{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:58:51Z","timestamp":1792432731084,"version":"4.5.0"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Nagpur University","award":["DS\/RTM\/2013\u201314\/2076"],"award-info":[{"award-number":["DS\/RTM\/2013\u201314\/2076"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.ejps.2016.12.009","type":"journal-article","created":{"date-parts":[[2016,12,8]],"date-time":"2016-12-08T05:45:23Z","timestamp":1481175923000},"page":"36-49","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":245,"special_numbering":"C","title":["Formulation and characterization of an apigenin-phospholipid phytosome (APLC) for improved solubility, in vivo bioavailability, and antioxidant potential"],"prefix":"10.1016","volume":"108","author":[{"given":"Darshan R.","family":"Telange","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun T.","family":"Patil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil M.","family":"Pethe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harshal","family":"Fegade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sridhar","family":"Anand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8074-758X","authenticated-orcid":false,"given":"Vivek S.","family":"Dave","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2016.12.009_bb0005","author":"Agency for Toxic Substances & Disease Registry, C"},{"key":"10.1016\/j.ejps.2016.12.009_bb0010","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ijpharm.2011.08.018","article-title":"Production and characterization of antioxidant apigenin nanocrystals as a novel UV skin protective formulation","volume":"420","author":"Al Shaal","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2016.12.009_bb0015","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/ptr.3245","article-title":"Preparation of novel apigenin-enriched, liposomal and non-liposomal, antiinflammatory topical formulations as substitutes for corticosteroid therapy","volume":"25","author":"Arsi\u0107","year":"2011","journal-title":"Phytother. Res."},{"key":"10.1016\/j.ejps.2016.12.009_bb0020","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/bdd.677","article-title":"Metabolism, oral bioavailability and pharmacokinetics of chemopreventive kaempferol in rats","volume":"30","author":"Barve","year":"2009","journal-title":"Biopharm. Drug Dispos."},{"key":"10.1016\/j.ejps.2016.12.009_bb0025","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0021-9258(19)50881-X","article-title":"A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase","volume":"195","author":"Beers","year":"1952","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejps.2016.12.009_bb0030","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.jphotobiol.2013.11.020","article-title":"Chlorogenic acid\u2013phospholipid complex improve protection against UVA induced oxidative stress","volume":"130","author":"Bhattacharyya","year":"2014","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"10.1016\/j.ejps.2016.12.009_bb0035","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ijpharm.2012.05.009","article-title":"Huperzine A\u2013phospholipid complex-loaded biodegradable thermosensitive polymer gel for controlled drug release","volume":"433","author":"Cai","year":"2012","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2016.12.009_bb0040","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1021\/jf062088r","article-title":"Absorption and excretion of luteolin and apigenin in rats after oral administration of Chrysanthemum morifolium extract","volume":"55","author":"Chen","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejps.2016.12.009_bb0045","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.fitote.2010.06.028","article-title":"Comparative pharmacokinetics and bioavailability studies of quercetin, kaempferol and isorhamnetin after oral administration of Ginkgo biloba extracts, Ginkgo biloba extract phospholipid complexes and Ginkgo biloba extract solid dispersions in rats","volume":"81","author":"Chen","year":"2010","journal-title":"Fitoterapia"},{"key":"10.1016\/j.ejps.2016.12.009_bb0050","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1016\/j.fitote.2012.09.011","article-title":"Pharmacokinetic study of luteolin, apigenin, chrysoeriol and diosmetin after oral administration of Flos Chrysanthemi extract in rats","volume":"83","author":"Chen","year":"2012","journal-title":"Fitoterapia"},{"key":"10.1016\/j.ejps.2016.12.009_bb0055","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.fct.2013.11.020","article-title":"Effects of C-glycosylation on anti-diabetic, anti-Alzheimer's disease and anti-inflammatory potential of apigenin","volume":"64","author":"Choi","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ejps.2016.12.009_bb0060","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.biochi.2013.02.010","article-title":"Apigenin shows synergistic anticancer activity with curcumin by binding at different sites of tubulin","volume":"95","author":"Choudhury","year":"2013","journal-title":"Biochimie"},{"key":"10.1016\/j.ejps.2016.12.009_bb0065","first-page":"217","article-title":"Kinetic modeling on drug release from controlled drug delivery systems","volume":"67","author":"Dash","year":"2010","journal-title":"Acta Pol. Pharm."