{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:24:19Z","timestamp":1793298259228,"version":"4.5.0"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:00:00Z","timestamp":1594684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.ejps.2020.105469","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T03:38:56Z","timestamp":1594784336000},"page":"105469","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":180,"special_numbering":"C","title":["Localised and sustained intradermal delivery of methotrexate using nanocrystal-loaded microneedle arrays: Potential for enhanced treatment of psoriasis"],"prefix":"10.1016","volume":"152","author":[{"given":"Ismaiel A.","family":"Tekko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0063-077X","authenticated-orcid":false,"given":"Andi Dian","family":"Permana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalitkumar","family":"Vora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taher","family":"Hatahet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen O.","family":"McCarthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0766-4147","authenticated-orcid":false,"given":"Ryan F.","family":"Donnelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2020.105469_bib0047","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics11070308","article-title":"Nanosuspension-based dissolving microneedle arrays for intradermal delivery of curcumin","volume":"11","author":"Abdelghany","year":"2019","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejps.2020.105469_bib0037","doi-asserted-by":"crossref","first-page":"543","DOI":"10.4155\/tde.13.24","article-title":"Transdermal delivery of methotrexate for pediatrics using silicon microneedles","volume":"4","author":"Abla","year":"2013","journal-title":"Ther. Deliv."},{"key":"10.1016\/j.ejps.2020.105469_bib0010","doi-asserted-by":"crossref","first-page":"554","DOI":"10.3109\/10837450.2015.1026605","article-title":"A novel nanogel formulation of methotrexate for topical treatment of psoriasis: optimization, in vitro and in vivo evaluation","volume":"21","author":"Avasatthi","year":"2016","journal-title":"Pharm. Dev. Technol"},{"key":"10.1016\/j.ejps.2020.105469_bib0043","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3389\/fbioe.2019.00296","article-title":"Non-invasive production of multi-compartmental biodegradable polymer microneedles for controlled intradermal drug release of labile molecules","volume":"7","author":"Battisti","year":"2019","journal-title":"Front. Bioeng. Biotechnol"},{"key":"10.1016\/j.ejps.2020.105469_bib0024","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1546-0096-12-54","article-title":"Procedural pain and patient-reported side effects with weekly injections of subcutaneous Methotrexate in children with rheumatic disorders","volume":"12","author":"Bechard","year":"2014","journal-title":"Pediatr. Rheumatol"},{"key":"10.1016\/j.ejps.2020.105469_bib0058","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/chromsci\/bmt081","article-title":"Simple and reliable HPLC method for the monitoring of methotrexate in osteosarcoma patients.","volume":"52","author":"Begas","year":"2014","journal-title":"J. Chromatogr. Sci."},{"key":"10.1016\/j.ejps.2020.105469_bib0025","first-page":"67","article-title":"Recommendations for optimizing methotrexate treatment for patients with rheumatoid arthritis","volume":"9","author":"Bello","year":"2017","journal-title":"Open Access Rheumatol. Res. Rev"},{"key":"10.1016\/j.ejps.2020.105469_bib0042","doi-asserted-by":"crossref","unstructured":"Bello A.E. , Perkins E.L., Jay R., Efthimiou P., 2017. Recommendations for optimizing methotrexate treatment for patients with rheumatoid arthritis. doi:10.2147\/OARRR.S131668.","DOI":"10.2147\/OARRR.S131668"},{"key":"10.1016\/j.ejps.2020.105469_bib0015","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s12325-015-0276-3","article-title":"Utilization of subcutaneous methotrexate in rheumatoid arthritis patients after failure or intolerance to oral methotrexate: a multicenter cohort study","volume":"33","author":"Branco","year":"2016","journal-title":"Adv. Ther"},{"key":"10.1016\/j.ejps.2020.105469_bib0016","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s12325-016-0295-8","article-title":"Methotrexate and rheumatoid arthritis: current evidence regarding subcutaneous versus oral routes of administration","volume":"33","author":"Bianchi","year":"2016","journal-title":"Adv. Ther"},{"key":"10.1016\/j.ejps.2020.105469_bib0021","doi-asserted-by":"crossref","first-page":"E182","DOI":"10.1152\/ajpendo.90459.2008","article-title":"Methotrexate induces intestinal mucositis and alters gut protein metabolism independently of reduced food intake","volume":"296","author":"Boukhettala","year":"2009","journal-title":"Am. J. Physiol. - Endocrinol. Metab"},{"key":"10.1016\/j.ejps.2020.105469_bib0018","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/art.23144","article-title":"Comparison of the clinical efficacy and safety of subcutaneous versus oral administration of