{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T14:24:18Z","timestamp":1775744658518,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006637","name":"UCL School of Pharmacy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006637","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.ejps.2018.07.049","type":"journal-article","created":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T03:32:53Z","timestamp":1532403173000},"page":"217-227","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Two strategies to enhance ungual drug permeation from UV-cured films: Incomplete polymerisation to increase drug release and incorporation of chemical enhancers"],"prefix":"10.1016","volume":"123","author":[{"given":"Laxmi Valji","family":"Kerai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep","family":"Bard\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Hilton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0834-7757","authenticated-orcid":false,"given":"Sudaxshina","family":"Murdan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2018.07.049_bb0005","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1007\/s12272-013-0191-6","article-title":"Effect of pressure sensitive adhesive and vehicles on permeation of terbinafine across porcine hoof membrane","volume":"36","author":"Ahn","year":"2013","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.ejps.2018.07.049_bb0010","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1159\/000073086","article-title":"Treatment failures and relapses in onychomycosis: a stubborn clinical problem","volume":"207","author":"Arrese","year":"2003","journal-title":"Dermatology"},{"key":"10.1016\/j.ejps.2018.07.049_bb0015","doi-asserted-by":"crossref","first-page":"773","DOI":"10.4155\/tde.15.26","article-title":"A pharmaceutics perspective on drug delivery to the nail: recent advances and challenges","volume":"6","author":"Delgado-Charro","year":"2015","journal-title":"Ther. Deliv."},{"key":"10.1016\/j.ejps.2018.07.049_bb0020","series-title":"Cosmetic Dermatology: Products and Procedures","author":"Draelos","year":"2010"},{"key":"10.1016\/j.ejps.2018.07.049_bb0025","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jconrel.2014.11.017","article-title":"Development of topical therapeutics for management of onychomycosis and other nail disorders: a pharmaceutical perspective","volume":"199","author":"Elsayed","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejps.2018.07.049_bb0030","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.ejps.2007.07.009","article-title":"Effect of hydration on the permeation of ketoconazole through human nail plate in vitro","volume":"32","author":"Gunt","year":"2007","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2018.07.049_bb0035","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0109-5641(02)00062-3","article-title":"The effect of filler and silane content on conversion of resin-based composite","volume":"19","author":"Halvorson","year":"2003","journal-title":"Dent. Mater."},{"key":"10.1016\/j.ejps.2018.07.049_bb0040","series-title":"The Rational Design of an Antifungal Nail Lacquer Using the Hansen Solubility Parameter Concept","author":"Hossin","year":"2015"},{"key":"10.1016\/j.ejps.2018.07.049_bb0045","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ejpb.2016.02.009","article-title":"Application of Hansen solubility parameters to predict drug-nail interactions, which can assist the design of nail medicines","volume":"102","author":"Hossin","year":"2016","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejps.2018.07.049_bb0050","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1002\/anie.200903924","article-title":"Thiol-ene click chemistry","volume":"49","author":"Hoyle","year":"2010","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.ejps.2018.07.049_bb0055","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ijpharm.2015.07.020","article-title":"UV-curable gel formulations: potential drug carriers for the topical treatment of nail diseases","volume":"492","author":"Kerai","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2018.07.049_bb0060","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.ijpharm.2016.08.025","article-title":"UV-curable gels as topical nail medicines: in vivo residence, anti-fungal efficacy and influence of gel components on their properties","volume":"514","author":"Kerai","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2018.07.049_bb0065","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.3109\/03639045.2015.1033426","article-title":"Emerging therapies for the treatment of ungual onychomycosis","volume":"41","author":"Kushwaha","year":"2015","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.ejps.2018.07.049_bb0070","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1021\/cr3005197","article-title":"Strategies to reduce oxygen inhibition in photoinduced polymerization","volume":"114","author":"Ligon","year":"2014","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejps.2018.07.049_bb0075","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/myc.12072","article-title":"Quality