{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:10:48Z","timestamp":1789647048877,"version":"4.0.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004564","name":"Ministarstvo Prosvete, Nauke i Tehnolo\u0161kog Razvoja","doi-asserted-by":"publisher","award":["172008"],"award-info":[{"award-number":["172008"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004564","name":"Ministarstvo Prosvete, Nauke i Tehnolo\u0161kog Razvoja","doi-asserted-by":"publisher","award":["172035"],"award-info":[{"award-number":["172035"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.ejps.2019.03.014","type":"journal-article","created":{"date-parts":[[2019,3,23]],"date-time":"2019-03-23T04:08:29Z","timestamp":1553314109000},"page":"264-274","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Solubility-pH profile of desipramine hydrochloride in saline phosphate buffer: Enhanced solubility due to drug-buffer aggregates"],"prefix":"10.1016","volume":"133","author":[{"given":"Olivera S.","family":"Markovi\u0107","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milo\u0161 P.","family":"Pe\u0161i\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankita V.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abu T.M.","family":"Serajuddin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana \u017d.","family":"Verbi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Avdeef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2019.03.014_bb0005","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1002\/jps.2600630649","article-title":"Micellar properties of drugs: properties of micellar aggregates of phenothiazines and their aqueous solutions","volume":"63","author":"Attwood","year":"1974","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2019.03.014_bb0010","doi-asserted-by":"crossref","first-page":"9586","DOI":"10.1021\/jp9721863","article-title":"Calorimetric study of the influence of electrolyte on the micellization of phenothiazine drugs in aqueous solution","volume":"101","author":"Attwood","year":"1997","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.ejps.2019.03.014_bb0015","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/jps.2600820214","article-title":"pH-metric log P. 2. Refinement of partition coefficients and ionization constants of multiprotic substances","volume":"82","author":"Avdeef","year":"1992","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2019.03.014_bb0020","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.addr.2007.05.008","article-title":"Solubility of sparingly-soluble drugs","volume":"59","author":"Avdeef","year":"2007","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejps.2019.03.014_bb0025","doi-asserted-by":"crossref","unstructured":"Avdeef, A., 2012. Absorption and Drug Development Second Edition, Wiley-Interscience, Hoboken NJ.","DOI":"10.1002\/9781118286067"},{"key":"10.1016\/j.ejps.2019.03.014_bb0030","first-page":"33","article-title":"Anomalous solubility behavior of several acidic drugs","volume":"2","author":"Avdeef","year":"2014","journal-title":"ADMET&DMPK"},{"key":"10.1016\/j.ejps.2019.03.014_bb0035","first-page":"43","article-title":"Phosphate precipitates and water-soluble aggregates in re-examined solubility-pH data of twenty-five basic drugs","volume":"2","author":"Avdeef","year":"2014","journal-title":"ADMET&DMPK"},{"key":"10.1016\/j.ejps.2019.03.014_bb0040","first-page":"84","article-title":"Suggested improvements for measurement of equilibrium solubility-pH of ionizable drugs","volume":"3","author":"Avdeef","year":"2015","journal-title":"ADMET&DMPK"},{"key":"10.1016\/j.ejps.2019.03.014_bb0045","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.ejps.2017.03.049","article-title":"Cocrystal solubility product analysis \u2013 dual concentration-pH mass action model not dependent on explicit solubility equations","volume":"110","author":"Avdeef","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2019.03.014_bb0050","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1021\/ac50036a045","article-title":"Accurate measurements of the concentration of hydrogen ions with a glass electrode: calibrations using the Prideaux and other universal buffer solutions and a computer-controlled automatic titrator","volume":"50","author":"Avdeef","year":"1978","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ejps.2019.03.014_bb0055","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1023\/A:1007526826979","article-title":"pH-metric solubility. 2. Correlation between the acid-base titration and the saturation shake-flask solubility-pH methods","volume":"17","author":"Avdeef","year":"2000","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejps.2019.03.014_bb0060","doi-asserted-by":"crossref","first-page":"117","DOI":"10.5599\/admet.4.2.292","article-title":"Equilibrium solubility measurement of ionizable drugs-consensus recommendations for improving data quality","volume":"4","author":"Avdeef","year":"2016","journal-title":"ADMET&DMPK"},{"key":"10.1016\/j.ejps.2019.03.014_bb0065","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1021\/jm020986i","article-title":"Absorption classification of oral drugs based on molecular surface properties","volume":"46","author":"Bergstr\u00f6m","year":"2003","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejps.2019.03.014_bb0070","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ejps.2004.04.006","article-title":"Accuracy of calculated pH-dependent aqueous drug solubility","volume":"22","author":"Bergstr\u00f6m","year":"2004","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2019.03.014_bb0075","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/jps.2600680218","article-title":"Solubility of doxycycline in aqueous solution","volume":"68","author":"Bogardus","year":"1979","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2019.03.014_bb0080","unstructured":"Bradley, J.-C., Williams, A., Lang A. Jean-Claude Bradley Open Melting Point Dataset - Version 2. http:\/\/www.chemspider.com\/DatasourceDetails.aspx?id=800, accessed 12 Feb 2018, 2018."