{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:14:04Z","timestamp":1793031244284,"version":"4.5.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012618","name":"National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012618","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.ejps.2019.104993","type":"journal-article","created":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T11:23:33Z","timestamp":1562844213000},"page":"104993","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["In situ antibody-loaded hydrogel for intravitreal delivery"],"prefix":"10.1016","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4430-2508","authenticated-orcid":false,"given":"Sahar","family":"Awwad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Abubakre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ukrit","family":"Angkawinitwong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng T.","family":"Khaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Brocchini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3\u20134","key":"10.1016\/j.ejps.2019.104993_bb0005","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.drudis.2007.11.002","article-title":"Current and future ophthalmic drug delivery systems. A shift to the posterior segment","volume":"13","author":"del Amo","year":"2008","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.ejps.2019.104993_bb0010","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ejpb.2015.01.003","article-title":"Intravitreal clearance and volume of distribution of compounds in rabbits: in silico prediction and pharmacokinetic simulations for drug development","volume":"95","author":"del Amo","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"3","key":"10.1016\/j.ejps.2019.104993_bb0015","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3390\/pharmaceutics10030083","article-title":"Overview of antibody drug delivery","volume":"10","author":"Awwad","year":"2018","journal-title":"Pharmaceutics"},{"issue":"10","key":"10.1016\/j.ejps.2019.104993_bb0020","doi-asserted-by":"crossref","first-page":"3330","DOI":"10.1002\/jps.24480","article-title":"The PK-Eye: a novel in vitro ocular flow model for use in preclinical drug development","volume":"104","author":"Awwad","year":"2015","journal-title":"J. Pharm. Sci."},{"issue":"1\u20132","key":"10.1016\/j.ejps.2019.104993_bb0025","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ijpharm.2017.02.047","article-title":"Sustained release ophthalmic dexamethasone: in vitro in vivo correlations derived from the PK-Eye","volume":"522","author":"Awwad","year":"2017","journal-title":"Int. J. Pharm."},{"issue":"2","key":"10.1016\/j.ejps.2019.104993_bb0030","doi-asserted-by":"crossref","DOI":"10.1002\/mabi.201700255","article-title":"Comparative study of in situ loaded antibody and PEG-Fab NIPAAM gels","volume":"18","author":"Awwad","year":"2018","journal-title":"Macromol. Biosci."},{"issue":"9","key":"10.1016\/j.ejps.2019.104993_bb0035","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1016\/j.biomaterials.2009.12.004","article-title":"A hydrogel-based stem cell delivery system to treat retinal degenerative diseases","volume":"31","author":"Ballios","year":"2010","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.ejps.2019.104993_bb0040","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1002\/jps.23008","article-title":"Formulation design and high-throughput excipient selection based on structural integrity and conformational stability of dilute and highly concentrated IgG1 monoclonal antibody solutions","volume":"101","author":"Bhambhani","year":"2012","journal-title":"J. Pharm. Sci."},{"issue":"3","key":"10.1016\/j.ejps.2019.104993_bb0045","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S1350-9462(99)00016-6","article-title":"Structural macromolecules and supramolecular organisation of the vitreous gel","volume":"19","author":"Bishop","year":"2000","journal-title":"Prog. Retin. Eye Res."},{"issue":"12","key":"10.1016\/j.ejps.2019.104993_bb0050","first-page":"41","article-title":"Hyaluronic acid hydrogels for biomedical applications","volume":"23","author":"Burdick","year":"2011","journal-title":"Adv. Healthc. Mater."