},{"key":"10.1016\/j.ejps.2016.12.009_bb0070","article-title":"Enhancement of the aqueous solubility and permeability of a poorly water soluble drug ritonavir via lyophilized milk-based solid dispersions","volume":"1-13","author":"Dhore","year":"2016","journal-title":"Pharm. Dev. Technol."},{"key":"10.1016\/j.ejps.2016.12.009_bb0075","first-page":"86","article-title":"The extraction of apigenin and luteolin from the sage saliva officinalis L. from Jordan","volume":"1","author":"\u0110or\u0111evi\u0107","year":"2000","journal-title":"Facta Universitatis"},{"key":"10.1016\/j.ejps.2016.12.009_bb0080","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jep.2011.01.002","article-title":"LC\u2013MS\/MS determination and pharmacokinetic study of five flavone components after solvent extraction\/acid hydrolysis in rat plasma after oral administration of Verbena officinalis L. extract","volume":"135","author":"Duan","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejps.2016.12.009_bb0085","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/sj.ejcn.1601916","article-title":"Absorption of kaempferol from endive, a source of kaempferol-3-glucuronide, in humans","volume":"58","author":"DuPont","year":"2004","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.ejps.2016.12.009_bb0090","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.ejps.2016.12.009_bb0095","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/S0022-3549(15)00186-0","article-title":"Solid phospholipid dispersions for oral delivery of poorly soluble drugs: investigation into celecoxib incorporation and solubility-in vitro permeability enhancement","volume":"105","author":"Fong","year":"2016","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2016.12.009_bb0100","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0378-5173(98)00092-1","article-title":"Effect of light and temperature on zeta potential and physical stability in solid lipid nanoparticle (SLN\u2122) dispersions","volume":"168","author":"Freitas","year":"1998","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2016.12.009_bb0105","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.intimp.2011.03.012","article-title":"Anti-inflammatory activity of structurally related flavonoids, Apigenin, Luteolin and Fisetin","volume":"11","author":"Funakoshi-Tago","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejps.2016.12.009_bb0110","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.chemphys.2006.09.017","article-title":"On the molecular and electronic structure of matrine-type alkaloids","volume":"330","author":"Galasso","year":"2006","journal-title":"Chem. Phys."},{"key":"10.1016\/j.ejps.2016.12.009_bb0115","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1042\/bj1280901","article-title":"Metabolism of apigenin and related compounds in the rat. Metabolite formation in vivo and by the intestinal microflora in vitro","volume":"128","author":"Griffiths","year":"1972","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejps.2016.12.009_bb0120","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.molliq.2012.02.001","article-title":"Solvent dependence on antioxidant activity of some water-insoluble flavonoids and their cerium(IV) complexes","volume":"168","author":"Jabbari","year":"2012","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.ejps.2016.12.009_bb0125","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.fct.2013.07.036","article-title":"Interactions between dietary flavonoids apigenin or luteolin and chemotherapeutic drugs to potentiate anti-proliferative effect on human pancreatic cancer cells, in vitro","volume":"60","author":"Johnson","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ejps.2016.12.009_bb0130","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.2147\/IJN.S112045","article-title":"Optimization, formulation, and characterization of multiflavonoids-loaded flavanosome by bulk or sequential technique","volume":"11","author":"Karthivashan","year":"2016","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.ejps.2016.12.009_bb0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1472-6882-12-90","article-title":"Hepatoprotective activity of Sonchus asper against carbon tetrachloride-induced injuries in male rats: a randomized controlled trial","volume":"12","author":"Khan","year":"2012","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.ejps.2016.12.009_bb0140","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1136\/jcp.7.4.322","article-title":"Estimation of plasma phosphatase by determination of hydrolysed phenol with amino-antipyrine","volume":"7","author":"Kind","year":"1954","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.ejps.2016.12.009_bb0145","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0021-9797(90)90119-9","article-title":"An NMR and DSC study of the interaction of phospholipid vesicles with some anti-inflammatory agents","volume":"139","author":"Lasonder","year":"1990","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.ejps.2016.12.009_bb0150","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3181\/00379727-159-40336","article-title":"Accumulation of latex in Peyer's patches and its subsequent appearance in villi and mesenteric lymph