{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T08:30:05Z","timestamp":1793953805348,"version":"4.8.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.ejps.2021.105911","type":"journal-article","created":{"date-parts":[[2021,6,12]],"date-time":"2021-06-12T11:26:07Z","timestamp":1623497167000},"page":"105911","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"special_numbering":"C","title":["Flow Structure and Particle Deposition Analyses for Optimization of a Pressurized Metered Dose Inhaler (pMDI) in a Model of Tracheobronchial Airway"],"prefix":"10.1016","volume":"164","author":[{"given":"Kaveh","family":"Ahookhosh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7423-334X","authenticated-orcid":false,"given":"Maysam","family":"Saidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mousa","family":"Mohammadpourfard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habib","family":"Aminfar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamed","family":"Hamishehkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9298-5497","authenticated-orcid":false,"given":"Ali","family":"Farnoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8012-7786","authenticated-orcid":false,"given":"Otmar","family":"Schmid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2-3","key":"10.1016\/j.ejps.2021.105911_bib0001","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s00348-007-0296-0","article-title":"Dynamic flow in a realistic model of the upper human lung airways","volume":"43","author":"Adler","year":"2007","journal-title":"Experiments in Fluids"},{"key":"10.1016\/j.ejps.2021.105911_bib0002","doi-asserted-by":"crossref","first-page":"105233","DOI":"10.1016\/j.ejps.2020.105233","article-title":"Development of human respiratory airway models: A review","author":"Ahookhosh","year":"2020","journal-title":"European Journal of Pharmaceutical Sciences"},{"key":"10.1016\/j.ejps.2021.105911_bib0003","doi-asserted-by":"crossref","first-page":"119599","DOI":"10.1016\/j.ijpharm.2020.119599","article-title":"Dry powder inhaler aerosol deposition in a model of tracheobronchial airways: Validating cfd predictions with in vitro data","author":"Ahookhosh","year":"2020","journal-title":"International Journal of Pharmaceutics"},{"key":"10.1016\/j.ejps.2021.105911_bib0004","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ijpharm.2019.05.058","article-title":"Experimental investigation of aerosol deposition through a realistic respiratory airway replica: An evaluation for mdi and dpi performance","volume":"566","author":"Ahookhosh","year":"2019","journal-title":"International journal of pharmaceutics"},{"issue":"11","key":"10.1016\/j.ejps.2021.105911_bib0005","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1016\/j.rmed.2007.06.008","article-title":"Can all patients with copd use the correct inhalation flow with all inhalers and does training help?","volume":"101","author":"Al-Showair","year":"2007","journal-title":"Respiratory medicine"},{"issue":"5","key":"10.1016\/j.ejps.2021.105911_bib0006","doi-asserted-by":"crossref","first-page":"505","DOI":"10.3109\/02770903.2013.783064","article-title":"Optimizing the inhalation flow and technique through metered dose inhalers of asthmatic adults and children attending a community pharmacy","volume":"50","author":"Ammari","year":"2013","journal-title":"Journal of Asthma"},{"key":"10.1016\/j.ejps.2021.105911_bib0007","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jaerosci.2014.03.005","article-title":"Measurements of total aerosol deposition in intrathoracic conducting airway replicas of children","volume":"73","author":"Borojeni","year":"2014","journal-title":"Journal of aerosol science"},{"key":"10.1016\/j.ejps.2021.105911_bib0008","doi-asserted-by":"crossref","first-page":"119341","DOI":"10.1016\/j.ijpharm.2020.119341","article-title":"In vitro assessment of an idealized nose for nasal spray testing: Comparison with regional deposition in realistic nasal replicas","author":"Chen","year":"2020","journal-title":"International Journal of Pharmaceutics"},{"issue":"2","key":"10.1016\/j.ejps.2021.105911_bib0009","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1089\/08942680152484180","article-title":"Respiratory