},{"issue":"7","key":"10.1016\/j.ejps.2019.104993_bb0055","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.ophtha.2012.04.015","article-title":"Ranibizumab versus bevacizumab to treat neovascular age-related macular degeneration: one-year findings from the IVAN randomized trial","volume":"119","author":"Chakravarthy","year":"2012","journal-title":"Ophthalmology"},{"issue":"12","key":"10.1016\/j.ejps.2019.104993_bb0060","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1021\/acsbiomaterials.7b00734","article-title":"Methods to assess shear-thinning hydrogels for application as injectable biomaterials","volume":"3","author":"Chen","year":"2017","journal-title":"ACS Biomater Sci. Eng."},{"issue":"1\u20133","key":"10.1016\/j.ejps.2019.104993_bb0065","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1163\/092050609X12578498952315","article-title":"Role of thermo-responsiveness and poly(ethylene glycol) diacrylate cross-link density on protein release from poly(N-isopropylacrylamide) hydrogels","volume":"22","author":"Drapala","year":"2011","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"10.1016\/j.ejps.2019.104993_bb0070","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ejpb.2017.12.019","article-title":"Antibody loaded collapsible hyaluronic acid hydrogels for intraocular delivery","volume":"124","author":"Egbu","year":"2018","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"6","key":"10.1016\/j.ejps.2019.104993_bb0075","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.eurpolymj.2003.12.024","article-title":"Synthesis, characterization and thermoreversible behaviours of poly(dimethyl siloxane)\/poly(N-isopropyl acrylamide) semi-interpenetrating networks","volume":"40","author":"Erbil","year":"2004","journal-title":"Eur. Polym. J."},{"issue":"7","key":"10.1016\/j.ejps.2019.104993_bb0080","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1002\/jctb.2657","article-title":"Stabilization of a monoclonal antibody during purification and formulation by addition of basic amino acid excipients","volume":"86","author":"Falconer","year":"2011","journal-title":"J. Chem. Technol. Biotechnol."},{"issue":"1","key":"10.1016\/j.ejps.2019.104993_bb0085","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1167\/iovs.13-13026","article-title":"Enzymatic degradation identifies components responsible for the structural properties of the vitreous body","volume":"55","author":"Filas","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.ejps.2019.104993_bb0090","first-page":"99","article-title":"Studies on thermoresponsive polymers: phase behaviour, drug delivery and biomedical applications","volume":"10","author":"Gandhi","year":"2015","journal-title":"Asian J. Pharm. Sci."},{"issue":"3","key":"10.1016\/j.ejps.2019.104993_bb0095","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1208\/s12248-010-9183-3","article-title":"Ocular drug delivery","volume":"12","author":"Gaudana","year":"2010","journal-title":"AAPS J."},{"key":"10.1016\/j.ejps.2019.104993_bb0100","author":"Genentech"},{"key":"10.1016\/j.ejps.2019.104993_bb0105","doi-asserted-by":"crossref","first-page":"14837","DOI":"10.1038\/ncomms14837","article-title":"Long-acting protein drugs for the treatment of ocular diseases","volume":"8","author":"Ghosh","year":"2017","journal-title":"Nat. Commun."},{"issue":"370","key":"10.1016\/j.ejps.2019.104993_bb0110","first-page":"1","article-title":"Effect of crosslinker structure and crosslinker\/monomer ratio on network parameters and thermodynamic properties of poly (N-isopropylacrylamide) hydrogels","volume":"21","author":"G\u00f6k\u00e7e\u00f6ren","year":"2014","journal-title":"J. Polym. Res."},{"key":"10.1016\/j.ejps.2019.104993_bb0115","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ejpb.2016.11.035","article-title":"Hyaluronan as a promising excipient for ocular drug delivery","volume":"113","author":"Guter","year":"2017","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"6","key":"10.1016\/j.ejps.2019.104993_bb0120","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1006\/exer.1997.0476","article-title":"Hyalocyte-like cells are more numerous in the posterior chamber than they are in the vitreous of the rabbit eye","volume":"66","author":"Haddad","year":"1998","journal-title":"Exp. Eye Res."