{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T11:39:55Z","timestamp":1791632395142,"version":"4.3.4"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.ejps.2021.105956","type":"journal-article","created":{"date-parts":[[2021,7,24]],"date-time":"2021-07-24T19:18:34Z","timestamp":1627154314000},"page":"105956","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Preclinical study of methotrexate-based hydrogels versus surfactant based liquid crystal systems on psoriasis treatment"],"prefix":"10.1016","volume":"165","author":[{"given":"Maria Tereza Carneiro Paschoal","family":"Bernardes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra Barbosa Neder","family":"Agostini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gislaine Ribeiro","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"La\u00edla Pereira","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssica Bassi","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Luciano","family":"Bruschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00f4mulo Dias","family":"Novaes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via Chiva","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2021.105956_bib0001","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1007\/s00280-012-2062-0","article-title":"A review of therapeutic challenges and achievements of methotrexate delivery systems for treatment of cancer and rheumatoid arthritis","volume":"71","author":"Abolmaali","year":"2013","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.ejps.2021.105956_bib0002","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1111\/j.1468-3083.2010.03619.x","article-title":"Patch testing in allergic contact dermatitis: Is it useful to perform the cosmetic series in addition to the European standard series?","volume":"24","author":"Ada","year":"2010","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.ejps.2021.105956_bib0003","first-page":"53","article-title":"IL-10 implications in psoriasis","volume":"2","author":"Al-Robaee","year":"2008","journal-title":"Int. J. Health Sci."},{"key":"10.1016\/j.ejps.2021.105956_bib0004","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3109\/1061186X.2015.1058804","article-title":"Microemulsions mediated effective delivery of methotrexate hydrogel: more than a tour de force in psoriasis therapeutics","volume":"24","author":"Amarji","year":"2016","journal-title":"J. Drug Target."},{"key":"10.1016\/j.ejps.2021.105956_bib0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2019.00536","article-title":"Defective induction of COX-2 expression by psoriatic fibroblasts promotes pro-inflammatory activation of macrophages","volume":"10","author":"Arasa","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejps.2021.105956_bib0006","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1001\/jama.2020.4006","article-title":"Pathophysiology, clinical presentation, and treatment of psoriasis: a review","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMA - J. Am. Med. Assoc."},{"key":"10.1016\/j.ejps.2021.105956_bib0007","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1517\/13543784.9.1.95","article-title":"The treatment of psoriasis with IL-10: rationale and review of the first clinical trials","volume":"9","author":"Asadullah","year":"2000","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.ejps.2021.105956_bib0008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/pharmaceutics12111055","article-title":"Development of a sildenafil citrate microemulsion-loaded hydrogel as a potential system for drug delivery to the penis and its cellular metabolic mechanism","volume":"12","author":"Atipairin","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejps.2021.105956_bib0009","doi-asserted-by":"crossref","first-page":"554","DOI":"10.3109\/10837450.2015.1026605","article-title":"A novel nanogel formulation of methotrexate for topical treatment of psoriasis: optimization, in vitro and in vivo evaluation","volume":"21","author":"Avasatthi","year":"2016","journal-title":"Pharm. Dev. Technol."},{"key":"10.1016\/j.ejps.2021.105956_bib0010","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.18632\/oncotarget.22260","article-title":"Serum levels of adipokines and cytokines in psoriasis patients: a systematic review and meta-analysis","volume":"9","author":"Bai","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejps.2021.105956_bib0011","article-title":"Thermoresponsive system composed of poloxamer 407 and HPMC or NaCMC: mechanical, rheological and sol-gel transition analysis","volume":"240","author":"Bassi da Silva","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejps.2021.105956_bib0012","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1016\/j.bbamem.2006.06.021","article-title":"The skin barrier in healthy and diseased state","volume":"1758","author":"Bouwstra","year":"2006","journal-title":"Biochim. Biophys. Acta - Biomembr."