methotrexate in patients with active rheumatoid arthritis: Results of a six-month, multicenter, randomized, double-blind, controlled, phase IV trial","volume":"58","author":"Braun","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.ejps.2020.105469_bib0019","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/BOR.0b013e328329c79d","article-title":"An update on methotrexate","volume":"21","author":"Braun","year":"2009","journal-title":"Curr. Opin. Rheumatol"},{"key":"10.1016\/j.ejps.2020.105469_bib0008","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1080\/09546634.2016.1273469","article-title":"Effectiveness and safety of methotrexate in psoriasis: an eight-year experience with 218 patients","volume":"28","author":"Cabello Zurita","year":"2017","journal-title":"J. Dermatolog. Treat."},{"key":"10.1016\/j.ejps.2020.105469_bib0029","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1080\/17425247.2019.1645119","article-title":"Site-specific drug delivery in the skin for the localized treatment of skin diseases","volume":"16","author":"Chen","year":"2019","journal-title":"Expert Opin. Drug Deliv"},{"key":"10.1016\/j.ejps.2020.105469_bib0011","doi-asserted-by":"crossref","first-page":"392","DOI":"10.5114\/pdia.2014.47121","article-title":"The possibilities and principles of methotrexate treatment of psoriasis - The updated knowledge","volume":"31","author":"Czarnecka-Operacz","year":"2014","journal-title":"Postep. Dermatologii i Alergol"},{"key":"10.1016\/j.ejps.2020.105469_bib0040","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.ijpharm.2017.03.068","article-title":"Computational and experimental approaches for development of methotrexate nanosuspensions by bottom-up nanoprecipitation","volume":"524","author":"dos Santos","year":"2017","journal-title":"Int. J. Pharm"},{"key":"10.1016\/j.ejps.2020.105469_bib0073","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1007\/s11095-014-1301-y","article-title":"Hydrogel-forming microneedle arrays can be effectively inserted in skin by self-application: A pilot study centred on pharmacist intervention and a patient information leaflet","volume":"31","author":"Donnelly","year":"2014","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejps.2020.105469_bib0005","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jconrel.2007.08.005","article-title":"Dermal and transdermal delivery of an anti-psoriatic agent via ethanolic liposomes","volume":"123","author":"Dubey","year":"2007","journal-title":"J. Control. Release."},{"key":"10.1016\/j.ejps.2020.105469_bib0012","doi-asserted-by":"crossref","first-page":"43588","DOI":"10.1021\/acsami.9b15668","article-title":"Hyaluronic acid-based dissolving microneedle patch loaded with methotrexate for improved treatment of psoriasis","volume":"11","author":"Du","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ejps.2020.105469_bib0034","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.ejpb.2012.07.008","article-title":"Laser-engineered dissolving microneedles for active transdermal delivery of nadroparin calcium","volume":"82","author":"Gomaa","year":"2012","journal-title":"Eur. J. Pharm. Biopharm"},{"key":"10.1016\/j.ejps.2020.105469_bib0030","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1517\/17425247.2012.686490","article-title":"Nanocarrier-based topical drug delivery for the treatment of skin diseases","volume":"9","author":"Gupta","year":"2012","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.ejps.2020.105469_bib0009","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/jdv.12495","article-title":"Current practice of methotrexate use for psoriasis: Results of a worldwide survey among dermatologists","volume":"29","author":"Gyulai","year":"2015","journal-title":"J. Eur. Acad. Dermatology Venereol."},{"key":"10.1016\/j.ejps.2020.105469_bib0066","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1016\/j.xphs.2018.05.017","article-title":"intradermal delivery of a near-infrared photosensitizer using dissolving microneedle arrays","volume":"107","author":"Hamdan","year":"2018","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2020.105469_bib0067","first-page":"1158","article-title":"Excretion and distribution studies in rats with two forms of 14carbon-labelled polyvinylpyrrolidone with a relatively low mean molecular weight after intravenous administration","volume":"27","author":"Hespe","year":"1977","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.ejps.2020.105469_bib0023","first-page":"481","article-title":"Splitting high-dose oral methotrexate improves bioavailability: A pharmacokinetic study in patients with rheumatoid arthritis","volume":"33","author":"Hoekstra","year":"2006","journal-title":"J. Rheumatol"},{"key":"10.1016\/j.ejps.2020.105469_bib0065","article-title":"Reduction-triggered breakable micelles of amphiphilic polyamide amine-g-polyethylene glycol for methotrexate delivery","volume":"2014","author":"Huang","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.ejps.2020.105469_bib0061","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.2042-7158.1995.tb05835.x","article-title":"Comparison