{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:40:25Z","timestamp":1788954025770,"version":"build-2803163510"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["GAP-407"],"award-info":[{"award-number":["GAP-407"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007854","name":"Central Institute of Medicinal and Aromatic Plants","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007854","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009104","name":"Department of Health Research, India","doi-asserted-by":"publisher","award":["GAP-432"],"award-info":[{"award-number":["GAP-432"]}],"id":[{"id":"10.13039\/501100009104","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.ejps.2020.105513","type":"journal-article","created":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T13:02:03Z","timestamp":1597410123000},"page":"105513","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"special_numbering":"C","title":["Fluorinated benzylidene indanone exhibits antiproliferative activity through modulation of microtubule dynamics and antiangiogenic activity"],"prefix":"10.1016","volume":"154","author":[{"given":"Ankita","family":"Srivastava","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaneez","family":"Fatima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eram","family":"Fatima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aastha","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparna","family":"Shukla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suaib","family":"Luqman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karuna","family":"Shanker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debabrata","family":"Chanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feroz","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1236-2493","authenticated-orcid":false,"given":"Arvind S.","family":"Negi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2020.105513_bib0001","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1016\/j.fct.2007.04.010","article-title":"Safety evaluation of a standardized phytochemical composition extracted from Bacopa monnieri in Sprague-Dawley rats","volume":"45","author":"Allan","year":"2007","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ejps.2020.105513_bib0002","doi-asserted-by":"crossref","first-page":"489","DOI":"10.3816\/CBC.2010.n.065","article-title":"CLEOPATRA: a phase III evaluation of pertuzumab and trastuzumab for HER2-positive metastatic breast cancer","volume":"10","author":"Baselga","year":"2010","journal-title":"Clin. Breast Cancer"},{"key":"10.1016\/j.ejps.2020.105513_bib0003","first-page":"1944","article-title":"Properties of the Ehrlich ascites tumour cell as determined by electron microscopy","volume":"28","author":"Beans","year":"1968","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejps.2020.105513_bib0004","unstructured":"Breast: Globocan: the global cancer observatory, March 2019."},{"key":"10.1016\/j.ejps.2020.105513_bib0005","unstructured":"Cancer: WHO factsheet, 12 September2018."},{"key":"10.1016\/j.ejps.2020.105513_bib0006","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/nature04478","article-title":"Angiogenesis in life, disease and medicine","volume":"438","author":"Carmeliet","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.ejps.2020.105513_bib0007","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature10144","article-title":"Molecular mechanisms and clinical applications of angiogenesis","volume":"473","author":"Carmeliet","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ejps.2020.105513_bib0008","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2131\/jts.34.99","article-title":"Safety evaluation of Trikatu, a generic Ayurvedic medicine in Charles Foster rat","volume":"34","author":"Chanda","year":"2008","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.ejps.2020.105513_bib0009","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1073\/pnas.94.7.2776","article-title":"The cell cycle and cancer","volume":"94","author":"Collins","year":"1997","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ejps.2020.105513_bib0010","doi-asserted-by":"crossref","first-page":"5750","DOI":"10.1021\/acs.jmedchem.8b01668","article-title":"Inhibitor of Apoptosis Protein (IAP) antagonists in anticancer agent discovery: current status and perspectives","volume":"62","author":"Cong","year":"2019","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejps.2020.105513_bib0011","doi-asserted-by":"crossref","first-page":"9356","DOI":"10.1158\/0008-5472.CAN-07-0509","article-title":"Class III \u03b2-tubulin mediates sensitivity to chemotherapeutic drugs in non-small lung cancer","volume":"67","author":"Gan","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejps.2020.105513_bib0012","series-title":"In: Fundamentals of Experimental Pharmacology","first-page":"156","author":"Ghosh","year":"1984"},{"key":"10.1016\/j.ejps.2020.105513_bib0013","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jsbmb.2013.05.011","article-title":"Current status on