{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:35:48Z","timestamp":1786988148208,"version":"build-2736575974"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100006316","name":"Drug Research Academy, K\u00f8benhavns Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007469","name":"Alfred Benzon Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007469","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004836","name":"Danmarks Frie Forskningsfond","doi-asserted-by":"publisher","award":["4005-00455"],"award-info":[{"award-number":["4005-00455"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF16OC0021948"],"award-info":[{"award-number":["NNF16OC0021948"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010767","name":"Innovative Medicines Initiative","doi-asserted-by":"publisher","award":["115363"],"award-info":[{"award-number":["115363"]}],"id":[{"id":"10.13039\/501100010767","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.ejps.2018.02.032","type":"journal-article","created":{"date-parts":[[2018,3,8]],"date-time":"2018-03-08T02:18:06Z","timestamp":1520475486000},"page":"144-153","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"special_numbering":"C","title":["Evaluation of drug permeation under fed state conditions using mucus-covered Caco-2 cell epithelium"],"prefix":"10.1016","volume":"118","author":[{"given":"Ditlev","family":"Birch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ragna G.","family":"Diedrichsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip C.","family":"Christophersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9246-3931","authenticated-orcid":false,"given":"Huiling","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7285-9100","authenticated-orcid":false,"given":"Hanne M.","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.ejps.2018.02.032_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/cshperspect.a008763","article-title":"Metabolic stress in autophagy and cell death pathways","volume":"4","author":"Altman","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"1\u20132","key":"10.1016\/j.ejps.2018.02.032_bb0010","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ijpharm.2015.01.028","article-title":"Biorelevant media resistant co-culture model mimicking permeability of human intestine","volume":"481","author":"Antoine","year":"2015","journal-title":"Int. J. Pharm."},{"issue":"1 Pt 1","key":"10.1016\/j.ejps.2018.02.032_bb0015","first-page":"G172","article-title":"Physicochemical characteristics of emulsions during fat digestion in human stomach and duodenum","volume":"271","author":"Armand","year":"1996","journal-title":"Am. J. Phys."},{"issue":"3","key":"10.1016\/j.ejps.2018.02.032_bb0020","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/0006-291X(91)91647-U","article-title":"Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells","volume":"175","author":"Artursson","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.ejps.2018.02.032_bb0025","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1208\/s12248-011-9307-4","article-title":"Absorption enhancers: applications and advances","volume":"14","author":"Aungst","year":"2012","journal-title":"AAPS J."},{"issue":"1","key":"10.1016\/j.ejps.2018.02.032_bb0030","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ejps.2013.10.015","article-title":"Early pharmaceutical profiling to predict oral drug absorption: current status and unmet needs","volume":"57","author":"Bergstr\u00f6m","year":"2014","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2018.02.032_bb0035","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jddst.2016.06.013","article-title":"Development of a \u03bcDissolution-Permeation model with in situ drug concentration monitoring","volume":"35","author":"Berthelsen","year":"2016","journal-title":"J. Drug Delivery Sci. Technol."},{"issue":"12","key":"10.1016\/j.ejps.2018.02.032_bb0040","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1016\/j.bbamem.2017.09.015","article-title":"Fluorophore labeling of a cell-penetrating peptide induces differential effects on its cellular distribution and affects cell viability","volume":"1859","author":"Birch","year":"2017","journal-title":"Biochim. Biophys. Acta Biomembr."},{"issue":"3","key":"10.1016\/j.ejps.2018.02.032_bb0045","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/bcpt.12342","article-title":"Mucus as a barrier to drug delivery - understanding and mimicking the barrier properties","volume":"116","author":"Boegh","year":"2015","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"4","key":"10.1016\/j.ejps.2018.02.032_bb0050","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S1773-2247(13)50055-4","article-title":"Mucosal drug delivery: barriers, in vitro models and formulation strategies","volume":"23","author":"Boegh","year":"2013","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"10.1016\/j.ejps.2018.02.032_bb0055","first-page":"233","article-title":"Development and rheological profiling of biosimilar mucus","volume":"21","author":"Boegh","year":"2013","journal-title":"Nord. Rheol. Soc. Annu. Trans."