of body distribution of poly(vinyl alcohol) with other water-soluble polymers after intravenous administration","volume":"47","author":"Ikada","year":"1995","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejps.2020.105469_bib0036","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3390\/pharmaceutics7030090","article-title":"Transdermal delivery of drugs with microneedles\u2014potential and challenges","volume":"7","author":"Ita","year":"2015","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejps.2020.105469_bib0017","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00431-018-3286-8","article-title":"The effect of repeated methotrexate injections on the quality of life of children with rheumatic diseases","volume":"178","author":"Jacobse","year":"2019","journal-title":"Eur. J. Pediatr"},{"key":"10.1016\/j.ejps.2020.105469_bib0060","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/905103","article-title":"Biocompatibility and toxicity of poly(vinyl alcohol)\/N,O-carboxymethyl chitosan scaffold","volume":"2014","author":"Kamarul","year":"2014","journal-title":"Sci. World J."},{"key":"10.1016\/j.ejps.2020.105469_bib0062","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1021\/mp034006h","article-title":"Molecular properties of WHO essential drugs and provisional biopharmaceutical classification","volume":"1","author":"Kasim","year":"2004","journal-title":"Mol. Pharm"},{"key":"10.1016\/j.ejps.2020.105469_bib0014","first-page":"278","article-title":"Diagnosis and management of psoriasis","volume":"63","author":"Kim","year":"2017","journal-title":"Can. Fam. Physician."},{"key":"10.1016\/j.ejps.2020.105469_bib0020","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3109\/15569527.2013.779278","article-title":"Methotrexate toxicity presenting as cutaneous ulcerations on psoriatic plaques","volume":"32","author":"Ko\u00e7ak","year":"2013","journal-title":"Cutan. Ocul. Toxicol"},{"key":"10.1016\/j.ejps.2020.105469_bib0071","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.actbio.2015.05.036","article-title":"Therapeutic intradermal delivery of tumor necrosis factor-alpha antibodies using tip-loaded dissolvable microneedle arrays","volume":"24","author":"Korkmaz","year":"2015","journal-title":"Acta Biomater"},{"key":"10.1016\/j.ejps.2020.105469_bib0069","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/BF03226376","article-title":"Variability of oral bioavailability for low dose methotrexate in rats","volume":"26","author":"Kuroda","year":"2001","journal-title":"Eur. J. Drug Metab. Pharmacokinet"},{"key":"10.1016\/j.ejps.2020.105469_bib0070","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1248\/bpb.23.334","article-title":"Species differences in oral bioavailability of methotrexate between rats and monkeys","volume":"23","author":"Kuroda","year":"2000","journal-title":"Biol. Pharm. Bull"},{"key":"10.1016\/j.ejps.2020.105469_bib0027","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mser.2016.03.001","article-title":"Microneedle arrays as transdermal and intradermal drug delivery systems: Materials science, manufacture and commercial development","volume":"104","author":"Larra\u00f1eta","year":"2016","journal-title":"Mater. Sci. Eng. R Reports"},{"key":"10.1016\/j.ejps.2020.105469_bib0053","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ijpharm.2014.05.042","article-title":"A proposed model membrane and test method for microneedle insertion studies","volume":"472","author":"Larra\u00f1eta","year":"2014","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2020.105469_bib0072","doi-asserted-by":"crossref","first-page":"e24","DOI":"10.1111\/bjd.15779","article-title":"A hyaluronic acid-based microneedle patch to treat psoriatic plaques: a pilot open trial","volume":"178","author":"Lee","year":"2018","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.ejps.2020.105469_bib0046","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jconrel.2018.11.002","article-title":"Design, formulation and evaluation of novel dissolving microarray patches containing a long-acting rilpivirine nanosuspension","volume":"292","author":"Mc Crudden","year":"2018","journal-title":"J. Control. Release."},{"key":"10.1016\/j.ejps.2020.105469_bib0056","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1007\/s001050050399","article-title":"[Comments on the suitability of swine skin as a biological model for human skin]","volume":"47","author":"Meyer","year":"1996","journal-title":"Hautarzt"},{"key":"10.1016\/j.ejps.2020.105469_bib0050","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.ijpharm.2011.04.034","article-title":"Potent dried drug nanosuspensions for oral bioavailability enhancement of poorly soluble drugs with pH-dependent solubility","volume":"413","author":"Mou","year":"2011","journal-title":"Int. J. Pharm"},{"key":"10.1016\/j.ejps.2020.105469_bib0006","article-title":"Quality-of-life issues in psoriasis","volume":"49","author":"Mukhtar","year":"2004","journal-title":"Dermatol. Clin."