development of steroids as anticancer agents","volume":"137","author":"Gupta","year":"2013","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.ejps.2020.105513_bib0014","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.ejps.2020.105513_bib0015","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1126\/science.2683079","article-title":"Checkpoints: controls that ensure the order of cell cycle events","volume":"246","author":"Hartwell","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.ejps.2020.105513_bib0016","first-page":"83","article-title":"Metabolic and pharmacological aspects of fluorinated compounds","author":"Johnson","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejps.2020.105513_bib0017","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1158\/1541-7786.MCR-09-0367","article-title":"HuR knockdown changes the oncogenic potential of oral cancer cells","volume":"8","author":"Kakuguchi","year":"2010","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.ejps.2020.105513_bib0018","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1021\/acs.jnatprod.9b00105","article-title":"Microtubule-targeting drugs: more than antimitotics","volume":"82","author":"Kaul","year":"2019","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.ejps.2020.105513_bib0019","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nrc905","article-title":"Clinical translation of angiogenesis inhibitors","volume":"2","author":"Kerbel","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ejps.2020.105513_bib0020","doi-asserted-by":"crossref","first-page":"e56643","DOI":"10.1371\/journal.pone.0056643","article-title":"Induction apoptosis in human breast cancer cells via caspase pathway by vernodalin isolated from Centratherum anthelminticum (L) seeds","author":"Looi","year":"2013","journal-title":"PLoS ONE 8"},{"key":"10.1016\/j.ejps.2020.105513_bib0021","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nrc2602","article-title":"Cell cycle, CDKs and cancer: a changing paradigm\"","volume":"9","author":"Malumbres","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ejps.2020.105513_bib0022","doi-asserted-by":"crossref","first-page":"5822","DOI":"10.1021\/acs.jmedchem.7b01788","article-title":"Fluorine and fluorinated motifs in the design and application of bioisosteres for drug design","volume":"61","author":"Meanwell","year":"2018","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejps.2020.105513_bib0023","doi-asserted-by":"crossref","first-page":"9357","DOI":"10.1039\/C6RA28613E","article-title":"Aryilidene indanone scaffold: medicinal chemisty and structure activity relationship","volume":"7","author":"Menezes","year":"2017","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejps.2020.105513_bib0024","doi-asserted-by":"crossref","first-page":"10797","DOI":"10.1021\/jm301085w","article-title":"Vascular endothelial growth factor (VEGF) receptors: drugs and new inhibitors, J","volume":"55","author":"Musumeci","year":"2012","journal-title":"Med. Chem."},{"key":"10.1016\/j.ejps.2020.105513_bib0025","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.bmc.2014.12.027","article-title":"Natural antitubulin agents: importance of 3,4,5-trimethoxyphenyl Fragment","volume":"23","author":"Negi","year":"2015","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejps.2020.105513_bib0026","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.2174\/138945010791591395","article-title":"Vascular endothelial growth factor as an anti-angiogenic target for cancer therapy","volume":"18","author":"Niu","year":"2010","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.ejps.2020.105513_bib0027","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.canlet.2011.11.022","article-title":"Molecular markers for cancer prognosis and treatment: have we struck gold?","volume":"327","author":"Nowsheen","year":"2012","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ejps.2020.105513_bib0028","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S1470-2045(19)30792-2","article-title":"Attrition in metastatic breast cancer: a metric to be reported in randomised clinical trials?","volume":"21","author":"Nuzzolese","year":"2020","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.ejps.2020.105513_bib0029","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1146\/annurev.pharmtox.41.1.443","article-title":"Metabolism of fluorine containing drugs","volume":"41","author":"Park","year":"2001","journal-title":"Ann. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.ejps.2020.105513_bib0030","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13098-017-0228-y","article-title":"Urinary podocyte-associated mRNA levels correlate with proximal tubule dysfunction in early diabetic nephropathy of type 2 diabetes mellitus","volume":"9","author":"Petrica","year":"2017","journal-title":"Diabetol. Metab. Syndr."