},{"issue":"2","key":"10.1016\/j.ejps.2018.02.032_bb0060","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.ejpb.2014.01.001","article-title":"Property profiling of biosimilar mucus in a novel mucus-containing in vitro model for assessment of intestinal drug absorption","volume":"87","author":"Boegh","year":"2014","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"1\u20132","key":"10.1016\/j.ejps.2018.02.032_bb0065","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.ijpharm.2016.06.010","article-title":"Apomorphine and its esters: differences in Caco-2 cell permeability and chylomicron affinity","volume":"509","author":"Borkar","year":"2016","journal-title":"Int. J. Pharm."},{"issue":"3","key":"10.1016\/j.ejps.2018.02.032_bb0070","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.ejpb.2014.10.008","article-title":"A head-to-head multi-parametric high content analysis of a series of medium chain fatty acid intestinal permeation enhancers in Caco-2 cells","volume":"88","author":"Brayden","year":"2014","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"6","key":"10.1016\/j.ejps.2018.02.032_bb0075","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1002\/jps.21576","article-title":"IVIVC in oral absorption for fenofibrate immediate release tablets using a dissolution\/permeation system","volume":"98","author":"Buch","year":"2009","journal-title":"J. Pharm. Sci."},{"issue":"1","key":"10.1016\/j.ejps.2018.02.032_bb0080","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s10295-010-0844-0","article-title":"Effect of soya lecithin on the enzymatic system of the white-rot fungi Anthracophyllum discolor","volume":"38","author":"Bustamante","year":"2011","journal-title":"J. Ind. Microbiol. Biotechnol."},{"issue":"5","key":"10.1016\/j.ejps.2018.02.032_bb0085","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1023\/A:1023481418576","article-title":"Human jejunal permeability of cyclosporin A: influence of surfactants on P-glycoprotein efflux in Caco-2 cells","volume":"20","author":"Chiu","year":"2003","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejps.2018.02.032_bb0090","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ejps.2013.09.007","article-title":"Fed and fasted state gastro-intestinal in vitro lipolysis: in vitro in vivo relations of a conventional tablet, a SNEDDS and a solidified SNEDDS","volume":"57","author":"Christophersen","year":"2014","journal-title":"Eur. J. Pharm. Sci."},{"issue":"2","key":"10.1016\/j.ejps.2018.02.032_bb0095","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.addr.2008.09.008","article-title":"Barrier properties of mucus","volume":"61","author":"Cone","year":"2009","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"4","key":"10.1016\/j.ejps.2018.02.032_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajo.2012.10.004","article-title":"Effects of light exposure, pH, osmolarity, and solvent on the retinal pigment epithelial toxicity of vital dyes","volume":"155","author":"Costa","year":"2013","journal-title":"Am J. Ophthalmol."},{"issue":"1","key":"10.1016\/j.ejps.2018.02.032_bb0105","doi-asserted-by":"crossref","first-page":"139","DOI":"10.2478\/s11658-008-0041-6","article-title":"Oral cyclosporine A - the current picture of its liposomal and other delivery systems","volume":"14","author":"Czogalla","year":"2009","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"9","key":"10.1016\/j.ejps.2018.02.032_bb0110","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1021\/acs.molpharmaceut.6b00514","article-title":"Regional intestinal permeability of three model drugs in human","volume":"13","author":"Dahlgren","year":"2016","journal-title":"Mol. Pharm."},{"issue":"5","key":"10.1016\/j.ejps.2018.02.032_bb0115","doi-asserted-by":"crossref","first-page":"852","DOI":"10.2215\/CJN.10741013","article-title":"Osmotic homeostasis","volume":"10","author":"Danziger","year":"2015","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"5","key":"10.1016\/j.ejps.2018.02.032_bb0120","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1172\/JCI109932","article-title":"Mechanism by which bile salt disrupts the gastric mucosal barrier in the dog","volume":"66","author":"Duane","year":"1980","journal-title":"J. Clin. Invest."},{"issue":"24","key":"10.1016\/j.ejps.2018.02.032_bb0125","doi-asserted-by":"crossref","first-page":"3757","DOI":"10.1021\/jm00076a002","article-title":"Solvent-dependent conformation and hydrogen-bonding capacity of cyclosporin A: evidence from partition coefficients and molecular dynamics simulations","volume":"36","author":"El Tayar","year":"1993","journal-title":"J. Med. Chem."