","author":"Akada","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejps.2016.10.037_bb0010","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.neures.2012.10.006","article-title":"A novel model of combined neuropathic and inflammatory pain displaying long-lasting allodynia and spontaneous pain-like behaviour","volume":"74","author":"Allchorne","year":"2012","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.ejps.2016.10.037_bb0015","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.jpain.2004.09.001","article-title":"Neuropathic pain symptoms relative to overall pain rating","volume":"5","author":"Backonja","year":"2004","journal-title":"J. Pain"},{"key":"10.1016\/j.ejps.2016.10.037_bb0020","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","article-title":"A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man","volume":"33","author":"Bennett","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.ejps.2016.10.037_bb0025","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0014-2999(02)01765-X","article-title":"A comparison of the anti-nociceptive effects of voltage-activated Na+ channel blockers in the formalin test","volume":"445","author":"Blackburn-Munro","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejps.2016.10.037_bb0030","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1097\/00000542-199204000-00005","article-title":"The use of oral mexiletine for the treatment of pain after peripheral nerve injury","volume":"76","author":"Chabal","year":"1992","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejps.2016.10.037_bb0035","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0022-3565(25)03823-6","article-title":"A method for determining loss of pain sensation","volume":"72","author":"D'Amour","year":"1941","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejps.2016.10.037_bb0040","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.physbeh.2014.10.009","article-title":"Behavioral study of non-evoked orofacial pain following different types of infraorbital nerve injury in rats","volume":"138","author":"Deseure","year":"2015","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.ejps.2016.10.037_bb0045","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0304-3959(77)90130-0","article-title":"The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats","volume":"4","author":"Dubuisson","year":"1977","journal-title":"Pain"},{"key":"10.1016\/j.ejps.2016.10.037_bb0050","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s00540-013-1646-0","article-title":"New index of pain triggered by spinal activation of voltage-dependent sodium channels","volume":"27","author":"Enomoto","year":"2013","journal-title":"J. Anesth."},{"key":"10.1016\/j.ejps.2016.10.037_bb0055","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0014-2999(02)02792-9","article-title":"A comparison of the antinociceptive effects of voltage-activated Na+ channel blockers in two rat models of neuropathic pain","volume":"458","author":"Erichsen","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejps.2016.10.037_bb0060","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0160-5402(88)90038-1","article-title":"An automated method to analyze vocalization of unrestrained rats submitted to noxious electrical stimuli","volume":"19","author":"Eschalier","year":"1988","journal-title":"J. Pharmacol. Methods"},{"key":"10.1016\/j.ejps.2016.10.037_bb0065","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.pain.2005.08.013","article-title":"Algorithm for neuropathic pain treatment: an evidence based proposal","volume":"118","author":"Finnerup","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.ejps.2016.10.037_bb0070","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1097\/00000542-200603000-00021","article-title":"Differential effect of ketamine and lidocaine on spontaneous and mechanical evoked pain in patients with nerve injury pain","volume":"104","author":"Gottrup","year":"2006","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejps.2016.10.037_bb0075","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.jpain.2015.06.006","article-title":"Spontaneous chronic pain after experimental thoracotomy revealed by conditioned place preference: morphine differentiates tactile evoked pain from spontaneous pain","volume":"16","author":"Hung","year":"2015","journal-title":"J. Pain"},{"key":"10.1016\/j.ejps.2016.10.037_bb0080","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.clinph.2009.12.034","article-title":"Mexiletine suppresses nodal persistent sodium currents in sensory axons of patients with neuropathic pain","volume":"121","author":"Isose","year":"2010","journal-title":"Clin. Neurophysiol."},{"key":"10.1016\/j.ejps.2016.10.037_bb0085","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.pain.2006.12.022","article-title":"Structural pathology in a rodent model of osteoarthritis is associated with neuropathic pain: increased expression of ATF-3 and pharmacological characterisation","volume":"128","author":"Ivanavicius","year":"2007","journal-title":"Pain"},{"key":"10.1016\/j.ejps.2016.10.037_bb0090","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s00213-010-1977-6","article-title":"Depression-like behavior and mechanical allodynia are reduced by bis selenide treatment in mice with chronic constriction injury: a comparison with fluoxetine, amitriptyline, and bupropion","volume":"212","author":"Jesse","year":"2010","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.ejps.2016.10.037_bb0095","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0304-3959(96)03231-9","article-title":"The effects of mexiletine, desipramine and fluoxetine in rat models involving central sensitization","volume":"69","author":"Jett","year":"1997","journal-title":"Pain"},{"key":"10.1016\/j.ejps.2016.10.037_bb0100","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0304-3959(97)03366-6","article-title":"A new automated method of pain scoring in the formalin test in rats","volume":"71","author":"Jourdan","year":"1997","journal-title":"Pain"},{"key":"10.1016\/j.ejps.2016.10.037_bb0105","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1213\/ANE.0000000000000571","article-title":"Spontaneous pain-like behaviors are more sensitive to morphine and buprenorphine than mechanically evoked behaviors in a rat model of acute postoperative pain","volume":"120","author":"Kabadi","year":"2015","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejps.2016.10.037_bb0110","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1002\/j.1532-2149.2012.00142.x","article-title":"Automated measurement of spontaneous pain-associated limb movement and drug efficacy evaluation in a rat model of neuropathic pain","volume":"16","author":"Kawasaki-Yatsugi","year":"2012","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.ejps.2016.10.037_bb0115","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1097\/00042560-199812010-00007","article-title":"Mexiletine for HIV-infected patients with painful peripheral neuropathy: a double-blind, placebo-controlled, crossover treatment trial","volume":"19","author":"Kemper","year":"1998","journal-title":"J. Acquir. Immune Defic. Syndr. Hum. Retrovirol."