},{"key":"10.1016\/j.ejps.2020.105513_bib0031","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1186\/s12885-016-2528-2","article-title":"Bile acids destabilise HIF-1\u03b1 and promote anti-tumour phenotypes in cancer cell models","volume":"16","author":"Phelan","year":"2016","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ejps.2020.105513_bib0032","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1016\/j.bmc.2012.02.057","article-title":"Gallic acid based benzylidene indanones as anticancer agents","volume":"20","author":"Prakasham","year":"2012","journal-title":"Bioorg. Med. Chem"},{"key":"10.1016\/j.ejps.2020.105513_bib0033","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1016\/j.ejca.2009.04.007","article-title":"Angiogenesis in pre-malignant conditions","volume":"45","author":"Raica","year":"2009","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.ejps.2020.105513_bib0034","doi-asserted-by":"crossref","first-page":"29768","DOI":"10.1038\/srep29768","article-title":"Bile signalling promotes chronic respiratory infections and antibiotictolerance","volume":"6","author":"Reen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejps.2020.105513_bib0035","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1038\/nprot.2006.238","article-title":"Analysis of apoptosis by propidium iodide staining and flow cytometry","volume":"1","author":"Riccardi","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ejps.2020.105513_bib0036","doi-asserted-by":"crossref","first-page":"5708","DOI":"10.1073\/pnas.1505979112","article-title":"Alternative to the soft-agar assay that permits high throughput drug and genetic screens for cellular transformation","volume":"112","author":"Rotem","year":"2015","journal-title":"Proc. Natl. Acad. Sci"},{"key":"10.1016\/j.ejps.2020.105513_bib0037","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.canlet.2014.04.018","article-title":"Estrogen metabolism and breast cancer","volume":"356","author":"Samavat","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ejps.2020.105513_bib0038","doi-asserted-by":"crossref","first-page":"3914","DOI":"10.1016\/j.bmcl.2008.06.039","article-title":"Gallic acid based indanone derivatives as anticancer agents","volume":"18","author":"Saxena","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejps.2020.105513_bib0039","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1080\/14756360701425014","article-title":"The role of fluorine in medicinal chemistry","volume":"22","author":"Shah","year":"2007","journal-title":"J. Enz. Inhib. Med. Chem."},{"key":"10.1016\/j.ejps.2020.105513_bib0041","doi-asserted-by":"crossref","first-page":"4435","DOI":"10.1073\/pnas.72.11.4435","article-title":"of virus-transformed cells in nude mice is correlated specifically with anchorage independent growth in vitro","volume":"72","author":"Shin","year":"1975","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ejps.2020.105513_bib0042","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1126\/science.274.5293.1672","article-title":"Cancer cell cycles","volume":"274","author":"Sher","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.ejps.2020.105513_bib0043","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1146\/annurev-cancerbio-040716-075628","article-title":"Cell cycle: targeted cancer therapies","volume":"1","author":"Sher","year":"2017","journal-title":"Ann. Rev Cancer Biol."},{"key":"10.1016\/j.ejps.2020.105513_bib0044","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12943-015-0321-5","article-title":"Apoptosis, autophagy, necroptosis, and cancer metastasis","volume":"14","author":"Su","year":"2015","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.ejps.2020.105513_bib0045","series-title":"Safety Monitoring of Medicinal Products","article-title":"The importance of pharmacovigilance","year":"2002"},{"key":"10.1016\/j.ejps.2020.105513_bib0046","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1021\/acs.jmedchem.7b01091","article-title":"Discovery of novel potent VEGFR-2 inhibitors exerting significant antiproliferative activity against cancer cell lines","volume":"61","author":"Zhang","year":"2018","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejps.2020.105513_bib0047","doi-asserted-by":"crossref","first-page":"8881","DOI":"10.1021\/acs.jmedchem.9b00017","article-title":"Rational design of multitarget-directed ligands: strategies and emerging paradigm","volume":"62","author":"Zhou","year":"2019","journal-title":"J. Med. Chem."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098720303018?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098720303018?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T16:16:01Z","timestamp":1778775361000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098720303018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":46,"alternative-id":["S0928098720303018"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2020.105513","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fluorinated benzylidene indanone exhibits antiproliferative activity through modulation of microtubule dynamics and antiangiogenic activity","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2020.105513","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105513"}}