{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:49:05Z","timestamp":1787161745326,"version":"build-2736575974"},"reference-count":17,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270560"],"award-info":[{"award-number":["81270560"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.ejps.2019.105062","type":"journal-article","created":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T11:25:34Z","timestamp":1568373934000},"page":"105062","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["The effects of scopolamine on the survival time and microcirculation of septic shock rats"],"prefix":"10.1016","volume":"141","author":[{"given":"Linlin","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rai","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4545-6119","authenticated-orcid":false,"given":"Zhongping","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ejps.2019.105062_bib0001","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nprot.2008.214","article-title":"Immunodesign of experimental sepsis by cecal ligation and puncture [J]","volume":"4","author":"Ritirsch","year":"2009","journal-title":"Nat. protoc."},{"issue":"8","key":"10.1016\/j.ejps.2019.105062_bib0002","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3) [J]","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"issue":"21","key":"10.1016\/j.ejps.2019.105062_bib0003","first-page":"2063","article-title":"Severe sepsis and septic shock [J]","volume":"369","author":"Angus","year":"2013","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.ejps.2019.105062_bib0004","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1056\/NEJMra021333","article-title":"The pathophysiology and treatment of sepsis [J]","volume":"348","author":"Hotchkiss","year":"2003","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.ejps.2019.105062_bib0005","first-page":"9","article-title":"Observation of the curative effect of high dose scopolamine on acute lung injury","volume":"7","author":"Tang","year":"2001","journal-title":"Med J Crit Care (Chinese)"},{"issue":"18","key":"10.1016\/j.ejps.2019.105062_bib0006","first-page":"2379","article-title":"Effect of scopolamine on acute respiratory distress syndrome caused by severe pulmonary infection [J]","volume":"29","author":"Zheng","year":"2009","journal-title":"Chin J Geriatr"},{"issue":"9","key":"10.1016\/j.ejps.2019.105062_bib0007","first-page":"277","article-title":"Comparison of two different models of sepsis induced by cecal ligation and puncture in rats","volume":"229","author":"Linlin","year":"2018","journal-title":"J Surg Res"},{"issue":"3","key":"10.1016\/j.ejps.2019.105062_bib0008","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.3892\/etm.2016.3534","article-title":"Probiotic pre-administration reduces mortality in a mouse model of cecal ligation and puncture-induced sepsis [J]","volume":"12","author":"Chen","year":"2016","journal-title":"Exp Ther Med"},{"issue":"6","key":"10.1016\/j.ejps.2019.105062_bib0009","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1097\/01.shk.0000126906.52367.dd","article-title":"Cecal ligation and puncture versus colon ascendens stent peritonitis: two distinct animal models for polymicrobial sepsis [J]","volume":"21","author":"Maler","year":"2004","journal-title":"Shock"},{"key":"10.1016\/j.ejps.2019.105062_bib0010","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1097\/01.shk.0000191414.94461.7e","article-title":"Cecal ligation and puncture [J]","volume":"24","author":"Hubbard","year":"2005","journal-title":"Shock"},{"issue":"6","key":"10.1016\/j.ejps.2019.105062_bib0011","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1159\/000073387","article-title":"Distance of cecum ligated influences mortality, tumor necrosis factor-alpha and interleukin-6 expression following cecal ligation and puncture in the rat [J]","volume":"35","author":"Singleton","year":"2003","journal-title":"Eur Surg Res"},{"issue":"3","key":"10.1016\/j.ejps.2019.105062_bib0012","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1097\/CCM.0b013e3182742e8b","article-title":"Microcirculatory alterations in patients with severe sepsis: impact of time of assessment and relationship with outcome [J]","volume":"41","author":"De Backer","year":"2013","journal-title":"Crit Care Med"},{"issue":"1","key":"10.1016\/j.ejps.2019.105062_bib0013","doi-asserted-by":"crossref","first-page":"H24","DOI":"10.1152\/ajpheart.00034.2016","article-title":"Microcirculatory dysfunction in sepsis: pathophysiology, clinical monitoring, and potential therapies [J]","volume":"311","author":"Miranda","year":"2016","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"5","key":"10.1016\/j.ejps.2019.105062_bib0014","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1097\/SHK.0000000000000954","article-title":"Micro- and Macro circulatory changes during sepsis and septic shock in a rat model [J]","volume":"49","author":"Hua","year":"2018","journal-title":"Shock. May"},{"issue":"1","key":"10.1016\/j.ejps.2019.105062_bib0015","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1097\/ALN.0000000000001431","article-title":"Ivabradine attenuates the microcirculatory derangements evoked by experimental sepsis [J]","volume":"126","author":"Miranda","year":"2017","journal-title":"Anesthesiology"},{"issue":"4","key":"10.1016\/j.ejps.2019.105062_bib0016","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1097\/ALN.0000000000001273","article-title":"Effects of different crystalloid solutions on hemodynamics, peripheral perfusion, and the microcirculation in experimental abdominal sepsis [J]","volume":"125","author":"Orbegoao","year":"2016","journal-title":"Anesthesiology"},{"issue":"1","key":"10.1016\/j.ejps.2019.105062_bib0017","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/SHK.0000000000000918","article-title":"Plasma resuscitation improved survival in a cecal ligation and puncture rat model of sepsis [J]","volume":"49","author":"Chang","year":"2018","journal-title":"Shock. Jan"}],"updated-by":[{"DOI":"10.1016\/j.ejps.2022.106240","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000}}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098719303331?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098719303331?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T10:18:47Z","timestamp":1573813127000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098719303331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":17,"alternative-id":["S0928098719303331"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2019.105062","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effects of scopolamine on the survival time and microcirculation of septic shock rats","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2019.105062","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105062"}}