{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:21:53Z","timestamp":1792444913925,"version":"4.5.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,15]],"date-time":"2022-10-15T00:00:00Z","timestamp":1665792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.ejps.2022.106308","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T12:21:55Z","timestamp":1666182115000},"page":"106308","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Biopharmaceutical, preclinical pharmacokinetic and pharmaco-dynamic investigations of an orally administered novel 3-nbutylphthalide prodrug for ischemic stroke treatment"],"prefix":"10.1016","volume":"180","author":[{"given":"Qiang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yikun","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglin","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhirong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9598-9111","authenticated-orcid":false,"given":"Qing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2022.106308_bib0048","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s11011-018-0378-0","article-title":"Neuroprotective effect of ethanol and Modafinil on focal cerebral ischemia in rats","volume":"34","author":"Abbasi","year":"2019","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.ejps.2022.106308_bib0016","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/5012341","article-title":"A Review of Recent Advances in Neuroprotective Potential of 3-N-Butylphthalide and Its Derivatives","volume":"2016","author":"Abdoulaye","year":"2016","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.ejps.2022.106308_bib0007","first-page":"1866","article-title":"Current advances in ischemic stroke research and therapies","author":"Barthels","year":"2020","journal-title":"Biochimica et Biophysica Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.ejps.2022.106308_bib0047","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.biopha.2016.11.057","article-title":"Brown propolis attenuates cerebral ischemia-induced oxidative damage via affecting antioxidant enzyme system in mice","volume":"85","author":"Bazmandegan","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejps.2022.106308_bib0053","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/S0168-8278(99)80281-5","article-title":"Antioxidant status and glutathione metabolism in peripheral blood mononuclear cells from patients with chronic hepatitis C","volume":"31","author":"Boya","year":"1999","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ejps.2022.106308_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104877","article-title":"Therapeutic targets of oxidative\/nitrosative stress and neuroinflammation in ischemic stroke: applications for natural product efficacy with omics and systemic biology","volume":"158","author":"Chen","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejps.2022.106308_bib0054","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.freeradbiomed.2005.06.025","article-title":"Potential markers of oxidative stress in stroke","volume":"39","author":"Cherubini","year":"2005","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejps.2022.106308_bib0029","unstructured":"China, M.O.P.H.O.T.P.S.R.O. Pharmacopoeia of the People's Republic of China, Place: China Medical Science Press; Vol. 646, 2020."},{"key":"10.1016\/j.ejps.2022.106308_bib0005","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1056\/NEJMoa1804492","article-title":"Global, regional, and country-specific lifetime risks of stroke, 1990 and 2016","volume":"379","author":"Feigin","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejps.2022.106308_bib0027","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcp.2018.06.010","article-title":"Evaluating the intestinal and oral absorption of the prodrug valacyclovir in wildtype and huPepT1 transgenic mice","volume":"155","author":"Epling","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejps.2022.106308_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2020.147046","article-title":"Dl-3-n-butylphthalide attenuates hypoxic-ischemic brain injury through inhibiting endoplasmic reticulum stress-induced cell apoptosis and alleviating blood-brain barrier disruption in newborn rats","volume":"1747","author":"Fang","year":"2020","journal-title":"Brain Res."