},{"issue":"15","key":"10.1016\/j.ejps.2019.104993_bb0125","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1016\/j.addr.2008.08.002","article-title":"Hydrogel nanoparticles in drug delivery","volume":"60","author":"Hamidi","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"5","key":"10.1016\/j.ejps.2019.104993_bb0130","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1097\/IAE.0b013e3181c70168","article-title":"Dose of intravitreal bevacizumab (Avastin) used as preoperative adjunct therapy for proliferative diabetic retinopathy","volume":"30","author":"Hattori","year":"2010","journal-title":"Retina (Philadelphia, Pa.)"},{"issue":"7","key":"10.1016\/j.ejps.2019.104993_bb0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0067495","article-title":"Study in vivo intraocular biocompatibility of in situ gelation hydrogels: poly(2-ethyl oxazoline)-block-poly(\u03b5-caprolactone)-block-poly(2-ethyl oxazoline) copolymer, matrigel and pluronic F127","volume":"8","author":"Hwang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ejps.2019.104993_bb0140","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0014-4835(84)90025-3","article-title":"Degradation of glycosaminoglycans by extracts of calf vitreous hyalocytes","volume":"39","author":"Jacobson","year":"1984","journal-title":"Exp. Eye Res."},{"issue":"5","key":"10.1016\/j.ejps.2019.104993_bb0145","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1097\/00006982-200410000-00002","article-title":"Risks of intravitreous injection: a comprehensive review","volume":"24","author":"Jager","year":"2004","journal-title":"Retina"},{"issue":"38","key":"10.1016\/j.ejps.2019.104993_bb0150","doi-asserted-by":"crossref","first-page":"6819","DOI":"10.1039\/C5PY00998G","article-title":"Tunable LCST behavior of poly(N-isopropylacrylamide\/ionic liquid) copolymers","volume":"6","author":"Jain","year":"2015","journal-title":"Polym. Chem."},{"issue":"2","key":"10.1016\/j.ejps.2019.104993_bb0155","first-page":"442","article-title":"Recent trends on hydrogel in human body","volume":"2","author":"Jatav","year":"2011","journal-title":"Int. J. Res. Pharmaceut. Biomed. Sci."},{"key":"10.1016\/j.ejps.2019.104993_bb0160","doi-asserted-by":"crossref","DOI":"10.1177\/2041731417726464","article-title":"Crosslinking method of hyaluronic-based hydrogel for biomedical applications","volume":"8","author":"Khunmanee","year":"2017","journal-title":"J. Tissue Eng."},{"issue":"1\u20133","key":"10.1016\/j.ejps.2019.104993_bb0165","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0168-3659(01)00557-0","article-title":"Temperature-responsive and degradable hyaluronic acid\/Pluronic composite hydrogels for controlled release of human growth hormone","volume":"80","author":"Kim","year":"2002","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejps.2019.104993_bb0170","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.ejpb.2015.05.017","article-title":"Thermoresponsive hydrogels in biomedical applications a seven-year update","author":"Klouda","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejps.2019.104993_bb0175","first-page":"17","article-title":"Hyaluronic acid: a natural biopolymer with a broad range of biomedical and industrial applications","author":"Kogan","year":"2007","journal-title":"Biotechnol. Lett."},{"key":"10.1016\/j.ejps.2019.104993_bb0180","unstructured":"Kumar, V. and Gross, R. A. (2009) \u2018Acrylated hyaluronic acid\u2019. Google Patents. Available at: http:\/\/www.google.com\/patents\/US20090118423."},{"issue":"34","key":"10.1016\/j.ejps.2019.104993_bb0185","doi-asserted-by":"crossref","first-page":"4312","DOI":"10.1039\/b506989k","article-title":"Injectable biodegradable hydrogels composed of hyaluronic acid tyramine conjugates for drug delivery and tissue engineering","volume":"53","author":"Kurisawa","year":"2005","journal-title":"Chem. Commun."