{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T04:27:10Z","timestamp":1774067230374,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"The National Key Research and Development Program of China","award":["2016YFD0501303"],"award-info":[{"award-number":["2016YFD0501303"]}]},{"name":"The Special Fund for Agro-Scientific Research in the Public Interest","award":["201303038\u20139"],"award-info":[{"award-number":["201303038\u20139"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.ejps.2018.02.010","type":"journal-article","created":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T13:35:19Z","timestamp":1518010519000},"page":"154-160","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Safety and clinical efficacy of tenvermectin, a novel antiparasitic 16-membered macrocyclic lactone antibiotics"],"prefix":"10.1016","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2345-6188","authenticated-orcid":false,"given":"Chenzhong","family":"Fei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rufeng","family":"She","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guiyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lifang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wushun","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"suhan","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feiqun","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2018.02.010_bb0005","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.vetpar.2016.01.001","article-title":"Comparative efficacy and toxic effects of carvacryl acetate and carvacrol on sheep gastrointestinal nematodes and mice","volume":"218","author":"Andre","year":"2016","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.ejps.2018.02.010_bb0010","article-title":"16-membered macrolide antibiotics: a review","author":"Arsic","year":"2017","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.ejps.2018.02.010_bb0015","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.mrgentox.2010.07.011","article-title":"Assessment of DNA damage induced by extracts, fractions and isolated compounds of Davilla nitida and Davilla elliptica (Dilleniaceae)","volume":"702","author":"Biso","year":"2010","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen."},{"key":"10.1016\/j.ejps.2018.02.010_bb0020","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1126\/science.79.2037.38","article-title":"The method of probits","volume":"79","author":"Bliss","year":"1934","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.ejps.2018.02.010_bb0025","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1744-7348.1935.tb07713.x","article-title":"The calculation of the dosage-mortality curve","volume":"22","author":"Bliss","year":"1935","journal-title":"Ann. Appl. Biol."},{"key":"10.1016\/j.ejps.2018.02.010_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2885.1984.tb00872.x","article-title":"Ivermectin: a review of efficacy and safety","volume":"7","author":"Campbell","year":"1984","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.ejps.2018.02.010_bb0035","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1126\/science.6308762","article-title":"Ivermectin: a potent new antiparasitic agent","volume":"221","author":"Campbell","year":"1983","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.ejps.2018.02.010_bb0040","first-page":"545","article-title":"The development of the WHO recommended classification of pesticides by hazard","volume":"66","author":"Copplestone","year":"1988","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.ejps.2018.02.010_bb0045","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.yrtph.2006.10.009","article-title":"Comparative evaluation of acute toxicity of ivermectin by two methods after single subcutaneous administration in rats","volume":"47","author":"Dadarkar","year":"2007","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.ejps.2018.02.010_bb0055","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.yrtph.2015.01.011","article-title":"Safety evaluation of a triazine compound nitromezuril by assessing bacterial reverse mutation, sperm abnormalities, micronucleus and chromosomal aberration","volume":"71","author":"Fei","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.ejps.2018.02.010_bb0060","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1046\/j.1471-4159.2002.01199.x","article-title":"Study of the nematode putative GABA type-A receptor subunits: evidence for modulation by ivermectin","volume":"83","author":"Feng","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejps.2018.02.010_bb0065","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1111\/bph.13936","article-title":"The macrolide antibiotic renaissance","volume":"174","author":"George","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejps.2018.02.010_bb0070","first-page":"163","article-title":"Anthelmintic resistance to ivermectin and moxidectin in gastrointestinal nematodes of cattle in Europe","volume":"5","author":"Geurden","year":"2015","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ejps.2018.02.010_bb0075","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.vetpar.2006.04.038","article-title":"World association for the advancement of veterinary parasitology (WAAVP): second edition of guidelines for evaluating the efficacy of anthelmintics in swine","volume":"141","author":"Hennessy","year":"2006","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.ejps.2018.02.010_bb0080","doi-asserted-by":"crossref","first-page":"5326","DOI":"10.1128\/AEM.01025-15","article-title":"Gene replacement for the generation of designed novel avermectin derivatives with enhanced acaricidal and nematicidal activities","volume":"81","author":"Huang","year":"2015","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ejps.2018.02.010_bb0085","first-page":"295","article-title":"Genotoxicity testing, a regulatory requirement for drug discovery and development: impact of ICH guidelines","volume":"328","author":"Jena","year":"2002","journal-title":"J. Electroanal. Chem."