{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T03:05:15Z","timestamp":1761102315569,"version":"3.37.3"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100009879","name":"Regione Emilia-Romagna","doi-asserted-by":"publisher","award":["2007-2013"],"award-info":[{"award-number":["2007-2013"]}],"id":[{"id":"10.13039\/501100009879","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.ejps.2018.07.035","type":"journal-article","created":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T08:20:20Z","timestamp":1531902020000},"page":"89-97","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Combined hyaluronate-based films loaded with pemetrexed and cisplatin for the treatment of malignant pleural mesothelioma: Preliminary evaluation in an orthotopic tumor recurrence model"],"prefix":"10.1016","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7372-1456","authenticated-orcid":false,"given":"Fabio","family":"Sonvico","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Barbieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Colombo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Barocelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Mucchino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Maria","family":"Cantoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pier Giorgio","family":"Petronini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Rusca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Carbognani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Ampollini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2018.07.035_bb0005","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.ejcts.2008.11.030","article-title":"Immuno-chemotherapy reduces recurrence of malignant pleural mesothelioma: an experimental setting","volume":"35","author":"Ampollini","year":"2009","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"10.1016\/j.ejps.2018.07.035_bb0010","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.ejcts.2009.08.012","article-title":"Intrapleural polymeric films containing cisplatin for malignant pleural mesothelioma in a rat tumour model: a preliminary study","volume":"37","author":"Ampollini","year":"2010","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"10.1016\/j.ejps.2018.07.035_bb0015","doi-asserted-by":"crossref","first-page":"S207","DOI":"10.21037\/jtd.2017.10.74","article-title":"Polymeric films loaded with cisplatin for malignant pleural mesothelioma: a pharmacokinetic study in an ovine model","volume":"10","author":"Ampollini","year":"2018","journal-title":"J. Thorac. Dis."},{"key":"10.1016\/j.ejps.2018.07.035_bb0020","doi-asserted-by":"crossref","first-page":"v31","DOI":"10.1093\/annonc\/mdv199","article-title":"Malignant pleural mesothelioma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up","volume":"26","author":"Baas","year":"2015","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.ejps.2018.07.035_bb0025","doi-asserted-by":"crossref","first-page":"S293","DOI":"10.21037\/jtd.2017.10.165","article-title":"The role of intracavitary therapies in the treatment of malignant pleural mesothelioma","volume":"10","author":"Bertoglio","year":"2018","journal-title":"J. Thorac. Dis."},{"key":"10.1016\/j.ejps.2018.07.035_bb0030","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1002\/jps.22016","article-title":"Pharmacokinetics and disposition of a localized lymphatic polymeric hyaluronan conjugate of cisplatin in rodents","volume":"99","author":"Cai","year":"2010","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2018.07.035_bb0035","doi-asserted-by":"crossref","first-page":"285","DOI":"10.21037\/tlcr.2017.05.04","article-title":"Intraoperative adjuncts for malignant pleural mesothelioma","volume":"6","author":"Chan","year":"2017","journal-title":"Transl. Lung Cancer. Res."},{"key":"10.1016\/j.ejps.2018.07.035_bb0040","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.actbio.2013.12.019","article-title":"Hyaluronan: a simple polysaccharide with diverse biological functions","volume":"10","author":"Dicker","year":"2014","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ejps.2018.07.035_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtcvs.2007.10.054","article-title":"Extrapleural pneumonectomy versus pleurectomy\/decortication in the surgical management of malignant pleural mesothelioma: results in 663 patients","volume":"135","author":"Flores","year":"2008","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.ejps.2018.07.035_bb0050","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.3109\/10717544.2015.1114047","article-title":"Loco-regional administration of nanomedicines for the treatment of lung cancer","volume":"23","author":"Garrastazu Pereira","year":"2016","journal-title":"Drug Deliv."},{"key":"10.1016\/j.ejps.2018.07.035_bb0055","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1038\/nrd1731","article-title":"Pemetrexed disodium","volume":"4","author":"Gibbs","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejps.2018.07.035_bb0060","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0939-6411(01)00174-6","article-title":"Eudragits: role as crystallization inhibitors in drug-in-adhesive transdermal systems of estradiol","volume":"52","author":"Kotiyan","year":"2001","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejps.2018.07.035_bb0065","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0939-6411(03)00042-0","article-title":"Crystallisation of estradiol containing TDDS determined by isothermal microcalorimetry, X-ray diffraction, and optical microscopy","volume":"56","author":"Latsch","year":"2003","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejps.2018.07.035_bb0070","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1517\/14656566.2013.813934","article-title":"Cisplatin: an old drug with a newfound efficacy \u2013 from mechanisms of action to cytotoxicity","volume":"14","author":"Macci\u00f2","year":"2013","journal-title":"Expert. Opin. Pharmacother."