{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T03:18:49Z","timestamp":1784690329070,"version":"3.55.0"},"reference-count":94,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007341","name":"Chhattisgarh Council of Science and Technology","doi-asserted-by":"publisher","award":["GUJCOST\/MRP\/2014-15\/105"],"award-info":[{"award-number":["GUJCOST\/MRP\/2014-15\/105"]}],"id":[{"id":"10.13039\/501100007341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.ejps.2018.05.026","type":"journal-article","created":{"date-parts":[[2018,5,28]],"date-time":"2018-05-28T04:00:06Z","timestamp":1527480006000},"page":"188-199","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Repurposing of sodium valproate in colon cancer associated with diabetes mellitus: Role of HDAC inhibition"],"prefix":"10.1016","volume":"121","author":[{"given":"Mayur M.","family":"Patel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0594-5452","authenticated-orcid":false,"given":"Bhoomika M.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2018.05.026_bb0005","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1038\/sj.bjc.6690553","article-title":"Regulation of vascular endothelial growth factor expression in human colon cancer by interleukin-1beta","volume":"80","author":"Akagi","year":"1999","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ejps.2018.05.026_bb0010","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.ejphar.2015.05.044","article-title":"Hypoglycemic, antilipid-emic and antioxidant effects of valproic acid in alloxan-induced diabetic rats","volume":"762","author":"Akindele","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejps.2018.05.026_bb0015","doi-asserted-by":"crossref","first-page":"18390","DOI":"10.3748\/wjg.v20.i48.18390","article-title":"Increased expression of tumor necrosis factor-\u03b1 is associated with advanced colorectal cancer stages","volume":"20","author":"Al Obeed","year":"2014","journal-title":"World J. Gastroenterol."},{"issue":"1","key":"10.1016\/j.ejps.2018.05.026_bb0020","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/jso.23352","article-title":"Preoperative carcinoembryonic antigen as an outcome predictor in colon cancer","volume":"108","author":"Amri","year":"2013","journal-title":"J. Surg. Oncol."},{"key":"10.1016\/j.ejps.2018.05.026_bb0025","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.ejca.2006.01.010","article-title":"Effects of micro-environment- and malignant cell-derived interleukin-1 in carcinogenesis, tumour invasiveness and tumour-host interactions","volume":"42","author":"Apte","year":"2006","journal-title":"Eur. J. Cancer"},{"issue":"2","key":"10.1016\/j.ejps.2018.05.026_bb0030","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.bbrc.2015.04.030","article-title":"Carvacrol exhibits anti-oxidant and anti-inflammatory effects against 1, 2-dimethyl hydrazine plus dextran sodium sulfate induced inflammation associated carcinogenicity in the colon of Fischer 344 rats","volume":"461","author":"Arigesavan","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejps.2018.05.026_bb0035","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1472-8206.2010.00814.x","article-title":"Angiogenic targets for potential disorders","volume":"25","author":"Bhadada","year":"2011","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.ejps.2018.05.026_bb0040","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1756-8935-6-27","article-title":"Histone deacetylases 1 and 2 maintain S-phase chromatin and DNA replication fork progression","volume":"6","author":"Bhaskara","year":"2013","journal-title":"Epigenetics Chromatin"},{"issue":"3","key":"10.1016\/j.ejps.2018.05.026_bb0045","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/sj.bjc.6605780","article-title":"5-Fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency","volume":"103","author":"Bracht","year":"2010","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ejps.2018.05.026_bb0050","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1182\/blood-2006-03-014126","article-title":"Histone deacetylase inhibitors prevent exocytosis of interleukin-1beta-containing secretory lysosomes: role of microtubules","volume":"108","author":"Carta","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.ejps.2018.05.026_bb0055","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/bjc.2016.36","article-title":"Inhibition of histone deacetylases in cancer therapy: lessons from leukaemia","volume":"114","author":"Ceccacci","year":"2016","journal-title":"Brit. J. Cancer"},{"key":"10.1016\/j.ejps.2018.05.026_bb0060","doi-asserted-by":"crossref","first-page":"378","DOI":"10.2119\/molmed.2011.00021","article-title":"Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus","volume":"17","author":"Christensen","year":"2011","journal-title":"Mol. Med."},{"key":"10.1016\/j.ejps.2018.05.026_bb0065","first-page":"116","article-title":"Glycated hemoglobin, diabetes treatment and cancer risk in type 2 diabetes. A case-control study","volume":"20","author":"D\u0105browski","year":"2013","journal-title":"Ann. Agric. Environ. Med."