},{"key":"10.1016\/j.ejps.2018.02.010_bb0090","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.pt.2017.02.004","article-title":"Ivermectin - old drug, new tricks?","volume":"33","author":"Laing","year":"2017","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.ejps.2018.02.010_bb0095","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1365-2885.1996.tb00062.x","article-title":"Avermectins and milbemycins","volume":"19","author":"McKellar","year":"1996","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.ejps.2018.02.010_bb0100","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.cvsm.2011.12.005","article-title":"Toxicology of avermectins and milbemycins (macrocylic lactones) and the role of P-glycoprotein in dogs and cats","volume":"42","author":"Merola","year":"2012","journal-title":"Vet. Clin. North Am. Small Anim. Pract."},{"key":"10.1016\/j.ejps.2018.02.010_bb0105","article-title":"OECD Guideline for the Testing of Chemicals","author":"OECD Guideline 420","year":"2001"},{"key":"10.1016\/j.ejps.2018.02.010_bb0110","article-title":"OECD Guideline for the Testing of Chemicals","author":"OECD Guideline 471","year":"1997"},{"key":"10.1016\/j.ejps.2018.02.010_bb0115","doi-asserted-by":"crossref","first-page":"3376","DOI":"10.1016\/j.bmcl.2016.04.033","article-title":"Three new 16-membered macrolide compounds from a genetically engineered strain S. avermitilis MHJ1011","volume":"26","author":"Pan","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejps.2018.02.010_bb0120","first-page":"241","article-title":"Efficacy of ivermectin against gastrointestinal nematodes of cattle in Denmark evaluated by different methods for analysis of faecal egg count reduction","volume":"6","author":"Pe\u00f1a-Espinoza","year":"2016","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ejps.2018.02.010_bb0125","first-page":"134","article-title":"Moxidectin and the avermectins: consanguinity but not identity","volume":"2","author":"Prichard","year":"2012","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ejps.2018.02.010_bb0130","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.vetpar.2010.12.010","article-title":"Calibration and diagnostic accuracy of simple flotation, McMaster and FLOTAC for parasite egg counts in sheep","volume":"177","author":"Rinaldi","year":"2011","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.ejps.2018.02.010_bb0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0174652","article-title":"The current status of resistance to alpha-cypermethrin, ivermectin, and amitraz of the cattle tick (Rhipicephalus microplus) in Ecuador","volume":"12","author":"Rodriguez-Hidalgo","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.ejps.2018.02.010_bb0140","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.vetpar.2013.11.025","article-title":"Acaricide and ivermectin resistance in a field population of Rhipicephalus microplus (Acari: Ixodidae) collected from red deer (Cervus elaphus) in the Mexican tropics","volume":"200","author":"Rodriguez-Vivas","year":"2014","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.ejps.2018.02.010_bb0145","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.fct.2007.10.036","article-title":"Safety evaluation of Elsholtzia splendens extracts: assessment of acute toxicity and mutagenicity","volume":"46","author":"Shim","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ejps.2018.02.010_bb0150","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0304-4017(94)00743-V","article-title":"Structure and activity of avermectins and milbemycins in animal health","volume":"59","author":"Shoop","year":"1995","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.ejps.2018.02.010_bb0155","first-page":"161","article-title":"Development, pharmacokinetics and mode of action of ivermectin","volume":"59","author":"Sutherland","year":"1990","journal-title":"Acta Leiden."},{"key":"10.1016\/j.ejps.2018.02.010_bb0160","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/ja.2016.91","article-title":"New tenvermectin analogs obtained by microbial conversion with Saccharopolyspora erythraea","volume":"70","author":"Wan","year":"2016","journal-title":"J. Antibiot."},{"key":"10.1016\/j.ejps.2018.02.010_bb0165","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1080\/10286020.2016.1197911","article-title":"Two new tenvermectins from a genetically engineered strain Streptomyces avermitilis MHJ1011","volume":"19","author":"Wan","year":"2017","journal-title":"J. Asian Nat. Prod. Res."},{"key":"10.1016\/j.ejps.2018.02.010_bb0170","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/ja.2016.91","article-title":"New tenvermectin analogs obtained by microbial conversion with Saccharopolyspora erythraea","volume":"70","author":"Wan","year":"2017","journal-title":"J. Antibiot. (Tokyo)"},{"key":"10.1016\/j.ejps.2018.02.010_bb0175","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1021\/acs.jnatprod.6b00200","article-title":"Aldgamycins J\u2013O, 16-membered macrolides with a branched Octose unit from Streptomycetessp. and their antibacterial activities","volume":"79","author":"Wang","year":"2016","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.ejps.2018.02.010_bb0180","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.yrtph.2014.05.017","article-title":"Acute and subchronic toxicity of arprinocid in Sprague-Dawley rats","volume":"69","author":"Wu","year":"2014","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.ejps.2018.02.010_bb0185","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.yrtph.2015.07.009","article-title":"Acute and sub-acute oral toxicological evaluations and mutagenicity of N-carbamylglutamate (NCG)","volume":"73","author":"Wu","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092809871830071X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092809871830071X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T13:51:03Z","timestamp":1549893063000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092809871830071X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":36,"alternative-id":["S092809871830071X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2018.02.010","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety and clinical efficacy of tenvermectin, a novel antiparasitic 16-membered macrocyclic lactone antibiotics","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2018.02.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}