{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:35:51Z","timestamp":1786988151382,"version":"build-2736575974"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005693","name":"Hainan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004761","name":"Natural Science Foundation of Hainan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.ejps.2020.105457","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T11:28:04Z","timestamp":1594034884000},"page":"105457","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Development of nimesulide amorphous solid dispersions via supercritical anti-solvent process for dissolution enhancement"],"prefix":"10.1016","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2175-3154","authenticated-orcid":false,"given":"Guijin","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiming","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2020.105457_bib0001","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jssc.2019.02.001","article-title":"Hybrid compounds for improving drugs solubility: synthesis, physico-chemical and pharmaceutical characterization of Nimesulide-LDH","volume":"272","author":"Bini","year":"2019","journal-title":"J. Solid State Chem."},{"key":"10.1016\/j.ejps.2020.105457_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2019.104967","article-title":"Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems","volume":"137","author":"Boyd","year":"2019","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2020.105457_bib0003","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ijpharm.2013.05.061","article-title":"Amorphous solid dispersions and nano-crystal technologies for poorly water-soluble drug delivery","volume":"453","author":"Brough","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2020.105457_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2019.102966","article-title":"Nimesulide analogues: from anti-inflammatory to antitumor agents","volume":"88","author":"Catarro","year":"2019","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejps.2020.105457_bib0005","doi-asserted-by":"crossref","first-page":"18759","DOI":"10.3390\/molecules201018759","article-title":"Polymorph impact on the bioavailability and stability of poorly soluble drugs","volume":"20","author":"Censi","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.ejps.2020.105457_bib0006","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1081\/DDC-100100995","article-title":"Nimesulide and \u03b2-cyclodextrin inclusion complexes: physicochemical characterization and dissolution rate studies","volume":"26","author":"Chowdary","year":"2000","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.ejps.2020.105457_bib0007","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ijpharm.2007.05.009","article-title":"Characterization and compaction behaviour of nimesulide crystal forms","volume":"342","author":"Di Martino","year":"2007","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2020.105457_bib0008","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.ijpharm.2018.11.015","article-title":"Selection of the suitable polymer for supercritical fluid assisted preparation of carvedilol solid dispersions","volume":"554","author":"Djuris","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2020.105457_bib0009","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1211\/jpp.61.12.0001","article-title":"Review: physical chemistry of solid dispersions","volume":"61","author":"Janssens","year":"2009","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejps.2020.105457_bib0010","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ijpharm.2017.10.051","article-title":"Amorphous solid dispersions and nanocrystal technologies for poorly water-soluble drug delivery \u2013 an update","volume":"535","author":"Jermain","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2020.105457_bib0011","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2011.08.032","article-title":"Formulation design for poorly water-soluble drugs based on biopharmaceutics classification system: basic approaches and practical applications","volume":"420","author":"Kawabata","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2020.105457_bib0012","first-page":"82","article-title":"Poor aqueous solubility\u2014an industry wide problem in drug discovery","volume":"5","author":"Lipinski","year":"2002","journal-title":"Am. Pharm. Rev."},{"key":"10.1016\/j.ejps.2020.105457_bib0013","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.addr.2012.09.019","article-title":"Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings","volume":"64","author":"Lipinski","year":"2012","journal-title":"Adv. Drug Deliver. Rev."},{"key":"10.1016\/j.ejps.2020.105457_bib0014","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.2174\/1381612821666150416101116","article-title":"Tailoring particle microstructures via supercritical CO2 processes for particular drug delivery","volume":"21","author":"Liu","year":"2015","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.ejps.2020.105457_bib0015","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jcou.2017.04.015","article-title":"Tailoring the particle microstructures of gefitinib by supercritical CO2 anti-solvent process","volume":"20","author":"Liu","year":"2017","journal-title":"J. CO2 Util."},{"key":"10.1016\/j.ejps.2020.105457_bib0016","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1021\/je960103q","article-title":"Solubility of anti-inflammatory drugs in supercritical carbon dioxide","volume":"41","author":"Macnaughton","year":"1996","journal-title":"J. Chem. Eng. Data"},{"key":"10.1016\/j.ejps.2020.105457_bib0017","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2174\/156720107781023901","article-title":"Supercritical antisolvent precipitation of nimesulide: preliminary experiments","volume":"4","author":"Moneghini","year":"2007","journal-title":"Curr. Drug Deliv."