},{"issue":"5","key":"10.1016\/j.ejps.2018.02.032_bb0130","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0928-0987(95)00027-B","article-title":"Experimental estimation of the effective unstirred water layer thickness in the human jejunum, and its importance in oral drug absorption","volume":"3","author":"Fagerholm","year":"1995","journal-title":"Eur. J. Pharm. Sci."},{"issue":"7","key":"10.1016\/j.ejps.2018.02.032_bb0135","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1111\/j.2042-7158.1997.tb06093.x","article-title":"Regional intestinal permeability in rats of compounds with different physicochemical properties and transport mechanisms","volume":"49","author":"Fagerholm","year":"1997","journal-title":"J. Pharm. Pharmacol."},{"issue":"d","key":"10.1016\/j.ejps.2018.02.032_bb0140","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1289\/ehp.9084107","article-title":"The role of calcium ions in toxic cell injury","volume":"84","author":"Farber","year":"1990","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ejps.2018.02.032_bb0145","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.addr.2017.11.002","article-title":"The role of mucus as an invisible cloak to transepithelial drug delivery by nanoparticles","volume":"124","author":"Garc\u00eda-D\u00edaz","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"3\u20134","key":"10.1016\/j.ejps.2018.02.032_bb0150","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s003830050544","article-title":"The effect of mucin on bacterial translocation in I-407 fetal and Caco-2 adult enterocyte cultured cell lines","volume":"15","author":"Gork","year":"1999","journal-title":"Pediatr. Surg. Int."},{"issue":"7","key":"10.1016\/j.ejps.2018.02.032_bb0155","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1021\/mp500776a","article-title":"Interaction with mixed micelles in the intestine attenuates the permeation enhancing potential of alkyl-maltosides","volume":"12","author":"Gradauer","year":"2015","journal-title":"Mol. Pharm."},{"issue":"1","key":"10.1016\/j.ejps.2018.02.032_bb0160","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/10717540590889691","article-title":"Solubilization and pharmacokinetic behaviors of sodium cholate\/lecithin-mixed micelles containing cyclosporine A","volume":"12","author":"Guo","year":"2004","journal-title":"Drug Deliv."},{"key":"10.1016\/j.ejps.2018.02.032_bb0165","series-title":"Exploring QSAR","author":"Hansch","year":"1995"},{"key":"10.1016\/j.ejps.2018.02.032_bb0170","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ejps.2015.05.023","article-title":"Gastrointestinal behavior of nano- and microsized fenofibrate: in vivo evaluation in man and in vitro simulation by assessment of the permeation potential","volume":"77","author":"Hens","year":"2015","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2018.02.032_bb0175","author":"Heuman"},{"issue":"96","key":"10.1016\/j.ejps.2018.02.032_bb0180","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/0016-5085(89)90897-4","article-title":"Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability","volume":"3","author":"Hidalgo","year":"1989","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.ejps.2018.02.032_bb0185","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/(SICI)1520-6017(200001)89:1<63::AID-JPS7>3.0.CO;2-6","article-title":"Caco-2 versus Caco-2\/HT29-MTX co-cultured cell lines: permeabilities via diffusion, inside- and outside-directed carrier-mediated transport","volume":"89","author":"Hilgendorf","year":"2000","journal-title":"J. Pharm. Sci."},{"issue":"2","key":"10.1016\/j.ejps.2018.02.032_bb0190","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0378-5173(94)00232-T","article-title":"Drug delivery studies in Caco-2 monolayers. II. Absorption enhancer effects of lysophosphatidylcholines","volume":"114","author":"Hovgaard","year":"1995","journal-title":"Int. J. Pharm."},{"issue":"1\u20132","key":"10.1016\/j.ejps.2018.02.032_bb0195","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0378-5173(01)00897-3","article-title":"Simulated intestinal fluid as transport medium in the Caco-2 cell culture model","volume":"232","author":"Ingels","year":"2002","journal-title":"Int. J. Pharm."},{"issue":"7","key":"10.1016\/j.ejps.2018.02.032_bb0200","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1007\/s11095-008-9569-4","article-title":"Dissolution media simulating conditions in the proximal human gastrointestinal tract: an update","volume":"25","author":"Jantratid","year":"2008","journal-title":"Pharm. Res."},{"issue":"1","key":"10.1016\/j.ejps.2018.02.032_bb0205","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1023\/A:1018973029651","article-title":"Prodrugs of peptides. 