},{"key":"10.1016\/j.ejps.2019.104993_bb0190","doi-asserted-by":"crossref","DOI":"10.1007\/s13346-016-0298-7","article-title":"In vivo and in vitro sustained release of ranibizumab from a nanoporous thin-film device","author":"Lance","year":"2016","journal-title":"Drug Deliv. Transl. Res."},{"issue":"2","key":"10.1016\/j.ejps.2019.104993_bb0195","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.biomaterials.2004.02.018","article-title":"Characterization of protein release from photocrosslinkable hyaluronic acid-polyethylene glycol hydrogel tissue engineering scaffolds","volume":"26","author":"Leach","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejps.2019.104993_bb0200","first-page":"4893","article-title":"Injectable hydrogel as stem cell scaffolds from the thermosensitive terpolymer of NIPAAm\/AAc\/HEMAPCL","volume":"7","author":"Lian","year":"2012","journal-title":"Int. J. Nanomedicine"},{"issue":"4","key":"10.1016\/j.ejps.2019.104993_bb0205","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0927-7765(00)00201-0","article-title":"Effects of thermosensitivity of poly (N-isopropylacrylamide) hydrogel upon the duration of a lag phase at the beginning of drug release from the hydrogel","volume":"20","author":"Makino","year":"2001","journal-title":"Colloids Surf. B: Biointerfaces"},{"issue":"7","key":"10.1016\/j.ejps.2019.104993_bb0210","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.ophtha.2012.03.053","article-title":"Ranibizumab and bevacizumab for treatment of neovascular age-related macular degeneration: two-year results","volume":"119","author":"Martin","year":"2012","journal-title":"Ophthalmology"},{"issue":"8","key":"10.1016\/j.ejps.2019.104993_bb0215","doi-asserted-by":"crossref","first-page":"397","DOI":"10.17221\/1930-VETMED","article-title":"Hyaluronic acid (hyaluronan): a review","volume":"53","author":"Necas","year":"2008","journal-title":"Vet. Med."},{"issue":"9","key":"10.1016\/j.ejps.2019.104993_bb0220","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1080\/02713683.2017.1302590","article-title":"In vivo efficacy of an injectable microsphere-hydrogel ocular drug delivery system","volume":"42","author":"Osswald","year":"2017","journal-title":"Curr. Eye Res."},{"issue":"14","key":"10.1016\/j.ejps.2019.104993_bb0225","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1039\/c3tb21360a","article-title":"A thermally triggered in situ hydrogel from poly(acrylic acid-co-N-isopropylacrylamide) for controlled release of anti-glaucoma drugs","volume":"2","author":"Prasannan","year":"2014","journal-title":"J. Mater. Chem. B"},{"issue":"2","key":"10.1016\/j.ejps.2019.104993_bb0230","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3109\/1547691X.2013.821564","article-title":"Immunogenicity of therapeutic proteins: influence of aggregation","volume":"11","author":"Ratanji","year":"2014","journal-title":"J. Immunotoxicol."},{"issue":"1","key":"10.1016\/j.ejps.2019.104993_bb0235","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1167\/iovs.13-13120","article-title":"Biocompatible reverse thermal gel sustains the release of intravitreal bevacizumab in vivo","volume":"55","author":"Rauck","year":"2013","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ejps.2019.104993_bb0240","author":"Regeneron"},{"key":"10.1016\/j.ejps.2019.104993_bb0245","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.carbpol.2013.09.004","article-title":"Synthesis, characterization, swelling and drug release behavior of semi-interpenetrating network hydrogels of sodium alginate and polyacrylamide","volume":"99","author":"Samanta","year":"2014","journal-title":"Carbohydr. Polym."},{"issue":"3","key":"10.1016\/j.ejps.2019.104993_bb0250","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1063\/1.455115","article-title":"Kinetics of discontinuous volume\u2013phase transition of gels","volume":"89","author":"Sato Matsuo","year":"1988","journal-title":"J. Chem. Phys."},{"issue":"12","key":"10.1016\/j.ejps.2019.104993_bb0255","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.3109\/02713689608995150","article-title":"Human vitreous hyaluronidase: isolation and characterization","volume":"15","author":"Schwartz","year":"1996","journal-title":"Curr. Eye Res."