{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T22:19:41Z","timestamp":1779142781351,"version":"3.51.4"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.ejps.2018.02.030","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T18:50:09Z","timestamp":1519757409000},"page":"236-244","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Continuous manufacturing and analytical characterization of fixed-dose, multilayer orodispersible films"],"prefix":"10.1016","volume":"117","author":[{"given":"Yasmin","family":"Thabet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3984-4035","authenticated-orcid":false,"given":"Dominique","family":"Lunter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3982-9823","authenticated-orcid":false,"given":"Joerg","family":"Breitkreutz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2018.02.030_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2015.03.006","article-title":"Oral films: current status and future perspectives: I\u2014galenical development and quality attributes","volume":"206","author":"Borges","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejps.2018.02.030_bb0015","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1002\/ebch.1974","article-title":"Pharmacological interventions for hypertension in children","volume":"9","author":"Chaturvedi","year":"2014","journal-title":"Evid. Based Child Health."},{"key":"10.1016\/j.ejps.2018.02.030_bb0020","author":"EMA"},{"key":"10.1016\/j.ejps.2018.02.030_bb0025","author":"EMA"},{"key":"10.1016\/j.ejps.2018.02.030_bb0030","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/j.1365-2125.2007.03089.x","article-title":"Fixed dose drug combinations (FDCs): rational or irrational: a view point","volume":"65","author":"Gautam","year":"2008","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejps.2018.02.030_bb0035","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1161\/HYPERTENSIONAHA.109.139816","article-title":"Compliance, safety, and effectiveness of fixed-dose combinations of antihypertensive agents","volume":"55","author":"Gupta","year":"2010","journal-title":"Hypertension"},{"key":"10.1016\/j.ejps.2018.02.030_bb0040","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1517\/17425247.2011.553217","article-title":"Advances in orodispersible films for drug delivery","volume":"8","author":"Hoffmann","year":"2011","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.ejps.2018.02.030_bb0045","series-title":"International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use: Validation of analytical Procedures: Text and Methodology Q2(R1),2005","author":"ICH","year":"2015"},{"key":"10.1016\/j.ejps.2018.02.030_bb0050","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.jsps.2015.02.024","article-title":"Orally disintegrating films: a modern expansion in drug delivery system","volume":"24","author":"Irfan","year":"2016","journal-title":"Saudi Pharm. J."},{"key":"10.1016\/j.ejps.2018.02.030_bb0055","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1136\/adc.70.1.35","article-title":"Efficacy and dosage of enalapril in congenital and acquired heart disease","volume":"70","author":"Leversha","year":"1994","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.ejps.2018.02.030_bb0060","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/j.1365-2125.2005.02410.x","article-title":"Formulation of medicines for children","volume":"59","author":"Nunn","year":"2005","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejps.2018.02.030_bb0065","series-title":"European Pharmacopoeia Comission, Oromucosal Preparations, European Pharmacopoeia","author":"Ph.Eur","year":"2014"},{"key":"10.1016\/j.ejps.2018.02.030_bb0070","series-title":"European Pharmacopoeia Commission, Residual Solvents, European Pharmacopoeia","author":"Ph.Eur","year":"2016"},{"key":"10.1016\/j.ejps.2018.02.030_bb0075","series-title":"European Pharmacopoeia Comission, Orodispersible tablets, European Pharmacopoeia","author":"Ph.Eur","year":"2017"},{"key":"10.1016\/j.ejps.2018.02.030_bb0080","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1208\/s12249-015-0313-1","article-title":"Orally disintegrating films and mini-tablets\u2014innovative dosage forms of choice for pediatric use","volume":"16","author":"Preis","year":"2015","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ejps.2018.02.030_bb0085","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1111\/jphp.12246","article-title":"Comparative study on novel test systems to determine disintegration time of orodispersible films","volume":"66","author":"Preis","year":"2014","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejps.2018.02.030_bb0090","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ijpharm.2013.11.033","article-title":"Mechanical strength test for orodispersible and buccal films","volume":"461","author":"Preis","year":"2014","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2018.02.030_bb0095","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/0079-6700(95)00008-4","article-title":"Interactions in cellulose derivative films for oral drug delivery","volume":"20","author":"Sakellariou","year":"1995","journal-title":"Prog. Polym. Sci."},{"key":"10.1016\/j.ejps.2018.02.030_bb0100","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.ejps.2015.02.015","article-title":"Orodispersible drug formulations for children and elderly","volume":"75","author":"Slavkova","year":"2015","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2018.02.030_bb0105","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.ijpharm.2017.11.021","article-title":"Orodispersible films: product transfer from lab-scale to continuous manufacturing","volume":"535","author":"Thabet","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2018.02.030_bb0110","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1208\/s12249-016-0515-1","article-title":"Personalized medicine in pediatrics: the clinical potential of orodispersible films","volume":"18","author":"Visser","year":"2017","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ejps.2018.02.030_bb0115","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1111\/j.1532-5415.2009.02131.x","article-title":"Multimorbidity and polypharmacy: how to reduce the harmful drug load and yet add needed drugs in the elderly? Proposal of a new drug classification: fit for the aged","volume":"57","author":"Wehling","year":"2009","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.ejps.2018.02.030_bb0120","author":"WHO"},{"key":"10.1016\/j.ejps.2018.02.030_bb0125","author":"WHO"}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098718301076?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098718301076?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,14]],"date-time":"2022-08-14T23:42:27Z","timestamp":1660520547000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098718301076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":24,"alternative-id":["S0928098718301076"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2018.02.030","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Continuous manufacturing and analytical characterization of fixed-dose, multilayer orodispersible films","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2018.02.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}