18. Synthesis and evaluation of various esters of desmopressin (dDAVP)","volume":"10","author":"Kahns","year":"1993","journal-title":"Pharm. Res."},{"issue":"11","key":"10.1016\/j.ejps.2018.02.032_bb0210","doi-asserted-by":"crossref","first-page":"3998","DOI":"10.1002\/jps.23708","article-title":"Mechanistic study of the uptake\/permeation of cell-penetrating peptides across a caco-2 monolayer and their stimulatory effect on epithelial insulin transport","volume":"102","author":"Kamei","year":"2013","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2018.02.032_bb0215","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ejpb.2015.04.030","article-title":"Effect of different intestinal conditions on the intermolecular interaction between insulin and cell-penetrating peptide penetratin and on its contribution to stimulation of permeation through intestinal epithelium","volume":"94","author":"Kamei","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejps.2018.02.032_bb0220","first-page":"25","article-title":"Calcium signaling and cytotoxicity","volume":"107","author":"Kass","year":"1999","journal-title":"Environ. Health Perspect."},{"issue":"3","key":"10.1016\/j.ejps.2018.02.032_bb0225","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/jps.2600830336","article-title":"Reduced inter- and intraindividual variability in cyclosporine pharmacokinetics from a microemulsion formulation","volume":"83","author":"Kovarik","year":"1994","journal-title":"J. Pharm. Sci."},{"issue":"5","key":"10.1016\/j.ejps.2018.02.032_bb0230","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1208\/s12248-015-9747-3","article-title":"Penetratin-mediated transepithelial insulin permeation: importance of cationic residues and pH for complexation and permeation","volume":"17","author":"Kristensen","year":"2015","journal-title":"AAPS J."},{"issue":"2","key":"10.1016\/j.ejps.2018.02.032_bb0235","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.addr.2008.09.012","article-title":"Micro- and macrorheology of mucus","volume":"61","author":"Lai","year":"2009","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"3","key":"10.1016\/j.ejps.2018.02.032_bb0240","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/jps.10324","article-title":"Properties of rapidly dissolving eutectic mixtures of poly(ethylene glycol) and fenofibrate: the eutectic microstructure","volume":"92","author":"Law","year":"2003","journal-title":"J. Pharm. Sci."},{"issue":"10\u201311","key":"10.1016\/j.ejps.2018.02.032_bb0245","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1080\/00498250701704819","article-title":"Intestinal permeability and its relevance for absorption and elimination","volume":"37","author":"Lennern\u00e4s","year":"2007","journal-title":"Xenobiotica"},{"issue":"4\u20135","key":"10.1016\/j.ejps.2018.02.032_bb0250","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ejps.2007.08.002","article-title":"Development of simulated intestinal fluids containing nutrients as transport media in the Caco-2 cell culture model: assessment of cell viability, monolayer integrity and transport of a poorly aqueous soluble drug and a substrate of efflux mechanisms","volume":"32","author":"Lind","year":"2007","journal-title":"Eur. J. Pharm. Sci."},{"issue":"2","key":"10.1016\/j.ejps.2018.02.032_bb0255","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/S0022-3565(25)12150-2","article-title":"Mechanisms of absorption enhancement by medium chain fatty acids in intestinal epithelial Caco-2 cell monolayers","volume":"275","author":"Lindmark","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"1","key":"10.1016\/j.ejps.2018.02.032_bb0260","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/S0022-3565(24)37216-7","article-title":"Absorption enhancement through intracellular regulation of tight junction permeability by medium chain fatty acids in Caco-2 cells","volume":"284","author":"Lindmark","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"3","key":"10.1016\/j.ejps.2018.02.032_bb0265","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.ejps.2011.11.025","article-title":"Soluplus\u00ae as an effective absorption enhancer of poorly soluble drugs in vitro and in vivo","volume":"45","author":"Linn","year":"2012","journal-title":"Eur. J. Pharm. Sci."},{"issue":"2","key":"10.1016\/j.ejps.2018.02.032_bb0270","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0378-5173(90)90267-8","article-title":"Absorption of a vasopressin analogue, 1-deamino-8-d-arginine-vasopressin (dDAVP), in a human intestinal epithelial cell line, Caco-2","volume":"64","author":"Lundin","year":"1990","journal-title":"Int. J. Pharm."