{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T19:31:10Z","timestamp":1784921470253,"version":"3.55.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001839","name":"University Grants Committee","doi-asserted-by":"publisher","award":["No.F.18-1\/2011(BSR)"],"award-info":[{"award-number":["No.F.18-1\/2011(BSR)"]}],"id":[{"id":"10.13039\/501100001839","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004151","name":"Maharaja Sayajirao University of Baroda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001427","name":"All India Council for Technical Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001427","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.ejps.2018.09.009","type":"journal-article","created":{"date-parts":[[2018,9,13]],"date-time":"2018-09-13T08:31:48Z","timestamp":1536827508000},"page":"11-22","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Drug-fortified liposomes as carriers for sustained release of NSAIDs: The concept and its validation in the animal model for the treatment of arthritis"],"prefix":"10.1016","volume":"125","author":[{"given":"Vijay A.","family":"Pawar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arehalli S.","family":"Manjappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant R.","family":"Murumkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tejal K.","family":"Gajaria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjisinh V.","family":"Devkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil K.","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mange Ram","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2018.09.009_bb0005","first-page":"34","article-title":"Synthesis of 2\u2011acetyl\u20116\u2011methoxynaphthalene","volume":"6","author":"Arsenijevic","year":"1998","journal-title":"Org. Synth."},{"key":"10.1016\/j.ejps.2018.09.009_bb0010","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/BF00541378","article-title":"Studies of pharmacokinetics and therapeutic effects of glucocorticoids entrapped in liposomes after intraarticular application in healthy rabbits and in rabbits with antigen-induced arthritis","volume":"7","author":"Bonanomi","year":"1987","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.ejps.2018.09.009_bb0015","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3109\/02652048709021812","article-title":"Fate of different kinds of liposomes containing dexamethasone palmitate after intra-articular injection into rabbit joints","volume":"4","author":"Bonanomi","year":"1987","journal-title":"J. Microencapsul."},{"issue":"3","key":"10.1016\/j.ejps.2018.09.009_bb0020","doi-asserted-by":"crossref","first-page":"R72","DOI":"10.1186\/ar2701","article-title":"Magnetically retainable microparticles for drug delivery to the joint: efficacy studies in an antigen-induced arthritis model in mice","volume":"11","author":"Butoescu","year":"2009","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.ejps.2018.09.009_bb0025","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1016\/j.biomaterials.2008.12.017","article-title":"Dexamethasone-containing PLGA superparamagnetic microparticles as carriers for the local treatment of arthritis","volume":"30","author":"Butoescu","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejps.2018.09.009_bb0030","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.ejpb.2009.06.009","article-title":"Intra-articular drug delivery systems for the treatment of rheumatic diseases: a review of the factors influencing their performance","volume":"73","author":"Butoescu","year":"2009","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejps.2018.09.009_bb0035","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0140-6736(58)92262-1","article-title":"Deleterious effect of intra-articular hydrocortisone","volume":"2","author":"Chandler","year":"1958","journal-title":"Lancet"},{"key":"10.1016\/j.ejps.2018.09.009_bb0040","doi-asserted-by":"crossref","first-page":"404","DOI":"10.2165\/00003088-199733060-00001","article-title":"Clinical pharmacokinetics of nabumetone. The dawn of selective cyclooxygenase-2 inhibition?","volume":"33","author":"Davies","year":"1997","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.ejps.2018.09.009_bb0045","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/S0140-6736(79)91951-2","article-title":"Liposomes in arthritis: a new approach","volume":"1","author":"De Silva","year":"1979","journal-title":"Lancet"},{"key":"10.1016\/j.ejps.2018.09.009_bb0050","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/01.bor.0000218944.89365.dd","article-title":"Crystal-induced arthropathies: recent investigative advances","volume":"18","author":"Ellman","year":"2006","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.ejps.2018.09.009_bb0055","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1023\/A:1018994712387","article-title":"Transsynovial drug distribution: synovial mean transit time of