{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:03:35Z","timestamp":1777529015751,"version":"3.51.4"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["#449490\/2014-9"],"award-info":[{"award-number":["#449490\/2014-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"name":"FIPE-HCPA","award":["#15-0365"],"award-info":[{"award-number":["#15-0365"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.ejps.2017.09.004","type":"journal-article","created":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T07:15:44Z","timestamp":1504595744000},"page":"29-37","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Optimization of alginate microcapsules containing cells overexpressing \u03b1-l-iduronidase using Box-Behnken design"],"prefix":"10.1016","volume":"111","author":[{"given":"Dirnete","family":"Diel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeska Lizzi","family":"Lagranha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roselena Silvestri","family":"Schuh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda","family":"Bruxel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ursula","family":"Matte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helder Ferreira","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2017.09.004_bb0005","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.smim.2007.11.004","article-title":"Foreign body reaction to biomaterials","volume":"20","author":"Anderson","year":"2008","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.ejps.2017.09.004_bb0010","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1159\/000327532","article-title":"Recombinant encapsulated cells overexpressing alpha-l-iduronidase correct enzyme deficiency in human mucopolysaccharidosis type i cells","volume":"195","author":"Baldo","year":"2012","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.ejps.2017.09.004_bb0015","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.lab.2003.07.002","article-title":"Delivery of recombinant gene product to canine brain with the use of microencapsulation","volume":"142","author":"Barsoum","year":"2003","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.ejps.2017.09.004_bb0020","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/gim.2014.25","article-title":"The natural history of MPS I: global perspectives from the MPS I registry","volume":"16","author":"Beck","year":"2014","journal-title":"Genet. Med."},{"key":"10.1016\/j.ejps.2017.09.004_bb0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep06856","article-title":"A novel multilayer immunoisolating encapsulation system overcoming protrusion of cells","volume":"4","author":"Bhujbal","year":"2014","journal-title":"Sci Rep"},{"key":"10.1016\/j.ejps.2017.09.004_bb0030","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1080\/00401706.1960.10489912","article-title":"Some new three level designs for the study of quantitative variables","volume":"2","author":"Box","year":"1960","journal-title":"Technometrics"},{"key":"10.1016\/j.ejps.2017.09.004_bb0035","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s11926-013-0389-0","article-title":"Mucopolysaccharidoses","volume":"16","author":"Cimaz","year":"2014","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.ejps.2017.09.004_bb0040","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1007\/s00431-011-1644-x","article-title":"Diagnosis and treatment trends in mucopolysaccharidosis I: findings from the MPS I registry","volume":"171","author":"D'Aco","year":"2012","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.ejps.2017.09.004_bb0045","doi-asserted-by":"crossref","first-page":"8208","DOI":"10.1039\/C4TB01241K","article-title":"Covalent layer-by-layer assembly of hyperbranched polymers on alginate microcapsulesto impart stability and permselectivity KM","volume":"2","author":"Gatt\u00e1s-Asfura","year":"2015","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.ejps.2017.09.004_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0107911","article-title":"Encapsulating non-human primate multipotent stromal cells in alginate via high voltage for cell-based therapies and cryopreservation","volume":"9","author":"Gryshkov","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ejps.2017.09.004_bb0055","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/jbm.a.10086","article-title":"Fourier transform infrared spectroscopy studies of alginate-PLL capsules with varying compositions","volume":"67","author":"van Hoogmoed","year":"2003","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.ejps.2017.09.004_bb0060","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0009-8981(79)90121-9","article-title":"A fluorometric assay using 4-methylumbelliferyl alpha-l-iduronide for the estimation of alpha-l-iduronidase activity and the detection of hurler and Scheie syndromes","volume":"92","author":"Hopwood","year":"1979","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.ejps.2017.09.004_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jbiosc.2012.02.024","article-title":"Microenvironment of alginate-based microcapsules for cell culture and tissue engineering","volume":"114","author":"Huang","year":"2012","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.ejps.2017.09.004_bb0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.2001.tb03818.x","article-title":"Allo transplants xeno: as bioartificial organs move to the clinic","volume":"944","author":"Hunkeler","year":"2001","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ejps.2017.09.004_bb0075","doi-asserted-by":"crossref","DOI":"10.1080\/02652040210144234","article-title":"Controlling the size of alginate gel beads by use of a high electrostatic potential","author":"Klokk","year":"2002","journal-title":"J. Microencapsul."