},{"key":"10.1016\/j.ejps.2021.105956_bib0013","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1002\/jps.20843","article-title":"Semisolid systems containing propolis for the treatment of periodontal disease: in vitro release kinetics, syringeability, rheological, textural, and mucoadhesive properties","volume":"96","author":"Bruschi","year":"2007","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2021.105956_bib0014","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.colsurfb.2014.01.014","article-title":"Amphotericin B topical microemulsion: formulation, characterization and evaluation","volume":"116","author":"Butani","year":"2014","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.ejps.2021.105956_bib0015","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.ad.2015.10.005","article-title":"Methotrexate in moderate to severe psoriasis: review of the literature and expert recommendations","volume":"107","author":"Carrascosa","year":"2016","journal-title":"Actas Dermo-Sifiliogr."},{"key":"10.1016\/j.ejps.2021.105956_bib0016","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.pdpdt.2015.05.003","article-title":"Investigation of anti-inflammatory and anti-proliferative activities promoted by photoactivated cationic porphyrin","volume":"12","author":"Carrenho","year":"2015","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"10.1016\/j.ejps.2021.105956_bib0017","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3390\/molecules21020231","article-title":"Bioadhesive surfactant systems for methotrexate skin delivery","volume":"21","author":"Cintra","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.ejps.2021.105956_bib0018","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/molecules22030419","article-title":"Spotlight on biomimetic systems based on lyotropic liquid crystal","volume":"22","author":"De Souza","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.ejps.2021.105956_bib0019","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ejpb.2016.05.012","article-title":"RNAi mediated IL-6 in vitro knockdown in psoriasis skin model with topical siRNA delivery system based on liquid crystalline phase","volume":"105","author":"Depieri","year":"2016","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejps.2021.105956_bib0020","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.jaad.2020.07.087","article-title":"Joint AAD\u2013NPF Guidelines of care for the management and treatment of psoriasis with topical therapy and alternative medicine modalities for psoriasis severity measures","volume":"84","author":"Elmets","year":"2021","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.ejps.2021.105956_bib0021","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1111\/j.1365-4632.2006.02911.x","article-title":"The treatment of psoriasis vulgaris: 1% topical methotrexate gel","volume":"45","author":"Eskicirak","year":"2006","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.ejps.2021.105956_bib0022","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jmbbm.2017.02.016","article-title":"Linear correlation between rheological, mechanical and mucoadhesive properties of polycarbophil polymer blends for biomedical applications","volume":"68","author":"Ferreira","year":"2017","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.ejps.2021.105956_bib0023","doi-asserted-by":"crossref","first-page":"931","DOI":"10.2217\/nnm-2018-0345","article-title":"Liquid crystalline nanoreservoir releasing a highly skin-penetrating berberine oleate complex for psoriasis management","volume":"14","author":"Freag","year":"2019","journal-title":"Nanomedicine"},{"key":"10.1016\/j.ejps.2021.105956_bib0024","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.ijpharm.2018.07.003","article-title":"Improvement of cutaneous delivery of methylene blue by liquid crystals","volume":"548","author":"Garcia","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2021.105956_bib0025","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.lfs.2016.03.019","article-title":"5\u03b1-Dihydrotestosterone enhances wound healing in diabetic rats","volume":"152","author":"Gon\u00e7alves","year":"2016","journal-title":"Life Sci"},{"key":"10.1016\/j.ejps.2021.105956_bib0026","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.prp.2013.07.006","article-title":"Comparative study of the effects of laser photobiomodulation and extract of Brassica oleracea on skin wounds in Wistar rats: a histomorphometric study","volume":"209","author":"Gon\u00e7alves","year":"2013","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.ejps.2021.105956_bib0027","first-page":"55","article-title":"Topical psoriasis therapies and unmet patient needs: the importance of optimizing methotrexate","volume":"97","author":"Greenberg","year":"2016","journal-title":"Cutis"},{"key":"10.1016\/j.ejps.2021.105956_bib0028","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.mvr.2014.10.007","article-title":"Trypanosoma cruzi antigens induce inflammatory angiogenesis in a mouse subcutaneous sponge model","volume":"97","author":"Guedes-da-Silva","year":"2015","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.ejps.2021.105956_bib0029","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/intimm\/dxy087","article-title":"Prostanoids and leukotrienes in the pathophysiology of atopic dermatitis and psoriasis","volume":"31","author":"Honda","year":"2019","journal-title":"Int. Immunol."