diclofenac and other nonsteroidal anti-inflammatory drugs","volume":"11","author":"Elmquist","year":"1994","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejps.2018.09.009_bb0060","article-title":"Impact of total knee replacement practice: cost effectiveness analysis of data from the osteoarthritis initiative","volume":"356","author":"Ferket","year":"2017","journal-title":"BMJ"},{"key":"10.1016\/j.ejps.2018.09.009_bb0065","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0022-1759(90)90187-Z","article-title":"MTT colorimetric assay for testing macrophage cytotoxic activity in vitro","volume":"131","author":"Ferrari","year":"1990","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.ejps.2018.09.009_bb0070","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2165\/00003495-199345010-00009","article-title":"Nabumetone: a reappraisal of its pharmacology and therapeutic use in rheumatic diseases","volume":"45","author":"Friedel","year":"1993","journal-title":"Drugs"},{"key":"10.1016\/j.ejps.2018.09.009_bb0075","series-title":"Vogel's Text Book of Practical Organic Chemistry","first-page":"987","author":"Furniss","year":"1996"},{"key":"10.1016\/j.ejps.2018.09.009_bb0080","first-page":"17","article-title":"Propranolol liposomes: formulation, characterization, and in vitro release","volume":"5","author":"Gamal","year":"2013","journal-title":"J. Optoelectron. Biomed. Mater."},{"key":"10.1016\/j.ejps.2018.09.009_bb0085","doi-asserted-by":"crossref","first-page":"242","DOI":"10.4172\/2167-7921.1000242","article-title":"Intra-articular injections for management of knee osteoarthritis","volume":"6","author":"Golding","year":"2017","journal-title":"J. Arthritis"},{"key":"10.1016\/j.ejps.2018.09.009_bb0090","doi-asserted-by":"crossref","first-page":"3779","DOI":"10.2147\/DDDT.S118145","article-title":"Increased localized delivery of piroxicam by cationic nanoparticles after intra-articular injection","volume":"10","author":"Kim","year":"2016","journal-title":"Drug Des. Devel. Ther."},{"issue":"11","key":"10.1016\/j.ejps.2018.09.009_bb0095","doi-asserted-by":"crossref","first-page":"4622","DOI":"10.1002\/jps.21346","article-title":"Intra-articular depot formulation principles: role in the management of postoperative pain and arthritic disorders","volume":"97","author":"Larsen","year":"2008","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2018.09.009_bb0100","doi-asserted-by":"crossref","first-page":"E641","DOI":"10.1208\/pt060480","article-title":"Liposomal dry powders as aerosols for pulmonary delivery of proteins","volume":"6","author":"Lu","year":"2005","journal-title":"AAPS Pharm. Sci. Tech."},{"key":"10.1016\/j.ejps.2018.09.009_bb0105","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ijpharm.2007.12.033","article-title":"Effect of sugars on storage stability of lyophilized liposome\/DNA complexes with high transfection efficiency","volume":"356","author":"Maitani","year":"2008","journal-title":"Int. J. Pharm."},{"issue":"19","key":"10.1016\/j.ejps.2018.09.009_bb0110","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1001\/jama.2017.5283","article-title":"Effect of intra-articular triamcinolone vs saline on knee cartilage volume and pain in patients with knee osteoarthritis: a randomized clinical trial","volume":"317","author":"McAlindon","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.ejps.2018.09.009_bb0115","doi-asserted-by":"crossref","first-page":"S1928","DOI":"10.1016\/j.arabjc.2014.10.017","article-title":"Technetium-labeled danofloxacin complex as a model for infection imaging","volume":"9","author":"Moustapha","year":"2016","journal-title":"Arab. J. Chem."},{"key":"10.1016\/j.ejps.2018.09.009_bb0120","series-title":"Preparation of Liposomes: A Practical Approach","first-page":"33","author":"New, R.R.C","year":"1990"},{"key":"10.1016\/j.ejps.2018.09.009_bb0125","doi-asserted-by":"crossref","first-page":"5235","DOI":"10.1021\/jm991120o","article-title":"New quaternary ammonium oxicam derivatives targeted toward cartilage: synthesis, pharmacokinetic studies, and anti-inflammatory potency","volume":"42","author":"Nicolas","year":"1999","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejps.2018.09.009_bb0130","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0021-5198(19)38076-X","article-title":"The mode of action of analgesic drugs in adjuvant arthritic rats as an experimental model of chronic inflammatory pain: possible central analgesic action of acidic nonsteroidal antiinflammatory drugs","volume":"35","author":"Okuyama","year":"1984","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.ejps.2018.09.009_bb0135","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1365-2125.1994.tb04365.x","article-title":"Disappearance kinetics of solutes from synovial fluid after intra-articular injection","volume":"38","author":"Owen","year":"1994","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejps.2018.09.009_bb0140","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ejps.2005.01.019","article-title":"Characterization of the rotating dialysis cell as an in vitro model potentially useful for simulation of the pharmacokinetic fate of intra-articularly administered drugs","volume":"25","author":"Pedersen","year":"2005","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2018.09.009_bb0150","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/acr.20014","article-title":"Total hip or knee replacement for osteoarthritis: mild and long term quality of life","volume":"62","author":"Rat","year":"2010","journal-title":"Arthritis Care Res."