deposition patterns of salbutamol pmdi with cfc and hfa-134a formulations in a human airway replica","volume":"14","author":"Cheng","year":"2001","journal-title":"Journal of aerosol medicine"},{"issue":"4","key":"10.1016\/j.ejps.2021.105911_bib0010","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1080\/027868299304165","article-title":"Particle deposition in a cast of human oral airways","volume":"31","author":"Cheng","year":"1999","journal-title":"Aerosol Science & Technology"},{"issue":"2","key":"10.1016\/j.ejps.2021.105911_bib0011","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1089\/jamp.2008.0687","article-title":"Characterization of the spray velocities from a pressurized metered-dose inhaler","volume":"22","author":"Crosland","year":"2009","journal-title":"Journal of aerosol medicine and pulmonary drug delivery"},{"key":"10.1016\/j.ejps.2021.105911_bib0099","doi-asserted-by":"crossref","DOI":"10.1016\/j.resp.2020.103468","article-title":"Investigation of airflow field in the upper airway under unsteady respiration pattern using large eddy simulation method","volume":"279","author":"Cui","year":"2020","journal-title":"Respiratory Physiology & Neurobiology"},{"issue":"3","key":"10.1016\/j.ejps.2021.105911_bib0012","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1089\/jamp.2009.0772","article-title":"Lung deposition of bdp\/formoterol hfa pmdi in healthy volunteers, asthmatic, and copd patients","volume":"23","author":"De Backer","year":"2010","journal-title":"Journal of aerosol medicine and pulmonary drug delivery"},{"issue":"243","key":"10.1016\/j.ejps.2021.105911_bib0013","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s40430-020-02345-y","article-title":"Numerical simulation of ellipsoidal particles deposition in the human nasal cavity under cyclic inspiratory flow","volume":"42","author":"Esmaeili","year":"2020","journal-title":"Journal of the Brazilian Society of Mechanical Sciences and Engineering"},{"issue":"8","key":"10.1016\/j.ejps.2021.105911_bib0014","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.jaerosci.2007.06.002","article-title":"Effects of mdi spray angle on aerosol penetration efficiency through an oral airway cast","volume":"38","author":"Fadl","year":"2007","journal-title":"Journal of aerosol science"},{"issue":"1-2","key":"10.1016\/j.ejps.2021.105911_bib0015","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.ijpharm.2018.06.016","article-title":"Effect of delayed pmdi actuation on the lung deposition of a fixed-dose combination aerosol drug","volume":"547","author":"Farkas","year":"2018","journal-title":"International journal of pharmaceutics"},{"key":"10.1016\/j.ejps.2021.105911_bib0016","doi-asserted-by":"crossref","first-page":"103816","DOI":"10.1016\/j.compbiomed.2020.103816","article-title":"Simulation of patient-specific bidirectional pulsating nasal aerosol dispersion and deposition with clockwise 45\u00b0 and 90\u00b0 nosepieces","author":"Farnoud","year":"2020","journal-title":"Computers in Biology and Medicine"},{"issue":"11","key":"10.1016\/j.ejps.2021.105911_bib0017","doi-asserted-by":"crossref","DOI":"10.1615\/AtomizSpr.2017020782","article-title":"Numerical simulation of the dispersion and deposition of a spray carried by a pulsating airflow in a patient-specific human nasal cavity","volume":"27","author":"Farnoud","year":"2017","journal-title":"Atomization and Sprays"},{"issue":"10","key":"10.1016\/j.ejps.2021.105911_bib0018","doi-asserted-by":"crossref","first-page":"101905","DOI":"10.1063\/5.0024264","article-title":"Large eddy simulations of airflow and particle deposition in pulsating bi-directional nasal drug delivery","volume":"32","author":"Farnoud","year":"2020","journal-title":"Physics of Fluids"},{"key":"10.1016\/j.ejps.2021.105911_bib0019","series-title":"Colloid and Interface Science in Pharmaceutical Research and Development","first-page":"79","article-title":"Surface interactions in propellant driven metered dose inhaler product design","author":"Hickey","year":"2014"},{"issue":"3","key":"10.1016\/j.ejps.2021.105911_bib0020","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1089\/jam.2005.18.273","article-title":"Comparison of the