},{"issue":"3","key":"10.1016\/j.ejps.2018.02.032_bb0275","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.ejpb.2013.10.017","article-title":"Biorelevant media for transport experiments in the Caco-2 model to evaluate drug absorption in the fasted and the fed state and their usefulness","volume":"86","author":"Markopoulos","year":"2014","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"1","key":"10.1016\/j.ejps.2018.02.032_bb0280","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1021\/la00091a030","article-title":"Critical micelle concentration behavior of sodium taurocholate in water","volume":"6","author":"Meyerhoffer","year":"1990","journal-title":"Langmuir"},{"issue":"10","key":"10.1016\/j.ejps.2018.02.032_bb0285","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1002\/jps.20712","article-title":"Involvement of intracellular Ca2+ dynamics in cytoprotective action by amino acids and cytotoxicity by sodium laurate, an absorption enhancer","volume":"95","author":"Okuda","year":"2006","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2018.02.032_bb0290","series-title":"The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals","author":"O'Neil","year":"1996"},{"issue":"10","key":"10.1016\/j.ejps.2018.02.032_bb0295","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1002\/jps.2600841019","article-title":"Different properties of the paracellular pathway account for the regional small intestinal permeability to the peptide desmopressin","volume":"84","author":"Pantzar","year":"1995","journal-title":"J. Pharm. Sci."},{"issue":"2","key":"10.1016\/j.ejps.2018.02.032_bb0300","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1080\/03639040500465991","article-title":"Use of simulated intestinal fluids with Caco-2 cells and rat ileum","volume":"32","author":"Patel","year":"2006","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.ejps.2018.02.032_bb0305","first-page":"8","article-title":"Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture","volume":"47","author":"Pinto","year":"1983","journal-title":"Biol. Cell."},{"issue":"4","key":"10.1016\/j.ejps.2018.02.032_bb0310","doi-asserted-by":"crossref","first-page":"324","DOI":"10.4236\/jbpc.2012.34040","article-title":"Surface tensometry studies on formulations of surfactants with preservatives as a tool for antimicrobial drug protection characterization","volume":"3","author":"Pogorzelski","year":"2012","journal-title":"J. Biophys. Chem."},{"issue":"1","key":"10.1016\/j.ejps.2018.02.032_bb0315","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.juro.2007.03.015","article-title":"The comparative safety of oral versus intranasal desmopressin for the treatment of children with nocturnal enuresis","volume":"178","author":"Robson","year":"2007","journal-title":"J. Urol."},{"issue":"10","key":"10.1016\/j.ejps.2018.02.032_bb0320","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1111\/j.2042-7158.1998.tb03319.x","article-title":"Cytotoxicity of absorption enhancers in Caco-2 cell monolayers","volume":"50","author":"Sakai","year":"1998","journal-title":"J. Pharm. Pharmacol."},{"issue":"3","key":"10.1016\/j.ejps.2018.02.032_bb0325","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1002\/jps.10071","article-title":"Interactions of cyclosporines with lipid membranes as studied by solid-state nuclear magnetic resonance spectroscopy and high-sensitivity titration calorimetry","volume":"91","author":"Schote","year":"2002","journal-title":"J. Pharm. Sci."},{"issue":"4","key":"10.1016\/j.ejps.2018.02.032_bb0330","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.ejps.2013.05.019","article-title":"In silico predictions of gastrointestinal drug absorption in pharmaceutical product development: application of the mechanistic absorption model GI-Sim","volume":"49","author":"Sj\u00f6gren","year":"2013","journal-title":"Eur. J. Pharm. Sci."},{"issue":"1","key":"10.1016\/j.ejps.2018.02.032_bb0335","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0016-5085(99)70551-2","article-title":"Epithelial permeability to proteins in the noninflamed ileum of Crohn's disease?","volume":"117","author":"S\u00f6derholm","year":"1999","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.ejps.2018.02.032_bb0340","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1172\/JCI116546","article-title":"Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role of ATP depletion and cytosolic free calcium","volume":"92","author":"Spivey","year":"1993","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.ejps.2018.02.032_bb0345","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ijpharm.2015.08.076","article-title":"Bioactive protein-based nanofibers interact with intestinal biological components resulting in transepithelial permeation of a therapeutic protein","volume":"495","author":"Stephansen","year":"2015","journal-title":"Int. J. Pharm."