of life in patients with toenail onychomycosis","volume":"56","author":"Milobratovic","year":"2013","journal-title":"Mycoses"},{"key":"10.1016\/j.ejps.2018.07.049_bb0080","series-title":"Topical Nail Products and Ungual Drug Delivery","first-page":"1","article-title":"The nail: anatomy, physiology, diseases, and treatment","author":"Murdan","year":"2012"},{"key":"10.1016\/j.ejps.2018.07.049_bb0085","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.ijpharm.2016.05.022","article-title":"Nail disorders in older people, and aspects of their pharmaceutical treatment","volume":"512","author":"Murdan","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2018.07.049_bb0090","doi-asserted-by":"crossref","first-page":"407","DOI":"10.2174\/156720110793566308","article-title":"Effect of polyethylene glycols on the trans-ungual delivery of terbinafine","volume":"7","author":"Nair","year":"2010","journal-title":"Curr. Drug Deliv."},{"key":"10.1016\/j.ejps.2018.07.049_bb0095","series-title":"Principles of Polymerisation","author":"Odian","year":"1991"},{"key":"10.1016\/j.ejps.2018.07.049_bb0100","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1468-3083.2009.03344.x","article-title":"Development and validation of nail psoriasis quality of life scale (NPQ10)","volume":"24","author":"Ortonne","year":"2010","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.ejps.2018.07.049_bb0105","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s13346-016-0287-x","article-title":"Formulation development and optimization of transungual drug delivery system of terbinafine hydrochloride for the treatment of onychomycosis","volume":"6","author":"Patel","year":"2016","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.ejps.2018.07.049_bb0110","series-title":"Radiation Curing in Polymer Science and Technology","first-page":"329","article-title":"Experimental and analytical methods for the investigation of radiation curing","author":"Rabek","year":"1993"},{"key":"10.1016\/j.ejps.2018.07.049_bb0115","series-title":"An Atlas of Diseases of the Nail","author":"Rich","year":"2003"},{"key":"10.1016\/j.ejps.2018.07.049_bb0120","doi-asserted-by":"crossref","first-page":"769","DOI":"10.3109\/1061186X.2014.929138","article-title":"Insights into drug delivery across the nail plate barrier","volume":"22","author":"Saner","year":"2014","journal-title":"J. Drug Target."},{"key":"10.1016\/j.ejps.2018.07.049_bb0125","series-title":"Nail Structure and Product Chemistry","author":"Schoon","year":"2005"},{"key":"10.1016\/j.ejps.2018.07.049_bb0130","series-title":"UV Coatings: Basics, Recent Developments and New Applications","first-page":"95","article-title":"Raw materials","author":"Schwalm","year":"2007"},{"key":"10.1016\/j.ejps.2018.07.049_bb0135","series-title":"The Story of the Modern Manicure","article-title":"Nails","author":"Shapiro","year":"2014"},{"key":"10.1016\/j.ejps.2018.07.049_bb0140","doi-asserted-by":"crossref","first-page":"901","DOI":"10.3109\/03639045.2011.637931","article-title":"Ungual and Transungual drug delivery","volume":"38","author":"Shivakumar","year":"2012","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.ejps.2018.07.049_bb0145","doi-asserted-by":"crossref","first-page":"3797","DOI":"10.1128\/AAC.46.12.3797-3801.2002","article-title":"Therapeutic efficacy of topically applied KP-103 against experimental tinea unguium in guinea pigs in comparison with amorolfine and terbinafine","volume":"46","author":"Tatsumi","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejps.2018.07.049_bb0150","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/j.1365-2710.2009.01107.x","article-title":"Toenail onychomycosis: an important global disease burden","volume":"35","author":"Thomas","year":"2010","journal-title":"J. Clin. Pharm. Ther."},{"key":"10.1016\/j.ejps.2018.07.049_bb0155","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1467-2494.1983.tb00348.x","article-title":"Permeability characteristics of the human nail plate","volume":"5","author":"Walters","year":"1983","journal-title":"Int. J. Cosmet. Sci."},{"key":"10.1016\/j.ejps.2018.07.049_bb0160","series-title":"Transdermal and Topical Drug Delivery","author":"Williams","year":"2003"}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098718303476?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098718303476?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T23:41:31Z","timestamp":1717285291000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098718303476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":32,"alternative-id":["S0928098718303476"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2018.07.049","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Two strategies to enhance ungual drug permeation from UV-cured films: Incomplete polymerisation to increase drug release and incorporation of chemical enhancers","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2018.07.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}