},{"key":"10.1016\/j.ejps.2018.09.009_bb0155","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jpha.2017.06.002","article-title":"Effect of nonionic surfactants in release media on accelerated in-vitro release profile of sirolimus eluting stents with biodegradable polymeric coating","volume":"8","author":"Raval","year":"2017","journal-title":"Chin. J. Pharm. Anal."},{"key":"10.1016\/j.ejps.2018.09.009_bb0160","series-title":"Physics and Radiobiology of Nuclear Medicine","first-page":"100","article-title":"Methods of radiolabeling","author":"Saha","year":"1993"},{"key":"10.1016\/j.ejps.2018.09.009_bb0165","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1042\/bj1580473","article-title":"Liposomal retention of a modified anti-inflammatory steroid","volume":"158","author":"Shaw","year":"1976","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejps.2018.09.009_bb0170","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1152\/jappl.1974.36.5.581","article-title":"Transsynovial exchange of small molecules in normal human subjects","volume":"36","author":"Simkin","year":"1974","journal-title":"J. Appl. Physiol."},{"issue":"3","key":"10.1016\/j.ejps.2018.09.009_bb0175","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1081\/DDC-100100359","article-title":"Preparation and pharmacodynamic evaluation of liposomes of indomethacin","volume":"26","author":"Srinath","year":"2000","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.ejps.2018.09.009_bb0180","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ijpharm.2005.02.017","article-title":"Scintigraphic imaging of radiolabeled drug delivery systems in rabbits with arthritis","volume":"296","author":"T\u00fcrker","year":"2005","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2018.09.009_bb0185","doi-asserted-by":"crossref","first-page":"496","DOI":"10.2165\/00003088-198308060-00002","article-title":"Antirheumatic drug concentrations in human synovial fluid and synovial tissue. Observations on extravascular pharmacokinetics","volume":"8","author":"Wallis","year":"1983","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.ejps.2018.09.009_bb0190","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1517\/17425247.2.6.1015","article-title":"Drug delivery strategies for cathepsin inhibitors in joint diseases","volume":"2","author":"Wang","year":"2005","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.ejps.2018.09.009_bb0195","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1093\/rheumatology\/35.8.719","article-title":"A single intraarticular injection of liposomally conjugated methotrexate suppresses joint inflammation in rat antigen-induced arthritis","volume":"35","author":"Williams","year":"1996","journal-title":"Br. J. Rheumatol."},{"key":"10.1016\/j.ejps.2018.09.009_bb0200","doi-asserted-by":"crossref","first-page":"9443","DOI":"10.1016\/j.bmc.2008.09.050","article-title":"Site specific chemical delivery of NSAIDs to inflamed joints: synthesis, biological activity and gamma-imaging studies of quaternary ammonium salts of tropinol esters of some NSAIDs or their active metabolites","volume":"16","author":"Yadav","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejps.2018.09.009_bb0205","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3109\/10717544.2012.700962","article-title":"Intra-articular lornoxicam loaded PLGA microspheres: enhanced therapeutic efficiency and decreased systemic toxicity in the treatment of osteoarthritis","volume":"19","author":"Zhang","year":"2012","journal-title":"Drug Deliv."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092809871830424X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092809871830424X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T19:28:49Z","timestamp":1749238129000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092809871830424X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":40,"alternative-id":["S092809871830424X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2018.09.009","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Drug-fortified liposomes as carriers for sustained release of NSAIDs: The concept and its validation in the animal model for the treatment of arthritis","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2018.09.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}