},{"key":"10.1016\/j.ejps.2018.05.026_bb0070","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0887-8994(00)00133-8","article-title":"Weight gain associated with valproate in childhood","volume":"22","author":"Demir","year":"2000","journal-title":"Pediatr. Neurol."},{"issue":"11","key":"10.1016\/j.ejps.2018.05.026_bb0075","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1002\/jbt.21513","article-title":"Sodium valproate sensitizes non-small lung cancer A549 cells to \u03b3\u03b4 T-cell-mediated killing through upregulating the expression of MICA","volume":"27","author":"Du","year":"2013","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"4","key":"10.1016\/j.ejps.2018.05.026_bb0080","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1093\/clinchem\/47.4.624","article-title":"Carcinoembryonic antigen as a marker for colorectal cancer: is it clinically useful?","volume":"47","author":"Duffy","year":"2001","journal-title":"Clin. Chem."},{"key":"10.1016\/j.ejps.2018.05.026_bb0085","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1158\/1078-0432.CCR-05-1603","article-title":"The role of interleukin 1 in growth and metastasis of human cancer xenografts","volume":"12","author":"Elaraj","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ejps.2018.05.026_bb0090","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.canlet.2008.11.012","article-title":"Targeting tumor angiogenesis with histone deacetylase inhibitors","volume":"280","author":"Ellis","year":"2009","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ejps.2018.05.026_bb0095","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3109\/00365527209180756","article-title":"Alkaline phosphatase in colorectal cancer","volume":"7","author":"Fabricius-Bjerre","year":"1972","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.ejps.2018.05.026_bb0100","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.seizure.2012.06.001","article-title":"Metabolic syndrome among Chinese obese patients with epilepsy on sodium valproate","volume":"21","author":"Fang","year":"2012","journal-title":"Seizure"},{"key":"10.1016\/j.ejps.2018.05.026_bb0105","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1463-1318.2012.03097.x","article-title":"Secondary diabetes associated with 5-fluorouracil-based chemotherapy regimens in non-diabetic patients with colorectal cancer: results from a single-centre cohort study","volume":"15","author":"Feng","year":"2013","journal-title":"Color. Dis."},{"key":"10.1016\/j.ejps.2018.05.026_bb0110","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1179\/joc.2006.18.4.415","article-title":"Synergistic effects of valproic acid and mitomycin C in adenocarcinoma cell lines and fresh tumor cells of patients with colon cancer","volume":"18","author":"Friedmann","year":"2006","journal-title":"J. Chemother."},{"key":"10.1016\/j.ejps.2018.05.026_bb0115","first-page":"6565","article-title":"Sodium valproate, a histone deacetylase inhibitor, enhances the efficacy of vinorelbine-cisplatin-based chemoradiation in non-small cell lung cancer cells","volume":"34","author":"Gavrilov","year":"2014","journal-title":"Anticancer Res."},{"key":"10.1016\/j.ejps.2018.05.026_bb0120","first-page":"4287","article-title":"Expression analysis of a subset of coregulators and three nuclear receptors in human colorectal carcinoma","volume":"25","author":"Giannini","year":"2005","journal-title":"Anticancer Res."},{"key":"10.1016\/j.ejps.2018.05.026_bb0125","doi-asserted-by":"crossref","first-page":"444","DOI":"10.3748\/wjg.v17.i4.444","article-title":"Is diabetes a causal agent for colorectal cancer? Pathophysiological and molecular mechanisms","volume":"17","author":"Giouleme","year":"2011","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.ejps.2018.05.026_bb0130","doi-asserted-by":"crossref","first-page":"3109s","DOI":"10.1093\/jn\/131.11.3109S","article-title":"Insulin, insulin-like growth factors and colon cancer: a review of the evidence","volume":"131","author":"Giovannucci","year":"2001","journal-title":"J. Nutr."},{"key":"10.1016\/j.ejps.2018.05.026_bb0135","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.2337\/dc10-0666","article-title":"Diabetes and cancer: a consensus report","volume":"33","author":"Giovannucci","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ejps.2018.05.026_bb0140","doi-asserted-by":"crossref","first-page":"5420","DOI":"10.1038\/sj.onc.1210610","article-title":"Histone deactylases and cancer","volume":"26","author":"Glozak","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.ejps.2018.05.026_bb0145","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1177\/0960327112450885","article-title":"Diabetic cardiomyopathy: pathophysiological mechanisms and cardiac dysfunction","volume":"32","author":"Goyal","year":"2013","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.ejps.2018.05.026_bb0150","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s11010-008-9772-y","article-title":"Effect of telmisartan on cardiovascular complications associated with STZ-diabetic