},{"key":"10.1016\/j.ejps.2021.105956_bib0030","doi-asserted-by":"crossref","first-page":"6978","DOI":"10.1039\/C7RA12008G","article-title":"Factors affecting the structure of lyotropic liquid crystals and the correlation between structure and drug diffusion","volume":"8","author":"Huang","year":"2018","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejps.2021.105956_bib0031","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0235076","article-title":"Biologic excipients: Importance of clinical awareness of inactive ingredients","volume":"15","author":"Ionova","year":"2020","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ejps.2021.105956_bib0032","doi-asserted-by":"crossref","first-page":"32","DOI":"10.32007\/jfacmedbagdad.5211047","article-title":"Topical methotrexate for treatment of psoriasis: formulation and clinical implications","volume":"52","author":"Jabur","year":"2010","journal-title":"J. Faculty Med."},{"key":"10.1016\/j.ejps.2021.105956_bib0033","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.colsurfb.2016.03.008","article-title":"Statistical modelling of the rheological and mucoadhesive properties of aqueous poly (methylvinylether-co-maleic-acid) networks: redefining biomedical applications and the relationship between viscoelasticity and mucoadhesion","volume":"144","author":"Jones","year":"2016","journal-title":"Colloids Surf. B"},{"key":"10.1016\/j.ejps.2021.105956_bib0034","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4049\/jimmunol.1101029","article-title":"Regulation of immune responses by prostaglandin E2","volume":"188","author":"Kalinski","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejps.2021.105956_bib0035","doi-asserted-by":"crossref","first-page":"161","DOI":"10.2310\/7750.2007.00045","article-title":"North American efficacy and safety of a novel pediculicide rinse, isopropyl myristate 50% (resultz)","volume":"11","author":"Kaul","year":"2007","journal-title":"J. Cutan. Med. Surg."},{"key":"10.1016\/j.ejps.2021.105956_bib0036","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1046\/j.1365-2230.2002.00975.x","article-title":"Evaluation of skin surface hydration in Korean psoriasis patients: a possible factor influencing psoriasis","volume":"27","author":"Kim","year":"2002","journal-title":"Clin. Exp. Dermatol."},{"key":"10.1016\/j.ejps.2021.105956_bib0037","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40005-014-0165-9","article-title":"Lyotropic liquid crystal systems in drug delivery: a review","volume":"45","author":"Kim","year":"2015","journal-title":"J. Pharm. Investig."},{"key":"10.1016\/j.ejps.2021.105956_bib0038","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.cis.2006.05.014","article-title":"Microemulsions as transdermal drug delivery vehicles","volume":"123\u2013126","author":"Kogan","year":"2006","journal-title":"Adv. Colloid Interface Sci."},{"key":"10.1016\/j.ejps.2021.105956_bib0039","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1111\/j.1346-8138.2004.tb00602.x","article-title":"Topical 0.25% methotrexate gel in a hydrogel base for palmoplantar psoriasis","volume":"31","author":"Kumar","year":"2004","journal-title":"J. Dermatol."},{"key":"10.1016\/j.ejps.2021.105956_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijadhadh.2021.102857","article-title":"Mucoadhesive properties of polyacrylates: structure \u2013 function relationship","volume":"107","author":"Lam","year":"2021","journal-title":"Int. J. Adhes. Adhes."},{"key":"10.1016\/j.ejps.2021.105956_bib0041","series-title":"M\u00e9todos quantitativos em morfologia","author":"Mandarin-de-Lacerda","year":"1995"},{"key":"10.1016\/j.ejps.2021.105956_bib0042","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1590\/S0365-05962004000300002","article-title":"Tratamento sist\u00eamico da psor\u00edase-Parte I: metotrexato e acitretina","volume":"79","author":"Martins","year":"2004","journal-title":"Anais Brasil. Dermatol."},{"key":"10.1016\/j.ejps.2021.105956_bib0043","unstructured":"Mendiburu, F., (2017). Tutorial de agricolae (Versi\u00f3n 1.2-8)."},{"key":"10.1016\/j.ejps.2021.105956_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104907","article-title":"Could phenothiazine-benzimidazole combined chemotherapy be effective in controlling heart parasitism and acute infectious myocarditis?","volume":"158","author":"Mendon\u00e7a","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejps.2021.105956_bib0045","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.3892\/ijmm.2017.2930","article-title":"Paeonol ameliorates imiquimod-induced psoriasis-like skin lesions in BALB\/c mice by inhibiting the maturation and activation of dendritic cells","volume":"39","author":"Meng","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.ejps.2021.105956_bib0046","doi-asserted-by":"crossref","first-page":"4326","DOI":"10.1039\/C4SM02786H","article-title":"Phase behavior of skin lipid mixtures: the effect of cholesterol on lipid organization","volume":"11","author":"Mojumdar","year":"2015","journal-title":"Soft Matter"},{"key":"10.1016\/j.ejps.2021.105956_bib0047","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1615\/CritRevTherDrugCarrierSyst.2013005268","article-title":"Psoriasis clinical implications and treatment: a review","volume":"30","author":"Raut","year":"2013","journal-title":"Crit. Rev. Ther. Drug Carrier Syst."