},{"key":"10.1016\/j.ejps.2017.09.004_bb0080","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.jconrel.2011.03.005","article-title":"A laboratory-scale device for the straightforward production of uniform, small sized cell microcapsules with long-term cell viability","volume":"152","author":"Kontturi","year":"2011","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejps.2017.09.004_bb0085","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1477-3155-9-24","article-title":"Determination of pore size distribution at the cell-hydrogel interface","volume":"9","author":"Leal-Ega\u00f1a","year":"2011","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.ejps.2017.09.004_bb0090","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1146\/annurev.physchem.56.092503.141205","article-title":"Fourier transform infrared vibrational spectroscopic imaging: integrating microscopy and molecular recognition","volume":"56","author":"Levin","year":"2005","journal-title":"Annu. Rev. Phys. Chem."},{"key":"10.1016\/j.ejps.2017.09.004_bb0095","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"The folin by oliver","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejps.2017.09.004_bb0100","series-title":"Investigations of Cell Immobilization in Alginate: Rheological and Electrostatic Extrusion Studies","first-page":"505","volume":"510","author":"Manojlovic","year":"2006"},{"key":"10.1016\/j.ejps.2017.09.004_bb0105","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1016\/j.jpeds.2009.07.005","article-title":"Guidelines for the management of mucopolysaccharidosis type I","volume":"155","author":"Martins","year":"2009","journal-title":"J. Pediatr."},{"key":"10.1016\/j.ejps.2017.09.004_bb0110","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1007\/s10545-011-9350-4","article-title":"Cell microencapsulation: a potential tool for the treatment of neuronopathic lysosomal storage diseases","volume":"34","author":"Matte","year":"2011","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.ejps.2017.09.004_bb0115","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/j.1525-1594.2009.00880.x","article-title":"Effects of cryopreservation and hypothermic storage on cell viability and enzyme activity in recombinant encapsulated cells overexpressing","volume":"34","author":"Mayer","year":"2010","journal-title":"Artif. Organs"},{"key":"10.1016\/j.ejps.2017.09.004_bb0120","first-page":"333","article-title":"Role of protein contaminants in the immunogenicity of alginates","volume":"93","author":"Menard","year":"2009","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"10.1016\/j.ejps.2017.09.004_bb0125","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.msec.2016.04.055","article-title":"Impact of alginate concentration on the viability, cryostorage, and angiogenic activity of encapsulated fi broblasts","volume":"65","author":"Mohanty","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.ejps.2017.09.004_bb0130","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1007\/s10545-011-9336-2","article-title":"Clinical manifestations and treatment of mucopolysaccharidosis type I patients in Latin America as compared with the rest of the world","volume":"34","author":"Munoz-rojas","year":"2011","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.ejps.2017.09.004_bb0135","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jconrel.2008.08.010","article-title":"Cell microencapsulation technology: towards clinical application","volume":"132","author":"Murua","year":"2008","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejps.2017.09.004_bb0140","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.jbiosc.2014.09.023","article-title":"Islets immunoisolation using encapsulation and PEGylation, simultaneously, as a novel design","volume":"119","author":"Nabavimanesh","year":"2015","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.ejps.2017.09.004_bb0145","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0928-0987(02)00220-8","article-title":"S urvival of different cell lines in alginate-agarose microcapsules","volume":"18","author":"Orive","year":"2003","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2017.09.004_bb0150","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1016\/j.biomaterials.2006.02.048","article-title":"Biocompatibility of alginate-poly-L-lysine microcapsules for cell therapy","volume":"27","author":"Orive","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejps.2017.09.004_bb0155","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.jconrel.2013.09.009","article-title":"The role of pathogen-associated molecular patterns in in fl ammatory responses against alginate based microcapsules","volume":"172","author":"Paredes-juarez","year":"2013","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejps.2017.09.004_bb0160","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/gt.2011.94","article-title":"Encapsulated engineered myoblasts can cure Hurler syndrome: preclinical experiments in the mouse model","volume":"19","author":"Piller Puicher","year":"2012","journal-title":"Gene Ther."