},{"key":"10.1016\/j.ejps.2020.105469_bib0048","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0378-5173(97)00311-6","article-title":"Nanosuspensions for the formulation of poorly soluble drugs. I. Preparation by a size-reduction technique","volume":"160","author":"M\u00fcller","year":"1998","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2020.105469_bib0032","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics10030117","article-title":"Electrically and ultrasonically enhanced transdermal delivery of methotrexate","volume":"10","author":"Nguyen","year":"2018","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejps.2020.105469_bib0039","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s11095-018-2369-6","article-title":"Delivery of methotrexate and characterization of skin treated by fabricated plga microneedles and fractional ablative laser","volume":"35","author":"Nguyen","year":"2018","journal-title":"Pharm. Res"},{"key":"10.1016\/j.ejps.2020.105469_bib0001","first-page":"1","article-title":"Psoriasis, a systemic disease beyond the skin, as evidenced by psoriatic arthritis and many comorbities \u2013 clinical cemission with a leishmania amastigotes vaccine, a serendipity finding","volume":"18","author":"ODaly","year":"2012","journal-title":"Psoriasis - A Syst. Dis"},{"key":"10.1016\/j.ejps.2020.105469_bib0041","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1089\/jop.2010.0037","article-title":"Toxicity of a biodegradable microneedle implant loaded with methotrexate as a sustained release device in normal rabbit eye: A pilot study","volume":"27","author":"Palakurthi","year":"2011","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.ejps.2020.105469_bib0068","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1007\/s11095-006-0028-9","article-title":"Polymer microneedles for controlled-release drug delivery","volume":"23","author":"Park","year":"2006","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejps.2020.105469_bib0057","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0006-3495(88)82980-1","article-title":"On the mechanism of injury to slowly frozen erythrocytes","volume":"54","author":"Pegg","year":"1988","journal-title":"Biophys. J."},{"key":"10.1016\/j.ejps.2020.105469_bib0002","doi-asserted-by":"crossref","DOI":"10.3109\/21691401.2013.837474","article-title":"Development and characterization of nanocarriers for topical treatment of psoriasis by using combination therapy","volume":"42","author":"Parnami","year":"2014","journal-title":"Artif. Cells, Nanomed. Biotechnol."},{"key":"10.1016\/j.ejps.2020.105469_bib0051","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics11070346","article-title":"Enhanced intradermal delivery of nanosuspensions of antifilariasis drugs using dissolving microneedles: A proof of concept study","volume":"11","author":"Permana","year":"2019","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejps.2020.105469_bib0055","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics11070346","article-title":"Enhanced intradermal delivery of nanosuspensions of antifilariasis drugs using dissolving microneedles: A proof of concept study","volume":"11","author":"Permana","year":"2019","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejps.2020.105469_bib0004","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.ijpharm.2014.10.067","article-title":"A new topical formulation for psoriasis: Development of methotrexate-loaded nanostructured lipid carriers","volume":"477","author":"Pinto","year":"2014","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2020.105469_bib0028","doi-asserted-by":"crossref","first-page":"315","DOI":"10.4155\/tde.12.3","article-title":"Transdermal delivery of methotrexate: Past, present and future prospects","volume":"3","author":"Prasad","year":"2012","journal-title":"Ther. Deliv."},{"key":"10.1016\/j.ejps.2020.105469_bib0003","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.2165\/11591580-000000000-00000","article-title":"The burden of moderate to severe psoriasis: An overview","volume":"30","author":"Raho","year":"2012","journal-title":"Pharmacoeconomics"},{"key":"10.1016\/j.ejps.2020.105469_bib0035","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.ijpharm.2019.05.066","article-title":"Rapidly dissolving bilayer microneedle arrays \u2013 A minimally invasive transdermal drug delivery system for vitamin B12","volume":"566","author":"Ram\u00f6ller","year":"2019","journal-title":"Int. J. Pharm"},{"key":"10.1016\/j.ejps.2020.105469_bib0074","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ijpharm.2017.02.011","article-title":"Successful application of large microneedle patches by human volunteers","volume":"521","author":"Ripolin","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2020.105469_bib0054","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.molimm.2014.10.023","article-title":"The immunology of the porcine skin and its value as a model for human