nodes","volume":"159","author":"LeFevre","year":"1978","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.ejps.2016.12.009_bb0155","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1021\/js960383s","article-title":"Evaluation of properties of apigenin and [G-3H]apigenin and analytic method development","volume":"86","author":"Li","year":"1997","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2016.12.009_bb0160","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ejpb.2012.09.021","article-title":"Bioavailability and foam cells permeability enhancement of Salvianolic acid B pellets based on drug\u2013phospholipids complex technique","volume":"83","author":"Li","year":"2013","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejps.2016.12.009_bb0165","first-page":"84","article-title":"Enhanced therapeutic benefit of quercetin\u2013phospholipid complex in carbon tetrachloride\u2013induced acute liver injury in rats: a comparative study","volume":"4","author":"Maiti","year":"2005","journal-title":"Iran. J. Pharmacol. Ther."},{"key":"10.1016\/j.ejps.2016.12.009_bb0170","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ijpharm.2006.09.025","article-title":"Curcumin\u2013phospholipid complex: preparation, therapeutic evaluation and pharmacokinetic study in rats","volume":"330","author":"Maiti","year":"2007","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2016.12.009_bb0175","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1208\/s12249-009-9282-6","article-title":"Exploring the effect of hesperetin\u2013HSPC complex\u2014a novel drug delivery system on the in vitro release, therapeutic efficacy and pharmacokinetics","volume":"10","author":"Maiti","year":"2009","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ejps.2016.12.009_bb0180","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0021-9258(18)74392-5","article-title":"The determination of bilirubin with the photoelectric colorimeter","volume":"119","author":"Malloy","year":"1937","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejps.2016.12.009_bb0185","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","article-title":"Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase","volume":"47","author":"Marklund","year":"1974","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.ejps.2016.12.009_bb0190","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1166\/jbn.2013.1704","article-title":"Micelles of TPGS modified apigenin phospholipid complex for oral administration: preparation, in vitro and in vivo evaluation","volume":"9","author":"Munyendo","year":"2013","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.ejps.2016.12.009_bb0195","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.bbamem.2012.10.013","article-title":"FTIR, (1)H NMR and EPR spectroscopy studies on the interaction of flavone apigenin with dipalmitoylphosphatidylcholine liposomes","volume":"1828","author":"Pawlikowska-Pawlega","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejps.2016.12.009_bb0200","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ijpharm.2004.09.007","article-title":"Enhancement of dissolution rate of poorly-soluble active ingredients by supercritical fluid processes: part I: micronization of neat particles","volume":"288","author":"Perrut","year":"2005","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2016.12.009_bb0205","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1016\/S0271-5317(98)00169-9","article-title":"Flavonoids: dietary occurrence and biochemical activity","volume":"18","author":"Peterson","year":"1998","journal-title":"Nutr. Res."},{"key":"10.1016\/j.ejps.2016.12.009_bb0210","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1078\/0944711041495254","article-title":"Protective role of Apigenin on the status of lipid peroxidation and antioxidant defense against hepatocarcinogenesis in Wistar albino rats","volume":"11","author":"Prince Vijeya Singh","year":"2004","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ejps.2016.12.009_bb0215","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/aps.2009.171","article-title":"Preparation, characterization and in vivo evaluation of bergenin-phospholipid complex","volume":"31","author":"Qin","year":"2010","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ejps.2016.12.009_bb0220","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0163-7258(89)90050-8","article-title":"Mechanisms of carbon tetrachloride toxicity","volume":"43","author":"Recknagel","year":"1989","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejps.2016.12.009_bb0225","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/ajcp\/28.1.56","article-title":"A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases","volume":"28","author":"Reitman","year":"1957","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.ejps.2016.12.009_bb0230","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.mrgentox.2012.08.001","article-title":"Attenuation of oxidative damage and inflammatory responses by apigenin given to mice after irradiation","volume":"749","author":"Rithidech","year":"2012","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen."