{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:54:40Z","timestamp":1787964880494,"version":"build-2784847793"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.ejps.2021.105935","type":"journal-article","created":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T02:31:32Z","timestamp":1626489092000},"page":"105935","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"special_numbering":"C","title":["Acid-base combination principles for preparation of anti-acne dissolving microneedles loaded with azelaic acid and matrine"],"prefix":"10.1016","volume":"165","author":[{"given":"Mengzhen","family":"Xing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guozhong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suohui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhua","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2021.105935_bib0001","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12895-020-00108-9","article-title":"Antibiotic resistant Cutibacterium acnes among acne patients in Jordan: a cross sectional study","volume":"20","author":"Alkhawaja","year":"2020","journal-title":"BMC Dermatol."},{"key":"10.1016\/j.ejps.2021.105935_bib0002","article-title":"Efficacy of 30% azelaic acid peel in the nonpharmacological treatment of facial acne","volume":"1657222","author":"Anna","year":"2019","journal-title":"J. Dermatol. Treat."},{"key":"10.1016\/j.ejps.2021.105935_bib0003","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.cmi.2016.12.022","article-title":"Role of inoculum and mutant frequency on fosfomycin MIC discrepancies by agar dilution and broth microdilution methods in Enterobacteriaceae","volume":"23","author":"Ballestero-Tellez","year":"2017","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.ejps.2021.105935_bib0004","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1111\/jocd.12812","article-title":"Evaluation of the efficacy of microneedle fractional radiofrequency in Turkish patients with atrophic facial acne scars","volume":"18","author":"Baskan","year":"2019","journal-title":"J. Cosmet. Dermatol."},{"key":"10.1016\/j.ejps.2021.105935_bib0005","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0733-8635(18)30436-4","article-title":"Sensitive and ethnic skin. A need for special skin-care agents?","volume":"9","author":"Berardesca","year":"1991","journal-title":"Dermatol. Clin."},{"key":"10.1016\/j.ejps.2021.105935_bib0006","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1093\/jac\/28.6.843","article-title":"The in-vitro antimicrobial effects of azelaic acid upon Propionibacterium acnes strain P37","volume":"28","author":"Bojar","year":"1991","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.ejps.2021.105935_bib0007","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.ejps.2003.12.006","article-title":"Evaluation of the antibacterial efficacy of diesters of azelaic acid","volume":"21","author":"Charnock","year":"2004","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2021.105935_bib0008","article-title":"Enhanced transdermal delivery of polydatin via a combination of inclusion complexes and dissolving microneedles for treatment of acute gout arthritis","volume":"55","author":"Chen","year":"2020","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.ejps.2021.105935_bib0009","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1001\/archderm.138.11.1462","article-title":"Mechanisms of photoaging and chronological skin aging","volume":"138","author":"Fisher","year":"2002","journal-title":"JAMA Dermatol."},{"key":"10.1016\/j.ejps.2021.105935_bib0010","doi-asserted-by":"crossref","first-page":"75","DOI":"10.4103\/japtr.JAPTR_289_18","article-title":"Formulation, characterization, and in vitro testing of azelaic acid ethosome-based cream against Propionibacterium acnes for the treatment of acne","volume":"10","author":"Fitria","year":"2019","journal-title":"J. Adv. Pharm. Technol. Res."},{"key":"10.1016\/j.ejps.2021.105935_bib0011","article-title":"Bacterial nanocellulose-hyaluronic acid microneedle patches for skin applications: in vitro and in vivo evaluation","volume":"C118","author":"Fonseca","year":"2021","journal-title":"Mater. Sci. Eng."},{"key":"10.1016\/j.ejps.2021.105935_bib0012","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1080\/14786419.2011.608675","article-title":"Anti-inammatory effects of active constituents extracted from Chinese medicinal herbs against Propionibacterium acnes","volume":"26","author":"Fu","year":"2012","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.ejps.2021.105935_bib0013","doi-asserted-by":"crossref","first-page":"11328","DOI":"10.1038\/s41598-018-28661-x","article-title":"Matrine inhibits itching by lowering the activity of calcium channel","volume":"8","author":"Geng","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejps.2021.105935_bib0014","first-page":"1083","article-title":"Combinatorial application of dissolving microneedle patch and cream for improvement of skin wrinkles, dermal density, elasticity, and hydration","volume":"18","author":"Geonwoo","year":"2018","journal-title":"J. Cosmet. Dermatol."