{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:57:23Z","timestamp":1792195043915,"version":"4.4.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation","doi-asserted-by":"publisher","award":["81273382"],"award-info":[{"award-number":["81273382"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011320","name":"Jishou University","doi-asserted-by":"crossref","award":["JGY201655"],"award-info":[{"award-number":["JGY201655"]}],"id":[{"id":"10.13039\/501100011320","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100011320","name":"Jishou University","doi-asserted-by":"crossref","award":["Jdy17019"],"award-info":[{"award-number":["Jdy17019"]}],"id":[{"id":"10.13039\/501100011320","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.ejps.2018.05.029","type":"journal-article","created":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T23:48:40Z","timestamp":1527810520000},"page":"293-300","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Resolution and evaluation of 3-chlorophenyl-3-hydroxypropionylhydroxamic acid as antivirulence agent with excellent eradication efficacy in Helicobacter pylori infected mice"],"prefix":"10.1016","volume":"121","author":[{"given":"Qi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Wei","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai-Fu","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan-Dan","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Jun","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Peng","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Li","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu-Ping","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Liang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2018.05.029_bb0005","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1021\/jm301816a","article-title":"Atropisomeric dihydroanthracenones as inhibitors of multiresistant Staphylococcus aureus","volume":"56","author":"Bara","year":"2013","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejps.2018.05.029_bb0010","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1021\/ja00707a024","article-title":"Optical rotatory dispersion studies. CXVII. Absolute configurational assignments of some \u03b1-substituted phenylacetic acids by circular dichroism measurements","volume":"92","author":"Barth","year":"1970","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejps.2018.05.029_bb0015","doi-asserted-by":"crossref","first-page":"3372","DOI":"10.1021\/acs.jmedchem.7b00138","article-title":"Enantiospecific recognition at the A2B adenosine receptor by alkyl 2-cyanoimino-4-substituted-6-methyl-1,2,3,4-tetrahydropyrimi-dine-5-carboxylates","volume":"60","author":"Carbajales","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejps.2018.05.029_bb0020","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1021\/acs.biochem.5b00109","article-title":"Targets for combating the evolution of acquired antibiotic resistance","volume":"54","author":"Culyba","year":"2015","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejps.2018.05.029_bb0025","doi-asserted-by":"crossref","first-page":"3707","DOI":"10.1021\/jm401685f","article-title":"Haloemodin as novel antibacterial agent inhibiting DNA gyrase and bacterial topoisomerase I","volume":"57","author":"Duan","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejps.2018.05.029_bb0030","series-title":"Gaussian 03, Revision C.02 Program","author":"Frisch","year":"2004"},{"key":"10.1016\/j.ejps.2018.05.029_bb0035","doi-asserted-by":"crossref","first-page":"6427","DOI":"10.1021\/cr500483r","article-title":"QSAR studies on hydroxamic acids: a fascinating family of chemicals with a wide Spectrum of activities","volume":"115","author":"Gupta","year":"2015","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejps.2018.05.029_bb0040","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.ejps.2016.08.042","article-title":"Single-cell level methods for studying the effect of antibiotics on bacteria during infection","volume":"95","author":"Kogermann","year":"2016","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2018.05.029_bb0045","doi-asserted-by":"crossref","first-page":"8125","DOI":"10.1021\/acs.jmedchem.6b00986","article-title":"1,2-Benzisoselenazol-3(2H)-one derivatives as a new class of bacterial urease inhibitors","volume":"59","author":"Macegoniuk","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejps.2018.05.029_bb0050","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1021\/ci500562t","article-title":"Reduction of urease activity by interaction with the flap covering the active site","volume":"55","author":"Macomber","year":"2015","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.ejps.2018.05.029_bb0055","doi-asserted-by":"crossref","first-page":"4121","DOI":"10.1021\/acs.biochem.5b00078","article-title":"Effect of 10.5 M aqueous urea on Helicobacter pylori urease: a molecular dynamics