},{"key":"10.1016\/j.ejps.2016.12.009_bb0235","first-page":"104","article-title":"Study of antioxidant effect of apigenin, luteolin and quercetin by DNA protective method","volume":"48","author":"Romanova","year":"2001","journal-title":"Neoplasma"},{"key":"10.1016\/j.ejps.2016.12.009_bb0240","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ijpharm.2009.11.026","article-title":"Preparation and evaluation of self-nanoemulsified drug delivery systems (SNEDDSs) of matrine based on drug\u2013phospholipid complex technique","volume":"386","author":"Ruan","year":"2010","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2016.12.009_bb0245","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2009.18","article-title":"Cytotoxicity of apigenin on leukemia cell lines: implications for prevention and therapy","volume":"1","author":"Ruela-de-Sousa","year":"2010","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejps.2016.12.009_bb0250","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1208\/s12248-015-9837-2","article-title":"Preparation and evaluation of phospholipid-based complex of standardized Centella extract (SCE) for the enhanced delivery of phytoconstituents","volume":"18","author":"Saoji","year":"2016","journal-title":"AAPS J."},{"key":"10.1016\/j.ejps.2016.12.009_bb0255","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1126\/science.1078192","article-title":"Micellar nanocontainers distribute to defined cytoplasmic organelles","volume":"300","author":"Savic","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.ejps.2016.12.009_bb0260","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1517\/17425247.2014.916271","article-title":"Cyclodextrin and phospholipid complexation in solubility and dissolution enhancement: a critical and meta-analysis","volume":"11","author":"Semalty","year":"2014","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.ejps.2016.12.009_bb0265","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1517\/17425240902967607","article-title":"Pharmacosomes: the lipid-based new drug delivery system","volume":"6","author":"Semalty","year":"2009","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.ejps.2016.12.009_bb0270","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.fitote.2009.11.001","article-title":"Supramolecular phospholipids-polyphenolics interactions: the PHYTOSOME strategy to improve the bioavailability of phytochemicals","volume":"81","author":"Semalty","year":"2010","journal-title":"Fitoterapia"},{"key":"10.1016\/j.ejps.2016.12.009_bb0275","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10847-011-0074-8","article-title":"Phyto-phospholipid complex of catechin in value added herbal drug delivery","volume":"73","author":"Semalty","year":"2012","journal-title":"J. Incl. Phenom. Macrocycl. Chem."},{"key":"10.1016\/j.ejps.2016.12.009_bb0280","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1007\/s10973-013-3463-y","article-title":"Preparation and characterization of cyclodextrin inclusion complex of naringenin and critical comparison with phospholipid complexation for improving solubility and dissolution","volume":"115","author":"Semalty","year":"2014","journal-title":"J. Therm. Anal. Calorim."},{"key":"10.1016\/j.ejps.2016.12.009_bb0285","series-title":"Antiproliferative Effect of Phytosome Complex of Methanolic Extact of Terminalia Arjuna Bark on Human Breast Cancer Cell Lines (MCF-7) International Journal of Drug Development and Research 7, 173\u2013182","author":"Sharma","year":"2015"},{"key":"10.1016\/j.ejps.2016.12.009_bb0290","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.ijpharm.2013.11.017","article-title":"Enhanced in vitro and in vivo skin deposition of apigenin delivered using ethosomes","volume":"460","author":"Shen","year":"2014","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2016.12.009_bb0295","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.virol.2014.05.024","article-title":"The flavonoid apigenin inhibits hepatitis C virus replication by decreasing mature microRNA122 levels","volume":"462\u2013463","author":"Shibata","year":"2014","journal-title":"Virology"},{"key":"10.1016\/j.ejps.2016.12.009_bb0300","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1007\/s11095-010-0089-7","article-title":"Apigenin: a promising molecule for cancer prevention","volume":"27","author":"Shukla","year":"2010","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejps.2016.12.009_bb0305","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1208\/s12249-007-9020-x","article-title":"Preparation, characterization and evaluation of marsupsin\u2013phospholipid complex","volume":"9","author":"Sikarwar","year":"2008","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ejps.2016.12.009_bb0310","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1007\/s10973-012-2448-6","article-title":"Chrysophanol\u2013phospholipid complex","volume":"111","author":"Singh","year":"2012","journal-title":"J. Therm. Anal. Calorim."