},{"key":"10.1016\/j.ejps.2021.105956_bib0048","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.niox.2017.02.013","article-title":"S. mansoni-T. cruzi co-infection modulates arginase-1\/iNOS expression, liver and heart disease in mice","volume":"66","author":"Rodrigues","year":"2017","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.ejps.2021.105956_bib0049","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3109\/10717544.2014.914601","article-title":"Effect of microemulsion in topical sertaconazole hydrogel: in vitro and in vivo study","volume":"23","author":"Sahoo","year":"2016","journal-title":"Drug Deliv."},{"key":"10.1016\/j.ejps.2021.105956_bib0050","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1111\/jphp.12451","article-title":"Modulation of oxidative and inflammatory cardiac response by nonselective 1- and 2-cyclooxygenase inhibitor and benznidazole in mice","volume":"67","author":"Santos","year":"2015","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejps.2021.105956_bib0051","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1080\/17425247.2020.1819979","article-title":"Advances in lyotropic liquid crystal systems for skin drug delivery","volume":"17","author":"Silvestrin","year":"2020","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.ejps.2021.105956_bib0052","first-page":"459","article-title":"Formulation of microemulsion gel systems for transdermal delivery of celecoxib\u00a0: in vitro permeation, anti-inflammatory activity and skin irritation tests","volume":"4","author":"Soliman","year":"2010","journal-title":"Drug Discov. Ther."},{"key":"10.1016\/j.ejps.2021.105956_bib0053","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.ijpharm.2012.01.045","article-title":"Physicochemical characteristics of methotrexate-entrapped oleic acid-containing deformable liposomes for in vitro transepidermal delivery targeting psoriasis treatment","volume":"427","author":"Srisuk","year":"2012","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2021.105956_bib0054","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1177\/120347540100500403","article-title":"Nordstrom, S M Ali, Management of psoriasis vulgaris with methotrexate 0.25% in a hydrophilic gel: a placebo-controlled, double-blind study","volume":"5","author":"Syed","year":"2001","journal-title":"J. Cutan. Med. Surg."},{"key":"10.1016\/j.ejps.2021.105956_bib0055","series-title":"Consenso Brasileiro de Psor\u00edase","author":"Takahashi","year":"2009"},{"key":"10.1016\/j.ejps.2021.105956_bib0056","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3109\/09546634.2012.755250","article-title":"Evaluation of the effect of tacrolimus-loaded liquid crystalline nanoparticles on psoriasis-like skin inflammation","volume":"25","author":"Thapa","year":"2014","journal-title":"J. Dermatolog. Treat."},{"key":"10.1016\/j.ejps.2021.105956_bib0057","unstructured":"Von Zuben, E.D.S. (2012). Desenvolvimento e caracteriza\u00e7\u00e3o de sistemas l\u00edquido-cristalinos para aplica\u00e7\u00e3o t\u00f3pica de metotrexato: estudos de libera\u00e7\u00e3o, reten\u00e7\u00e3o e permea\u00e7\u00e3o in vitro. http:\/\/bdtd.ibict.br\/vufind\/Record\/UNSP_92ce6c2fdcf5a9b226d56621ccd6678d (acessed 19 jan. 2021)."},{"key":"10.1016\/j.ejps.2021.105956_bib0058","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ejpb.2012.05.016","article-title":"Transdermal delivery of the anti-rheumatic agent methotrexate using a solid-in-oil nanocarrier","volume":"82","author":"Yang","year":"2012","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejps.2021.105956_bib0059","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ijpharm.2014.12.055","article-title":"Transdermal baicalin delivery using diethylene glycol monoethyl ether-mediated cubic phase gel","volume":"479","author":"Zhang","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2021.105956_bib60","unstructured":"R Core Team (2020). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna. (Version 4.0.2)."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098721002591?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098721002591?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T12:01:07Z","timestamp":1760529667000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098721002591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":60,"alternative-id":["S0928098721002591"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2021.105956","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preclinical study of methotrexate-based hydrogels versus surfactant based liquid crystal systems on psoriasis treatment","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2021.105956","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105956"}}