skin","volume":"66","author":"Summerfield","year":"2015","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.ejps.2020.105469_bib0031","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1211\/jpp.58.9.0002","article-title":"Permeation of bioactive constituents from Arnica montana preparations through human skin in-vitro","volume":"58","author":"Tekko","year":"2006","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejps.2020.105469_bib0038","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1211\/jpp.60.1.0004","article-title":"Synergistic effect of iontophoresis and soluble microneedles for transdermal delivery of methotrexate","volume":"60","author":"Vemulapalli","year":"2008","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejps.2020.105469_bib0026","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2147\/TCRM.S154745","article-title":"Update on subcutaneous methotrexate for inflammatory arthritis and psoriasis","volume":"14","author":"Vena","year":"2018","journal-title":"Ther. Clin. Risk Manag."},{"key":"10.1016\/j.ejps.2020.105469_bib0044","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/B978-0-323-48063-5.00002-2","article-title":"Nanotechnologies for tissue engineering and regeneration","author":"Ventre","year":"2018","journal-title":"Nanotechnol. Prev. Regen. Med"},{"key":"10.1016\/j.ejps.2020.105469_bib0045","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/jin2.41","article-title":"Novel nanosuspension-based dissolving microneedle arrays for transdermal delivery of a hydrophobic drug","volume":"3","author":"Vora","year":"2018","journal-title":"J. Interdiscip. Nanomedicine."},{"key":"10.1016\/j.ejps.2020.105469_bib0063","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.jconrel.2013.08.006","article-title":"Stability of nanosuspensions in drug delivery","volume":"172","author":"Wang","year":"2013","journal-title":"J. Control. Release."},{"key":"10.1016\/j.ejps.2020.105469_bib0022","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.ejmech.2018.09.027","article-title":"Side effects of methotrexate therapy for rheumatoid arthritis: A systematic review","volume":"158","author":"Wang","year":"2018","journal-title":"Eur. J. Med. Chem"},{"key":"10.1016\/j.ejps.2020.105469_bib0033","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1001\/archderm.1989.01670140079014","article-title":"Topical Methotrexate Therapy for Psoriasis","volume":"125","author":"Weinstein","year":"1989","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.ejps.2020.105469_bib0013","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0153740","article-title":"Safety and efficacy of methotrexate in psoriasis: a meta-analysis of published trials","volume":"11","author":"West","year":"2016","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ejps.2020.105469_bib0064","first-page":"518","article-title":"Enhanced transdermal delivery of meloxicam by nanocrystals: Preparation, in vitro and in vivo evaluation","volume":"13","author":"Yu","year":"2018","journal-title":"Asian J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2020.105469_bib0049","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ijpharm.2014.04.060","article-title":"Nanocrystals of medium soluble actives - Novel concept for improved dermal delivery and production strategy","volume":"470","author":"Zhai","year":"2014","journal-title":"Int. J. Pharm"},{"key":"10.1016\/j.ejps.2020.105469_bib0052","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1208\/s12248-010-9185-1","article-title":"DDSolver: An add-in program for modeling and comparison of drug dissolution profiles","volume":"12","author":"Zhang","year":"2010","journal-title":"AAPS J."},{"key":"10.1016\/j.ejps.2020.105469_bib0007","doi-asserted-by":"crossref","first-page":"14040","DOI":"10.1039\/D0RA00735H","article-title":"Microneedles: A potential strategy in transdermal delivery and application in the management of psoriasis","volume":"10","author":"Zhao","year":"2020","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejps.2020.105469_bib0059","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/j.2042-7158.2012.01599.x","article-title":"A nanoparticle depot formulation of 4-(N)-stearoyl gemcitabine shows a strong anti-tumour activity","volume":"65","author":"Zhu","year":"2013","journal-title":"J. Pharm. Pharmacol."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092809872030258X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092809872030258X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T11:56:51Z","timestamp":1760529411000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092809872030258X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":74,"alternative-id":["S092809872030258X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2020.105469","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Localised and sustained intradermal delivery of methotrexate using nanocrystal-loaded microneedle arrays: Potential for enhanced treatment of psoriasis","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2020.105469","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105469"}}