},{"key":"10.1016\/j.ejps.2021.105935_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11064-016-2040-8","article-title":"Neuroprotective effect of matrine in mouse model of vincristine-induced neuropathic pain","volume":"41","author":"Gong","year":"2016","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejps.2021.105935_bib0016","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25215024","article-title":"Plant derived natural products against Pseudomonas aeruginosa and Staphylococcus aureus: antibiofilm activity and molecular mechanisms","volume":"25","author":"Guzzo","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.ejps.2021.105935_bib0017","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.xphs.2017.11.013","article-title":"Dissolving microneedles loaded with etonogestrel microcrystal particles for intradermal sustained delivery","volume":"107","author":"He","year":"2018","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2021.105935_bib0018","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S1357-4310(99)01544-0","article-title":"P38 MAPK signalling cascades in inflammatory disease","volume":"5","author":"Herlaar","year":"1999","journal-title":"Mol. Med. Today"},{"key":"10.1016\/j.ejps.2021.105935_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2019.103698","article-title":"Total alkaloids of Sophora alopecuroides and matrine inhibit auto-inducer 2 in the biofilms of Staphylococcus epidermidis","volume":"136","author":"Jia","year":"2019","journal-title":"Microb. Pathogenesis"},{"key":"10.1016\/j.ejps.2021.105935_bib0020","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/ics.12115","article-title":"Novel cosmetic patches for wrinkle improvement: retinyl retinoate- and ascorbic acid-loaded dissolving microneedles","volume":"36","author":"Kim","year":"2014","journal-title":"Int. J. Cosmet."},{"key":"10.1016\/j.ejps.2021.105935_bib0021","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/jocd.12178","article-title":"4-n-butylresorcinol dissolving microneedle patch for skin depigmentation: a randomized, double-blind, placebo-controlled trial","volume":"15","author":"Kim","year":"2016","journal-title":"J. Cosmet. Dermatol."},{"key":"10.1016\/j.ejps.2021.105935_bib0022","first-page":"134","article-title":"Expression of functional ICAM-1 on cultured human keratocytes induced by tumor necrosis factor-\u03b1","volume":"47","author":"Kumagai","year":"2003","journal-title":"Jpn. J. Ophthal."},{"key":"10.1016\/j.ejps.2021.105935_bib0023","article-title":"Enhancing efficacy and safety of azelaic acid via encapsulation in cyclodextrin nanosponges: development, characterization and evaluation","volume":"1\u201328","author":"Kumar","year":"2020","journal-title":"Polym. Bull."},{"key":"10.1016\/j.ejps.2021.105935_bib0024","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/jocd.12982","article-title":"Combined treatment of recalcitrant papulopustular rosacea involving pulsed dye laser and fractional microneedling radiofrequency with low-dose isotretinoin","volume":"19","author":"Kwon","year":"2020","journal-title":"J. Cosmet. Dermatol."},{"key":"10.1016\/j.ejps.2021.105935_bib0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mser.2016.03.001","article-title":"Microneedle arrays as transdermal and intradermal drug delivery systems: Materials science, manufacture and commercial development","volume":"104","author":"Larra\u00f1eta","year":"2016","journal-title":"Mater. Sci. Eng. R"},{"key":"10.1016\/j.ejps.2021.105935_bib0026","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/ics.12299","article-title":"Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study","volume":"38","author":"Lee","year":"2016","journal-title":"Int. J. Cosmet. Sci."},{"key":"10.1016\/j.ejps.2021.105935_bib0027","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/lsm.22200","article-title":"Assessment of treatment efficacy and sebosuppressive effect of fractional radiofrequency microneedle on acne vulgaris","volume":"45","author":"Lee","year":"2013","journal-title":"Lasers Surg. Med."},{"key":"10.1016\/j.ejps.2021.105935_bib0028","article-title":"Alstonia scholaris R. Br. Significantly inhibits retinoid-induced skin irritation in vitro and in vivo","volume":"2012","author":"Lee","year":"2012","journal-title":"Evid. Based. Complem. Altern. Med."