},{"key":"10.1016\/j.ejps.2022.106308_bib0004","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S1474-4422(09)70025-0","article-title":"Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review","volume":"8","author":"Feigin","year":"2009","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ejps.2022.106308_bib0001","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S1474-4422(16)30073-4","article-title":"Global burden of stroke and risk factors in 188 countries, during 1990\u20132013: a systematic analysis for the Global Burden of Disease Study 2013","volume":"15","author":"Feigin","year":"2016","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ejps.2022.106308_bib0050","first-page":"3445","article-title":"Animal models of ischemic stroke and their application in clinical research","volume":"9","author":"Fluri","year":"2015","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.ejps.2022.106308_bib0028","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ejps.2017.06.005","article-title":"Evaluation of the cytotoxicity and intestinal absorption of a self-emulsifying drug delivery system containing sodium taurocholate","volume":"106","author":"Gao","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2022.106308_bib0035","first-page":"424","article-title":"Determination of ionization constant of sophoridine by spectrophotometric indicator method","volume":"17","author":"GuoQing","year":"2000","journal-title":"J. Shenyang Pharmaceut. Univ."},{"key":"10.1016\/j.ejps.2022.106308_bib0058","doi-asserted-by":"crossref","unstructured":"Han, P., Ma, X. & Yin, J. The effects of lipoic acid on soybean Archives of Animal Nutrition. 2010; 64: 254\u2013264.","DOI":"10.1080\/17450391003625003"},{"key":"10.1016\/j.ejps.2022.106308_bib0011","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0140-6736(16)30962-X","article-title":"Stroke","volume":"389","author":"Hankey","year":"2017","journal-title":"Lancet."},{"key":"10.1016\/j.ejps.2022.106308_bib0057","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1159\/000485089","article-title":"Antioxidants maintain cellular redox homeostasis by elimination of reactive oxygen species","volume":"44","author":"He","year":"2017","journal-title":"Cell Physiol. Biochem."},{"key":"10.1016\/j.ejps.2022.106308_bib0049","first-page":"17","article-title":"Neuroprotective effect of salvianolic acids against cerebral ischemia\/reperfusion injury","author":"Hou","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejps.2022.106308_bib0019","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.phrs.2018.08.007","article-title":"From stroke to neurodegenerative diseases: the multi-target neuroprotective effects of 3-n-butylphthalide and its derivatives","volume":"135","author":"Huang","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejps.2022.106308_bib0039","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.ejps.2009.03.015","article-title":"Application of biorelevant dissolution tests to the prediction of in vivo performance of diclofenac sodium from an oral modified-release pellet dosage form","volume":"37","author":"Jantratid","year":"2009","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.ejps.2022.106308_bib0010","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/jcbfm.2013.203","article-title":"Hemorrhagic transformation after ischemic stroke in animals and humans","volume":"34","author":"Jickling","year":"2013","journal-title":"J. Cereb. Blood Flow Metabol."},{"key":"10.1016\/j.ejps.2022.106308_bib0055","first-page":"153","article-title":"Role of propolis on oxidative stress in fish brain","volume":"4","author":"Kakoolaki","year":"2013","journal-title":"Basic Clin. Neurosci."},{"key":"10.1016\/j.ejps.2022.106308_bib0044","doi-asserted-by":"crossref","first-page":"433","DOI":"10.5507\/bp.2005.075","article-title":"Intestinal single-pass in situ perfusion technique in rat: the influence of l-carnitine on absorption of 7-methoxytacrine","volume":"149","author":"Kunes","year":"2005","journal-title":"Biomed. Pap."},{"key":"10.1016\/j.ejps.2022.106308_bib0045","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.ejps.2013.08.025","article-title":"Regional intestinal drug permeation: biopharmaceutics and drug development","volume":"57","author":"Lennernas","year":"2014","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2022.106308_bib0023","doi-asserted-by":"crossref","first-page":"3174","DOI":"10.1021\/mp500352p","article-title":"Brain-specific delivery of dopamine mediated by n,n-dimethyl amino group for the treatment of Parkinson's disease","volume":"11","author":"Li","year":"2014","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejps.2022.106308_bib0020","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/aps.2017.90","article-title":"Conversion and pharmacokinetics profiles of a novel pro-drug of 3-n-butylphthalide, potassium 2-(1-hydroxypentyl)-benzoate, in rats and dogs","volume":"39","author":"Li","year":"2018","journal-title":"Acta Pharmacol. Sin"},{"key":"10.1016\/j.ejps.2022.106308_bib0033","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/aps.2015.27","article-title":"Intestinal absorption characteristics of imperialine: in vitro and in situ assessments","volume":"36","author":"Lin","year":"2015","journal-title":"Acta Pharmacol. Sin"},{"key":"10.1016\/j.ejps.2022.106308_bib0008","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1136\/svn-2020-000378","article-title":"Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders: executive summary and 2019 update of clinical management of ischaemic cerebrovascular diseases","volume":"5","author":"Liu","year":"2020","journal-title":"Stroke Vasc. Neurol."