},{"issue":"8","key":"10.1016\/j.ejps.2019.104993_bb0260","first-page":"1867","article-title":"Morphology and ultrastructure of human vitreous fibers","volume":"30","author":"Sebag","year":"1989","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"5","key":"10.1016\/j.ejps.2019.104993_bb0265","doi-asserted-by":"crossref","first-page":"055007","DOI":"10.1088\/1748-6041\/8\/5\/055007","article-title":"Preparation and characterization of a hydrogel carrier to deliver gatifloxacin and its application as a therapeutic contact lens for bacterial keratitis therapy","volume":"8","author":"Shi","year":"2013","journal-title":"Biomed. Mater. (Bristol, England)"},{"issue":"1","key":"10.1016\/j.ejps.2019.104993_bb0270","first-page":"1","article-title":"Hyaluronidase in ophthalmology","volume":"12","author":"Silverstein","year":"2012","journal-title":"J. Appl. Res."},{"issue":"22","key":"10.1016\/j.ejps.2019.104993_bb0275","doi-asserted-by":"crossref","first-page":"7370","DOI":"10.1021\/ma990130w","article-title":"Synthesis and characterization of injectable poly (N-isopropylacrylamide)-based hydrogels that support tissue formation in vitro","volume":"32","author":"Stile","year":"1999","journal-title":"Macromolecules"},{"issue":"14","key":"10.1016\/j.ejps.2019.104993_bb0280","doi-asserted-by":"crossref","first-page":"3620","DOI":"10.1016\/j.biomaterials.2011.01.058","article-title":"The effects of cross-linked thermo-responsive PNIPAAm-based hydrogel injection on retinal function","volume":"32","author":"Turturro","year":"2011","journal-title":"Biomaterials"},{"issue":"5","key":"10.1016\/j.ejps.2019.104993_bb0285","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1021\/cr200157d","article-title":"Hydrogels for protein delivery","volume":"112","author":"Vermonden","year":"2012","journal-title":"Chem. Rev."},{"issue":"1","key":"10.1016\/j.ejps.2019.104993_bb0290","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jps.20727","article-title":"Antibody structure, instability, and formulation","volume":"96","author":"Wang","year":"2007","journal-title":"J. Pharm. Sci."},{"issue":"4","key":"10.1016\/j.ejps.2019.104993_bb0295","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1021\/bm101233m","article-title":"Photoresponsive PEG-anthracene grafted hyaluronan as a controlled-delivery biomaterial","volume":"12","author":"Wells","year":"2011","journal-title":"Biomacromolecules"},{"issue":"2","key":"10.1016\/j.ejps.2019.104993_bb0300","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jconrel.2004.10.008","article-title":"Evaluating proteins release from, and their interactions with, thermosensitive poly (N-isopropylacrylamide) hydrogels","volume":"102","author":"Wu","year":"2005","journal-title":"J. Control. Release"},{"issue":"10","key":"10.1016\/j.ejps.2019.104993_bb0305","doi-asserted-by":"crossref","first-page":"4791","DOI":"10.1021\/ma1004953","article-title":"Comparison of the thermoresponsive deswelling kinetics of poly(2-(2-methoxyethoxy)ethyl methacrylate) hydrogels prepared by ATRP and FRP","volume":"43","author":"Yoon","year":"2010","journal-title":"Macromolecules"},{"issue":"2","key":"10.1016\/j.ejps.2019.104993_bb0310","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1167\/tvst.4.2.5","article-title":"Injectable chemically crosslinked hydrogel for the controlled release of bevacizumab in vitreous: a 6-month in vivo study","volume":"4","author":"Yu","year":"2015","journal-title":"Transl. Vis. Sci. Technol."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098719302568?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098719302568?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T11:50:06Z","timestamp":1760529006000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098719302568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":62,"alternative-id":["S0928098719302568"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2019.104993","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In situ antibody-loaded hydrogel for intravitreal delivery","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2019.104993","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104993"}}