},{"key":"10.1016\/j.ejps.2021.105935_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2020.105269","article-title":"Hyaluronan molecular weight: effects on dissolution time of dissolving microneedles in the skin and on immunogenicity of antigen","volume":"146","author":"Leone","year":"2020","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2021.105935_bib0030","doi-asserted-by":"crossref","first-page":"985","DOI":"10.3109\/03639045.2011.635376","article-title":"Effect of ionization and vehicle on skin absorption and penetration of azelaic acid","volume":"38","author":"Li","year":"2012","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.ejps.2021.105935_bib0031","doi-asserted-by":"crossref","first-page":"3810","DOI":"10.1016\/j.vaccine.2019.05.055","article-title":"Transcutaneous immunization of recombinant Staphylococcal enterotoxin B protein using a dissolving microneedle provides potent protection against lethal enterotoxin challenge","volume":"37","author":"Liu","year":"2019","journal-title":"Vaccine"},{"key":"10.1016\/j.ejps.2021.105935_bib0032","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jconrel.2014.02.007","article-title":"Design and physicochemical characterisation of novel dissolving polymeric microneedle arrays for transdermal delivery of high dose, low molecular weight drugs","volume":"180","author":"McCrudden","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejps.2021.105935_bib0033","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0923-1811(93)90002-7","article-title":"Activated keratinocytes present bacterial-derived superantigens to T lymphocytes: relevance to psoriasis","volume":"6","author":"Nickoloff","year":"1993","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.ejps.2021.105935_bib0034","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jgar.2017.09.005","article-title":"Effect of total alkaloid extract of local Sophora alopecuroides on minimum inhibitory concentration and intracellular accumulation of ciprofloxacin, and acrA expression in highly resistant Escherichia coli clones","volume":"12","author":"Pourahmad","year":"2018","journal-title":"J. Glob. Antimicrob. Resist."},{"key":"10.1016\/j.ejps.2021.105935_bib0035","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1038\/nbt.1504","article-title":"Transdermal drug delivery","volume":"26","author":"Prausnitz","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ejps.2021.105935_bib0036","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1467-2494.2004.00243.x","article-title":"Sensitive skin: mechanisms and diagnosis","volume":"27","author":"Primavera","year":"2005","journal-title":"Int. J. Cosmet. Sci."},{"key":"10.1016\/j.ejps.2021.105935_bib0038","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2016.05.006","article-title":"Systemic delivery of artemether by dissolving microneedles","volume":"508","author":"Qiu","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2021.105935_bib0039","first-page":"67","article-title":"Azelaic acid gel 15% in the management of papulopustular rosacea: a status report on available efficacy data and clinical application","volume":"88","author":"Rosso","year":"2011","journal-title":"Cutis"},{"key":"10.1016\/j.ejps.2021.105935_bib0040","article-title":"The versatility of azelaic acid in dermatology","author":"Searle","year":"2020","journal-title":"J. Dermatol. Treat"},{"key":"10.1016\/j.ejps.2021.105935_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2020.105620","article-title":"Non-ionic surfactants as innovative skin penetration enhancers: insight in the mechanism of interaction with simple 2D stratum corneum model system","volume":"157","author":"Strati","year":"2021","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2021.105935_bib0042","doi-asserted-by":"crossref","first-page":"11775","DOI":"10.1021\/acsnano.0c04527","article-title":"Dissolvable microneedles coupled with nanofiber dressings eradicate biofilms via effectively delivering a database-designed antimicrobial peptide","volume":"14","author":"Su","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.ejps.2021.105935_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2020.105469","article-title":"Localised and sustained intradermal delivery of methotrexate using nanocrystal-loaded microneedle arrays: potential for enhanced treatment of psoriasis","volume":"152","author":"Tekko","year":"2020","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2021.105935_bib0044","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.jcis.2021.03.086","article-title":"Stiffness-tuneable nanocarriers for controlled delivery of ASC-J9 into colorectal cancer cells","volume":"594","author":"Tomeh","year":"2021","journal-title":"J. Colloid. Interf. Sci."