},{"key":"10.1016\/j.ejps.2020.105457_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2020.105276","article-title":"Amorphous solid dispersions containing residual crystallinity: influence of seed properties and polymer adsorption on dissolution performance","volume":"146","author":"Moseson","year":"2020","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2020.105457_bib0019","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1021\/js960298k","article-title":"Study of the influence of both cyclodextrins and L-lysine on the aqueous solubility of nimesulide; isolation and characterization of nimesulide\u2013L-lysine\u2013cyclodextrin complexes","volume":"86","author":"Piel","year":"1997","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2020.105457_bib0020","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.supflu.2018.04.021","article-title":"Supercritical antisolvent coprecipitation mechanisms","volume":"138","author":"Prosapio","year":"2018","journal-title":"J. Supercrit. Fluids"},{"key":"10.1016\/j.ejps.2020.105457_bib0021","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.supflu.2016.07.023","article-title":"Formation of PVP\/nimesulide microspheres by supercritical antisolvent coprecipitation","volume":"118","author":"Prosapio","year":"2016","journal-title":"J. Supercrit. Fluids"},{"key":"10.1016\/j.ejps.2020.105457_bib0022","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.cej.2011.02.064","article-title":"Mechanisms controlling supercritical antisolvent precipitate morphology","volume":"169","author":"Reverchon","year":"2011","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.ejps.2020.105457_bib0023","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0896-8446(00)00045-0","article-title":"Process parameters and morphology in amoxicillin micro and submicro particles generation by supercritical antisolvent precipitation","volume":"17","author":"Reverchon","year":"2000","journal-title":"J. Supercrit. Fluids"},{"key":"10.1016\/j.ejps.2020.105457_bib0024","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.supflu.2011.11.023","article-title":"Solute solubility as criterion for the appearance of amorphous particle precipitation or crystallization in the supercritical antisolvent (SAS) process","volume":"66","author":"Rossmann","year":"2012","journal-title":"J. Supercrit. Fluids"},{"key":"10.1016\/j.ejps.2020.105457_bib0025","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ejpb.2009.04.005","article-title":"In vitro and in vivo evaluation of nimesulide lyophilized orally disintegrating tablets","volume":"73","author":"Shoukri","year":"2009","journal-title":"Eur. J. Pharm. Biopharm"},{"key":"10.1016\/j.ejps.2020.105457_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119156","article-title":"Enhanced solid-state stability of amorphous ibrutinib formulations prepared by hot-melt extrusion","volume":"579","author":"Sim\u00f5es","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2020.105457_bib0027","series-title":"Analytical Profiles of Drug Substances and Excipients","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S1075-6280(01)28006-9","article-title":"Nimesulide","author":"Singh","year":"2001"},{"key":"10.1016\/j.ejps.2020.105457_bib0028","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.ijpharm.2013.01.019","article-title":"Bottom-up approaches for preparing drug nanocrystals: formulations and factors affecting particle size","volume":"453","author":"Sinha","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2020.105457_bib0029","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ijpharm.2008.07.023","article-title":"Top-down production of drug nanocrystals: nanosuspension stabilization, miniaturization and transformation into solid products","volume":"364","author":"Van Eerdenbrugh","year":"2008","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2020.105457_bib0030","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.ejpb.2013.09.007","article-title":"Current trends and future perspectives of solid dispersions containing poorly water-soluble drugs","volume":"85","author":"Vo","year":"2013","journal-title":"Eur. J. Pharm. Biopharm"},{"key":"10.1016\/j.ejps.2020.105457_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2020.105294","article-title":"Exploring the physical stability of three nimesulide\u2013indomethacin co-amorphous systems from the perspective of molecular aggregates","volume":"147","author":"Wang","year":"2020","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2020.105457_bib0032","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jcrysgro.2016.12.017","article-title":"Modification of solid-state property of sulfasalazine by using the supercritical antisolvent process","volume":"460","author":"Wu","year":"2017","journal-title":"J. Cryst. Growth"},{"key":"10.1016\/j.ejps.2020.105457_bib0033","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.addr.2007.03.025","article-title":"Particle design of poorly water-soluble drug substances using supercritical fluid technologies","volume":"60","author":"Yasuji","year":"2008","journal-title":"Adv. Drug Deliver. Rev."},{"key":"10.1016\/j.ejps.2020.105457_bib0034","doi-asserted-by":"crossref","first-page":"349","DOI":"10.2174\/13816128113199990404","article-title":"Supercritical fluid particle design for poorly water-soluble drugs (review)","volume":"20","author":"Yongda","year":"2014","journal-title":"Curr. Pharm. Des."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098720302463?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098720302463?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T11:55:12Z","timestamp":1760529312000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098720302463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":34,"alternative-id":["S0928098720302463"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2020.105457","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of nimesulide amorphous solid dispersions via supercritical anti-solvent process for dissolution enhancement","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2020.105457","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105457"}}