},{"issue":"8","key":"10.1016\/j.ejps.2018.02.032_bb0350","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrd3187","article-title":"Coexistence of passive and carrier-mediated processes in drug transport","volume":"9","author":"Sugano","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"issue":"6","key":"10.1016\/j.ejps.2018.02.032_bb0355","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1038\/sj.bjp.0707678","article-title":"Comparative study on transduction and toxicity of protein transduction domains","volume":"153","author":"Sugita","year":"2008","journal-title":"Br. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.ejps.2018.02.032_bb0360","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1517\/17425255.4.4.395","article-title":"The Caco-2 cell monolayer: usefulness and limitations","volume":"4","author":"Sun","year":"2008","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"issue":"4","key":"10.1016\/j.ejps.2018.02.032_bb0365","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1472-765X.2005.01775.x","article-title":"Porcine gastric mucin binds to recombinant norovirus particles and competitively inhibits their binding to histo-blood group antigens and Caco-2 cells","volume":"41","author":"Tian","year":"2005","journal-title":"Lett. Appl. Microbiol."},{"issue":"5","key":"10.1016\/j.ejps.2018.02.032_bb0370","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1021\/mp200479f","article-title":"Luminal lipid phases after administration of a triglyceride solution of danazol in the fed state and their contribution to the flux of danazol across Caco-2 cell monolayers","volume":"9","author":"Vertzoni","year":"2012","journal-title":"Mol. Pharm."},{"issue":"1","key":"10.1016\/j.ejps.2018.02.032_bb0375","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.bios.2008.04.010","article-title":"A potentiometric protein sensor built with surface molecular imprinting method","volume":"24","author":"Wang","year":"2008","journal-title":"Biosens. Bioelectron."},{"issue":"3","key":"10.1016\/j.ejps.2018.02.032_bb0380","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1021\/mp500809f","article-title":"Toward oral delivery of biopharmaceuticals: an assessment of the gastrointestinal stability of 17 peptide drugs","volume":"12","author":"Wang","year":"2015","journal-title":"Mol. Pharm."},{"issue":"8","key":"10.1016\/j.ejps.2018.02.032_bb0385","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1007\/s11095-007-9488-9","article-title":"Safe and effective permeation enhancers for oral drug delivery","volume":"25","author":"Whitehead","year":"2008","journal-title":"Pharm. Res."},{"issue":"3","key":"10.1016\/j.ejps.2018.02.032_bb0390","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0928-0987(95)00007-Z","article-title":"Co-cultures of human intestinal goblet (HT29-H) and absorptive (Caco-2) cells for studies of drug and peptide absorption","volume":"3","author":"Wikman-Larhed","year":"1995","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2018.02.032_bb0395","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.ejps.2014.11.010","article-title":"Evaluation of fasted state human intestinal fluid as apical solvent system in the Caco-2 absorption model and comparison with FaSSIF","volume":"67","author":"Wuyts","year":"2015","journal-title":"Eur. J. Pharm. Sci."},{"issue":"2","key":"10.1016\/j.ejps.2018.02.032_bb0400","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.ijpharm.2014.12.021","article-title":"Evaluation of fasted and fed state simulated and human intestinal fluids as solvent system in the Ussing chambers model to explore food effects on intestinal permeability","volume":"478","author":"Wuyts","year":"2015","journal-title":"Int. J. Pharm."},{"issue":"9","key":"10.1016\/j.ejps.2018.02.032_bb0405","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1023\/A:1011930411574","article-title":"Correlating partitioning and Caco-2 cell permeability of structurally diverse small molecular weight compounds","volume":"15","author":"Yazdanian","year":"1998","journal-title":"Pharm. Res."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092809871830109X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092809871830109X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T11:31:03Z","timestamp":1751455863000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092809871830109X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":81,"alternative-id":["S092809871830109X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2018.02.032","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of drug permeation under fed state conditions using mucus-covered Caco-2 cell epithelium","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2018.02.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}