},{"key":"10.1016\/j.ejps.2021.105935_bib0045","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.1128\/iai.63.8.3158-3165.1995","article-title":"Induction of proinflammatory cytokines by a soluble factor of Propionibacterium acnes: implications for chronic inflammatory acne","volume":"63","author":"Vowels","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ejps.2021.105935_bib0046","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112172","article-title":"Sophora alopecuroides L.: an ethnopharmacological, phytochemical, and pharmacological review","volume":"248","author":"Wang","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejps.2021.105935_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2020.129234","article-title":"Pegylated azelaic acid: synthesis, tyrosinase inhibitory activity, antibacterial activity and cytotoxic studies","volume":"1224","author":"Wang","year":"2021","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.ejps.2021.105935_bib0048","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.120406","article-title":"Novel dissolving microneedles preparation for synergistic melasma therapy: combined effects of tranexamic acid and licorice extract","volume":"600","author":"Xing","year":"2021","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2021.105935_bib0049","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.actbio.2020.12.004","article-title":"Microneedle-mediated transdermal drug delivery for treating diverse skin diseases","volume":"121","author":"Yang","year":"2021","journal-title":"Acta. Biomater."},{"key":"10.1016\/j.ejps.2021.105935_bib0050","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1080\/03639045.2017.1414230","article-title":"An acryl resin-based swellable microneedles for controlled release intradermal delivery of granisetron","volume":"44","author":"Yang","year":"2017","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.ejps.2021.105935_bib0051","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.3390\/pharmaceutics12111067","article-title":"Development of lidocaine-loaded dissolving microneedle for rapid and efficient local anesthesia","volume":"12","author":"Yang","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejps.2021.105935_bib0052","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1111\/j.1365-2133.2005.06794.x","article-title":"Does facial sebum excretion really affect the development of acne?","volume":"153","author":"Youn","year":"2005","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.ejps.2021.105935_bib0053","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0923-1811(02)00046-4","article-title":"Differential regulation of thymus- and activation-regulated chemokine induced by IL-4, IL-13, TNF-\u03b1 and IFN-\u03b3 in human keratinocyte and fibroblast","volume":"30","author":"Yu","year":"2002","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.ejps.2021.105935_bib0054","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.actbio.2020.08.023","article-title":"Active pharmaceutical ingredient poly(ionic liquid)-based microneedles for the treatment of skin acne infection","volume":"115","author":"Zhang","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ejps.2021.105935_bib0055","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.addr.2018.12.006","article-title":"Advances in transdermal insulin delivery","volume":"139","author":"Zhang","year":"2018","journal-title":"Adv. Drug. Deliv. Rev."},{"key":"10.1016\/j.ejps.2021.105935_bib0056","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3390\/polym12010059","article-title":"Exploring trehalose on the release of levonorgestrel from implantable PLGA microneedles","volume":"12","author":"Zhao","year":"2020","journal-title":"Polymers"},{"key":"10.1016\/j.ejps.2021.105935_bib0057","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodhyd.2020.105702","article-title":"Fabrication and characterization of matrine-loaded konjac glucomannan\/fish gelatin composite hydrogel as antimicrobial wound dressing","volume":"104","author":"Zhou","year":"2020","journal-title":"Food Hydrocoll."},{"key":"10.1016\/j.ejps.2021.105935_bib0058","first-page":"727","article-title":"Cumulative irritation potential of metronidazole gel compared to azelaic acid gel after repeated applications to healthy skin","volume":"4","author":"Ziel","year":"2005","journal-title":"J. Drugs Dermatol."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098721002384?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098721002384?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T11:59:47Z","timestamp":1760529587000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098721002384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":57,"alternative-id":["S0928098721002384"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2021.105935","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acid-base combination principles for preparation of anti-acne dissolving microneedles loaded with azelaic acid and matrine","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2021.105935","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105935"}}