study","volume":"54","author":"Minkara","year":"2015","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejps.2018.05.029_bb0060","doi-asserted-by":"crossref","first-page":"11098","DOI":"10.1021\/acs.jmedchem.6b01333","article-title":"Structure\u2212activity relationship for sulfonamide inhibition of Helicobacter pylori \u03b1-carbonic anhydrase","volume":"59","author":"Modak","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejps.2018.05.029_bb0065","doi-asserted-by":"crossref","first-page":"8903","DOI":"10.1021\/jm401407w","article-title":"Stereochemistry of the tadalafil diastereoisomers: a critical assessment of vibrational circular dichroism, electronic circular dichroism, and optical rotatory dispersion","volume":"56","author":"Qiu","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejps.2018.05.029_bb0070","doi-asserted-by":"crossref","DOI":"10.1021\/acs.jmedchem.7b00215","article-title":"Pharmaceutical approaches to target antibiotic resistance mechanisms","author":"Schillaci","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejps.2018.05.029_bb0075","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ejps.2016.04.022","article-title":"Development of microbial trigger based oral formulation of tinidazole and its gamma scintigraphy evaluation: a promising tool against anaerobic microbes associated GI problems","volume":"89","author":"Sharma","year":"2016","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2018.05.029_bb0080","doi-asserted-by":"crossref","first-page":"4519","DOI":"10.1016\/j.bmc.2016.07.052","article-title":"3-Arylpropionylhydroxamic acid derivatives as Helicobacter pylori urease inhibitors: synthesis, molecular docking and biological evaluation","volume":"24","author":"Shi","year":"2016","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejps.2018.05.029_bb0085","doi-asserted-by":"crossref","first-page":"9162","DOI":"10.1021\/acs.chemrev.6b00184","article-title":"Plant natural products targeting bacterial virulence factors","volume":"116","author":"Silva","year":"2016","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejps.2018.05.029_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2017.02.004","article-title":"Epiberberine, a natural protoberberine alkaloid, inhibits urease of Helicobacter pylori and jack bean: susceptibility and mechanism","volume":"110","author":"Tan","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2018.05.029_bb0095","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1021\/cr030100y","article-title":"Introduction: antibiotic resistance","volume":"105","author":"Walsh","year":"2005","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejps.2018.05.029_bb0100","doi-asserted-by":"crossref","first-page":"4860","DOI":"10.1016\/j.bmc.2015.05.026","article-title":"Synthesis, molecular docking and biological evaluation of 3-Arylfuran-2(5H)-ones as anti-gastric ulcer agent","volume":"23","author":"Wang","year":"2015","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejps.2018.05.029_bb0105","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1021\/ac60252a045","article-title":"Linear regression analysis of the released ammonia, determined by conversion to indophenol","volume":"39","author":"Weatherburn","year":"1967","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ejps.2018.05.029_bb0110","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1021\/id500052s","article-title":"Solving the antibiotic crisis","volume":"1","author":"Wright","year":"2015","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.ejps.2018.05.029_bb0115","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ejmech.2013.07.047","article-title":"Synthesis, molecular docking and kinetic properties of \u03b2-hydroxy-\u03b2-phenylpropionylhydroxamic acids as Helicobacter pylori urease inhibitors","volume":"68","author":"Xiao","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejps.2018.05.029_bb0120","doi-asserted-by":"crossref","first-page":"4508","DOI":"10.1016\/j.bmc.2015.06.014","article-title":"Synthesis and evaluation of N-analogues of 1,2-diarylethane as Helicobacter pylori urease inhibitors","volume":"23","author":"Xiao","year":"2015","journal-title":"Bioorg. Med. Chem."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098718302549?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098718302549?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T11:49:57Z","timestamp":1760528997000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098718302549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":24,"alternative-id":["S0928098718302549"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2018.05.029","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Resolution and evaluation of 3-chlorophenyl-3-hydroxypropionylhydroxamic acid as antivirulence agent with excellent eradication efficacy in Helicobacter pylori infected mice","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2018.05.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}