aerosol velocity and spray duration of respimat\u00ae soft mist\u2122inhaler and pressurized metered dose inhalers","volume":"18","author":"Hochrainer","year":"2005","journal-title":"Journal of aerosol medicine"},{"issue":"2","key":"10.1016\/j.ejps.2021.105911_bib0021","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1152\/jappl.1971.31.2.207","article-title":"Models of the human bronchial tree.","volume":"31","author":"Horsfield","year":"1971","journal-title":"Journal of applied physiology"},{"key":"10.1016\/j.ejps.2021.105911_bib0022","doi-asserted-by":"crossref","first-page":"105508","DOI":"10.1016\/j.ejps.2020.105508","article-title":"Numerical simulation of the effect of inhalation parameters, gender, age and disease severity on the lung deposition of dry powder aerosol drugs emitted by turbuhaler\u00ae, breezhaler\u00ae and genuair\u00ae in copd patients","volume":"154","author":"Horv\u00e1th","year":"2020","journal-title":"European Journal of Pharmaceutical Sciences"},{"issue":"6","key":"10.1016\/j.ejps.2021.105911_bib0023","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1089\/jamp.2019.1523","article-title":"In vitro measurement of regional nasal drug delivery with flonase,\u00ae flonase\u00ae sensimist,\u2122and mad nasal\u2122in anatomically correct nasal airway replicas of pediatric and adult human subjects","volume":"32","author":"Hosseini","year":"2019","journal-title":"Journal of aerosol medicine and pulmonary drug delivery"},{"issue":"10","key":"10.1016\/j.ejps.2021.105911_bib0024","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.medengphy.2010.08.012","article-title":"Micron particle deposition in a tracheobronchial airway model under different breathing conditions","volume":"32","author":"Inthavong","year":"2010","journal-title":"Medical engineering & physics"},{"issue":"8","key":"10.1016\/j.ejps.2021.105911_bib0025","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1080\/08958370050085156","article-title":"Measurement of total lung deposition of inhaled ultrafine particles in healthy men and women","volume":"12","author":"Jaques","year":"2000","journal-title":"Inhalation toxicology"},{"issue":"3","key":"10.1016\/j.ejps.2021.105911_bib0026","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jaerosci.2006.09.008","article-title":"Large eddy simulation of inhaled particle deposition within the human upper respiratory tract","volume":"38","author":"Jin","year":"2007","journal-title":"Journal of Aerosol Science"},{"issue":"6","key":"10.1016\/j.ejps.2021.105911_bib0027","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1152\/jappl.1998.84.6.1834","article-title":"Regional deposition of inhaled particles in human lungs: comparison between men and women","volume":"84","author":"Kim","year":"1998","journal-title":"Journal of Applied Physiology"},{"issue":"3","key":"10.1016\/j.ejps.2021.105911_bib0028","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1089\/jam.2006.0617","article-title":"Computational analyses of a pressurized metered dose inhaler and a new drug\u2013aerosol targeting methodology","volume":"20","author":"Kleinstreuer","year":"2007","journal-title":"Journal of aerosol medicine"},{"issue":"2","key":"10.1016\/j.ejps.2021.105911_bib0029","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0301-9322(02)00131-3","article-title":"Laminar-to-turbulent fluid-particle flows in a human airway model","volume":"29","author":"Kleinstreuer","year":"2003","journal-title":"International Journal of Multiphase Flow"},{"key":"10.1016\/j.ejps.2021.105911_bib0030","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev-fluid-121108-145453","article-title":"Airflow and particle transport in the human respiratory system","volume":"42","author":"Kleinstreuer","year":"2010","journal-title":"Annual review of fluid mechanics"},{"key":"10.1016\/j.ejps.2021.105911_bib0031","series-title":"Essential chemistry for formulators of semisolid and liquid dosages","author":"Kulkarni","year":"2015"},{"issue":"7","key":"10.1016\/j.ejps.2021.105911_bib0032","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.rmed.2011.03.012","article-title":"Retail sales of inhalation devices in european countries: so much for a global