},{"key":"10.1016\/j.ejps.2017.09.004_bb0165","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.bpc.2006.07.008","article-title":"FTIR spectra of solid poly-l-lysine in the stretching NH mode range","volume":"125","author":"Rozenberg","year":"2007","journal-title":"Biophys. Chem."},{"key":"10.1016\/j.ejps.2017.09.004_bb0170","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/978-1-4419-5786-3_3","article-title":"Development of subsieve-size capsules and application to cell therapy","volume":"670","author":"Sakai","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.ejps.2017.09.004_bb0175","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/978-1-4419-5786-3_2","article-title":"Biomaterials in cell microencapsulation","volume":"670","author":"Santos","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.ejps.2017.09.004_bb0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2013.04.015","article-title":"Therapeutic cell encapsulation: ten steps towards clinical translation","volume":"170","author":"Santos","year":"2013","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejps.2017.09.004_bb0185","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1097\/00007890-199405150-00003","article-title":"Effect of microencapsulation on oxygen distribution in islets organs","volume":"57","author":"Schrezenmeir","year":"1994","journal-title":"Transplantation"},{"key":"10.1016\/j.ejps.2017.09.004_bb0190","first-page":"1","article-title":"Nanotechnology applied to treatment of mucopolysaccharidoses","author":"Schuh","year":"2016","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.ejps.2017.09.004_bb0195","doi-asserted-by":"crossref","first-page":"6950","DOI":"10.1016\/j.biomaterials.2005.05.007","article-title":"Physicochemical model of alginate-poly-l-lysine microcapsules defined at the micrometric\/nanometric scale using ATR-FTIR, XPS, and ToF-SIMS","volume":"26","author":"Tam","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejps.2017.09.004_bb0200","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1016\/j.actbio.2010.12.006","article-title":"Biocompatibility and physicochemical characteristics of alginate-polycation microcapsules","volume":"7","author":"Tam","year":"2011","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ejps.2017.09.004_bb0205","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/jbm.b.31648","article-title":"Characterization of viability and proliferation of alginate-poly-l-lysine \u2013 alginate encapsulated myoblasts using flow cytometry","volume":"94","author":"Thakur","year":"2010","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"10.1016\/j.ejps.2017.09.004_bb0210","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/rheumatology\/ker396","article-title":"Therapy for the mucopolysaccharidoses","volume":"50","author":"Valayannopoulos","year":"2011","journal-title":"Rheumatology"},{"key":"10.1016\/j.ejps.2017.09.004_bb0215","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/nmat4290","article-title":"Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates","volume":"14","author":"Veiseh","year":"2015","journal-title":"Nat. Mater."},{"key":"10.1016\/j.ejps.2017.09.004_bb0220","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1007\/s11892-013-0412-x","article-title":"Bioengineered sites for islet cell transplantation","volume":"13","author":"V\u00e9riter","year":"2013","journal-title":"Curr. Diab. Rep."},{"key":"10.1016\/j.ejps.2017.09.004_bb0225","doi-asserted-by":"crossref","first-page":"5552","DOI":"10.1016\/j.biomaterials.2012.04.039","article-title":"The association between in vivo physicochemical changes and inflammatory responses against alginate based microcapsules","volume":"33","author":"de Vos","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejps.2017.09.004_bb0230","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1517\/17425247.2015.966682","article-title":"Gene therapy for neurologic manifestations of mucopolysaccharidoses","volume":"12","author":"Wolf","year":"2015","journal-title":"Expert Opin. Drug Deliv."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098717305006?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098717305006?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T12:26:08Z","timestamp":1692966368000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098717305006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":46,"alternative-id":["S0928098717305006"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2017.09.004","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Optimization of alginate microcapsules containing cells overexpressing \u03b1-l-iduronidase using Box-Behnken design","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2017.09.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}