rats","volume":"314","author":"Goyal","year":"2008","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.ejps.2018.05.026_bb0155","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1097\/FJC.0b013e3181be75cc","article-title":"Investigation into the cardiac effects of spironolactone in the experimental model of type 1 diabetes","volume":"54","author":"Goyal","year":"2009","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.ejps.2018.05.026_bb0160","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/S1734-1140(11)70611-9","article-title":"Beneficial role of telmisartan on cardiovascular complications associated with STZ-induced type-2 diabetic rats","volume":"63","author":"Goyal","year":"2011","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.ejps.2018.05.026_bb0165","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000497705","article-title":"Comparative evaluation of spironolactone, atenolol, metoprolol, ramipril and perindopril on diabetes induced cardiovascular complications in type 1 diabetes in rats","volume":"19","author":"Goyal","year":"2011","journal-title":"Int. J. Diab. Metab."},{"key":"10.1016\/j.ejps.2018.05.026_bb0170","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.7314\/APJCP.2012.13.9.4393","article-title":"Amelioration of 1,2 dimethylhydrazine (DMH) induced colon oxidative stress, inflammation and tumor promotion response by tannic acid in Wistar rats","volume":"13","author":"Hamiza","year":"2012","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.ejps.2018.05.026_bb0175","author":"International Diabetes Federation"},{"issue":"10","key":"10.1016\/j.ejps.2018.05.026_bb0180","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.2337\/dc11-1447","article-title":"Metformin and colorectal cancer risk in diabetic patients","volume":"34","author":"Ioannou","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ejps.2018.05.026_bb0185","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.surg.2011.07.001","article-title":"Histone deacetylase inhibitors enhance endothelial cell sprouting angiogenesis in vitro","volume":"150","author":"Jin","year":"2011","journal-title":"Surgery"},{"issue":"23","key":"10.1016\/j.ejps.2018.05.026_bb0190","article-title":"Acetylation of insulin receptor substrate-1 is permissive for tyrosine phosphorylation","volume":"2","author":"Kaiser","year":"2004","journal-title":"BMC Biol."},{"key":"10.1016\/j.ejps.2018.05.026_bb0195","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.taap.2006.01.001","article-title":"Effect of dietary caraway (Carum carvi L.) on aberrant crypt foci development, fecal steroids, and intestinal alkaline phosphatase activities in 1,2-dimethylhydrazine-induced colon carcinogenesis","volume":"214","author":"Kamaleeswari","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ejps.2018.05.026_bb0200","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1002\/jbt.21807","article-title":"Valproic acid improves glucose homeostasis by increasing beta-cell proliferation, function, and reducing its apoptosis through HDAC inhibition in juvenile diabetic rat","volume":"30","author":"Khan","year":"2016","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.ejps.2018.05.026_bb0205","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.biochi.2016.02.014","article-title":"Valproic acid reduces insulin-resistance, fat deposition and FOXO1-mediated gluconeogenesis in type-2 diabetic rat","volume":"125","author":"Khan","year":"2016","journal-title":"Biochimie"},{"key":"10.1016\/j.ejps.2018.05.026_bb0210","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1093\/emboj\/cdg315","article-title":"The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2","volume":"22","author":"Kraemer","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.ejps.2018.05.026_bb0215","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1007\/s00125-006-0562-3","article-title":"Inhibition of histone deacetylases prevents cytokine-induced toxicity in beta cells","volume":"50","author":"Larsen","year":"2007","journal-title":"Diabetologia"},{"issue":"2","key":"10.1016\/j.ejps.2018.05.026_bb0220","doi-asserted-by":"crossref","first-page":"139","DOI":"10.12717\/DR.2017.21.2.139","article-title":"Metformin synergistically potentiates the antitumor effects of imatinib in colorectal cancer cells","volume":"21","author":"Lee","year":"2017","journal-title":"Dev. Reprod. Biol."},{"key":"10.1016\/j.ejps.2018.05.026_bb0225","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1073\/pnas.052702999","article-title":"The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines","volume":"99","author":"Leoni","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejps.2018.05.026_bb0230","doi-asserted-by":"crossref","first-page":"369","DOI":"10.2119\/molmed.2010.00152","article-title":"The oral histone deacetylase inhibitor ITF2357 reduces cytokines and protects islet \u03b2 cells in vivo and in vitro","volume":"17","author":"Lewis","year":"2011","journal-title":"Mol. Med."