},{"key":"10.1016\/j.ejps.2019.03.014_bb0090","first-page":"131","article-title":"pKa-critical interpretations of solubility\u2013pH profiles: PG-300995 and NSC-639829 case studies","volume":"3","author":"Butcher","year":"2015","journal-title":"ADMET&DMPK"},{"key":"10.1016\/j.ejps.2019.03.014_bb0095","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0378-5173(95)04102-8","article-title":"Solubility and solubilization properties of non-steroidal antiinflammatory drugs","volume":"126","author":"Fini","year":"1995","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2019.03.014_bb0100","doi-asserted-by":"crossref","first-page":"3554","DOI":"10.1021\/j100692a012","article-title":"Micelle formation by some phenothiazine derivatives. II. Nuclear magnetic resonance studies in deuterium oxide","volume":"76","author":"Florence","year":"1971","journal-title":"J. Phys. Chem."},{"issue":"43","key":"10.1016\/j.ejps.2019.03.014_bb0105","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1039\/C3CS60451A","article-title":"Pre-nucleation clusters as solute precursors in crystallization","volume":"2014","author":"Gebauer","year":"2014","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.ejps.2019.03.014_bb0110","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.2042-7158.1967.tb07987.x","article-title":"Ionization constants and water solubilities of some aminoalkylphenothiazine tranquilizers and related compounds","volume":"19","author":"Green","year":"1967","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejps.2019.03.014_bb0115","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/jps.3030420311","article-title":"Influence of electrolytes, pH, and alcohol concentration on the solubilities of acidic drugs","volume":"42","author":"Higuchi","year":"1953","journal-title":"J. Amer. Pharm. Assoc. (Sci. Ed.)"},{"key":"10.1016\/j.ejps.2019.03.014_bb0130","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0378-5173(98)00257-9","article-title":"Effects of surface active characteristics and solid state forms on the pH solubility profiles of drug-salt systems","volume":"174","author":"Ledwidge","year":"1998","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2019.03.014_bb0135","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/0021-9797(77)90302-2","article-title":"The effect of micelle formation on solubility and pKa determination of acetylpromazine maleate","volume":"60","author":"Liu","year":"1977","journal-title":"J. Colloid Int. Sci."},{"key":"10.1016\/j.ejps.2019.03.014_bb0150","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ejps.2016.07.013","article-title":"Phenothiazines solution complexity \u2013 determination of pKa and solubility-pH profiles exhibiting sub-micellar aggregation at 25 and 37 \u00b0C","volume":"93","author":"Pobudkowska","year":"2016","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2019.03.014_bb0155","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/jps.2600740208","article-title":"Effect of diffusion layer pH and solubility on the dissolution rate of pharmaceutical bases and their hydrochloride salts. I: phenazopyridine","volume":"74","author":"Serajuddin","year":"1985","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2019.03.014_bb0160","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1002\/jps.2600730905","article-title":"pH-solubility profile of papaverine hydrochloride and its relationship to the dissolution rate of sustained-release pellets","volume":"73","author":"Serajuddin","year":"1984","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2019.03.014_bb0165","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ejps.2012.10.028","article-title":"Solubility\u2013pH profiles of some acidic, basic and amphoteric drugs","volume":"48","author":"Shoghi","year":"2013","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2019.03.014_bb0170","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/jps.2600550807","article-title":"Adsorption of phenothiazine derivatives by solid adsorbents","volume":"55","author":"Sorby","year":"1966","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2019.03.014_bb0175","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ejps.2017.05.064","article-title":"Equilibrium solubility measurement of compounds with low dissolution rate by Higuchi's Facilitated Dissolution Method. A validation study","volume":"106","author":"Tak\u00e1cs-Nov\u00e1k","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2019.03.014_bb0180","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.aca.2010.05.022","article-title":"Study of pH-dependent solubility of organic bases. Revisit of Henderson-Hasselbalch relationship","volume":"673","author":"V\u00f6lgyi","year":"2010","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.ejps.2019.03.014_bb0185","first-page":"48","article-title":"Salt solubility products of diprenorphine hydrochloride, codeine and lidocaine hydrochlorides and phosphates \u2013 novel method of data analysis not dependent on explicit solubility equations","volume":"1","author":"V\u00f6lgyi","year":"2013","journal-title":"ADMET&DMPK"},{"key":"10.1016\/j.ejps.2019.03.014_bb0190","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0378-5173(95)04220-2","article-title":"Investigation of drug self-association in aqueous solution using calorimetry, conductivity","volume":"130","author":"Zhu","year":"1996","journal-title":"and osmometry. Int. J. Pharm."},{"key":"10.1016\/j.ejps.2019.03.014_bb0195","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/0006-2952(66)90026-8","article-title":"The surface activity of phenothiazine derivatives at the air-solution interface","volume":"15","author":"Zografi","year":"1966","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejps.2019.03.014_bb0200","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/jps.2600530528","article-title":"Interfacial properties of phenothiazine derivatives","volume":"53","author":"Zografi","year":"1964","journal-title":"J. Pharm. Sci."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098719301174?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098719301174?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T11:48:57Z","timestamp":1760528937000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098719301174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":35,"alternative-id":["S0928098719301174"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2019.03.014","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Solubility-pH profile of desipramine hydrochloride in saline phosphate buffer: Enhanced solubility due to drug-buffer aggregates","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2019.03.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}