},{"key":"10.1016\/j.ejps.2016.12.009_bb0315","doi-asserted-by":"crossref","first-page":"5702","DOI":"10.3390\/s90705702","article-title":"Antioxidant activity and total phenolic and flavonoid contents of Hieracium pilosella L","volume":"9","author":"Stanojevi\u0107","year":"2009","journal-title":"Extracts. Sensors"},{"key":"10.1016\/j.ejps.2016.12.009_bb0320","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1365-2141.1971.tb00790.x","article-title":"The autoxidation of human red cell lipids induced by hydrogen peroxide","volume":"20","author":"Stocks","year":"1971","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.ejps.2016.12.009_bb0325","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1590\/S1516-93322003000400007","article-title":"Antimicrobial activity of flavonoids and steroids isolated from two Chromolaena species","volume":"39","author":"Taleb-Contini","year":"2003","journal-title":"Rev. Bras. Cienc. Farm."},{"key":"10.1016\/j.ejps.2016.12.009_bb0330","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1208\/s12249-012-9772-9","article-title":"Design and evaluation of a novel evodiamine-phospholipid complex for improved oral bioavailability","volume":"13","author":"Tan","year":"2012","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ejps.2016.12.009_bb0335","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/0021-9797(88)90013-6","article-title":"The interactions of phospholipid vesicles with some anti-inflammatory agents","volume":"125","author":"Venema","year":"1988","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.ejps.2016.12.009_bb0340","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.jchromb.2007.05.007","article-title":"Quantitative determination of apigenin and its metabolism in rat plasma after intravenous bolus administration by HPLC coupled with tandem mass spectrometry","volume":"855","author":"Wan","year":"2007","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.ejps.2016.12.009_bb0345","doi-asserted-by":"crossref","first-page":"545","DOI":"10.2147\/IJN.S39526","article-title":"A novel drug-phospholipid complex enriched with micelles: preparation and evaluation in vitro and in vivo","volume":"8","author":"Xia","year":"2013","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.ejps.2016.12.009_bb0350","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jpba.2013.01.011","article-title":"Pharmacokinetic study of major bioactive components in rats after oral administration of extract of Ilex hainanensis by high-performance liquid chromatography\/electrospray ionization mass spectrometry","volume":"77","author":"Yang","year":"2013","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.ejps.2016.12.009_bb0355","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ijpharm.2005.10.001","article-title":"The preparation of silybin\u2013phospholipid complex and the study on its pharmacokinetics in rats","volume":"307","author":"Yanyu","year":"2006","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2016.12.009_bb0360","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1208\/s12249-008-9040-1","article-title":"Process optimization, characterization and pharmacokinetic evaluation in rats of ursodeoxycholic acid-phospholipid complex","volume":"9","author":"Yue","year":"2008","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ejps.2016.12.009_bb0365","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ijpharm.2009.12.008","article-title":"Process optimization, characterization and evaluation in vivo of oxymatrine\u2013phospholipid complex","volume":"387","author":"Yue","year":"2010","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2016.12.009_bb0370","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.1016\/j.jchromb.2009.08.046","article-title":"Sensitive determination of kaempferol in rat plasma by high-performance liquid chromatography with chemiluminescence detection and application to a pharmacokinetic study","volume":"877","author":"Zhang","year":"2009","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.ejps.2016.12.009_bb0375","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.ijpharm.2012.07.002","article-title":"Biopharmaceutics classification and intestinal absorption study of apigenin","volume":"436","author":"Zhang","year":"2012","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2016.12.009_bb0380","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ijpharm.2013.03.021","article-title":"Development and evaluation of a novel phytosome-loaded chitosan microsphere system for curcumin delivery","volume":"448","author":"Zhang","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2016.12.009_bb0385","doi-asserted-by":"crossref","first-page":"662","DOI":"10.3109\/03639045.2012.687378","article-title":"Design and evaluation of a self-microemulsifying drug delivery system for apigenin","volume":"39","author":"Zhao","year":"2013","journal-title":"Drug Dev. Ind. Pharm."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092809871630536X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092809871630536X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T12:36:22Z","timestamp":1657974982000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092809871630536X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":77,"alternative-id":["S092809871630536X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2016.12.009","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Formulation and characterization of an apigenin-phospholipid phytosome (APLC) for improved solubility, in vivo bioavailability, and antioxidant potential","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2016.12.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}