},{"issue":"1","key":"10.1016\/j.ejps.2018.05.026_bb0235","doi-asserted-by":"crossref","first-page":"77","DOI":"10.4238\/2012.January.13.1","article-title":"Sodium valproate inhibits MDA-MB-231 breast cancer cell migration by upregulating NM23H1 expression","volume":"11","author":"Li","year":"2012","journal-title":"Genet. Mol. Res."},{"issue":"13","key":"10.1016\/j.ejps.2018.05.026_bb0240","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.3748\/wjg.v13.i13.1947","article-title":"Celecoxib attenuates 5-fluorouracil-induced apoptosis in HCT-15 and HT-29 human colon cancer cells","volume":"13","author":"Lim","year":"2007","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.ejps.2018.05.026_bb0245","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0920-1211(03)00091-3","article-title":"Valproic acid modulates islet cell insulin secretion: a possible mechanism of weight gain in epilepsy patients","volume":"55","author":"Luef","year":"2003","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.ejps.2018.05.026_bb0250","doi-asserted-by":"crossref","first-page":"5063239","DOI":"10.1155\/2017\/5063239","article-title":"Metformin improves overall survival of colorectal cancer patients with diabetes: a meta-analysis","volume":"2017","author":"Meng","year":"2017","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.ejps.2018.05.026_bb0255","doi-asserted-by":"crossref","first-page":"20974","DOI":"10.1074\/jbc.M202504200","article-title":"Proliferating cell nuclear antigen associates with histone deacetylase activity, integrating DNA replication and chromatin modification","volume":"277","author":"Milutinovic","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejps.2018.05.026_bb0260","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.seizure.2016.03.002","article-title":"Metabolic syndrome in young adults with epilepsy","volume":"37","author":"Nair","year":"2016","journal-title":"Seizure"},{"key":"10.1016\/j.ejps.2018.05.026_bb0265","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1038\/nprot.2006.339","article-title":"Clonogenic assay of cells in vitro","volume":"1","author":"Nicolaas","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ejps.2018.05.026_bb0500","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s10350-007-9083-5","article-title":"The comparison of the risk factors and clinical manifestations of proximal and distal colorectal cancer","volume":"51","author":"Oh","year":"2008","journal-title":"Dis. Colon Rectum"},{"key":"10.1016\/j.ejps.2018.05.026_bb0270","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12012-017-9406-2","article-title":"Sodium butyrate controls cardiac hypertrophy in experimental models of rats","volume":"181","author":"Patel","year":"2018","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.ejps.2018.05.026_bb0275","doi-asserted-by":"crossref","first-page":"340","DOI":"10.3109\/10641963.2013.827699","article-title":"Type 2 diabetes induced cardiovascular complications: comparative evaluation of spironolactone, atenolol, metoprolol, ramipril and perindopril","volume":"36","author":"Patel","year":"2014","journal-title":"Clin. Exp. Hypertens."},{"key":"10.1016\/j.ejps.2018.05.026_bb0280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2012.09.034","article-title":"Aldosterone and angiotensin: role in diabetes and cardiovascular diseases","volume":"697","author":"Patel","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejps.2018.05.026_bb0285","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1177\/1479164113485250","article-title":"The choice of anti-hypertensive agents in diabetic subjects","volume":"10","author":"Patel","year":"2013","journal-title":"Diab. Vasc. Dis. Res."},{"key":"10.1016\/j.ejps.2018.05.026_bb0290","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.lfs.2016.11.033","article-title":"TNF-\u03b1 and cancer cachexia: molecular insights and clinical implications","volume":"170","author":"Patel","year":"2017","journal-title":"Life Sci."},{"issue":"2016","key":"10.1016\/j.ejps.2018.05.026_bb0510","first-page":"733","article-title":"Secoisolariciresinol diglucoside rich extract of L. usitatissimum prevents diabetic colon cancer through inhibition of CDK4","volume":"83","author":"Patel","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejps.2018.05.026_bb0295","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1177\/0960327112446817","article-title":"Perindopril protects against streptozotocin induced hyperglycemic myocardial damage\/alterations","volume":"31","author":"Patel","year":"2012","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.ejps.2018.05.026_bb0300","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1055\/s-0033-1345168","article-title":"Effect of spironolactone on cardiovascular complications associated with type-2 diabetes in rats","volume":"121","author":"Patel","year":"2013","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.ejps.2018.05.026_bb0305","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ejphar.2014.01.063","article-title":"Cardioprotective effects of magnesium valproate in type 2 diabetes mellitus","volume":"728","author":"Patel","year":"2014","journal-title":"Eur. J. Pharmacol."