policy","volume":"105","author":"Lavorini","year":"2011","journal-title":"Respiratory medicine"},{"issue":"5","key":"10.1016\/j.ejps.2021.105911_bib0033","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.euromechflu.2007.02.003","article-title":"Simulation of airflow fields and microparticle deposition in realistic human lung airway models. part i: Airflow patterns","volume":"26","author":"Li","year":"2007","journal-title":"European Journal of Mechanics-B\/Fluids"},{"issue":"2-3","key":"10.1016\/j.ejps.2021.105911_bib0034","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.resp.2007.02.006","article-title":"Characteristics of the turbulent laryngeal jet and its effect on airflow in the human intra-thoracic airways","volume":"157","author":"Lin","year":"2007","journal-title":"Respiratory physiology & neurobiology"},{"issue":"4","key":"10.1016\/j.ejps.2021.105911_bib0035","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1136\/oem.37.4.337","article-title":"Deposition, retention, and clearance of inhaled particles.","volume":"37","author":"Lippmann","year":"1980","journal-title":"Occupational and Environmental Medicine"},{"issue":"3","key":"10.1016\/j.ejps.2021.105911_bib0036","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1177\/0954411911430188","article-title":"Development of a realistic human airway model","volume":"226","author":"Lizal","year":"2012","journal-title":"Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine"},{"key":"10.1016\/j.ejps.2021.105911_bib0037","series-title":"EPJ Web of Conferences","first-page":"01050","article-title":"Aerosol transport in a model of human lungs","volume":"25","author":"Lizal","year":"2012"},{"key":"10.1016\/j.ejps.2021.105911_bib0038","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ejps.2017.08.021","article-title":"Experimental methods for flow and aerosol measurements in human airways and their replicas","volume":"113","author":"Lizal","year":"2018","journal-title":"European Journal of Pharmaceutical Sciences"},{"issue":"7","key":"10.1016\/j.ejps.2021.105911_bib0039","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.jaerosci.2008.03.008","article-title":"Comparison of ambient and spray aerosol deposition in a standard induction port and more realistic mouth\u2013throat geometry","volume":"39","author":"Longest","year":"2008","journal-title":"Journal of Aerosol Science"},{"issue":"6","key":"10.1016\/j.ejps.2021.105911_bib0040","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1007\/s11095-012-0691-y","article-title":"Comparing mdi and dpi aerosol deposition using in vitro experiments and a new stochastic individual path (sip) model of the conducting airways","volume":"29","author":"Longest","year":"2012","journal-title":"Pharmaceutical research"},{"issue":"2","key":"10.1016\/j.ejps.2021.105911_bib0041","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1017\/S0022112072001806","article-title":"An investigation of particle trajectories in two-phase flow systems","volume":"55","author":"Morsi","year":"1972","journal-title":"Journal of Fluid mechanics"},{"key":"10.1016\/j.ejps.2021.105911_bib0042","series-title":"Proceedings of the World Congress on Engineering","article-title":"pmdi spray plume analysis: a cfd study","volume":"3","author":"Oliveira","year":"2013"},{"key":"10.1016\/j.ejps.2021.105911_bib0043","article-title":"pmdi sprays: Theory, experiment and numerical simulation","volume":"300","author":"Oliveira","year":"2012","journal-title":"Advances in Modeling of Fluid Dynamics"},{"issue":"21","key":"10.1016\/j.ejps.2021.105911_bib0044","doi-asserted-by":"crossref","first-page":"4511","DOI":"10.1016\/j.scitotenv.2011.07.020","article-title":"Effects of physical activity on the deposition of traffic-related particles into the human lungs in silico","volume":"409","author":"Oravisj\u00e4rvi","year":"2011","journal-title":"Science of the total environment"},{"issue":"5","key":"10.1016\/j.ejps.2021.105911_bib0045","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1007\/s10237-016-0768-3","article-title":"Magnetic drug targeting through a realistic model of human tracheobronchial airways using computational fluid and particle