},{"key":"10.1016\/j.ejps.2016.10.037_bb0120","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1212\/WNL.51.6.1682","article-title":"A randomized trial of amitriptyline and mexiletine for painful neuropathy in HIV infection. AIDS Clinical Trial Group 242 protocol team","volume":"51","author":"Kieburtz","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.ejps.2016.10.037_bb0125","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.neuroscience.2008.02.031","article-title":"Pharmacological characterization and gene expression profiling of an L5\/L6 spinal nerve ligation model for neuropathic pain in mice","volume":"153","author":"Kiso","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejps.2016.10.037_bb0130","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/0006-8993(92)90688-6","article-title":"Intrathecal MK-801 and local nerve anesthesia synergistically reduce nociceptive behaviors in rats with experimental peripheral mononeuropathy","volume":"576","author":"Mao","year":"1992","journal-title":"Brain Res."},{"key":"10.1016\/j.ejps.2016.10.037_bb0135","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/0006-8993(92)90873-8","article-title":"Post-injury treatment with GM1 ganglioside reduces nociceptive behaviors and spinal cord metabolic activity in rats with experimental peripheral mononeuropathy","volume":"584","author":"Mao","year":"1992","journal-title":"Brain Res."},{"key":"10.1016\/j.ejps.2016.10.037_bb0140","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1124\/jpet.106.109736","article-title":"Inflammation-induced reduction of spontaneous activity by adjuvant: a novel model to study the effect of analgesics in rats","volume":"320","author":"Matson","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejps.2016.10.037_bb0145","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.pain.2004.09.028","article-title":"What should we be measuring in behavioral studies of chronic pain in animals?","volume":"112","author":"Mogil","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.ejps.2016.10.037_bb0150","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1292\/jvms.71.991","article-title":"Effect of mexiletine on dynamic allodynia induced by chronic constriction injury of the sciatic nerve in rats","volume":"71","author":"Nakazato-Imasato","year":"2009","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.ejps.2016.10.037_bb0155","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3233\/NRE-2000-14103","article-title":"Neuropathic pain: review of mechanisms and pharmacologic management","volume":"14","author":"Orza","year":"2000","journal-title":"NeuroRehabilitation"},{"key":"10.1016\/j.ejps.2016.10.037_bb0160","first-page":"409","article-title":"A method for measurement of analgesic activity on inflamed tissue","volume":"111","author":"Randall","year":"1957","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.ejps.2016.10.037_bb0165","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00726-013-1484-2","article-title":"Side-effects of analgesic kyotorphin derivatives: advantages over clinical opioid drugs","volume":"45","author":"Ribeiro","year":"2013","journal-title":"Amino Acids"},{"key":"10.1016\/j.ejps.2016.10.037_bb0170","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/1056-8719(94)90046-9","article-title":"Weight bearing as an objective measure of arthritic pain in the rat","volume":"31","author":"Sch\u00f6tt","year":"1994","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.ejps.2016.10.037_bb0175","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0304-3959(90)91074-S","article-title":"A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury","volume":"43","author":"Seltzer","year":"1990","journal-title":"Pain"},{"key":"10.1016\/j.ejps.2016.10.037_bb0180","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1111\/jphp.12419","article-title":"Co-application of lidocaine and QX-572 induces divergent pain behaviours in mice","volume":"67","author":"Shao","year":"2015","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejps.2016.10.037_bb0185","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1097\/ALN.0b013e318278cade","article-title":"Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state","volume":"118","author":"Suter","year":"2013","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejps.2016.10.037_bb0190","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ejphar.2009.11.016","article-title":"Analysis of the antinociceptive interactions in two-drug combinations of gabapentin, oxcarbazepine and amitriptyline in streptozotocin-induced diabetic mice","volume":"628","author":"Tomi\u0107","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejps.2016.10.037_bb0195","first-page":"459","article-title":"Efficacy of oral mexiletine for neuropathic pain with allodynia: a double-blind, placebo-controlled, crossover study","volume":"25","author":"Wallace","year":"2000","journal-title":"Reg. Anesth. Pain Med."},{"key":"10.1016\/j.ejps.2016.10.037_bb0200","doi-asserted-by":"crossref","first-page":"544","DOI":"10.3181\/00379727-111-27849","article-title":"Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs","volume":"111","author":"Winter","year":"1962","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.ejps.2016.10.037_bb0205","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1526-4637.2007.00301.x","article-title":"Experimental studies of potential analgesics for the treatment of chemotherapy-evoked painful peripheral neuropathies","volume":"9","author":"Xiao","year":"2008","journal-title":"Pain Med."},{"key":"10.1016\/j.ejps.2016.10.037_bb0210","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1213\/00000539-199205000-00005","article-title":"Systemic mexiletine relieves chronic allodynialike symptoms in rats with ischemic spinal cord injury","volume":"74","author":"Xu","year":"1992","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejps.2016.10.037_bb0215","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jphs.2015.08.006","article-title":"Behavioral and pharmacological characteristics of bortezomib-induced peripheral neuropathy in rats","volume":"129","author":"Yamamoto","year":"2015","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.ejps.2016.10.037_bb0220","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1254\/jphs.13249SC","article-title":"Pharmacological characterization of standard analgesics on oxaliplatin-induced acute cold hypersensitivity in mice","volume":"124","author":"Zhao","year":"2014","journal-title":"J. Pharmacol. Sci."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098716304754?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098716304754?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T23:10:11Z","timestamp":1749683411000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098716304754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":44,"alternative-id":["S0928098716304754"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2016.10.037","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An automated method by which effects of compounds on locomotor activity and spontaneous neuropathic pain-specific movements can be simultaneously evaluated in rats with chronic-constriction nerve injury","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2016.10.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}