},{"issue":"38","key":"10.1016\/j.ejps.2018.05.026_bb0310","doi-asserted-by":"crossref","first-page":"495","DOI":"10.2337\/dc14-1175","article-title":"The risk of colorectal cancer in patients with type 2 diabetes: associations with treatment stage and obesity","volume":"2015","author":"Peeters","year":"2015","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ejps.2018.05.026_bb0315","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1111\/j.1528-1167.2006.00546.x","article-title":"Characterization of insulin secre-tion in valproate-treated patients with epilepsy","volume":"47","author":"Pylvanen","year":"2006","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejps.2018.05.026_bb0320","doi-asserted-by":"crossref","first-page":"268","DOI":"10.4103\/1319-3767.98435","article-title":"Immunohistochemical expression of PCNA and CD34 in colorectal adenomas and carcinomas using specified automated cellular image analysis system: a clinicopathologic study","volume":"18","author":"Qasim","year":"2012","journal-title":"Saudi J. Gastroenterol."},{"key":"10.1016\/j.ejps.2018.05.026_bb0325","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.biopha.2017.10.137","article-title":"Magnesium valproate ameliorates type 1 diabetes and cardiomyopathy in diabetic rats through estrogen receptors","volume":"97","author":"Rabadiya","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.ejps.2018.05.026_bb0330","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/948427","article-title":"Evaluation of buspirone on streptozotocin induced Type 1 Diabetes and its associated complications","volume":"2014","author":"Raghunathan","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.ejps.2018.05.026_bb0335","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1139\/cjpp-2016-0542","article-title":"Selective inhibition of HDAC2 by magnesium valproate attenuates cardiac hypertrophy","volume":"95","author":"Raghunathan","year":"2017","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.ejps.2018.05.026_bb0340","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2017.00147","article-title":"Does valproic acid have potential in the treatment of diabetes mellitus?","volume":"8","author":"Rakitin","year":"2017","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.ejps.2018.05.026_bb0345","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0103856","article-title":"Comparison of the metabolic syndrome risk in valproate-treated patients with epilepsy and the general population in Estonia","volume":"9","author":"Rakitin","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ejps.2018.05.026_bb0350","doi-asserted-by":"crossref","first-page":"e172","DOI":"10.1111\/epi.13114","article-title":"Valproate modulates glucose metabolism in patients with epilepsy after first exposure","volume":"56","author":"Rakitin","year":"2015","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejps.2018.05.026_bb0355","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.seizure.2016.03.008","article-title":"Metabolic syndrome and anticonvulsants: a comparative study of valproic acid and carbamazepine","volume":"38","author":"Rakitin","year":"2016","journal-title":"Seizure"},{"issue":"2016","key":"10.1016\/j.ejps.2018.05.026_bb0360","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.biopha.2016.07.041","article-title":"Secoisolariciresinol diglucoside rich extract of L. usitatissimum prevents diabetic colon cancer through inhibition of CDK4","volume":"83","author":"Shah","year":"2016","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.ejps.2018.05.026_bb0365","doi-asserted-by":"crossref","first-page":"95","DOI":"10.4137\/BMI.S38440","article-title":"Significance of HbA1c test in diagnosis and prognosis of diabetic patients","volume":"11","author":"Sherwani","year":"2016","journal-title":"Biomark. Insights"},{"issue":"7","key":"10.1016\/j.ejps.2018.05.026_bb0370","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.seizure.2013.03.014","article-title":"Blood levels of cytokines in children with idiopathic partial and generalized epilepsy","volume":"22","author":"Sonmez","year":"2013","journal-title":"Seizure"},{"issue":"2","key":"10.1016\/j.ejps.2018.05.026_bb0375","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/mc.20373","article-title":"HDAC3 overexpression and colon cancer cell proliferation and differentiation","volume":"47","author":"Spurling","year":"2008","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.ejps.2018.05.026_bb0380","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.phrs.2005.05.004","article-title":"Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening","volume":"52","author":"Srinivasan","year":"2005","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejps.2018.05.026_bb0385","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1080\/13102818.2014.965047","article-title":"Colorectal cancer severity and survival in correlation with tumour necrosis factor-alpha","volume":"28","author":"Stanilov","year":"2014","journal-title":"Biotechnol. Biotechnol. Equip."