},{"key":"10.1016\/j.ejps.2022.106308_bib0009","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1001\/jama.286.4.442","article-title":"Bolus Fibrinolytic therapy in acute myocardial infarction","volume":"286","author":"Llevadot","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.ejps.2022.106308_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2020.105338","article-title":"Successful oral delivery of fexofenadine hydrochloride by improving permeability via phospholipid complexation","volume":"149","author":"Mandeep","year":"2020","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.ejps.2022.106308_bib0056","doi-asserted-by":"crossref","first-page":"31426","DOI":"10.1074\/jbc.M212549200","article-title":"Malondialdehyde, a product of lipid peroxidation, is mutagenic in human cells","volume":"278","author":"Niedernhofer","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejps.2022.106308_bib0046","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0140-6736(10)60834-3","article-title":"Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study","volume":"376","author":"O'Donnell","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.ejps.2022.106308_bib0025","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1124\/dmd.108.022087","article-title":"Involvement of the pyrilamine transporter, a putative organic cation transporter, in blood-brain barrier transport of oxycodone","volume":"36","author":"Okura","year":"2008","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejps.2022.106308_bib0036","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1177\/2472555218812821","article-title":"OCTN: a small transporter subfamily with great relevance to human pathophysiology, drug discovery, and diagnostics","volume":"24","author":"Pochini","year":"2018","journal-title":"SLAS DISCOVERY"},{"key":"10.1016\/j.ejps.2022.106308_bib0060","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1055\/s-0033-1348262","article-title":"Antioxidant defense in overt and subclinical hypothyroidism","volume":"45","author":"Reddy","year":"2013","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.ejps.2022.106308_bib0026","doi-asserted-by":"crossref","first-page":"3912","DOI":"10.1002\/jps.22567","article-title":"Diphenhydramine active uptake at the blood\u2013brain barrier and its interaction with oxycodone in vitro and in vivo","volume":"100","author":"Sadiq","year":"2011","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2022.106308_bib0003","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1212\/WNL.0b013e3182a4a451","article-title":"Recognition and management of stroke in young adults and adolescents","volume":"81","author":"Singhal","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.ejps.2022.106308_bib0032","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.ijpharm.2014.11.035","article-title":"In situ perfusion in rodents to explore intestinal drug absorption: challenges and opportunities","volume":"478","author":"Stappaerts","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2022.106308_bib0042","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ejpb.2020.03.019","article-title":"Effect of supersaturation on absorption of indomethacin and tadalafil in a single pass intestinal perfusion rat model, in the absence and presence of a precipitation inhibitor","volume":"151","author":"Strindberg","year":"2020","journal-title":"Eur. J. Pharmaceut. Biopharmaceut."},{"key":"10.1016\/j.ejps.2022.106308_bib0052","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ab.2016.10.021","article-title":"Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: analytical and biological challenges","volume":"524","author":"Tsikas","year":"2017","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ejps.2022.106308_bib0041","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ejps.2019.04.013","article-title":"Impact of regional differences along the gastrointestinal tract of healthy adults on oral drug absorption: an UNGAP review","volume":"134","author":"Vertzoni","year":"2019","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.ejps.2022.106308_bib0030","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1021\/mp200162b","article-title":"Provisional biopharmaceutical classification of some common herbs used in western medicine","volume":"9","author":"Waldmann","year":"2012","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejps.2022.106308_bib0021","doi-asserted-by":"crossref","first-page":"3078","DOI":"10.1021\/jm4001693","article-title":"Novel hybrids of optically active ring-opened 3-n-butylphthalide derivative and isosorbide as potential anti-ischemic stroke agents","volume":"56","author":"Wang","year":"2013","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejps.2022.106308_bib0051","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2020.00848","article-title":"Melatonin enhances the therapeutic effect of plasma exosomes against cerebral ischemia-induced pyroptosis through the TLR4\/NF-\u03baB pathway","volume":"14","author":"Wang","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.ejps.2022.106308_bib0037","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/BF01064809","article-title":"Shift of pH-absorption curves","volume":"5","author":"Winne","year":"1977","journal-title":"J. Pharmacokinet. Biopharm."