dynamics","volume":"15","author":"Pourmehran","year":"2016","journal-title":"Biomechanics and modeling in mechanobiology"},{"issue":"4","key":"10.1016\/j.ejps.2021.105911_bib0046","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.compmedimag.2004.01.001","article-title":"A digital reference model of the human bronchial tree","volume":"28","author":"Schmidt","year":"2004","journal-title":"Computerized Medical Imaging and Graphics"},{"issue":"12","key":"10.1016\/j.ejps.2021.105911_bib0047","doi-asserted-by":"crossref","DOI":"10.21037\/atm.2016.06.05","article-title":"Total deposition of ultrafine particles in the lungs of healthy men and women: experimental and theoretical results","volume":"4","author":"Sturm","year":"2016","journal-title":"Annals of translational medicine"},{"key":"10.1016\/j.ejps.2021.105911_bib0048","series-title":"Computational fluid and particle dynamics in the human respiratory system","author":"Tu","year":"2012"},{"key":"10.1016\/j.ejps.2021.105911_bib0049","series-title":"Morphometry of the human lung","first-page":"136","article-title":"Geometric and dimensional airway models of conductive, transitory and respiratory zones of the human lung","author":"Weibel","year":"1963"},{"key":"10.1016\/j.ejps.2021.105911_bib0050","series-title":"Turbulence modeling for CFD","volume":"2","author":"Wilcox","year":"1998"},{"issue":"6","key":"10.1016\/j.ejps.2021.105911_bib0051","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1152\/japplphysiol.01233.2007","article-title":"Effects of the laryngeal jet on nano-and microparticle transport and deposition in an approximate model of the upper tracheobronchial airways","volume":"104","author":"Xi","year":"2008","journal-title":"Journal of Applied Physiology"},{"key":"10.1016\/j.ejps.2021.105911_bib0052","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.compbiomed.2014.08.001","article-title":"Transport and deposition of pharmaceutical particles in three commercial spacer\u2013mdi combinations","volume":"54","author":"Yazdani","year":"2014","journal-title":"Computers in biology and medicine"},{"issue":"3","key":"10.1016\/j.ejps.2021.105911_bib0053","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0092-8240(80)80060-7","article-title":"Models of human lung airways and their application to inhaled particle deposition","volume":"42","author":"Yeh","year":"1980","journal-title":"Bulletin of mathematical biology"},{"issue":"5","key":"10.1016\/j.ejps.2021.105911_bib0054","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1089\/jamp.2016.1299","article-title":"Effect of pressurized metered dose inhaler spray characteristics and particle size distribution on drug delivery efficiency","volume":"30","author":"Yousefi","year":"2017","journal-title":"Journal of aerosol medicine and pulmonary drug delivery"},{"issue":"6","key":"10.1016\/j.ejps.2021.105911_bib0055","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1007\/s10237-017-0936-0","article-title":"Cfd simulation of aerosol delivery to a human lung via surface acoustic wave nebulization","volume":"16","author":"Yousefi","year":"2017","journal-title":"Biomechanics and modeling in mechanobiology"},{"issue":"6","key":"10.1016\/j.ejps.2021.105911_bib0056","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1080\/027868291001385","article-title":"Particle deposition in a cast of human tracheobronchial airways","volume":"39","author":"Zhou","year":"2005","journal-title":"Aerosol Science and Technology"}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098721002128?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098721002128?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T10:54:20Z","timestamp":1744282460000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098721002128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":57,"alternative-id":["S0928098721002128"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2021.105911","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Flow Structure and Particle Deposition Analyses for Optimization of a Pressurized Metered Dose Inhaler (pMDI) in a Model of Tracheobronchial Airway","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2021.105911","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105911"}}