},{"key":"10.1016\/j.ejps.2018.05.026_bb0390","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0064600","article-title":"HDAC up-regulation in early colon field carcinogenesis is involved in cell tumorigenicity through regulation of chromatin structure","volume":"8","author":"Stypula-Cyrus","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ejps.2018.05.026_bb0395","doi-asserted-by":"crossref","first-page":"661","DOI":"10.3892\/mmr.2015.4580","article-title":"Valproate attenuates diabetic nephropathy through inhibition of endoplasmic reticulum stress-in-duced apoptosis","volume":"13","author":"Sun","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ejps.2018.05.026_bb0400","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1271\/bbb.67.1499","article-title":"Stimulation of glucose uptake in muscle cells by prolonged treatment with scriptide, a histone deacetylase inhibitor","volume":"67","author":"Takigawa-Imamura","year":"2003","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.ejps.2018.05.026_bb0405","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.bbrc.2004.03.066","article-title":"Butyrate suppresses Cox-2 activation in colon cancer cells through HDAC inhibition","volume":"317","author":"Tong","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejps.2018.05.026_bb0410","first-page":"62","article-title":"Sodium valproate enhances doxorubicin cytotoxicity in breast cancer cells in vitro","volume":"35","author":"Tong","year":"2015","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"10.1016\/j.ejps.2018.05.026_bb0415","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s10238-001-8024-1","article-title":"Effect of anticonvulsant drugs on interleukins-1, -2 and -6 and monocyte-chemoattractant protein","volume":"1","author":"Verrotti","year":"2001","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.ejps.2018.05.026_bb0420","author":"WHO"},{"key":"10.1016\/j.ejps.2018.05.026_bb0425","doi-asserted-by":"crossref","first-page":"13548","DOI":"10.1074\/jbc.M510023200","article-title":"Histone deacetylase 3 (HDAC3) and other class I HDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer","volume":"281","author":"Wilson","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.ejps.2018.05.026_bb0430","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.bbrc.2015.05.078","article-title":"The novel HDAC inhibitor AR-42-induced anti-colon cancer cell activity is associated with ceramide production","volume":"463","author":"Xu","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"12","key":"10.1016\/j.ejps.2018.05.026_bb0435","doi-asserted-by":"crossref","first-page":"6429","DOI":"10.7314\/APJCP.2012.13.12.6429","article-title":"Effects of sodium valproate on the growth of human ovarian cancer cell line HO8910","volume":"13","author":"Yan","year":"2012","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.ejps.2018.05.026_bb0505","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S1542-3565(05)00152-7","article-title":"Type 2 diabetes mellitus and the risk of colorectal cancer","volume":"3","author":"Yang","year":"2005","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ejps.2018.05.026_bb0440","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1472-6750-4-21","article-title":"A high-throughput cell migration assay using scratch wound healing, a comparison of image-based readout methods","volume":"4","author":"Yarrow","year":"2004","journal-title":"BMC Biotechnol."},{"key":"10.1016\/j.ejps.2018.05.026_bb0445","doi-asserted-by":"crossref","first-page":"685","DOI":"10.2337\/db12-1354","article-title":"Improving insulin sensitivity with HDAC inhibitor","volume":"62","author":"Ye","year":"2013","journal-title":"Diabetes"},{"issue":"44","key":"10.1016\/j.ejps.2018.05.026_bb0450","doi-asserted-by":"crossref","first-page":"16090","DOI":"10.1073\/pnas.0505585102","article-title":"Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim","volume":"102","author":"Zhao","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejps.2018.05.026_bb0455","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.2174\/13816128113199990531","article-title":"Comprehensive analysis for histone acetylation of human colon cancer cells treated with a novel HDAC inhibitor","volume":"20","author":"Zhao","year":"2014","journal-title":"Curr. Pharm. Des."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098718302513?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098718302513?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T11:48:28Z","timestamp":1760528908000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098718302513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":94,"alternative-id":["S0928098718302513"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2018.05.026","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Repurposing of sodium valproate in colon cancer associated with diabetes mellitus: Role of HDAC inhibition","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2018.05.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}