},{"key":"10.1016\/j.ejps.2022.106308_bib0034","doi-asserted-by":"crossref","DOI":"10.1177\/00368504211016935","article-title":"Body surface area-based equivalent dose calculation in tree shrew","volume":"104","author":"Xia","year":"2021","journal-title":"Sci. Prog."},{"key":"10.1016\/j.ejps.2022.106308_bib0024","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.jconrel.2021.05.045","article-title":"Novel brain-targeting 3-n-butylphthalide prodrugs for ischemic stroke treatment","volume":"335","author":"Xiang","year":"2021","journal-title":"J. Controlled Rel."},{"key":"10.1016\/j.ejps.2022.106308_bib0017","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.3892\/etm.2016.3139","article-title":"Efficacy and safety comparison of DL-3-n-butylphthalide and Cerebrolysin: effects on neurological and behavioral outcomes in acute ischemic stroke","volume":"11","author":"Xue","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.ejps.2022.106308_bib0059","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ejphar.2015.12.003","article-title":"Protective effects of mangiferin on cerebral ischemia-reperfusion injury and its mechanisms","volume":"771","author":"Yang","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejps.2022.106308_bib0012","doi-asserted-by":"crossref","first-page":"964","DOI":"10.14336\/AD.2019.0608","article-title":"Dl-3-n-butylphthalide reduces neurovascular inflammation and ischemic brain injury in mice","volume":"10","author":"Yang","year":"2019","journal-title":"Aging Dis."},{"key":"10.1016\/j.ejps.2022.106308_bib0043","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.00711","article-title":"The absorption characteristics of nonvolatile components in a water extraction from Amomi fructus as determined by in situ single-pass intestinal perfusion and high-performance liquid chromatography","volume":"11","author":"Yao","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.ejps.2022.106308_bib0031","first-page":"501","article-title":"Determination of apparent solubility, apparent partition coefficient and dissociation constant of tetrandrine","volume":"28","author":"Ying","year":"2013","journal-title":"West China J. Pharmaceut. Sci."},{"key":"10.1016\/j.ejps.2022.106308_bib0006","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1161\/01.STR.0000087149.42294.8C","article-title":"Proportion of different subtypes of stroke in China","volume":"34","author":"Zhang","year":"2003","journal-title":"Stroke."},{"key":"10.1016\/j.ejps.2022.106308_bib0022","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1055\/s-0032-1306273","article-title":"Novel brain targeting prodrugs of naproxen based on dimethylamino group with various linkages","volume":"62","author":"Zhang","year":"2012","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.ejps.2022.106308_bib0018","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.1469","article-title":"Effects of dl-3-n-butylphthalide on serum lipoprotein-associated phospholipase A2 and hypersensitive C-reactive protein levels in acute cerebral infarction","volume":"9","author":"Zhang","year":"2019","journal-title":"Brain Behav."},{"key":"10.1016\/j.ejps.2022.106308_bib0040","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1208\/s12249-020-01906-7","article-title":"Determination and comparison of the solubility, oil\u2013water partition coefficient, intestinal absorption, and biliary excretion of carvedilol enantiomers","volume":"22","author":"Zhang","year":"2021","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ejps.2022.106308_bib0015","doi-asserted-by":"crossref","first-page":"719","DOI":"10.4103\/1673-5374.131576","article-title":"3-N-butylphthalide improves neuronal morphology after chronic cerebral ischemia","volume":"9","author":"Zhao","year":"2014","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.ejps.2022.106308_bib0002","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/S0140-6736(19)30427-1","article-title":"Mortality, morbidity, and risk factors in China and its provinces, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"394","author":"Zhou","year":"2019","journal-title":"Lancet"}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098722001932?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098722001932?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T12:04:07Z","timestamp":1760529847000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098722001932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":60,"alternative-id":["S0928098722001932"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2022.106308","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biopharmaceutical, preclinical pharmacokinetic and pharmaco-dynamic investigations of an orally administered novel 3-nbutylphthalide prodrug for ischemic stroke treatment","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2022.106308","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106308"}}