},{"key":"10.1016\/j.ejps.2018.07.035_bb0075","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/00001813-199304000-00006","article-title":"Antitumor activity of a new series of platinum complexes: trans(+\/\u2212)-1,2-cyclohexanediammineplatinum(II) conjugated to acid polysaccharides","volume":"4","author":"Maeda","year":"1993","journal-title":"Anti-Cancer Drugs"},{"key":"10.1016\/j.ejps.2018.07.035_bb0080","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.lungcan.2007.12.022","article-title":"Local recurrence of tumor at sites of intervention in malignant pleural mesothelioma","volume":"61","author":"Metintas","year":"2008","journal-title":"Lung Cancer"},{"key":"10.1016\/j.ejps.2018.07.035_bb0085","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.ejcts.2007.01.047","article-title":"Local recurrence model of malignant pleural mesothelioma for investigation of intrapleural treatment","volume":"31","author":"Opitz","year":"2007","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"10.1016\/j.ejps.2018.07.035_bb0090","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.ijbiomac.2014.03.033","article-title":"Effect of plasticizer on drug crystallinity of hydroxypropyl methylcellulose matrix film","volume":"67","author":"Panda","year":"2014","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejps.2018.07.035_bb0095","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ejps.2016.01.002","article-title":"Hyaluronate nanoparticles included in polymer films for the prolonged release of vitamin E for the management of skin wounds","volume":"83","author":"Pereira","year":"2016","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2018.07.035_bb0100","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1183\/09059180.00007014","article-title":"Malignant pleural mesothelioma: history, controversy and future of a manmade epidemic","volume":"24","author":"R\u00f8e","year":"2015","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.ejps.2018.07.035_bb0105","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.clinthera.2005.09.010","article-title":"Pemetrexed: a multitargeted antifolate","volume":"27","author":"Rollins","year":"2005","journal-title":"Clin. Ther."},{"key":"10.1016\/j.ejps.2018.07.035_bb0110","doi-asserted-by":"crossref","first-page":"S194","DOI":"10.21037\/jtd.2017.10.12","article-title":"Physicochemical and pharmacokinetic properties of polymeric films loaded with cisplatin for the treatment of malignant pleural mesothelioma","volume":"10","author":"Sonvico","year":"2018","journal-title":"J. Thorac. Dis."},{"key":"10.1016\/j.ejps.2018.07.035_bb0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cllc.2015.07.002","article-title":"Pemetrexed with platinum combination as a backbone for targeted therapy in non-small-cell lung cancer","volume":"17","author":"Stinchcombe","year":"2016","journal-title":"Clin. Lung Cancer"},{"key":"10.1016\/j.ejps.2018.07.035_bb0120","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1183\/09031936.00207213","article-title":"Multimodal management of malignant pleural mesothelioma: where are we today?","volume":"44","author":"Van Schil","year":"2014","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.ejps.2018.07.035_bb0125","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1200\/JCO.2003.11.136","article-title":"Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma","volume":"21","author":"Vogelzang","year":"2003","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ejps.2018.07.035_bb0130","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ejpb.2015.04.031","article-title":"Physicochemical properties of tadalafil solid dispersions - impact of polymer on the apparent solubility and dissolution rate of tadalafil","volume":"94","author":"Wlodarski","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejps.2018.07.035_bb0135","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ijpharm.2016.06.131","article-title":"Ethyl oleate-containing nanostructured lipid carriers improve oral bioavailability of trans-ferulic acid as compared with conventional solid lipid nanoparticles","volume":"511","author":"Zhang","year":"2016","journal-title":"Int. J. Pharm."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098718303336?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098718303336?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T08:10:40Z","timestamp":1536048640000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098718303336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":27,"alternative-id":["S0928098718303336"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2018.07.035","relation":{},"ISSN":["0928-0987"],"issn-type":[{"type":"print","value":"0928-0987"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combined hyaluronate-based films loaded with pemetrexed and cisplatin for the treatment of malignant pleural mesothelioma: Preliminary evaluation in an orthotopic tumor recurrence model","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2018.07.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}